T63, a new 4-arylidene curcumin analogue, induces cell cycle arrest and apoptosis through activation of the reactive oxygen species-FOXO3a pathway in lung cancer cells

Free Radical Biology and Medicine

Volumn 53, Issue 12, 2012, Pages 2204-2217

  Liu, Hao ^a   Zhou, Bin Hua ^a   Qiu, Xu ^a   Wang, Hong Sheng ^a   Zhang, Fan ^a   Fang, Rui ^a   Wang, Xian Feng ^a   Cai, Shao Hui ^b   Du, Jun ^a   Bu, Xian Zhang ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b JINAN UNIVERSITY   (China)

Author keywords

Cell apoptosis; Cell cycle arrest; FOXO3a; Free radicals; Lung cancer; ROS; T63

Indexed keywords

BIM PROTEIN; CASPASE 3; CURCUMIN; CYCLIN D1; PROTEIN P21; PROTEIN P27; REACTIVE OXYGEN METABOLITE; T 63; TRANSCRIPTION FACTOR FKHRL1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; HUMAN; HUMAN CELL; LUNG CANCER; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR XENOGRAFT;

CELL APOPTOSIS; CELL CYCLE ARREST; FOXO3A; FREE RADICALS; LUNG CANCER; ROS; T63;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CATALASE; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CURCUMIN; FORKHEAD TRANSCRIPTION FACTORS; GLUTATHIONE; HUMANS; LUNG NEOPLASMS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE; TRANSCRIPTIONAL ACTIVATION; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

CURCUMA LONGA;

EID: 84869862834     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.10.537     Document Type: Article

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