Protein-protein docking and hot-spot prediction for drug discovery

Current Pharmaceutical Design

Volumn 18, Issue 30, 2012, Pages 4607-4618

  Grosdidier, Solène ^a   Fernández Recio, Juan ^b  

^a HOSPITAL DEL MAR   (Spain)

^b BARCELONA SUPERCOMPUTING CENTER   (Spain)

Author keywords

Docking; Drug discovery; Hot spots; Interface prediction; Protein protein interactions

Indexed keywords

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; DISHEVELLED PROTEIN; PROTEIN BAD; PROTEIN BAK; PROTEIN BCL XL; PROTEIN MDM2; TUMOR NECROSIS FACTOR ALPHA; WNT PROTEIN;

BINDING SITE; CARCINOGENESIS; CONFORMATIONAL TRANSITION; DRUG TARGETING; FOURIER TRANSFORMATION; HOT SPOT IDENTIFICATION; HUMAN; ISOTHERMAL TITRATION CALORIMETRY; MECHANICAL TORSION; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MONTE CARLO METHOD; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; REVIEW; SOLVATION;

BINDING SITES; COMPUTER SIMULATION; DRUG DISCOVERY; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN INTERACTION MAPPING;

EID: 84866354446     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/138161212802651599     Document Type: Review

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