ATP release from non-excitable cells

Purinergic Signalling

Volumn 5, Issue 4, 2009, Pages 433-446

  Praetorius, Helle A ^a   Leipziger, Jens ^a  

^a AARHUS UNIVERSITY   (Denmark)

Author keywords

ATP secretion; Biosensor; Epithelia; Exocytosis; Luciferase; Mechano sensation; P2 receptor

Indexed keywords

EID: 70949092462     PISSN: 15739538     EISSN: 15739546     Source Type: Journal    
DOI: 10.1007/s11302-009-9146-2     Document Type: Review

References (140)

1. KM Spyer N Dale AV Gourine 2004 ATP is a key mediator of central and peripheral chemosensory transduction Exp Physiol 89 53 59 15109209
2. A Fabbro A Skorinkin M Grandolfo A Nistri R Giniatullin 2004 Quantal release of ATP from clusters of PC12 cells J Physiol 560 505 517 15331685
3. TE Finger V Danilova J Barrows DL Bartel AJ Vigers L Stone G Hellekant SC Kinnamon 2005 ATP signaling is crucial for communication from taste buds to gustatory nerves Science 310 1495 1499 16322458
4. AV Gourine E Llaudet N Dale KM Spyer 2005 ATP is a mediator of chemosensory transduction in the central nervous system Nature 436 108 111 16001070
5. AV Gourine E Llaudet N Dale KM Spyer 2005 Release of ATP in the ventral medulla during hypoxia in rats: role in hypoxic ventilatory response J Neurosci 25 1211 1218 15689558
6. CC Hegg D Greenwood W Huang P Han MT Lucero 2003 Activation of purinergic receptor subtypes modulates odor sensitivity J Neurosci 23 8291 8301 12967991
7. GD Housley DJ Jagger D Greenwood NP Raybould SG Salih LE Jarlebark SM Vlajkovic R Kanjhan P Nikolic DJ Munoz PR Thorne 2002 Purinergic regulation of sound transduction and auditory neurotransmission Audiol Neurootol 7 55 61 11914528
8. EA Newman 2006 A purinergic dialogue between glia and neurons in the retina Novartis Found Symp 276 193 202 16805431
9. 4 receptors induced in spinal microglia gate tactile allodynia after nerve injury Nature 424 778 783 12917686
10. YJ Huang Y Maruyama G Dvoryanchikov E Pereira N Chaudhari SD Roper 2007 The role of pannexin 1 hemichannels in ATP release and cell-cell communication in mouse taste buds Proc Natl Acad Sci U S A 104 6436 6441 17389364
11. P Komlosi J Peti-Peterdi AL Fuson A Fintha L Rosivall PD Bell 2004 Macula densa basolateral ATP release is regulated by luminal [NaCl] and dietary salt intake Am J Physiol Renal Physiol 286 F1054 F1058 14749255
12. J Schnermann DZ Levine 2003 Paracrine factors in tubuloglomerular feedback: adenosine, ATP, and nitric oxide Annu Rev Physiol 65 501 529 12208992
13. Y Chen R Corriden Y Inoue L Yip N Hashiguchi A Zinkernagel V Nizet PA Insel WG Junger 2006 ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors Science 314 1792 1795 17170310
14. C Gachet 2006 Regulation of platelet functions by p2 receptors Annu Rev Pharmacol Toxicol 46 277 300 16402906
15. P Bodin G Burnstock 2001 Purinergic signalling: ATP release Neurochem Res 26 959 969 11699948
16. I von Kügelgen J Goncalves B Driessen K Starke 1998 Corelease of noradrenaline and adenosine triphosphate from sympathetic neurones Adv Pharmacol 42 120 125
17. S Obermuller A Lindqvist J Karanauskaite J Galvanovskis P Rorsman S Barg 2005 Selective nucleotide-release from dense-core granules in insulin-secreting cells J Cell Sci 118 4271 4282 16141231
18. I Novak 2003 ATP as a signaling molecule: the exocrine focus News Physiol Sci 18 12 17 12531926
19. ER Lazarowski RC Boucher TK Harden 2003 Mechanisms of release of nucleotides and integration of their action as P2X- and P2Y-receptor activating molecules Mol Pharmacol 64 785 795 14500734
20. EM Schwiebert A Zsembery 2003 Extracellular ATP as a signaling molecule for epithelial cells Biochim Biophys Acta 1615 7 32 12948585
21. MP Abbracchio G Burnstock JM Boeynaems EA Barnard JL Boyer C Kennedy GE Knight M Fumagalli C Gachet KA Jacobson GA Weisman 2006 International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy Pharmacol Rev 58 281 341 16968944
22. KV Wood YA Lam WD McElroy 1989 Introduction to beetle luciferases and their applications J Biolumin Chemilumin 4 289 301 2678917
23. Z Wang PG Haydon ES Yeung 2000 Direct observation of calcium-independent intercellular ATP signaling in astrocytes Anal Chem 72 2001 2007 10815957
24. JL Denburg WD McElroy 1970 Anion inhibition of firefly luciferase Arch Biochem Biophys 141 668 675 5497150
25. JA Gruenhagen P Lovell LL Moroz ES Yeung 2004 Monitoring real-time release of ATP from the molluscan central nervous system J Neurosci Methods 139 145 152 15488226
26. JA Gruenhagen ES Yeung 2004 Investigation of G protein-initiated, Ca2+-dependent release of ATP from endothelial cells Biochim Biophys Acta 1693 135 146 15313015
27. F Boudreault R Grygorczyk 2002 Cell swelling-induced ATP release and gadolinium-sensitive channels Am J Physiol Cell Physiol 282 C219 C226 11742815
28. GJ Liu EL Werry MR Bennett 2005 Secretion of ATP from Schwann cells in response to uridine triphosphate Eur J Neurosci 21 151 160 15654852
29. Okada, S., Paradiso, A. M., Lazarowski, E. R., and Boucher, R. C. A calcium-dependent pathway in swelling-induced ATP release from airway epithelial cells. J Physiol 567P, C53. 2006. Abstract
30. SM Joseph MR Buchakjian GR Dubyak 2003 Colocalization of ATP release sites and ecto-ATPase activity at the extracellular surface of human astrocytes J Biol Chem 278 23331 23342 12684505
31. R Beigi E Kobatake M Aizawa GR Dubyak 1999 Detection of local ATP release from activated platelets using cell surface-attached firefly luciferase Am J Physiol 276 C267 C278 9886943
32. SF Okada RA Nicholas SM Kreda ER Lazarowski RC Boucher 2006 Physiological regulation of ATP release at the apical surface of human airway epithelia J Biol Chem 281 22992 23002 16754672
33. M Nakamura M Mie H Funabashi K Yamamoto J Ando E Kobatake 2006 Cell-surface-localized ATP detection with immobilized firefly luciferase Anal Biochem 352 61 67 16564487
34. P Pellegatti S Falzoni P Pinton R Rizzuto F Di Virgilio 2005 A novel recombinant plasma membrane-targeted luciferase reveals a new pathway for ATP secretion Mol Biol Cell 16 3659 3665 15944221
35. EA Newman 2001 Propagation of intercellular calcium waves in retinal astrocytes and Muller cells J Neurosci 21 2215 2223 11264297
36. G Arcuino JH Lin T Takano C Liu L Jiang Q Gao J Kang M Nedergaard 2002 Intercellular calcium signaling mediated by point-source burst release of ATP Proc Natl Acad Sci U S A 99 9840 9845 12097649
37. CE Sorensen I Novak 2001 Visualization of ATP release in pancreatic acini in response to cholinergic stimulus. Use of fluorescent probes and confocal microscopy J Biol Chem 276 32925 32932 11387334
38. R Corriden PA Insel WG Junger 2007 A novel method using fluorescence microscopy for real-time assessment of ATP release from individual cells Am J Physiol Cell Physiol 293 C1420 C1425 17699635
39. TR Cheek TR Jackson AJ O'Sullivan RB Moreton MJ Berridge RD Burgoyne 1989 Simultaneous measurements of cytosolic calcium and secretion in single bovine adrenal chromaffin cells by fluorescent imaging of fura-2 in cocultured cells J Cell Biol 109 1219 1227 2768340
40. V Ralevic G Burnstock 1998 Receptors for purines and pyrimidines Pharmacol Rev 50 413 492 9755289
41. Y Osipchuk M Cahalan 1992 Cell-to-cell spread of calcium signals mediated by ATP receptors in mast cells Nature 359 241 244 1388246
42. A Hazama S Hayashi Y Okada 1998 Cell surface measurements of ATP release from single pancreatic beta cells using a novel biosensor technique Pflügers Arch Eur J Physiol 437 31 35
43. S Hayashi A Hazama AK Dutta RZ Sabirov Y Okada 2004 Detecting ATP release by a biosensor method Sci STKE 2004 l14
44. PD Bell JY Lapointe R Sabirov S Hayashi J Peti-Peterdi K Manabe G Kovacs Y Okada 2003 Macula densa cell signaling involves ATP release through a maxi anion channel Proc Natl Acad Sci U S A 100 4322 4327 12655045
45. S Coco F Calegari E Pravettoni D Pozzi E Taverna P Rosa M Matteoli C Verderio 2003 Storage and release of ATP from astrocytes in culture J Biol Chem 278 1354 1362 12414798
46. - channels J Gen Physiol 114 525 533 10498671
47. P Brown N Dale 2002 Spike-independent release of ATP from Xenopus spinal neurons evoked by activation of glutamate receptors J Physiol 540 851 860 11986374
48. 2 receptors by locally released ATP J Am Soc Nephrol 17 297A Abstract
49. A Kueng C Kranz B Mizaikoff 2004 Amperometric ATP biosensor based on polymer entrapped enzymes Biosens Bioelectron 19 1301 1307 15046763
50. E Llaudet S Hatz M Droniou N Dale 2005 Microelectrode biosensor for real-time measurement of ATP in biological tissue Anal Chem 77 3267 3273 15889918
51. E Llaudet NP Botting JA Crayston N Dale 2003 A three-enzyme microelectrode sensor for detecting purine release from central nervous system Biosens Bioelectron 18 43 52 12445443
52. A Kueng C Kranz A Lugstein E Bertagnolli B Mizaikoff 2005 AFM-tip-integrated amperometric microbiosensors: high-resolution imaging of membrane transport Angew Chem Int Ed Engl 44 3419 3422 15861452
53. A Kueng C Kranz B Mizaikoff 2005 Imaging of ATP membrane transport with dual micro-disk electrodes and scanning electrochemical microscopy Biosens Bioelectron 21 346 353 16023962
54. SW Schneider ME Egan BP Jena WB Guggino H Oberleithner JP Geibel 1999 Continuous detection of extracellular ATP on living cells by using atomic force microscopy Proc Natl Acad Sci U S A 96 12180 12185 10518596
55. GG Yegutkin T Henttinen SS Samburski J Spychala S Jalkanen 2002 The evidence for two opposite, ATP-generating and ATP-consuming, extracellular pathways on endothelial and lymphoid cells Biochem J 367 121 128 12099890
56. GG Yegutkin A Mikhailov SS Samburski S Jalkanen 2006 The detection of micromolar pericellular ATP pool on lymphocyte surface by using lymphoid ecto-adenylate kinase as intrinsic ATP sensor Mol Biol Cell 17 3378 3385 16707571
57. DS Miller SB Horowitz 1986 Intracellular compartmentalization of adenosine triphosphate J Biol Chem 261 13911 13915 3490471
58. NC Melchior 1954 Sodium and potassium complexes of adenosinetriphosphate: equilibrium studies J Biol Chem 208 615 627 13174572
59. HF Cantiello 2001 Electrodiffusional ATP movement through CFTR and other ABC transporters Pflugers Arch 443 Suppl 1 S22 S27 11845298
60. EM Schwiebert ME Egan T-H Hwang SB Fulmer SS Allen GR Cutting WB Guggino 1995 CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP Cell 81 1063 1073 7541313
61. TJ Jentsch V Stein F Weinreich AA Zdebik 2002 Molecular structure and physiological function of chloride channels Physiol Rev 82 503 568 11917096
62. R Dutzler EB Campbell M Cadene BT Chait R MacKinnon 2002 X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of anion selectivity Nature 415 287 294 11796999
63. GY Rychkov M Pusch ML Roberts TJ Jentsch AH Bretag 1998 Permeation and block of the skeletal muscle chloride channel, ClC-1, by foreign anions J Gen Physiol 111 653 665 9565403
64. BL De Groot H Grubmuller 2001 Water permeation across biological membranes: mechanism and dynamics of aquaporin-1 and GlpF Science 294 2353 2357 11743202
65. R MacKinnon 2003 Potassium channels FEBS Lett 555 62 65 14630320
66. K Hisadome T Koyama C Kimura G Droogmans Y Ito M Oike 2002 Volume-regulated anion channels serve as an auto/paracrine nucleotide release pathway in aortic endothelial cells J Gen Physiol 119 511 520 12034759
67. F Boudreault R Grygorczyk 2004 Cell swelling-induced ATP release is tightly dependent on intracellular calcium elevations J Physiol 561 499 513 15579539
68. Y Wang RM Roman SD Lidofsky JG Fitz 1996 Autocrine signaling through ATP release represents a novel mechanism for cell volume regulation Proc Natl Acad Sci U S A 93 12020 12025 8876255
69. K Strange F Emma PS Jackson 1996 Cellular and molecular physiology of volume-sensitive anion channels Am J Physiol 270 C711 C730 8638650
70. RZ Sabirov AK Dutta Y Okada 2001 Volume-dependent ATP-conductive large-conductance anion channel as a pathway for swelling-induced ATP release J Gen Physiol 118 251 266 11524456
71. AK Dutta Y Okada RZ Sabirov 2002 Regulation of an ATP-conductive large-conductance anion channel and swelling-induced ATP release by arachidonic acid J Physiol 542 803 816 12154180
72. - currents in C1300 neuroblastoma cells J Biol Chem 278 33284 33289 12794078
73. SF Okada WK O'Neal P Huang RA Nicholas LE Ostrowski WJ Craigen ER Lazarowski RC Boucher 2004 Voltage-dependent anion channel-1 (VDAC-1) contributes to ATP release and cell volume regulation in murine cells J Gen Physiol 124 513 526 15477379
74. T Koyama M Oike Y Ito 2001 Involvement of Rho-kinase and tyrosine kinase in hypotonic stress-induced ATP release in bovine aortic endothelial cells J Physiol 532 759 769 11313444
75. M Hirakawa M Oike Y Karashima Y Ito 2004 Sequential activation of RhoA and FAK/paxillin leads to ATP release and actin reorganization in human endothelium J Physiol 558 479 488 15155793
76. Q Jiang D Mak S Devidas EM Schwiebert A Bragin Y Zhang WR Skach WB Guggino JK Foskett JF Engelhardt 1998 Cystic fibrosis transmembrane conductance regulator-associated ATP release is controlled by a chloride sensor J Cell Biol 143 645 657 9813087
77. D Reigada CH Mitchell 2005 Release of ATP from retinal pigment epithelial cells involves both CFTR and vesicular transport Am J Physiol Cell Physiol 288 C132 C140 15371258
78. MM Reddy PM Quinton C Haws JJ Wine R Grygorczyk JA Tabcharani JW Hanrahan KL Gunderson RR Kopito 1996 Failure of the cystic fibrosis transmembrane conductance regulator to conduct ATP Science 271 1876 1879 8596959
79. WC Watt ER Lazarowski RC Boucher 1998 Cystic fibrosis transmembrane regulator-independent release of ATP. Its implications for the regulation of P2Y2 receptors in airway epithelia J Biol Chem 273 14053 14058 9593757
80. SH Donaldson ER Lazarowski M Picher MR Knowles MJ Stutts RC Boucher 2000 Basal nucleotide levels, release, and metabolism in normal and cystic fibrosis airways Mol Med 6 969 982 11147574
81. R Grygorczyk JW Hanrahan 1997 CFTR-independent ATP release from epithelial cells triggered by mechanical stimuli Am J Physiol 272 C1058 C1066 9124508
82. GJ Liu A Kalous EL Werry MR Bennett 2006 Purine release from spinal cord microglia after elevation of calcium by glutamate Mol Pharmacol 70 851 859 16760362
83. RS Sprague ML Ellsworth AH Stephenson ME Kleinhenz AJ Lonigro 1998 Deformation-induced ATP release from red blood cells requires CFTR activity Am J Physiol 275 H1726 H1732 9815080
84. RA North 2002 Molecular physiology of P2X receptors Physiol Rev 82 1013 1067 12270951
85. J Li D Liu HZ Ke RL Duncan CH Turner 2005 The P2X7 nucleotide receptor mediates skeletal mechanotransduction J Biol Chem 280 42952 42959 16269410
86. 7 Receptor-dependent cell death is modulated during murine T cell maturation and mediated by dual signaling pathways J Immunol 177 2842 2850 16920919
87. T Fry JH Evans MJ Sanderson 2001 Propagation of intercellular calcium waves in C6 glioma cells transfected with connexins 43 or 32 Microsc Res Tech 52 289 300 11180621
88. T Kono T Nishikori H Kataoka Y Uchio M Ochi K Enomoto 2006 Spontaneous oscillation and mechanically induced calcium waves in chondrocytes Cell Biochem Funct 24 103 111 16342135
89. 2+ concentration induced by mechanical stimulation is propagated via release of pyrophosphorylated nucleotides in mammary epithelial cells Pflügers Arch Eur J Physiol 427 533 542
90. ML Cotrina JH Lin A Alves-Rodrigues S Liu J Li H Azmi-Ghadimi J Kang CC Naus M Nedergaard 1998 Connexins regulate calcium signaling by controlling ATP release Proc Natl Acad Sci U S A 95 15735 15740 9861039 (Pubitemid 29018769)
91. A Hofer R Dermietzel 1998 Visualization and functional blocking of gap junction hemichannels (connexons) with antibodies against external loop domains in astrocytes Glia 24 141 154 9700496
92. MT Barbe H Monyer R Bruzzone 2006 Cell-cell communication beyond connexins: the pannexin channels Physiology 21 103 114 16565476
93. R Bruzzone MT Barbe NJ Jakob H Monyer 2005 Pharmacological properties of homomeric and heteromeric pannexin hemichannels expressed in Xenopus oocytes J Neurochem 92 1033 1043 15715654
94. R Bruzzone SG Hormuzdi MT Barbe A Herb H Monyer 2003 Pannexins, a family of gap junction proteins expressed in brain Proc Natl Acad Sci U S A 100 13644 13649 14597722
95. L Bao S Locovei G Dahl 2004 Pannexin membrane channels are mechanosensitive conduits for ATP FEBS Lett 572 65 68 15304325
96. RJ Thompson N Zhou BA MacVicar 2006 Ischemia opens neuronal gap junction hemichannels Science 312 924 927 16690868
97. S Locovei J Wang G Dahl 2006 Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium FEBS Lett 580 239 244 16364313
98. 7 receptor EMBO J 25 5071 5082 17036048
99. 7 receptor death complex FEBS Lett 581 483 488 17240370
100. Y Pankratov U Lalo A Verkhratsky RA North 2006 Vesicular release of ATP at central synapses Pflügers Arch Eur J Physiol 452 589 597
101. RA North A Verkhratsky 2006 Purinergic transmission in the central nervous system Pflügers Arch Eur J Physiol 452 479 485
102. D Njus PM Kelley GJ Harnadek 1986 Bioenergetics of secretory vesicles Biochim Biophys Acta 853 237 265 2887202
103. O Pascual KB Casper C Kubera J Zhang R Revilla-Sanchez JY Sul H Takano SJ Moss K McCarthy PG Haydon 2005 Astrocytic purinergic signaling coordinates synaptic networks Science 310 113 116 16210541
104. DN Bowser BS Khakh 2007 Vesicular ATP is the predominant cause of intercellular calcium waves in astrocytes J Gen Physiol 129 485 491 17504911
105. R Maroto OP Hamill 2001 Brefeldin A block of integrin-dependent mechanosensitive ATP release from Xenopus oocytes reveals a novel mechanism of mechanotransduction J Biol Chem 276 23867 23872 11320093
106. U Lalo Y Pankratov RA North A Verkhratsky 2007 Spontaneous autocrine release of protons activates ASIC-mediated currents in HEK293 cells J Cell Physiol 212 473 480 17443677
107. S Locovei L Bao G Dahl 2006 Pannexin 1 in erythrocytes: function without a gap Proc Natl Acad Sci U S A 103 7655 7659 16682648
108. RD Beigi GR Dubyak 2000 Endotoxin activation of macrophages does not induce ATP release and autocrine stimulation of P2 nucleotide receptors J Immunol 165 7189 7198 11120851
109. i oscillations reflect nucleotide release from renal epithelia Pflugers Archiv 455 6 1105 1117 18026749
110. SM Joseph MA Pifer RJ Przybylski GR Dubyak 2004 Methylene ATP analogs as modulators of extracellular ATP metabolism and accumulation Br J Pharmacol 142 1002 1014 15210578
111. RS Ostrom C Gregorian PA Insel 2000 Cellular release of and response to ATP as key determinants of the set-point of signal transduction pathways J Biol Chem 275 11735 11739 10766795
112. + and water excretion FASEB J 13 3717 3726
113. + absorption in isolated perfused mouse CCD J Am Soc Nephrol 13 10 18 11752016
114. J Leipziger 2003 Control of epithelial transport via luminal P2 receptors Am J Physiol Renal Physiol 284 F419 F432 12556361
115. D Rouse M Leite WN Suki 1994 ATP inhibits the hydrostatic effect of AVP in rabbit CCT: evidence for a nucleotide P2U receptor Am J Physiol 267 F289 F295 8067390
116. H Sauer C Hofmann M Wartenberg AM Wobus J Hescheler 1998 Spontaneous calcium oscillations in embryonic stem cell-derived primitive endodermal cells Exp Cell Res 238 13 22 9457052
117. S Kawano K Otsu A Kuruma S Shoji E Yanagida Y Muto F Yoshikawa Y Hirayama K Mikoshiba T Furuichi 2006 ATP autocrine/paracrine signaling induces calcium oscillations and NFAT activation in human mesenchymal stem cells Cell Calcium 39 4 313 324 16445977
118. B Hellman H Dansk E Grapengiesser 2004 Pancreatic {beta}-cells communicate via intermittent release of ATP Am J Physiol Endocrinol Metab 286 5 E759 E765 14722025
119. 2+ signaling in the isolated Caenorhabditis elegans intestine: role of the inositol-1, 4, 5-trisphosphate receptor and phospholipases C beta and gamma J Gen Physiol 126 379 392 16186564
120. ER Lazarowski L Homolya RC Boucher TK Harden 1997 Direct demonstration of mechanically induced release of cellular UTP and its implication for uridine nucleotide receptor activation J Biol Chem 272 24348 24354 9305892
121. HA Praetorius J Frokiaer J Leipziger 2005 Transepithelial pressure pulses induce nucleotide release in polarized MDCK cells Am J Physiol Renal Physiol 288 F133 F141 15367389
122. TK Harden ER Lazarowski RC Boucher 1997 Release, metabolism and interconversion of adenine and uridine nucleotides: implications for G protein-coupled P2 receptor agonist selectivity Trends Pharmacol Sci 18 43 46 9090307
123. P Bodin G Burnstock 2001 Evidence that release of adenosine triphosphate from endothelial cells during increased shear stress is vesicular J Cardiovasc Pharmacol 38 900 908 11707694
124. ME Jensen E Odgaard MH Christensen HA Praetorius J Leipziger 2007 Flow-induced [Ca2+]I increase depends on nucleotide release and subsequent purinergic signaling in the intact nephron J Am Soc Nephrol 18 2062 2070 17554149
125. R Tarran B Button M Picher AM Paradiso CM Ribeiro ER Lazarowski L Zhang PL Collins RJ Pickles JJ Fredberg RC Boucher 2005 Normal and cystic fibrosis airway surface liquid homeostasis. The effects of phasic shear stress and viral infections J Biol Chem 280 35751 35759 16087672
126. T Voets B Nilius 2003 TRPs make sense J Membr Biol 192 1 8 12647029
127. P Bodin D Bailey G Burnstock 1991 Increased flow-induced ATP release from isolated vascular endothelial cells but not smooth muscle cells Br J Pharmacol 103 1203 1205 1652343
128. B Saiag P Bodin V Shacoori M Catheline B Rault G Burnstock 1995 Uptake and flow-induced release of uridine nucleotides from isolated vascular endothelial cells Endothelium 2 279 285
129. 4-deficient mice Nat Med 12 133 137 16327800
130. HA Praetorius KR Spring 2001 Bending the MDCK cell primary cilium increases intracellular calcium J Membr Biol 184 71 79 11687880
131. HA Praetorius KR Spring 2003 Removal of the MDCK cell primary cilium abolishes flow sensing J Membr Biol 191 69 76 12532278
132. i response of principal and intercalated cells in cortical collecting duct Am J Physiol Renal Physiol 285 F998 F1012 12837680
133. SM Nauli FJ Alenghat Y Luo E Williams P Vassilev X Li AE Elia W Lu EM Brown SJ Quinn DE Ingber J Zhou 2003 Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells Nat Genet 33 129 137 12514735
134. HA Praetorius KR Spring 2005 A physiological view of the primary cilium Annu Rev Physiol 67 515 529 15709968
135. 2+ Signaling in MDCK Cells J Am Soc Nephrol 17 705A Abstract
136. CH Mitchell DA Carre AM McGlinn RA Stone MM Civan 1998 A release mechanism for stored ATP in ocular ciliary epithelial cells Proc Natl Acad Sci U S A 95 7174 7178 9618558
137. T van der Wijk HR De Jonge BC Tilly 1999 Osmotic cell swelling-induced ATP release mediates the activation of extracellular signal-regulated protein kinase (Erk)-1/2 but not the activation of osmo-sensitive anion channels Biochem J 343 579 586 10527936
138. T van der Wijk SF Tomassen AB Houtsmuller HR De Jonge BC Tilly 2003 Increased vesicle recycling in response to osmotic cell swelling. Cause and consequence of hypotonicity-provoked ATP release J Biol Chem 278 40020 40025 12871943
139. J Gorelik Y Zhang D Sanchez A Shevchuk G Frolenkov M Lab D Klenerman C Edwards Y Korchev 2005 Aldosterone acts via an ATP autocrine/paracrine system: the Edelman ATP hypothesis revisited Proc Natl Acad Sci U S A 102 15000 15005 16230642
140. SR Macfarlane MJ Seatter T Kanke GD Hunter R Plevin 2001 Proteinase-activated receptors Pharmacol Rev 53 245 282 11356985