Hepatic steatosis and peroxisomal fatty acid beta-oxidation

Current Drug Metabolism

Volumn 13, Issue 10, 2012, Pages 1412-1421

  Cherkaoui Malki, Mustapha ^a   Surapureddi, Sailesh ^b   El Hajj, Hammam I ^a   Vamecq, Joseph ^c   Andreoletti, Pierre ^a  

^a Faculté des Sciences Gabriel   (France)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c Department of Biochemistry and Molecular Biology   (France)

Author keywords

ACOX1; Beta oxidation; Coactivators; Hepatic steatosis; Hepatocarcinogenesis; MED1; NASH; Peroxisome; Peroxisomes proliferation; PPARalpha

Indexed keywords

ACYL COENZYME A; ACYL COENZYME A OXIDASE; ACYL COENZYME A OXIDASE 1; ADENOSINE TRIPHOSPHATE; BILE ACID; CELL NUCLEUS RECEPTOR; CIPROFIBRATE; CLOFIBRATE; CYCLIN B1; GEMFIBROZIL; LONG CHAIN FATTY ACID; MITOCHONDRIAL ENZYME; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR BINDING PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIRINIXIC ACID; SIRTUIN 1; UNCLASSIFIED DRUG;

ARTICLE; BILE ACID METABOLISM; CELL PROLIFERATION; DISORDERS OF PEROXISOMAL FUNCTIONS; DNA SYNTHESIS; ENZYME ACTIVITY; ENZYME DEFICIENCY; FATTY ACID OXIDATION; FATTY LIVER; GENE CONTROL; GENE EXPRESSION; HEPATOMEGALY; HUMAN; KUPFFER CELL; LIPID DIET; LIVER CARCINOGENESIS; LIVER FIBROSIS; LIVER REGENERATION; NONALCOHOLIC FATTY LIVER; NONHUMAN; OXIDATIVE STRESS; PEROXISOME; PROTEIN EXPRESSION;

ANIMALS; FATTY ACIDS; FATTY LIVER; HUMANS; LIVER NEOPLASMS; OXIDATION-REDUCTION; PEROXISOMES; PPAR ALPHA;

EID: 84870463157     PISSN: 13892002     EISSN: 18755453     Source Type: Journal    
DOI: 10.2174/138920012803762765     Document Type: Article

References (156)

1. Garrow, J.S. (1988). Obesity and related diseases. Elsevier, ed. (Edinburgh: Churchill Livingstone), pp. 1-16.
2. The World Health Organization (1995). The World Health report 1995: bridging the gaps. (Geneva: The World Health Organization).
3. Adams, L.A.; Lymp, J.F.; St Sauver, J.; Sanderson, S.O.; Lindor, K.D.; Feldstein, A.; Angulo, P. The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology, 2005, 129, 113-121.
4. Browning, J.D.; Horton, J.D. Molecular mediators of hepatic steatosis and liver injury. J. Clin. Invest., 2004, 114, 147-152.
5. Tiniakos, D.G.; Vos, M.B.; Brunt, E.M. Nonalcoholic fatty liver disease: pathology and pathogenesis. Annu. Rev. Pathol., 2010, 5, 145-171.
6. Reddy, J.K.; Rao, M.S. Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation. Am. J. Physiol. Gastrointest. Liver Physiol., 2006, 290, G852-858.
7. Mannaerts, G.P.; van Veldhoven, P.P. Functions and organization of peroxisomal beta-oxidation. Ann. N. Y. Acad. Sci., 1996, 804, 99-115.
8. Palosaari, P.M.; Hiltunen, J.K. Peroxisomal bifunctional protein from rat liver is a trifunctional enzyme possessing 2-enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, and delta 3, delta 2-enoyl-CoA isomerase activities. J. Biol. Chem., 1990, 265, 2446-2449.
9. Wanders, R.J. Metabolic and molecular basis of peroxisomal disorders: a review. Am. J. Med. Genet. Part A, 2004, 126A, 355-375.
10. Rhodin, J. (1954). Correlation of ultrastructural organization and function in normal and experimentally changed proximal tubule cells of the mouse kidney. (Stockholm: Karolinska Institutet), p. 76.
11. Mannaerts, G.P.; Van Veldhoven, P.P.; Casteels, M. Peroxisomal lipid degradation via beta- and alpha-oxidation in mammals. Cell Biochem. Biophys., 2000, 32 Spring, 73-87.
12. De Duve, C.; Pressman, B.C.; Gianetto, R.; Wattiaux, R.; Appelmans, F. Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue. Biochem. J., 1955, 60, 604-617.
13. Hashimoto, T. Peroxisomal beta-oxidation: enzymology and molecular biology. Ann. N. Y. Acad. Sci., 1996, 804, 86-98.
14. Lazarow, P.B. Peroxisome biogenesis: advances and conundrums. Curr. Opin. Cell Biol., 2003, 15, 489-497.
15. Kunau, W.H. Peroxisome biogenesis: end of the debate. Curr. Biol., 2005, 15, R774-776.
16. Ma, C.; Subramani, S. Peroxisome matrix and membrane protein biogenesis. IUBMB life, 2009, 61, 713-722.
17. Wolf, J.; Schliebs, W.; Erdmann, R. Peroxisomes as dynamic organelles: peroxisomal matrix protein import. FEBS J., 2010, 277, 3268-3278.
18. Schrader, M.; Fahimi, H.D. Peroxisomes and oxidative stress. Biochim. Biophys. Acta, 2006, 1763, 1755-1766.
19. Latruffe, N.; Vamecq, J.; Cherkaoui Malki, M. Genetic-dependency of peroxisomal cell functions - emerging aspects. J. Cell. Mol. Med., 2003, 7, 238-248.
20. Moser, H.W. Molecular genetics of peroxisomal disorders. Front. Biosci., 2000, 5, D298-306.
21. Wanders, R.J.; Waterham, H.R. Peroxisomal disorders I: biochemistry and genetics of peroxisome biogenesis disorders. Clin. Genet., 2005, 67, 107-133.
22. Baes, M.; Aubourg, P. Peroxisomes, myelination, and axonal integrity in the CNS. Neuroscientist, 2009, 15, 367-379.
23. Baes, M.; Van Veldhoven, P.P. Lessons from knockout mice. I: Phenotypes of mice with peroxisome biogenesis disorders. Adv. Exp. Med. Biol., 2003, 544, 113-122.
24. Lazarow, P.B.; De Duve, C. A fatty acyl-CoA oxidizing system in rat liver peroxisomes; enhancement by clofibrate, a hypolipidemic drug. Proc. Natl. Acad. Sci. U. S. A., 1976, 73, 2043-2046.
25. Caira, F.; Cherkaoui-Malki, M.; Hoefler, G.; Latruffe, N. Cloning and tissue expression of two cDNAs encoding the peroxisomal 2- enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase in the guinea pig liver. FEBS Lett., 1996, 378, 57-60.
26. Osumi, T.; Ishii, N.; Hijikata, M.; Kamijo, K.; Ozasa, H.; Furuta, S.; Miyazawa, S.; Kondo, K.; Inoue, K.; Kagamiyama, H., et al. Molecular cloning and nucleotide sequence of the cDNA for rat peroxisomal enoyl-CoA: hydratase-3-hydroxyacyl-CoA dehydrogenase bifunctional enzyme. J. Biol. Chem., 1985, 260, 8905-8910.
27. Novikov, D.K.; Vanhove, G.F.; Carchon, H.; Asselberghs, S.; Eyssen, H.J.; Van Veldhoven, P.P.; Mannaerts, G.P. Peroxisomal beta-oxidation. Purification of four novel 3-hydroxyacyl-CoA dehydrogenases from rat liver peroxisomes. J. Biol. Chem., 1994, 269, 27125-27135.
28. Dieuaide-Noubhani, M.; Asselberghs, S.; Mannaerts, G.P.; Van Veldhoven, P.P. Evidence that multifunctional protein 2, and not multifunctional protein 1, is involved in the peroxisomal betaoxidation of pristanic acid. Biochem. J., 1997, 325 (Pt 2), 367-373.
29. Dieuaide-Noubhani, M.; Novikov, D.; Baumgart, E.; Vanhooren, J.C.; Fransen, M.; Goethals, M.; Vandekerckhove, J.; Van Veldhoven, P.P.; Mannaerts, G.P. Further characterization of the peroxisomal 3-hydroxyacyl-CoA dehydrogenases from rat liver. Relationship between the different dehydrogenases and evidence that fatty acids and the C27 bile acids di- and trihydroxycoprostanic acids are metabolized by separate multifunctional proteins. Eur. J. Biochem., 1996, 240, 660-666.
30. Caira, F.; Clemencet, M.C.; Cherkaoui-Malki, M.; Dieuaide-Noubhani, M.; Pacot, C.; Van Veldhoven, P.P.; Latruffe, N. Differential regulation by a peroxisome proliferator of the different multifunctional proteins in guinea pig: cDNA cloning of the guinea pig D-specific multifunctional protein 2. Biochem. J., 1998, 330 (Pt 3), 1361-1368.
31. Seedorf, U.; Brysch, P.; Engel, T.; Schrage, K.; Assmann, G. Sterol carrier protein X is peroxisomal 3-oxoacyl coenzyme A thiolase with intrinsic sterol carrier and lipid transfer activity. J. Biol. Chem., 1994, 269, 21277-21283.
32. Osumi, T.; Hashimoto, T. Purification and properties of mitochondrial and peroxisomal 3-hydroxyacyl-CoA dehydrogenase from rat liver. Arch. Biochem. Biophys., 1980, 203, 372-383.
33. Qin, Y.M.; Poutanen, M.H.; Helander, H.M.; Kvist, A.P.; Siivari, K.M.; Schmitz, W.; Conzelmann, E.; Hellman, U.; Hiltunen, J.K. Peroxisomal multifunctional enzyme of beta-oxidation metabolizing D-3-hydroxyacyl-CoA esters in rat liver: molecular cloning, expression and characterization. Biochem. J., 1997, 321, 21-28.
34. Xu, R.; Cuebas, D.A. The reactions catalyzed by the inducible bifunctional enzyme of rat liver peroxisomes cannot lead to the formation of bile acids. Biochem. Biophys. Res. Commun., 1996, 221, 271-278.
35. Clayton, P.T. Clinical consequences of defects in peroxisomal betaoxidation. Biochem. Soc. Trans., 2001, 29, 298-305.
36. Lazarow, P.B.; Moser, H.W. (1989). Disorders of peroxisome biogenesis. In The Metabolic and Molecular Basis of Inherited Disease, McGraw Hill Edition, S. CR, B. AL, S. WS and V. D, eds. (New York).
37. Wanders, R.J.; Schutgens, R.B.; Barth, P.G.; Tager, J.M.; van den Bosch, H. Postnatal diagnosis of peroxisomal disorders: a biochemical approach. Biochimie, 1993, 75, 269-279.
38. Wanders, R.J.; Waterham, H.R. Peroxisomal disorders: the single peroxisomal enzyme deficiencies. Biochim. Biophys. Acta, 2006, 1763, 1707-1720.
39. Poll-The, B.T.; Roels, F.; Ogier, H.; Scotto, J.; Vamecq, J.; Schutgens, R.B.; Wanders, R.J.; van Roermund, C.W.; van Wijland, M.J.; Schram, A.W., et al. A new peroxisomal disorder with enlarged peroxisomes and a specific deficiency of acyl-CoA oxidase (pseudo-neonatal adrenoleukodystrophy). Am. J. Hum. Genet., 1988, 42, 422-434.
40. Fournier, B.; Smeitink, J.A.; Dorland, L.; Berger, R.; Saudubray, J.M.; Poll-The, B.T. Peroxisomal disorders: a review. J. Inherited Metab. Dis., 1994, 17, 470-486.
41. Fan, C.Y.; Pan, J.; Usuda, N.; Yeldandi, A.V.; Rao, M.S.; Reddy, J.K. Steatohepatitis, spontaneous peroxisome proliferation and liver tumors in mice lacking peroxisomal fatty acyl-CoA oxidase. Implications for peroxisome proliferator-activated receptor alpha natural ligand metabolism. J. Biol. Chem., 1998, 273, 15639-15645.
42. Osumi, T.; Ishii, N.; Miyazawa, S.; Hashimoto, T. Isolation and structural characterization of the rat acyl-CoA oxidase gene. J. Biol. Chem., 1987, 262, 8138-8143.
43. Miyazawa, S.; Hayashi, H.; Hijikata, M.; Ishii, N.; Furuta, S.; Kagamiyama, H.; Osumi, T.; Hashimoto, T. Complete nucleotide sequence of cDNA and predicted amino acid sequence of rat acyl-CoA oxidase. J. Biol. Chem., 1987, 262, 8131-8137.
44. Cook, W.S.; Jain, S.; Jia, Y.; Cao, W.Q.; Yeldandi, A.V.; Reddy, J.K.; Rao, M.S. Peroxisome proliferator-activated receptor alpharesponsive genes induced in the newborn but not prenatal liver of peroxisomal fatty acyl-CoA oxidase null mice. Exp. Cell Res., 2001, 268, 70-76.
45. Fan, C.Y.; Pan, J.; Chu, R.; Lee, D.; Kluckman, K.D.; Usuda, N.; Singh, I.; Yeldandi, A.V.; Rao, M.S.; Maeda, N., et al. Hepatocellular and hepatic peroxisomal alterations in mice with a disrupted peroxisomal fatty acyl-coenzyme A oxidase gene. J. Biol. Chem., 1996, 271, 24698-24710.
46. Qi, C.; Zhu, Y.; Pan, J.; Usuda, N.; Maeda, N.; Yeldandi, A.V.; Rao, M.S.; Hashimoto, T.; Reddy, J.K. Absence of spontaneous peroxisome proliferation in enoyl-CoA Hydratase/L-3-hydroxyacyl-CoA dehydrogenase-deficient mouse liver. Further support for the role of fatty acyl CoA oxidase in PPARalpha ligand metabolism. J. Biol. Chem., 1999, 274, 15775-15780.
47. Jia, Y.; Qi, C.; Zhang, Z.; Hashimoto, T.; Rao, M.S.; Huyghe, S.; Suzuki, Y.; Van Veldhoven, P.P.; Baes, M.; Reddy, J.K. Overexpression of peroxisome proliferator-activated receptor-alpha (PPARalpha)-regulated genes in liver in the absence of peroxisome proliferation in mice deficient in both L- and D-forms of enoyl-CoA hydratase/dehydrogenase enzymes of peroxisomal betaoxidation system. J. Biol. Chem., 2003, 278, 47232-47239.
48. Baes, M.; Huyghe, S.; Carmeliet, P.; Declercq, P.E.; Collen, D.; Mannaerts, G.P.; Van Veldhoven, P.P. Inactivation of the peroxisomal multifunctional protein-2 in mice impedes the degradation of not only 2-methyl-branched fatty acids and bile acid intermediates but also of very long chain fatty acids. J. Biol. Chem., 2000, 275, 16329-16336.
49. Nguyen, S.D.; Baes, M.; Van Veldhoven, P.P. Degradation of very long chain dicarboxylic polyunsaturated fatty acids in mouse hepatocytes, a peroxisomal process. Biochim. Biophys. Acta, 2008, 1781, 400-405.
50. Chevillard, G.; Clemencet, M.C.; Latruffe, N.; Nicolas-Frances, V. Targeted disruption of the peroxisomal thiolase B gene in mouse: a new model to study disorders related to peroxisomal lipid metabolism. Biochimie, 2004, 86, 849-856.
51. Arnauld, S.; Fidaleo, M.; Clemencet, M.C.; Chevillard, G.; Athias, A.; Gresti, J.; Wanders, R.J.; Latruffe, N.; Nicolas-Frances, V.; Mandard, S. Modulation of the hepatic fatty acid pool in peroxisomal 3-ketoacyl-CoA thiolase B-null mice exposed to the selective PPARalpha agonist Wy14,643. Biochimie, 2009, 91, 1376-1386.
52. Seedorf, U.; Raabe, M.; Ellinghaus, P.; Kannenberg, F.; Fobker, M.; Engel, T.; Denis, S.; Wouters, F.; Wirtz, K.W.; Wanders, R.J., et al. Defective peroxisomal catabolism of branched fatty acyl coenzyme A in mice lacking the sterol carrier protein-2/sterol carrier protein-x gene function. Genes Dev., 1998, 12, 1189-1201.
53. Reddy, J.K. Peroxisome proliferators and peroxisome proliferator- activated receptor alpha: biotic and xenobiotic sensing. Am. J. Pathol., 2004, 164, 2305-2321.
54. Cherkaoui-Malki, M.; Meyer, K.; Cao, W.Q.; Latruffe, N.; Yeldandi, A.V.; Rao, M.S.; Bradfield, C.A.; Reddy, J.K. Identification of novel peroxisome proliferator-activated receptor alpha (PPARalpha) target genes in mouse liver using cDNA microarray analysis. Gene Expr., 2001, 9, 291-304.
55. Vainio, H.; Linnainmaa, K.; Kahonen, M.; Nickels, J.; Hietanen, E.; Marniemi, J.; Peltonen, P. Hypolipidemia and peroxisome proliferation induced by phenoxyacetic acid herbicides in rats. Biochem. Pharmacol., 1983, 32, 2775-2779.
56. Ishii, H.; Fukumori, N.; Horie, S.; Suga, T. Effects of fat content in the diet on hepatic peroxisomes of the rat. Biochim. Biophys. Acta, 1980, 617, 1-11.
57. Reddy, M.K.; Qureshi, S.A.; Hollenberg, P.F.; Reddy, J.K. Immunochemical identity of peroxisomal enoyl-CoA hydratase with the peroxisome-proliferation- associated 80,000 mol wt polypeptide in rat liver. J. Cell Biol., 1981, 89, 406-417.
58. Frenkel, R.A.; Slaughter, C.A.; Orth, K.; Moomaw, C.R.; Hicks, S.H.; Snyder, J.M.; Bennett, M.; Prough, R.A.; Putnam, R.S.; Milewich, L. Peroxisome proliferation and induction of peroxisomal enzymes in mouse and rat liver by dehydroepiandrosterone feeding. J. Steroid Biochem., 1990, 35, 333-342.
59. Moody, D.E.; Reddy, J.K. Hepatic peroxisome (microbody) proliferation in rats fed plasticizers and related compounds. Toxicol. Appl. Pharmacol., 1978, 45, 497-504.
60. Lock, E.A.; Mitchell, A.M.; Elcombe, C.R. Biochemical mechanisms of induction of hepatic peroxisome proliferation. Annu. Rev. Pharmacol. Toxicol., 1989, 29, 145-163.
61. Styles, J.A.; Kelly, M.D.; Pritchard, N.R.; Foster, J.R. Effects produced by the non-genotoxic hepatocarcinogen methylclofenapate in dwarf mice: peroxisome induction uncoupled from DNA synthesis and nuclearity changes. Carcinogenesis, 1990, 11, 387-391.
62. Cohen, A.J.; Grasso, P. Review of the hepatic response to hypolipidaemic drugs in rodents and assessment of its toxicological significance to man. Food Cosmet. Toxicol., 1981, 19, 585-605.
63. Cherkaoui-Malki, M.; Bardot, O.; Lhuguenot, J.C.; Latruffe, N. Expression of liver peroxisomal proteins as compared to other organelle marker enzymes in rats treated with hypolipidemic agents. Biol. Cell, 1990, 69, 83-92.
64. Caira, F.; Pacot, C.; Bardot, O.; Cherkaoui Malki, M.; Latruffe, N. Transcriptional and post-transcriptional analysis of peroxisomal protein encoding genes from rat treated with an hypolipemic agent, ciprofibrate. Effect of an intermittent treatment and influence of obesity. Biochem. Pharmacol., 1995, 49, 611-619.
65. Reddy, J.K.; Scarpelli, D.G.; Subbarao, V.; Lalwani, N.D. Chemical carcinogens without mutagenic activity: peroxisome proliferators as a prototype. Toxicol. Pathol., 1983, 11, 172-180.
66. Stott, W.T. Chemically induced proliferation of peroxisomes: implications for risk assessment. Regul. Toxicol. Pharmacol., 1988, 8, 125-159.
67. Horie, S.; Ishii, H.; Suga, T. Developmental changes in the characteristics of peroxisomal fatty acid oxidation system in rat liver. Life Sci., 1981, 29, 1649-1656.
68. Osmundsen, H. Peroxisomal beta-oxidation of long fatty acids: effects of high fat diets. Ann. N. Y. Acad. Sci., 1982, 386, 13-29.
69. Lhuguenot, J.C.; Mitchell, A.M.; Milner, G.; Lock, E.A.; Elcombe, C.R. The metabolism of di(2-ethylhexyl) phthalate (DEHP) and mono-(2-ethylhexyl) phthalate (MEHP) in rats: in vivo and in vitro dose and time dependency of metabolism. Toxicol. Appl. Pharmacol., 1985, 80, 11-22.
70. Feige, J.N.; Gelman, L.; Rossi, D.; Zoete, V.; Metivier, R.; Tudor, C.; Anghel, S.I.; Grosdidier, A.; Lathion, C.; Engelborghs, Y., et al. The endocrine disruptor monoethyl-hexyl-phthalate is a selective peroxisome proliferator-activated receptor gamma modulator that promotes adipogenesis. J. Biol. Chem., 2007, 282, 19152-19166.
71. Reddy, J.K.; Krishnakantha, T.P. Hepatic peroxisome proliferation: induction by two novel compounds structurally unrelated to clofibrate. Science, 1975, 190, 787-789.
72. Nemali, M.R.; Usuda, N.; Reddy, M.K.; Oyasu, K.; Hashimoto, T.; Osumi, T.; Rao, M.S.; Reddy, J.K. Comparison of constitutive and inducible levels of expression of peroxisomal beta-oxidation and catalase genes in liver and extrahepatic tissues of rat. Cancer Res., 1988, 48, 5316-5324.
73. Rao, M.S.; Thorgeirsson, S.; Reddy, M.K.; Lalwani, N.D.; Evarts, R.E.; Usman, M.I.; Singh, B.; Reddy, J.K. Induction of peroxisome proliferation in hepatocytes transplanted into the anterior chamber of the eye. A model system for the evaluation of xenobiotic-induced effects. Am. J. Pathol., 1986, 124, 519-527.
74. Reddy, J.K.; Goel, S.K.; Nemali, M.R.; Carrino, J.J.; Laffler, T.G.; Reddy, M.K.; Sperbeck, S.J.; Osumi, T.; Hashimoto, T.; Lalwani, N.D., et al. Transcription regulation of peroxisomal fatty acyl-CoA oxidase and enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase in rat liver by peroxisome proliferators. Proc. Natl. Acad. Sci. USA, 1986, 83, 1747-1751.
75. Lalwani, N.D.; Alvares, K.; Reddy, M.K.; Reddy, M.N.; Parikh, I.; Reddy, J.K. Peroxisome proliferator-binding protein: identification and partial characterization of nafenopin-, clofibric acid-, and ciprofibrate-binding proteins from rat liver. Proc. Natl. Acad. Sci. U. S. A., 1987, 84, 5242-5246.
76. Issemann, I.; Green, S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature, 1990, 347, 645-650.
77. Dreyer, C.; Krey, G.; Keller, H.; Givel, F.; Helftenbein, G.; Wahli, W. Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors. Cell, 1992, 68, 879-887.
78. Zhu, Y.; Qi, C.; Korenberg, J.R.; Chen, X.N.; Noya, D.; Rao, M.S.; Reddy, J.K. Structural organization of mouse peroxisome proliferator-activated receptor gamma (mPPAR gamma) gene: alternative promoter use and different splicing yield two mPPAR gamma isoforms. Proc. Natl. Acad. Sci. U. S. A., 1995, 92, 7921-7925.
79. Braissant, O.; Foufelle, F.; Scotto, C.; Dauca, M.; Wahli, W. Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and - gamma in the adult rat. Endocrinology, 1996, 137, 354-366.
80. Jain, S.; Pulikuri, S.; Zhu, Y.; Qi, C.; Kanwar, Y.S.; Yeldandi, A.V.; Rao, M.S.; Reddy, J.K. Differential expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) and its coactivators steroid receptor coactivator-1 and PPARbinding protein PBP in the brown fat, urinary bladder, colon, and breast of the mouse. Am. J. Pathol., 1998, 153, 349-354.
81. Kliewer, S.A.; Umesono, K.; Noonan, D.J.; Heyman, R.A.; Evans, R.M. Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors. Nature, 1992, 358, 771-774.
82. Gonzalez, F.J.; Peters, J.M.; Cattley, R.C. Mechanism of action of the nongenotoxic peroxisome proliferators: role of the peroxisome proliferator-activator receptor alpha. J. Natl. Cancer Inst., 1998, 90, 1702-1709.
83. Lee, S.S.; Pineau, T.; Drago, J.; Lee, E.J.; Owens, J.W.; Kroetz, D.L.; Fernandez-Salguero, P.M.; Westphal, H.; Gonzalez, F.J. Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol. Cell. Biol., 1995, 15, 3012-3022.
84. Reddy, J.K.; Chu, R. Peroxisome proliferator-induced pleiotropic responses: pursuit of a phenomenon. Ann. N. Y. Acad. Sci., 1996, 804, 176-201.
85. Palmer, C.N.; Hsu, M.H.; Griffin, H.J.; Johnson, E.F. Novel sequence determinants in peroxisome proliferator signaling. J. Biol. Chem., 1995, 270, 16114-16121.
86. Vluggens, A.; Andreoletti, P.; Viswakarma, N.; Jia, Y.; Matsumoto, K.; Kulik, W.; Khan, M.; Huang, J.; Guo, D.; Yu, S., et al. Reversal of mouse Acyl-CoA oxidase 1 (ACOX1) null phenotype by human ACOX1b isoform [corrected]. Lab. Invest., 2010, 90, 696-708.
87. Gulick, T.; Cresci, S.; Caira, T.; Moore, D.D.; Kelly, D.P. The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression. Proc. Natl. Acad. Sci. U. S. A., 1994, 91, 11012-11016.
88. Rakhshandehroo, M.; Knoch, B.; Muller, M.; Kersten, S. Peroxisome proliferator-activated receptor alpha target genes. PPAR Res., 2010, 2010.
89. Schoonjans, K.; Peinado-Onsurbe, J.; Lefebvre, A.M.; Heyman, R.A.; Briggs, M.; Deeb, S.; Staels, B.; Auwerx, J. PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene. EMBO J., 1996, 15, 5336-5348.
90. Motojima, K.; Passilly, P.; Peters, J.M.; Gonzalez, F.J.; Latruffe, N. Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner. J. Biol. Chem., 1998, 273, 16710-16714.
91. Issemann, I.; Prince, R.; Tugwood, J.; Green, S. A role for fatty acids and liver fatty acid binding protein in peroxisome proliferation? Biochem. Soc. Trans., 1992, 20, 824-827.
92. Landrier, J.F.; Thomas, C.; Grober, J.; Duez, H.; Percevault, F.; Souidi, M.; Linard, C.; Staels, B.; Besnard, P. Statin induction of liver fatty acid-binding protein (L-FABP) gene expression is peroxisome proliferator- activated receptor-alpha-dependent. J. Biol. Chem., 2004, 279, 45512-45518.
93. Schoonjans, K.; Watanabe, M.; Suzuki, H.; Mahfoudi, A.; Krey, G.; Wahli, W.; Grimaldi, P.; Staels, B.; Yamamoto, T.; Auwerx, J. Induction of the acyl-coenzyme A synthetase gene by fibrates and fatty acids is mediated by a peroxisome proliferator response element in the C promoter. J. Biol. Chem., 1995, 270, 19269-19276.
94. Gondcaille, C.; Depreter, M.; Fourcade, S.; Lecca, M.R.; Leclercq, S.; Martin, P.G.; Pineau, T.; Cadepond, F.; ElEtr, M.; Bertrand, N., et al. Phenylbutyrate up-regulates the adrenoleukodystrophy-related gene as a nonclassical peroxisome proliferator. J. Cell Biol., 2005, 169, 93-104.
95. Bardot, O.; Aldridge, T.C.; Latruffe, N.; Green, S. PPAR-RXR heterodimer activates a peroxisome proliferator response element upstream of the bifunctional enzyme gene. Biochem. Biophys. Res. Commun., 1993, 192, 37-45.
96. Nicolas-Frances, V.; Dasari, V.K.; Abruzzi, E.; Osumi, T.; Latruffe, N. The peroxisome proliferator response element (PPRE) present at positions -681/-669 in the rat liver 3-ketoacyl-CoA thiolase B gene functionally interacts differently with PPARalpha and HNF-4. Biochem. Biophys. Res. Commun., 2000, 269, 347-351.
97. Tugwood, J.D.; Issemann, I.; Anderson, R.G.; Bundell, K.R.; McPheat, W.L.; Green, S. The mouse peroxisome proliferator activated receptor recognizes a response element in the 5' flanking sequence of the rat acyl CoA oxidase gene. EMBO J., 1992, 11, 433-439.
98. Zhang, B.; Marcus, S.L.; Sajjadi, F.G.; Alvares, K.; Reddy, J.K.; Subramani, S.; Rachubinski, R.A.; Capone, J.P. Identification of a peroxisome proliferator-responsive element upstream of the gene encoding rat peroxisomal enoyl-CoA hydratase/3-hydroxyacyl- CoA dehydrogenase. Proc. Natl. Acad. Sci. USA, 1992, 89, 7541-7545.
99. Brandt, J.M.; Djouadi, F.; Kelly, D.P. Fatty acids activate transcription of the muscle carnitine palmitoyltransferase I gene in cardiac myocytes via the peroxisome proliferator-activated receptor alpha. J. Biol. Chem., 1998, 273, 23786-23792.
100. Mascaro, C.; Acosta, E.; Ortiz, J.A.; Marrero, P.F.; Hegardt, F.G.; Haro, D. Control of human muscle-type carnitine palmitoyltransferase I gene transcription by peroxisome proliferator-activated receptor. J. Biol. Chem., 1998, 273, 8560-8563.
101. Aoyama, T.; Peters, J.M.; Iritani, N.; Nakajima, T.; Furihata, K.; Hashimoto, T.; Gonzalez, F.J. Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARalpha). J. Biol. Chem., 1998, 273, 5678-5684.
102. Hashimoto, T.; Fujita, T.; Usuda, N.; Cook, W.; Qi, C.; Peters, J.M.; Gonzalez, F.J.; Yeldandi, A.V.; Rao, M.S.; Reddy, J.K. Peroxisomal and mitochondrial fatty acid beta-oxidation in mice nullizygous for both peroxisome proliferator-activated receptor alpha and peroxisomal fatty acyl-CoA oxidase. Genotype correlation with fatty liver phenotype. J. Biol. Chem., 1999, 274, 19228-19236.
103. Heery, D.M.; Kalkhoven, E.; Hoare, S.; Parker, M.G. A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature, 1997, 387, 733-736.
104. Pourcet, B.; Pineda-Torra, I.; Derudas, B.; Staels, B.; Glineur, C. SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoR. J. Biol. Chem., 2010, 285, 5983-5992.
105. Bugge, A.; Grontved, L.; Aagaard, M.M.; Borup, R.; Mandrup, S. The PPARgamma2 A/B-domain plays a gene-specific role in transactivation and cofactor recruitment. Mol. Endocrinol., 2009, 23, 794-808.
106. Bugge, A.; Mandrup, S. Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation. PPAR Res., 2010, 2010.
107. Gelman, L.; Zhou, G.; Fajas, L.; Raspé, E.; Fruchart, J.C.; Auwerx, J. p300 Interacts with the N- and C-terminal part of PPARγ2 in a ligand- independent and -dependent manner, respectively. J. Biol. Chem., 1999, 274, 7681-7688.
108. McKenna, N.J.; O'Malley, B.W. Minireview: nuclear receptor coactivators-an update. Endocrinology, 2002, 143, 2461-2465.
109. McKenna, N.J.; O'Malley, B.W. Combinatorial control of gene expression by nuclear receptors and coregulators. Cell, 2002, 108, 465-474.
110. Roeder, R.G. Transcriptional regulation and the role of diverse coactivators in animal cells. FEBS Lett., 2005, 579, 909-915.
111. Malik, S.; Roeder, R.G. The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation. Nat. Rev. Genet., 2010, 11, 761-772.
112. Taatjes, D.J. The human Mediator complex: a versatile, genomewide regulator of transcription. Trends Biochem. Sci., 2010, 35, 315-322.
113. Viswakarma, N.; Jia, Y.; Bai, L.; Vluggens, A.; Borensztajn, J.; Xu, J.; Reddy, J.K. Coactivators in PPAR-Regulated Gene Expression. PPAR Res., 2010, 2010.
114. Yu, S.; Reddy, J.K. Transcription coactivators for peroxisome proliferator-activated receptors. Biochim. Biophys. Acta, 2007, 1771, 936-951.
115. Qi, C.; Zhu, Y.; Pan, J.; Yeldandi, A.V.; Rao, M.S.; Maeda, N.; Subbarao, V.; Pulikuri, S.; Hashimoto, T.; Reddy, J.K. Mouse steroid receptor coactivator-1 is not essential for peroxisome proliferator-activated receptor α-regulated gene expression. Proc. Natl. Acad. Sci. USA, 1999, 96, 1585-1590.
116. Mark, M.; Yoshida-Komiya, H.; Gehin, M.; Liao, L.; Tsai, M.J.; O'Malley, B.W.; Chambon, P.; Xu, J. Partially redundant functions of SRC-1 and TIF2 in postnatal survival and male reproduction. Proc. Natl. Acad. Sci. U. S. A., 2004, 101, 4453-4458.
117. Wang, Z.; Qi, C.; Krones, A.; Woodring, P.; Zhu, X.; Reddy, J.K.; Evans, R.M.; Rosenfeld, M.G.; Hunter, T. Critical roles of the p160 transcriptional coactivators p/CIP and SRC-1 in energy balance. Cell Metab., 2006, 3, 111-122.
118. Rachez, C.; Lemon, B.D.; Suldan, Z.; Bromleigh, V.; Gamble, M.; Naar, A.M.; Erdjument-Bromage, H.; Tempst, P.; Freedman, L.P. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. Nature, 1999, 398, 824-828.
119. Surapureddi, S.; Yu, S.; Bu, H.; Hashimoto, T.; Yeldandi, A.V.; Kashireddy, P.; Cherkaoui-Malki, M.; Qi, C.; Zhu, Y.J.; Rao, M.S., et al. Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator. Proc. Natl. Acad. Sci. U. S. A., 2002, 99, 11836-11841.
120. Yuan, C.X.; Ito, M.; Fondell, J.D.; Fu, Z.Y.; Roeder, R.G. The TRAP220 component of a thyroid hormone receptor-associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion. Proc. Natl. Acad. Sci. U.S. A., 1998, 95, 7939-7944.
121. Zhang, X.; Krutchinsky, A.; Fukuda, A.; Chen, W.; Yamamura, S.; Chait, B.T.; Roeder, R.G. MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. Mol. Cell, 2005, 19, 89-100.
122. Zhu, Y.; Kan, L.; Qi, C.; Kanwar, Y.S.; Yeldandi, A.V.; Rao, M.S.; Reddy, J.K. Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR. J. Biol. Chem., 2000, 275, 13510-13516.
123. Zhu, Y.; Qi, C.; Jain, S.; Le Beau, M.M.; Espinosa Iii, R.; Atkins, G.B.; Lazar, M.A.; Yeldandi, A.V.; Rao, M.S.; Reddy, J.K. Amplification and overexpression of peroxisome proliferator-activated receptor binding protein (PBP/PPARBP) gene in breast cancer. Proc. Natl. Acad. Sci. U. S. A., 1999, 96, 10848-10853.
124. Zhu, Y.; Qi, C.; Jain, S.; Rao, M.S.; Reddy, J.K. Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor. J. Biol. Chem., 1997, 272, 25500-25506.
125. Ito, M.; Yuan, C.X.; Malik, S.; Gu, W.; Fondell, J.D.; Yamamura, S.; Fu, Z.Y.; Zhang, X.; Qin, J.; Roeder, R.G. Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. Mol. Cell, 1999, 3, 361-370.
126. Bjorklund, S.; Gustafsson, C.M. The yeast Mediator complex and its regulation. Trends Biochem. Sci., 2005, 30, 240-244.
127. Ito, M.; Yuan, C.X.; Okano, H.J.; Darnell, R.B.; Roeder, R.G. Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action. Mol. Cell, 2000, 5, 683-693.
128. Zhu, Y.; Qi, C.; Jia, Y.; Nye, J.S.; Rao, M.S.; Reddy, J.K. Deletion of PBP/PARBP, the gene for nuclear receptor coactivator peroxisome proliferator-activated receptor-binding protein, results in embryonic lethality. J. Biol. Chem., 2000, 275, 14779-14782.
129. Jia, Y.; Qi, C.; Kashireddi, P.; Surapureddi, S.; Zhu, Y.J.; Rao, M.S.; Le Roith, D.; Chambon, P.; Gonzalez, F.J.; Reddy, J.K. Transcription coactivator PBP, the peroxisome proliferator-activated receptor (PPAR)-binding protein, is required for PPARα-regulated gene expression in liver. J. Biol. Chem., 2004, 279, 24427-24434.
130. Jia, Y.; Guo, G.L.; Surapureddi, S.; Sarkar, J.; Qi, C.; Guo, D.; Xia, J.; Kashireddi, P.; Yu, S.; Cho, Y.W., et al. Transcription coactivator peroxisome proliferator-activated receptor-binding protein/mediator 1 deficiency abrogates acetaminophen hepatotoxicity. Proc. Natl. Acad. Sci. USA, 2005, 102, 12531-12536.
131. Matsumoto, K.; Yu, S.; Jia, Y.; Ahmed, M.R.; Viswakarma, N.; Sarkar, J.; Kashireddy, P.V.; Rao, M.S.; Karpus, W.; Gonzalez, F.J., et al. Critical role for transcription coactivator peroxisome proliferator-activated receptor (PPAR)-binding protein/TRAP220 in liver regeneration and PPARalpha ligand-induced liver tumor development. J. Biol. Chem., 2007, 282, 17053-17060.
132. Rana, R.; Surapureddi, S.; Kam, W.; Ferguson, S.; Goldstein, J.A. Med25 is required for RNA polymerase II recruitment to specific promoters, thus regulating xenobiotic and lipid metabolism in human liver. Mol. Cell Biol., 2011, 31, 466-481.
133. Purushotham, A.; Schug, T.T.; Xu, Q.; Surapureddi, S.; Guo, X.; Li, X. Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. Cell Metab, 2009, 9, 327-338.
134. Chen, W.; Yang, Q.; Roeder, R.G. Dynamic interactions and cooperative functions of PGC-1alpha and MED1 in TRalphamediated activation of the brown-fat-specific UCP-1 gene. Mol. Cell, 2009, 35, 755-768.
135. Peters, J.M.; Cheung, C.; Gonzalez, F.J. Peroxisome proliferator- activated receptor-alpha and liver cancer: where do we stand? J. Mol. Med., 2005, 83, 774-785.
136. Hashimoto, T.; Cook, W.S.; Qi, C.; Yeldandi, A.V.; Reddy, J.K.; Rao, M.S. Defect in peroxisome proliferator-activated receptor alpha-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting. J. Biol. Chem., 2000, 275, 28918-28928.
137. Rosen, E.D.; Walkey, C.J.; Puigserver, P.; Spiegelman, B.M. Transcriptional regulation of adipogenesis. Genes Dev., 2000, 14, 1293-1307.
138. Tontonoz, P.; Hu, E.; Spiegelman, B.M. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell, 1994, 79, 1147-1156.
139. Yu, S.; Matsusue, K.; Kashireddy, P.; Cao, W.Q.; Yeldandi, V.; Yeldandi, A.V.; Rao, M.S.; Gonzalez, F.J.; Reddy, J.K. Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor gamma1 (PPARgamma1) overexpression. J. Biol. Chem., 2003, 278, 498-505.
140. Day, C.P.; James, O.F. Steatohepatitis: a tale of two "hits"? Gastroenterology, 1998, 114, 842-845.
141. Jou, J.; Choi, S.S.; Diehl, A.M. Mechanisms of disease progression in nonalcoholic fatty liver disease. Semin. Liver Dis., 2008, 28, 370-379.
142. Chu, S.; Huang, Q.; Alvares, K.; Yeldandi, A.V.; Rao, M.S.; Reddy, J.K. Transformation of mammalian cells by overexpressing H2O2-generating peroxisomal fatty acyl-CoA oxidase. Proc. Natl. Acad. Sci. U. S. A., 1995, 92, 7080-7084.
143. Dadras, S.S.; Thorgeirsson, S.S.; Rao, M.S.; Reddy, J.K. Implication of hydrogen peroxide generation and apoptosis in the neoplastic transformation of mouse fibroblasts overexpressing peroxisomal fatty acyl-CoA oxidase. Int. J. Oncol., 1998, 12, 37-44.
144. Bojes, H.K.; Germolec, D.R.; Simeonova, P.; Bruccoleri, A.; Schoonhoven, R.; Luster, M.I.; Thurman, R.G. Antibodies to tumor necrosis factor alpha
145. Rose, M.L.; Germolec, D.R.; Schoonhoven, R.; Thurman, R.G. Kupffer cells are causally responsible for the mitogenic effect of peroxisome proliferators. Carcinogenesis, 1997, 18, 1453-1456.
146. Anderson, S.P.; Dunn, C.S.; Cattley, R.C.; Corton, J.C. Hepatocellular proliferation in response to a peroxisome proliferator does not require TNFalpha signaling. Carcinogenesis, 2001, 22, 1843-1851.
147. Lawrence, J.W.; Wollenberg, G.K.; DeLuca, J.G. Tumor necrosis factor alpha is not required for WY14,643-induced cell proliferation. Carcinogenesis, 2001, 22, 381-386.
148. West, D.A.; James, N.H.; Cosulich, S.C.; Holden, P.R.; Brindle, R.; Rolfe, M.; Roberts, R.A. Role for tumor necrosis factor alpha receptor 1 and interleukin-1 receptor in the suppression of mouse hepatocyte apoptosis by the peroxisome proliferator nafenopin. Hepatology, 1999, 30, 1417-1424.
149. Gyamfi, M.A.; Wan, Y.J. Mechanisms of resistance of hepatocyte retinoid X receptor alpha-null mice to WY-14,643-induced hepatocyte proliferation and cholestasis. J. Biol. Chem., 2009, 284, 9321-9330.
150. Yang, Q.; Ito, S.; Gonzalez, F.J. Hepatocyte-restricted constitutive activation of PPAR alpha induces hepatoproliferation but not hepatocarcinogenesis. Carcinogenesis, 2007, 28, 1171-1177.
151. Bardot, O.; Clemencet, M.C.; Cherkaoui Malki, M.; Latruffe, N. Delayed effects of ciprofibrate on rat liver peroxisomal properties and proto-oncogene expression. Biochem. Pharmacol., 1995, 50, 1001-1006.
152. Peters, J.M.; Aoyama, T.; Cattley, R.C.; Nobumitsu, U.; Hashimoto, T.; Gonzalez, F.J. Role of peroxisome proliferator-activated receptor alpha in altered cell cycle regulation in mouse liver. Carcinogenesis, 1998, 19, 1989-1994.
153. Shah, Y.M.; Morimura, K.; Yang, Q.; Tanabe, T.; Takagi, M.; Gonzalez, F.J. Peroxisome proliferator-activated receptor alpha regulates a microRNA-mediated signaling cascade responsible for hepatocellular proliferation. Mol. Cell. Biol., 2007, 27, 4238-4247.
154. Elsner, M.; Gehrmann, W.; Lenzen, S. Peroxisome-generated hydrogen peroxide as important mediator of lipotoxicity in insulin-producing cells. Diabetes, 2010, 60, 200-208.
155. Hall, D.; Poussin, C.; Velagapudi, V.R.; Empsen, C.; Joffraud, M.; Beckmann, J.S.; Geerts, A.E.; Ravussin, Y.; Ibberson, M.; Oresic, M., et al. Peroxisomal and microsomal lipid pathways associated with resistance to hepatic steatosis and reduced pro-inflammatory state. J. Biol. Chem., 2010, 285, 31011-31023.
156. Puri, P.; Wiest, M.M.; Cheung, O.; Mirshahi, F.; Sargeant, C.; Min, H.K.; Contos, M.J.; Sterling, R.K.; Fuchs, M.; Zhou, H., et al. The plasma lipidomic signature of nonalcoholic steatohepatitis. Hepatology, 2009, 50, 1827-1838.