MicroRNAs in Common Human Diseases

Genomics, Proteomics and Bioinformatics

Volumn 10, Issue 5, 2012, Pages 246-253

  Li, Yu ^a   Kowdley, Kris V ^a  

^a BENAROYA RESEARCH INSTITUTE   (United States)

Author keywords

Biomarker; Diagnostics; Human diseases; MicroRNA; Therapeutics

Indexed keywords

CAVEOLIN 1; GELATINASE A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LEUCINE RICH REPEAT KINASE 2; LOCKED NUCLEIC ACID; MICRORNA; MICRORNA 107; MICRORNA 122; MICRORNA 145; MICRORNA 146A; MICRORNA 155; MICRORNA 16; MICRORNA 182; MICRORNA 200A; MICRORNA 200B; MICRORNA 29A; MICRORNA 34A; MICRORNA 9; TRANSCRIPTION FACTOR E2F1;

ALZHEIMER DISEASE; BIOINFORMATICS; CANCER INVASION; CELL DEATH; CELL PROLIFERATION; CHRONIC LYMPHATIC LEUKEMIA; DOWN REGULATION; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENOMICS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; INSULIN SENSITIVITY; METASTASIS; MULTIPLE SCLEROSIS; NONALCOHOLIC FATTY LIVER; NONHUMAN; PARKINSON DISEASE; PROSTATE CANCER; PROTEIN EXPRESSION; REVIEW; SURVIVAL; UPREGULATION; VIRUS REPLICATION;

ANIMALIA;

EID: 84870351507     PISSN: 16720229     EISSN: 22103244     Source Type: Journal    
DOI: 10.1016/j.gpb.2012.07.005     Document Type: Review

References (109)

1. Bartel D.P. MicroRNAs: genomics, biogenesis, mechanism, and Function. Cell 2004, 116:281-297.
2. Lee R.C., Feinbaum R.L., Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993, 75:843-854.
3. Reinhart B.J., Slack F.J., Basson M., Pasquinelli A.E., Bettinger J.C., Rougvie A.E., et al. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature 2000, 403:901-906.
4. Kozomara A., Griffiths-Jones S. MiRBase: integrating microRNA annotation and deep-sequencing data. Nucleic Acids Res 2011, 39:D152-D157.
5. Pasquinelli A.E., Reinhart B.J., Slack F., Martindale M.Q., Kuroda M.I., Maller B., et al. Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature 2000, 408:86-89.
6. McManus M.T. MicroRNAs and cancer. Semin Cancer Biol 2003, 13:253-258.
7. Lagos-Quintana M., Rauhut R., Lendeckel W., Tuschl T. Identification of novel genes coding for small expressed RNAs. Science 2001, 294:853-858.
8. Lau N.C., Lim L.P., Weinstein E.G., Bartel D.P. An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science 2001, 294:858-862.
9. Lee R.C., Ambros V. An extensive class of small RNAs in Caenorhabditis elegans. Science 2001, 294:862-864.
10. Luciano D.J., Mirsky H., Vendetti N.J., Maas S. RNA editing of a miRNA precursor. RNA 2004, 10:1174-1177.
11. Yang W., Chendrimada T.P., Wang Q., Higuchi M., Seeburg P.H., Shiekhattar R., et al. Modulation of microRNA processing and expression through RNA editing by ADAR deaminases. Nat Struct Mol Biol 2006, 13:13-21.
12. Waterston R.H., Lindblad-Toh K., Birney E., Rogers J., Abril J.F., Agarwal P., et al. Initial sequencing and comparative analysis of the mouse genome. Nature 2002, 420:520-562. Mouse Genome Sequencing Consortium.
13. Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., et al. Evolutionary and biomedical insights from the rhesus macaque genome. Science 2007, 316:222-234. Rhesus Macaque Genome Sequencing and Analysis Consortium.
14. Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., et al. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature 2004, 428:493-521.
15. Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., et al. The sequence of the human genome. Science 2001, 291:1304-1351.
16. Griffiths-Jones S., Grocock R.J., van Dongen S., Bateman A., Enright A.J. MiRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res 2005, 34:D140-D144.
17. Bonnet E., Wuyts J., Rouzé P., Van de Peer Y. Evidence that microRNA precursors, unlike other non-coding RNAs, have lower folding free energies than random sequences. Bioinformatics 2004, 20:2911-2917.
18. Kim V.N. MicroRNA biogenesis: coordinated cropping and dicing. Nat Rev Mol Cell Biol 2005, 6:376-385.
19. Lewis B.P., Burge C.B., Bartel D.P. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 2005, 120:15-20.
20. Chendrimada T.P., Gregory R.I., Kumaraswamy E., Norman J., Cooch N., Nishikura K., et al. TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature 2005, 436:740-744.
21. Gregory R.I., Chendrimada T.P., Cooch N., Shiekhattar R. Human RISC couples microRNA biogenesis and posttranscriptional gene silencing. Cell 2005, 123:631-640.
22. Perron M.P., Provost P. Protein components of the microRNA pathway and human diseases. Methods Mol Biol 2009, 487:369-385.
23. MacRae I.J., Ma E., Zhou M., Robinson C.V., Doudna J.A. In vitro reconstitution of the human RISC-loading complex. Proc Natl Acad Sci U S A 2008, 105:512-517.
24. He L., Hannon G.J. MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet 2004, 5:522-531.
25. Lewis B.P., Shih Ih., Jones-Rhoades M.W., Bartel D.P., Burge C.B. Prediction of mammalian microRNA targets. Cell 2003, 115:787-798.
26. Krek A., Grun D., Poy M.N., Wolf R., Rosenberg L., Epstein E.J., et al. Combinatorial microRNA target predictions. Nat Genet 2005, 37:495-500.
27. John B., Enright A.J., Aravin A., Tuschl T., Sander C., Marks D.S. Human microRNA targets. PLoS Biol 2004, 2:e363.
28. Krüger J., Rehmsmeier M. RNAhybrid: microRNA target prediction easy, fast and flexible. Nucleic Acids Res 2006, 34:W451-W454.
29. Maragkakis M., Reczko M., Simossis V.A., Alexiou P., Papadopoulos G.L., Dalamagas T., et al. DIANA-microT web server: elucidating microRNA functions through target prediction. Nucleic Acids Res 2009, 37:W273-W276.
30. Griffiths-Jones S., Saini H.K., van Dongen S., Enright A.J. MiRBase: tools for microRNA genomics. Nucleic Acids Res 2008, 36:D154-D158.
31. Lim L.P., Lau N.C., Garrett-Engele P., Grimson A., Schelter J.M., Castle J., et al. Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 2005, 433:769-773.
32. Sood P., Krek A., Zavolan M., Macino G., Rajewsky N. Cell-type-specific signatures of microRNAs on target mRNA expression. Proc Natl Acad Sci U S A 2006, 103:2746-2751.
33. Huang J.C., Babak T., Corson T.W., Chua G., Khan S., Gallie B.L., et al. Using expression profiling data to identify human microRNA targets. Nat Methods 2007, 4:1045-1049.
34. Guo H., Ingolia N.T., Weissman J.S., Bartel D.P. Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature 2010, 466:835-840.
35. Bandiera S., Rüberg S., Girard M., Cagnard N., Hanein S., Chrétien D., et al. Nuclear outsourcing of RNA interference components to human mitochondria. PLoS One 2011, 6:e20746.
36. Beibei C. Bo Zhang, Huaxia Luo, Jiao Yuan, Geir Skogerbø, Runsheng Chen. Distinct microRNA subcellular size and expression patterns in human cancer cells. Int J Cell Biol 2012, 2012:672462.
37. Lagos-Quintana M., Rauhut R., Yalcin A., Meyer J., Lendeckel W., Tuschl T. Identification of tissue-specific microRNAs from mouse. Curr Biol 2002, 12:735-739.
38. Lu J., Getz G., Miska E.A., Alvarez-Saavedra E., Lamb J., Peck D., et al. MicroRNA expression profiles classify human cancers. Nature 2005, 435:834-838.
39. Ng R., Song G., Roll G.R., Frandsen N.M., Willenbring H. A microRNA-21 surge facilitates rapid cyclin D1 translation and cell cycle progression in mouse liver regeneration. J Clin Invest 2012, 122:1097-1108.
40. Rayner K.J., Esau C.C., Hussain F.N., McDaniel A.L., Marshall S.M., van Gils J.M., et al. Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides. Nature 2011, 478:404-407.
41. Zhang P., Bill K., Liu J., Young E., Peng T., Bolshakov S., et al. MiR-155 is a liposarcoma oncogene that targets casein kinase-1α and enhances β-catenin signaling. Cancer Res 2012, 72:1751-1762.
42. Taganov K.D., Boldin M.P., Chang K.-J., Baltimore D. NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci U S A 2006, 103:12481-12486.
43. Png K.J., Halberg N., Yoshida M., Tavazoie S.F. A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells. Nature 2012, 481:190-194.
44. Calin G.A., Dumitru C.D., Shimizu M., Bichi R., Zupo S., Noch E., et al. Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A 2002, 99:15524-15529.
45. Calin G.A., Sevignani C., Dumitru C.D., Hyslop T., Noch E., Yendamuri S., et al. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci U S A 2004, 101:2999-3004.
46. Iorio M.V., Ferracin M., Liu C.-G., Veronese A., Spizzo R., Sabbioni S., et al. MicroRNA gene expression deregulation in human breast cancer. Cancer Res 2005, 65:7065-7070.
47. Yanaihara N., Caplen N., Bowman E., Seike M., Kumamoto K., Yi M., et al. Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell 2006, 9:189-198.
48. Shimizu S., Takehara T., Hikita H., Kodama T., Miyagi T., Hosui A., et al. The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma. J Hepatol 2010, 52:698-704.
49. Kong W., He L., Coppola M., Guo J., Esposito N.N., Coppola D., et al. MicroRNA-155 regulates cell survival, growth, and chemosensitivity by targeting FOXO3a in breast cancer. J Biol Chem 2010, 285:17869-17879.
50. Cho W.C.S., Chow A.S.C., Au J.S.K. MiR-145 inhibits cell proliferation of human lung adenocarcinoma by targeting EGFR and NUDT1. RNA Biol 2011, 8:125-131.
51. Chan J.A., Krichevsky A.M., Kosik K.S. MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res 2005, 65:6029-6033.
52. Cimmino A., Calin G.A., Fabbri M., Iorio M.V., Ferracin M., Shimizu M., et al. MiR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci U S A 2005, 102:13944-13949.
53. Johnson S.M., Grosshans H., Shingara J., Byrom M., Jarvis R., Cheng A., et al. RAS is regulated by the let-7 microRNA family. Cell 2005, 120:635-647.
54. Valeri N., Gasparini P., Fabbri M., Braconi C., Veronese A., Lovat F., et al. Modulation of mismatch repair and genomic stability by miR-155. Proc Natl Acad Sci U S A 2010, 107:6982-6987.
55. Gao P., Xing A.Y., Zhou G.Y., Zhang T.G., Zhang J.P., Gao C., et al. The molecular mechanism of microRNA-145 to suppress invasion-metastasis cascade in gastric cancer. Oncogene 2012, http://dx.doi.org/10.1038/onc.2012.61.
56. Peng X., Guo W., Liu T., Wang X., Tu Xa, Xiong D., et al. Identification of miRs-143 and -145 that is associated with bone metastasis of prostate cancer and involved in the regulation of EMT. PLoS One 2011, 6:e20341.
57. Volinia S., Galasso M., Sana M.E., Wise T.F., Palatini J., Huebner K., et al. Breast cancer signatures for invasiveness and prognosis defined by deep sequencing of microRNA. Proc Natl Acad Sci U S A 2012, 109:3024-3029.
58. Fang Y.X., Xue J.-L., Shen Q., Chen J., Tian L. MiR-7 inhibits tumor growth and metastasis by targeting the PI3K/AKT pathway in hepatocellular carcinoma. Hepatology 2012, 55:1852-1862.
59. Fang J.H., Zhou H.C., Zeng C., Yang J., Liu Y., Huang X., et al. MicroRNA-29b suppresses tumor angiogenesis, invasion, and metastasis by regulating matrix metalloproteinase 2 expression. Hepatology 2011, 54:1729-1740.
60. Pfeffer S., Zavolan M., Grässer F.A., Chien M., Russo J.J., Ju J., et al. Identification of virus-encoded microRNAs. Science 2004, 304:734-736.
61. Sullivan C.S., Grundhoff A.T., Tevethia S., Pipas J.M., Ganem D. SV40-encoded microRNAs regulate viral gene expression and reduce susceptibility to cytotoxic T cells. Nature 2005, 435:682-686.
62. Andersson M.G., Haasnoot P.C.J., Xu N., Berenjian S., Berkhout B., Akusjärvi G. Suppression of RNA interference by adenovirus virus-associated RNA. J Virol 2005, 79:9556-9565.
63. Cai X., Lu S., Zhang Z., Gonzalez C.M., Damania B., Cullen B.R. Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells. Proc Natl Acad Sci U S A 2005, 102:5570-5575.
64. Grey F., Antoniewicz A., Allen E., Saugstad J., McShea A., Carrington J.C., et al. Identification and characterization of human cytomegalovirus-encoded microRNAs. J Virol 2005, 79:12095-12099.
65. Pfeffer S., Sewer A., Lagos-Quintana M., Sheridan R., Sander C., Grasser F.A., et al. Identification of microRNAs of the herpesvirus family. Nat Methods 2005, 2:269-276.
66. Omoto S., Ito M., Tsutsumi Y., Ichikawa Y., Okuyama H., Brisibe E., et al. HIV-1 nef suppression by virally encoded microRNA. Retrovirology 2004, 1:44.
67. Ouellet D.L., Plante I., Landry P., Barat C., Janelle M.-è., Flamand L., et al. Identification of functional microRNAs released through asymmetrical processing of HIV-1 TAR element. Nucleic Acids Res 2008, 36:2353-2365.
68. Schopman N.C.T., Willemsen M., Liu Y.P., Bradley T., van Kampen A., Baas F., et al. Deep sequencing of virus-infected cells reveals HIV-encoded small RNAs. Nucleic Acids Res 2012, 40:414-427.
69. Lin J., Cullen B.R. Analysis of the interaction of primate retroviruses with the human RNA interference machinery. J Virol 2007, 81:12218-12226.
70. Gatto G., Rossi A., Rossi D., Kroening S., Bonatti S., Mallardo M. Epstein-Barr virus latent membrane protein 1 trans-activates miR-155 transcription through the NF-κB pathway. Nucleic Acids Res 2008, 36:6608-6619.
71. Gottwein E., Mukherjee N., Sachse C., Frenzel C., Majoros W.H., Chi J.-T.A., et al. A viral microRNA functions as an orthologue of cellular miR-155. Nature 2007, 450:1096-1099.
72. Linnstaedt S.D., Gottwein E., Skalsky R.L., Luftig M.A., Cullen B.R. Virally induced cellular microRNA miR-155 plays a key role in B-cell immortalization by Epstein-Barr virus. J Virol 2010, 84:11670-11678.
73. Jopling C.L., Yi M., Lancaster A.M., Lemon S.M., Sarnow P. Modulation of hepatitis C virus RNA abundance by a liver-specific microRNA. Science 2005, 309:1577-1581.
74. Lanford R.E., Hildebrandt-Eriksen E.S., Petri A., Persson R., Lindow M., Munk M.E., et al. Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection. Science 2010, 327:198-201.
75. Randall G., Panis M., Cooper J.D., Tellinghuisen T.L., Sukhodolets K.E., Pfeffer S., et al. Cellular cofactors affecting hepatitis C virus infection and replication. Proc Natl Acad Sci U S A 2007, 104:12884-12889.
76. + T lymphocytes. Nat Med 2007, 13:1241-1247.
77. Li Y., Chan E.Y., Li J., Ni C., Peng X., Rosenzweig E., et al. MicroRNA expression and virulence in pandemic influenza virus-infected mice. J Virol 2010, 84:3023-3032.
78. Li Y., Li J., Belisle S., Baskin C.R., Tumpey T.M., Katze M.G. Differential microRNA expression and virulence of avian, 1918 reassortant, and reconstructed 1918 influenza A viruses. Virology 2011, 421:105-113.
79. Zhang Y., Wei W., Cheng N., Wang K., Li B., Jiang X., et al. Hepatitis C Virus-induced upregulation of miR-155 promotes hepatocarcinogenesis by activating Wnt signaling. Hepatology 2012, 56:1631-1640.
80. Keller A., Leidinger P., Lange J., Borries A., Schroers H., Scheffler M., et al. Multiple sclerosis: microRNA expression profiles accurately differentiate patients with relapsing-remitting disease from healthy controls. PLoS One 2009, 4:e7440.
81. Junker A., Krumbholz M., Eisele S., Mohan H., Augstein F., Bittner R., et al. MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47. Brain 2009, 132:3342-3352.
82. Du C., Liu C., Kang J., Zhao G., Ye Z., Huang S., et al. MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis. Nat Immunol 2009, 10:1252-1259.
83. Luo X., Yang W., Ye D.-Q., Cui H., Zhang Y., Hirankarn N., et al. A functional variant in microRNA-146a promoter modulates its expression and confers disease risk for systemic lupus erythematosus. PLoS Genet 2011, 7:e1002128.
84. Lofgren S.E., Frostegard J., Truedsson L., Pons-Estel B.A., D'Alfonso S., Witte T., et al. Genetic association of miRNA-146a with systemic lupus erythematosus in Europeans through decreased expression of the gene. Genes Immun 2012, 13:268-274.
85. Karolina D.S., Armugam A., Tavintharan S., Wong M.T.K., Lim S.C., Sum C.F., et al. MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in Type 2 Diabetes Mellitus. PLoS One 2011, 6:e22839.
86. Trajkovski M., Hausser J., Soutschek J., Bhat B., Akin A., Zavolan M., et al. MicroRNAs 103 and 107 regulate insulin sensitivity. Nature 2011, 474:649-653.
87. Alisi A., Da Sacco L., Bruscalupi G., Piemonte F., Panera N., De Vito R., et al. Mirnome analysis reveals novel molecular determinants in the pathogenesis of diet-induced nonalcoholic fatty liver disease. Lab Invest 2011, 91:283-293.
88. Pogribny I.P., Starlard-Davenport A., Tryndyak V.P., Han T., Ross S.A., Rusyn I., et al. Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. Lab Invest 2010, 90:1437-1446.
89. Cheung O., Puri P., Eicken C., Contos M.J., Mirshahi F., Maher J.W., et al. Nonalcoholic steatohepatitis is associated with altered hepatic microRNA expression. Hepatology 2008, 48:1810-1820.
90. Xiao B., Liu Z., Li B.-S., Tang B., Li W., Guo G., et al. Induction of microRNA-155 during Helicobacter pylori infection and its negative regulatory role in the inflammatory response. J Infect Dis 2009, 200:916-925.
91. Martins M., Rosa A., Guedes L.C., Fonseca B.V., Gotovac K., Violante S., et al. Convergence of miRNA expression profiling, α-synuclein Interacton and GWAS in Parkinson's Disease. PLoS One 2011, 6:e25443.
92. Kim J., Inoue K., Ishii J., Vanti W.B., Voronov S.V., Murchison E., et al. A microRNA feedback circuit in midbrain dopamine neurons. Science 2007, 317:1220-1224.
93. Gehrke S., Imai Y., Sokol N., Lu B. Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression. Nature 2010, 466:637-641.
94. Nunez-Iglesias J., Liu C.C., Morgan T.E., Finch C.E., Zhou X.J. Joint genome-wide profiling of miRNA and mRNA expression in Alzheimer's disease cortex reveals altered miRNA regulation. PLoS One 2010, 5:e8898.
95. Hébert S.S., Horré K., Nicolaï L., Papadopoulou A.S., Mandemakers W., Silahtaroglu A.N., et al. Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression. Proc Natl Acad Sci U S A 2008, 105:6415-6420.
96. Willem M., Garratt A.N., Novak B., Citron M., Kaufmann S., Rittger A., et al. Control of peripheral nerve myelination by the ß-secretase BACE1. Science 2006, 314:664-666.
97. Cho W.C.S. MicroRNAs: potential biomarkers for cancer diagnosis, prognosis and targets for therapy. Int J Biochem Cell Biol 2010, 42:1273-1281.
98. Kauppinen S., Vester B., Wengel J. Locked nucleic acid: high-affinity targeting of complementary RNA for RNomics. Handb Exp Pharmacol 2006, 173:405-422.
99. Mitchell P.S., Parkin R.K., Kroh E.M., Fritz B.R., Wyman S.K., Pogosova-Agadjanyan E.L., et al. Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci U S A 2008, 105:10513-10518.
100. Bianchi F., Nicassio F., Marzi M., Belloni E., Dall'Olio V., Bernard L., et al. A serum circulating miRNA diagnostic test to identify asymptomatic high-risk individuals with early stage lung cancer. EMBO Mol Med 2011, 3:495-503.
101. Hennessey P.T., Sanford T., Choudhary A., Mydlarz W.W., Brown D., Adai A.T., et al. Serum microRNA biomarkers for detection of non-small cell lung cancer. PLoS One 2012, 7:e32307.
102. Qi P., Cheng S.-Q., Wang H., Li N. Chen Y-f, Gao C-f. Serum microRNAs as biomarkers for hepatocellular carcinoma in Chinese patients with chronic hepatitis B virus infection. PLoS One 2011, 6:e28486.
103. Roth C., Rack B., Muller V., Janni W., Pantel K., Schwarzenbach H. Circulating microRNAs as blood-based markers for patients with primary and metastatic breast cancer. Breast Cancer Res 2010, 12:R90.
104. Arroyo J.D., Chevillet J.R., Kroh E.M., Ruf I.K., Pritchard C.C., Gibson D.F., et al. Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proc Natl Acad Sci U S A 2011, 108:5003-5008.
105. Elmén J., Lindow M., Silahtaroglu A., Bak M., Christensen M., Lind-Thomsen A., et al. Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver. Nucleic Acids Res 2008, 36:1153-1162.
106. Elmen J., Lindow M., Schutz S., Lawrence M., Petri A., Obad S., et al. LNA-mediated microRNA silencing in non-human primates. Nature 2008, 452:896-899.
107. Yue D., Liu H., Huang Y. Survey of computational algorithms for microRNA target prediction. Curr Genomics 2009, 10:478-492.
108. Karginov F.V., Conaco C., Xuan Z., Schmidt B.H., Parker J.S., Mandel G., et al. A biochemical approach to identifying microRNA targets. Proc Natl Acad Sci U S A 2007, 104:19291-19296.
109. Chi S.W., Zang J.B., Mele A., Darnell R.B. Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps. Nature 2009, 460:479-486.