Porter domain opening and closing motions in the multi-drug efflux transporter AcrB

Biochimica et Biophysica Acta - Biomembranes

Volumn 1828, Issue 2, 2013, Pages 632-641

  Fischer, Nadine ^a   Kandt, Christian ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

Antibiotics resistance; Hydrophobic binding pocket; Membrane protein; Molecular dynamics simulation; Proximal binding pocket; Reaction cycle

Indexed keywords

ACRIFLAVINE; ACRIFLAVINE RESISTANCE PROTEIN B; ADAPTOR PROTEIN; THREONINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CHEMICAL REACTION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG TRANSPORT; HYDROPHOBICITY; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN TRANSPORT; REGULATORY MECHANISM; STEADY STATE; STRUCTURE ANALYSIS;

ACRIFLAVINE; BIOLOGICAL TRANSPORT, ACTIVE; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI PROTEINS; MEMBRANE TRANSPORT PROTEINS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR DYNAMICS SIMULATION; MOTION; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY; X-RAYS;

ESCHERICHIA COLI;

EID: 84870228316     PISSN: 00052736     EISSN: 18792642     Source Type: Journal    
DOI: 10.1016/j.bbamem.2012.10.016     Document Type: Article

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