Effects of ApC, a sea anemone toxin, on sodium currents of mammalian neurons

Brain Research

Volumn 1110, Issue 1, 2006, Pages 136-143

  Salceda, Emilio ^a   Garateix, Anoland ^b   Aneiros, Abel ^b   Salazar, Héctor ^a   López, Omar ^a   Soto, Enrique ^a  

^a BENEMÉRITA UNIVERSIDAD AUTÓNOMA DE PUEBLA   (Mexico)

^b CITMA   (Cuba)

Author keywords

Anthopleura elegantissima toxin; Dorsal root ganglia neuron; Fast inactivation; Site 3 toxin; Voltage gated sodium channel

Indexed keywords

POLYPEPTIDE; SEA ANEMONE TOXIN; SEA ANEMONE TOXIN APC; SODIUM ION; TETRODOTOXIN; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHANNEL GATING; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; FEMALE; HYPERPOLARIZATION; MALE; NERVE CELL MEMBRANE; NERVE CELL MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; RAT; SODIUM CURRENT; SPINAL GANGLION; VOLTAGE CLAMP;

ANIMALS; CELLS, CULTURED; CNIDARIAN VENOMS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, RADIATION; ELECTRIC STIMULATION; FEMALE; GANGLIA, SPINAL; MALE; MEMBRANE POTENTIALS; NEURONS; NEUROTOXINS; PATCH-CLAMP TECHNIQUES; PEPTIDES; RATS; RATS, WISTAR; SEA ANEMONES; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; TETRODOTOXIN;

ACTINIARIA; ANEMONE; ANTHOPLEURA ELEGANTISSIMA; MAMMALIA; RATTUS NORVEGICUS;

EID: 33748429853     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2006.06.113     Document Type: Article

References (41)

1. + channels in pain pathways. Trends Pharmacol. Sci. 4 (2001) 27-31
2. Benzinger G.R., Drum C.L., Chen L.Q., Kallen R.G., and Hanck D.A. Differences in the binding sites of two site-3 sodium channel toxins. Pflüg. Arch. 434 (1997) 742-749
3. Benzinger G.R., Kyle J.W., Blumenthal K.M., and Hanck D.A. A specific interaction between the cardiac sodium channel and site-3 toxin anthopleurin B. J. Biol. Chem. 273 (1998) 80-84
4. Beress L., Beress R., and Wunderer G. Isolation and characterization of three polypeptides with neurotoxic action from Anemonia sulcata. FEBS Lett. 50 (1975) 311-314
5. Beress L., Beress R., and Wunderer G. Purification of three polypeptides with neurotoxic and cardiotoxic activity from the sea anemone Anemonia sulcata. Toxicon 13 (1975) 359-367
6. Blumenthal K.M., and Seibert A.L. Voltage-gated sodium channel toxins. Cell Biochem. Biophys. 38 (2003) 215-237
7. Bosmans F., Aneiros A., and Tytgat J. The sea anemone Bunodosoma granulifera contains surprisingly efficacious and potent insect-selective toxins. FEBS Lett. 532 (2002) 131-134
8. Bruhn T., Schaller C., Schulze C., Sanchez-Rodriguez J., Dannmeier C., Ravens U., Heubach J.F., Eckhardt K., Schmidtmayer J., Schmidt H., Aneiros A., Wachter E., and Beress L. Isolation and characterisation of five neurotoxic and cardiotoxic polypeptides from the sea anemone Anthopleura elegantissima. Toxicon 39 (2001) 693-702
9. Cahine M., Plante E., and Kallen R.G. Sea anemone toxin (ATX II) modulation of heart and skeletal muscle sodium channel α-subunits expressed in tsA201 cells. J. Membr. Biol. 152 (1996) 39-48
10. + channel inactivation by anemone toxin (ATX II) mimics the myotonic state in hyperkalemic periodic paralysis. J. Physiol. 466 (1993) 501-520
11. Caterall W.A. From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. Neuron 26 (2000) 13-25
12. Chen H., Gordon D., and Heinemann S.H. Modulation of cloned skeletal muscle sodium channels by the scorpion toxins Lqh II, Lqh III and LqhαIT. Plfug. Arch. Eur. J. Physiol. 439 (2000) 423-432
13. Chen H., Lu S., Leipold E., Gordon D., Hansel A., and Heinemann S.H. Differential sensitivity of sodium channels from the central and peripheral nervous system to the scorpion toxins Lqh-2 and Lqh-3. Eur. J. Neurosci. 16 (2002) 767-770
14. Elliot A.A., and Elliot J.R. Characterization of TTX-sensitive and TTX-resistant sodium currents in small cells from adult rat dorsal root ganglia. J. Physiol. (London) 463 (1993) 39-56
15. Fainzilber M., Kofman O., Zlotkin E., and Gordon D. A new neurotoxin receptor site on sodium channels is identified by a conotoxin that affects sodium channel inactivation in molluscs and acts as an antagonist in rat brain. J. Biol. Chem. 269 (1994) 2574-2580
16. Fernandez J.M., Fox A.P., and Krasne S. Membrane patches and whole-cell membranes: a comparison of electrical properties in rat clonal pituitary (GH3) cells. J. Physiol. 356 (1984) 565-585
17. Fletcher J.I., Chapman B.E., Mackay J.P., Howden M.E., and King G.F. The structure of versutoxin (δ-atracotoxin-Hv1) provides insights into the binding of site 3 neurotoxins to the voltage-gated sodium channel. Structure 5 (1997) 1525-1535
18. Gallagher M.J., and Blumenthal K.M. Importance of the unique cationic residues arginine 12 and lysine 49 in the activity of the cardiotonic polypeptide anthopleurin B. J. Biol. Chem. 269 (1994) 254-259
19. Gilles N., Harrison G., Karbat I., Gurevitz M., Nicholson G.M., and Gordon D. Variations in receptor site-3 on rat brain and insect sodium channels highlighted by binding of a funnel-web spider δ-atracotoxin. Eur. J. Biochem. 269 (2002) 1500-1510
20. Gordon D., Martin-Euclaire M.F., Castèle S., Kopeyan C., Carlier E., Khalifa R.B., Pelhate M., and Rochat H. Scorpion toxins affecting sodium current inactivation bind to distinct homologous receptor sites on rat brain and insect sodium channels. J. Biol. Chem. 271 (1996) 8034-8045
21. Jurkat-Rott K., Mitrovic N., Hang C., Kouzmekine A., Iaizzo P., Herzog J., Lerche H., Nicole S., Vale-Santos J., Chauveau D., Fontaine B., and Lehmann-Horn F. Voltage-sensor sodium channel mutations cause hypokalemic periodic paralysis type 2 by enhanced inactivation and reduced current. Proc. Natl. Acad. Sci. 97 (2000) 9549-9554
22. Khera P.K., and Blumenthal K.M. Importance of highly conserved anionic residues and electrostatic interactions in the activity and structure of the cardiotonic polypeptide anthopleurin B. Biochemistry 35 (1996) 3503-3507
23. Kinoshita E., Maejima H., Yamaoka K., Konno K., Kawai N., Shimizu E., Yokote S., Nakayama H., and Seyama I. Novel wasp toxin discriminates between neuronal and cardiac sodium channels. Mol. Pharmacol. 59 (2001) 1457-1463
24. Lehmann-Horn F., and Jurkat-Rott K. Voltage-gated ion channels and hereditary disease. Physiol. Rev. 79 (1999) 1317-1372
25. Little M.J., Zappia C., Gilles N., Connor M., Tyler M.I., Martin-Eauclaire M.F., Gordon D., and Nicholson G.M. δ-Atracotoxins from Australian funnel-web spiders compete with scorpion α-toxin binding but differentially modulate alkaloid toxin activation of voltage-gated sodium channels. J. Biol. Chem. 273 (1998) 27076-27083
26. Loret E.P., Menendez Soto del Valle R., Mansuelle P., Sampieri F., and Rochat H. Positively charged amino acid residues located similarly in sea anemone and scorpion toxins. J. Biol. Chem. 269 (1994) 16785-16788
27. Meves H., Simard J.M., and Watt D.D. Interactions of scorpion toxins with the sodium channel. Ann. N. Y. Acad. Sci. 479 (1986) 113-132
28. Nicholson G.M., Willow M., Howden M.E.H., and Narahashi T. Modification of sodium channel gating and kinetics by versutoxin from the Australian funnel-web spider Hadronyche versuta. Pflüg. Arch. 428 (1994) 400-409
29. Norton R.S. Structure and structure-function relationships of sea anemone proteins that interact with the sodium channel. Toxicon 29 (1991) 1051-1084
30. + channel distribution in the nervous system. Trends Neurosci. 24 (2001) 473-478
31. Oliveira J.C., Redaelli E., Zaharenko A.J., Restano-Cassulini R., Konno K., Pimenta D.C., Freitas J.C., Clare J.J., and Wanke E. Binding specificity of sea anemone toxins to Nav 1.1-1.6. J. Biol. Chem. 279 (2004) 33323-33335
32. + current by primaquine. Br. J. Pharmacol. 135 (2002) 226-238
33. + channels. Eur. J. Biochem. 264 (1999) 287-300
34. Rathmayer W., and Beress L. The effect of toxins of Anemonia sulcata (Coelenterata) on neuromuscular transmission and nerve action potentials in the crayfish (Astacus leptodactylus). J. Comp. Physiol. 109 (1976) 373-382
35. + channel α subunit. J. Biol. Chem. 271 (1996) 15950-15962
36. Romey G., Abita J.P., Schweitz H., Wunderer G., and Lazdunski M. Sea anemone toxin: a tool to study molecular mechanisms of nerve conduction and excitation-secretion coupling. Proc. Natl. Acad. Sci. U. S. A. 73 (1976) 4055-4059
37. Sahara Y., Gotoh M., Konno K., Miwa A., Tsubokawa H., Robinson H.P.C., and Kawai N. A new class of neurotoxin from wasp venom slows inactivation of sodium current. Eur. J. Neurosci. 12 (2000) 1961-1970
38. Salceda E., Garateix A., and Soto E. The sea anemone toxins BgII and BgIII prolong the inactivation time course of the tetrodotoxin sensitive sodium current in dorsal root ganglion neurons. J. Pharmacol. Exp. Ther. 303 (2002) 1067-1074
39. Shapiro B.I., and Lilleheil G. The action of anemone toxin on crustacean neurons. Comp. Biochem. Physiol. 28 (1969) 1225-1241
40. Strachan L.C., Lewis R.J., and Nicholson G.M. Differential actions of Pacific ciguatoxin-1 on sodium channel subtypes in mammalian sensory neurons. J. Pharmacol. Exp. Ther. 288 (1999) 379-388
41. Strichartz G., Rando T., and Wang G.K. An integrated view of the molecular toxinology of sodium channel gating in excitable cells. Annu. Rev. Neurosci. 10 (1987) 237-267