Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome

Journal of Biological Chemistry

Volumn 283, Issue 9, 2008, Pages 5876-5887

  Kotzsch, Alexander ^a   Nickel, Joachim ^a   Seher, Axel ^a   Heinecke, Kai ^a   Van Geersdaele, Laura ^a   Herrmann, Thomas ^b   Sebald, Walter ^a,c   Mueller, Thomas D ^a,c,d  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c UNIVERSITY OF WÜRZBURG   (Germany)

^d UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BINDING ENERGY; BONE; EPITOPES; LIGANDS; TISSUE HOMEOSTASIS;

BINDING AFFINITIES; BIOPHYSICAL ANALYSIS; BONE MORPHOGENETIC PROTEIN-2; BONE MORPHOGENETIC PROTEINS; LIGAND-RECEPTOR INTERACTIONS; STRUCTURE ANALYSIS; TRANSMEMBRANE RECEPTORS; TUMOR SUPPRESSORS;

PROTEINS;

BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN RECEPTOR 1A; BONE MORPHOGENETIC PROTEIN RECEPTOR 1B; BONE MORPHOGENETIC PROTEIN RECEPTOR 2; SMAD2 PROTEIN; SMAD3 PROTEIN; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN RECEPTOR 1; EPITOPE; LIGAND; TRANSFORMING GROWTH FACTOR BETA; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; BINDING AFFINITY; CELL PROLIFERATION; CELL STRAIN HEK293; CELLULAR DISTRIBUTION; CHIMERA; CIRCULAR DICHROISM; JUVENILE POLYPOSIS SYNDROME; LIGAND BINDING; MISSENSE MUTATION; POLYPOSIS; PRIORITY JOURNAL; PROTEIN STRUCTURE; REPORTER GENE; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; ADULT; BINDING SITE; CHEMISTRY; COLON; COLON POLYPOSIS; EMBRYO DEVELOPMENT; GENETICS; HOMEOSTASIS; HUMAN; INTESTINE CELL; METABOLISM; MUTATION; PATHOLOGY; PROTEIN BINDING; PROTEIN QUATERNARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION;

ADENOMATOUS POLYPOSIS COLI; ADULT; BINDING SITES; BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE I; BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE II; BONE MORPHOGENETIC PROTEINS; COLON; EMBRYONIC DEVELOPMENT; ENTEROCYTES; EPITOPES; HOMEOSTASIS; HUMANS; LIGANDS; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFORMING GROWTH FACTOR BETA; TUMOR SUPPRESSOR PROTEINS;

EID: 41949085434     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M706029200     Document Type: Article

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