ROS-driven Akt dephosphorylation at Ser-473 is involved in 4-HPR-mediated apoptosis in NB4 cells

Free Radical Biology and Medicine

Volumn 47, Issue 5, 2009, Pages 536-547

  Cao, Ji ^a   Xu, Danqing ^a   Wang, Duoduo ^a   Wu, Rui ^a   Zhang, Lei ^a   Zhu, Hong ^a   He, Qiaojun ^a   Yang, Bo ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

4 HPR; Akt; Dephosphorylation; Disulfide bond; Free radicals; ROS

Indexed keywords

ACETYLCYSTEINE; DISULFIDE; FENRETINIDE; GLUTATHIONE; HEAT SHOCK PROTEIN 90; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SERINE DERIVATIVE; THIOL DERIVATIVE;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME CONFORMATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; FEMALE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CHROMONES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FEMALE; FENRETINIDE; HL-60 CELLS; HUMANS; K562 CELLS; LEUKEMIA; MICE; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MORPHOLINES; ONCOGENE PROTEIN V-AKT; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; SERINE;

EID: 67650726507     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2009.05.024     Document Type: Article

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