Novel P2X 7 receptor antagonists ease the pain

British Journal of Pharmacology

Volumn 151, Issue 5, 2007, Pages 565-567

  King, B F ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Analgesic; Antinociception; ATP; Inflammation; Microglia; P2X 7 receptor; P2Z receptor; Pain

Indexed keywords

1 [N,O BIS(5 ISOQUINOLINESULFONYL) N METHYLTYROSYL] 4 PHENYLPIPERAZINE; 3 [5 (2,3 DICHLOROPHENYL) 1H TETRAZOL 1 YL]METHYLPYRIDINE; 5 [[3 PHENOXYBENZYL(1,2,3,4 TETRAHYDRO 1 NAPHTHALENYL)AMINO]CARBONYL] 1,2,4 BENZENETRICARBOXYLIC ACID; A 317491; A 438079; A 740003; ADENOSINE TRIPHOSPHATE; AMILORIDE; CALMODAZOLIUM; CIBACRON BLUE F3GA; GUANIDINE DERIVATIVE; N [1 [[CYANOIMINO(5 QUINOLINYLAMINO)METHYL]AMINO] 2,2 DIMETHYLPROPYL] 2 (3,4 DIMETHOXYPHENYL)ACETAMIDE; PROTEIN KINASE (CALCIUM,CALMODULIN) II; PROTEIN SERINE THREONINE KINASE INHIBITOR; PURINE P2X RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID; SURAMIN; TETRAZOLE DERIVATIVE; UNCLASSIFIED DRUG; (N (1 (((CYANOIMINO)(5 QUINOLINYLAMINO) METHYL) AMINO) 2,2 DIMETHYLPROPYL) 2 (3,4 DIMETHOXYPHENYL)ACETAMIDE); (N-(1-(((CYANOIMINO)(5-QUINOLINYLAMINO) METHYL) AMINO)-2,2-DIMETHYLPROPYL)-2-(3,4-DIMETHOXYPHENYL)ACETAMIDE); A-317491; ACETAMIDE DERIVATIVE; ANALGESIC AGENT; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE TYPE 2; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; MAGNESIUM; PHENOL DERIVATIVE; POLYCYCLIC HYDROCARBON; PROTEIN KINASE (CALCIUM,CALMODULIN); PURINE P2 RECEPTOR; PURINE P2X7 RECEPTOR; QUINOLINE DERIVATIVE;

ANALGESIA; CHRONIC PAIN; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; HUMAN; MICROGLIA; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; ANIMAL; ARTICLE; DRUG ANTAGONISM; DRUG EFFECT; NERVE ENDING; PAIN; PHYSIOLOGY; SENSORY NERVE CELL;

ACETAMIDES; ANALGESICS, NON-NARCOTIC; ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; HUMANS; MAGNESIUM; NERVE ENDINGS; NEURONS, AFFERENT; PAIN; PHENOLS; POLYCYCLIC COMPOUNDS; QUINOLINES; RECEPTORS, PURINERGIC P2;

EID: 34347349007     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0707266     Document Type: Review

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