Degradation of very long chain dicarboxylic polyunsaturated fatty acids in mouse hepatocytes, a peroxisomal process

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1781, Issue 8, 2008, Pages 400-405

  Nguyen, Su Duy ^a   Baes, Myriam ^a   Van Veldhoven, Paul P ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

oxidation; Arachidonic acid; Multifunctional protein 1; Peroxisomes; Pex5; PPAR ; Zellweger syndrome

Indexed keywords

CARBON DIOXIDE; MULTIFUNCTIONAL PROTEIN 1; MULTIFUNCTIONAL PROTEIN 2; POLYUNSATURATED FATTY ACID; PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DAMAGE; CONTROLLED STUDY; FATTY ACID OXIDATION; LIVER CELL; MITOCHONDRION; MOUSE; NONHUMAN; PEROXISOMAL DYSFUNCTION; PEROXISOME; PRIORITY JOURNAL;

ANIMALS; FATTY ACIDS, UNSATURATED; HEPATOCYTES; MICE; MICE, KNOCKOUT; OXIDATION-REDUCTION; PEROXISOMES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TIME FACTORS;

MUS;

EID: 48649110209     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbalip.2008.06.004     Document Type: Article

References (31)

1. Kaduce T.L., Fang X., Harmon S.D., Oltman C.L., Dellsperger K.C., Teesch L.M., Gopal V.R., Falck J.R., Campbell W.B., Weintraub N.L., and Spector A.A. 20-hydroxyeicosatetraenoic acid (20-HETE) metabolism in coronary endothelial cells. J. Biol. Chem. 279 (2004) 2648-2656
2. Carroll M.A., Sala A., Dunn C.E., McGiff J.C., and Murphy R.C. Structural identification of cytochrome P450-dependent arachidonate metabolites formed by rabbit medullary thick ascending limb cells. J. Biol. Chem. 266 (1991) 12306-12312
3. Hatzelmann A., and Ullrich V. The omega-hydroxylation of arachidonic acid by human polymorphonuclear leukocytes. Eur. J. Biochem. 173 (1988) 445-452
4. Bjorkhem I. On the quantitative importance of omega-oxidation of fatty acids. J. Lipid Res. 19 (1978) 585-590
5. Bjorkhem I. On the mechanism of regulation of omega oxidation of fatty acids. J. Biol. Chem. 251 (1976) 5259-5266
6. Kam W., Kumaran K., and Landau B.R. Contribution of omega-oxidation to fatty acid oxidation by liver of rat and monkey. J. Lipid Res. 19 (1978) 591-600
7. Komen J.C., Duran M., and Wanders R.J. Omega-hydroxylation of phytanic acid in rat liver microsomes: implications for Refsum disease. J. Lipid Res. 45 (2004) 1341-1346
8. Mingrone G., and Castagneto M. Medium-chain, even-numbered dicarboxylic acids as novel energy substrates: an update. Nutr. Rev. 64 (2006) 449-456
9. Suzuki H., Yamada J., Watanabe T., and Suga T. Compartmentation of dicarboxylic acid beta-oxidation in rat liver: importance of peroxisomes in the metabolism of dicarboxylic acids. Biochim. Biophys. Acta 990 (1989) 25-30
10. Bergseth S., Poisson J.P., and Bremer J. Metabolism of dicarboxylic acids in rat hepatocytes. Biochim. Biophys. Acta 1042 (1990) 182-187
11. Kolvraa S., and Gregersen N. In vitro studies on the oxidation of medium-chain dicarboxylic acids in rat liver. Biochim. Biophys. Acta 876 (1986) 515-525
12. Ferdinandusse S., Denis S., Van Roermund C.W., Wanders R.J., and Dacremont G. Identification of the peroxisomal beta-oxidation enzymes involved in the degradation of long-chain dicarboxylic acids. J. Lipid Res. 45 (2004) 1104-1111
13. Dirkx R., Vanhorebeek I., Martens K., Schad A., Grabenbauer M., Fahimi D., Declercq P., Van Veldhoven P.P., and Baes M. Absence of peroxisomes in mouse hepatocytes causes mitochondrial and ER abnormalities. Hepatology 41 (2005) 868-878
14. Dirkx R., Meyhi E., Asselberghs S., Reddy J., Baes M., and Van Veldhoven P.P. Beta-oxidation in hepatocyte cultures from mice with peroxisomal gene knockouts. Biochem. Biophys. Res. Commun. 357 (2007) 718-723
15. Baes M., Huyghe S., Carmeliet P., Declercq P.E., Collen D., Mannaerts G.P., and Van Veldhoven P.P. Inactivation of the peroxisomal multifunctional protein-2 in mice impedes the degradation of not only 2-methyl-branched fatty acids and bile acid intermediates but also of very long chain fatty acids. J. Biol. Chem. 275 (2000) 16329-16336
16. Qi C., Zhu Y., Pan J., Usuda N., Maeda N., Yeldandi A.V., Rao M.S., Hashimoto T., and Reddy J.K. Absence of spontaneous peroxisome proliferation in enoyl-CoA Hydratase/l-3-hydroxyacyl-CoA dehydrogenase-deficient mouse liver. Further support for the role of fatty acyl CoA oxidase in PPARalpha ligand metabolism. J. Biol. Chem. 274 (1999) 15775-15780
17. Van Veldhoven P.P., Huang S., Eyssen H.J., and Mannaerts G.P. The deficient degradation of synthetic 2- and 3-methyl-branched fatty acids in fibroblasts from patients with peroxisomal disorders. J. Inherit. Metab Dis. 16 (1993) 381-391
18. Van Veldhoven P.P., and Bell R.M. Effect of harvesting methods, growth conditions and growth phase on diacylglycerol levels in cultured human adherent cells. Biochim. Biophys. Acta 959 (1988) 185-196
19. Collins X.H., Harmon S.D., Kaduce T.L., Berst K.B., Fang X., Moore S.A., Raju T.V., Falck J.R., Weintraub N.L., Duester G., Plapp B.V., and Spector A.A. Omega-oxidation of 20-hydroxyeicosatetraenoic acid (20-HETE) in cerebral microvascular smooth muscle and endothelium by alcohol dehydrogenase 4. J. Biol. Chem. 280 (2005) 33157-33164
20. Rocchiccioli F., Aubourg P., and Bougneres P.F. Medium- and long-chain dicarboxylic aciduria in patients with Zellweger syndrome and neonatal adrenoleukodystrophy. Pediatr. Res. 20 (1986) 62-66
21. Diczfalusy U., Kase B.F., Alexson S.E., and Bjorkhem I. Metabolism of prostaglandin F2 alpha in Zellweger syndrome. Peroxisomal beta-oxidation is a major importance for in vivo degradation of prostaglandins in humans. J. Clin. Invest 88 (1991) 978-984
22. Mayatepek E., Lehmann W.D., Fauler J., Tsikas D., Frolich J.C., Schutgens R.B., Wanders R.J., and Keppler D. Impaired degradation of leukotrienes in patients with peroxisome deficiency disorders. J. Clin. Invest 91 (1993) 881-888
23. Mayatepek E., and Lehmann W.D. 12- and 15-hydroxyeicosatetraenoic acid are excreted in the urine of peroxisome-deficient patients: evidence for peroxisomal metabolism in vivo. Pediatr. Res. 39 (1996) 146-149
24. Mayatepek E., and Flock B. Increased urinary excretion of LTB4 and omega-carboxy-LTB4 in patients with Zellweger syndrome. Clin. Chim. Acta 282 (1999) 151-155
25. Mayatepek E., Ferdinandusse S., Meissner T., and Wanders R.J. Analysis of cysteinyl leukotrienes and their metabolites in bile of patients with peroxisomal or mitochondrial beta-oxidation defects. Clin. Chim. Acta 345 (2004) 89-92
26. Ferdinandusse S., Meissner T., Wanders R.J., and Mayatepek E. Identification of the peroxisomal beta-oxidation enzymes involved in the degradation of leukotrienes. Biochem. Biophys. Res. Commun. 293 (2002) 269-273
27. Jedlitschky G., Huber M., Volkl A., Muller M., Leier I., Muller J., Lehmann W.D., Fahimi H.D., and Keppler D. Peroxisomal degradation of leukotrienes by beta-oxidation from the omega-end. J. Biol. Chem. 266 (1991) 24763-24772
28. Mayatepek E., and Tiepelmann B. Defective degradation of leukotrienes in peroxisomal-deficient human hepatocytes. Biochem. Biophys. Res. Commun. 227 (1996) 131-134
29. Stene D.O., and Murphy R.C. Metabolism of leukotriene E4 in isolated rat hepatocytes. Identification of beta-oxidation products of sulfidopeptide leukotrienes. J. Biol. Chem. 263 (1988) 2773-2778
30. Rizzo C., Boenzi S., Wanders R.J., Duran M., Caruso U., and onisi-Vici C. Characteristic acylcarnitine profiles in inherited defects of peroxisome biogenesis: a novel tool for screening diagnosis using tandem mass spectrometry. Pediatr. Res. 53 (2003) 1013-1018
31. Fang X., Dillon J.S., Hu S., Harmon S.D., Yao J., Anjaiah S., Falck J.R., and Spector A.A. 20-carboxy-arachidonic acid is a dual activator of peroxisome proliferator-activated receptors alpha and gamma. Prostaglandins Other Lipid Mediat. 82 (2007) 175-184