The IL6R variation Asp358Ala is a potential modifier of lung function in subjects with asthma

Journal of Allergy and Clinical Immunology

Volumn 130, Issue 2, 2012, Pages

  Hawkins, Gregory A ^a,b   Robinson, Mac B ^a   Hastie, Annette T ^a,b   Li, Xingnan ^a,b   Li, Huashi ^a,b   Moore, Wendy C ^a,b   Howard, Timothy D ^a   Busse, William W ^b   Erzurum, Serpil C ^b   Wenzel, Sally E ^b   Peters, Stephen P ^a,b   Meyers, Deborah A ^a,b   Bleecker, Eugene R ^a,b  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b Severe Asthma Research Program (SARP)   (United States)

Author keywords

asthma; genetic variation; IL 6; IL 6 transsignaling; pulmonary lung function; severe asthma; single nucleotide polymorphism rs2228145; Soluble IL 6 receptor

Indexed keywords

ALANINE; ASPARAGINE; CORTICOSTEROID; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; INTERLEUKIN 6 RECEPTOR ALPHA;

ADULT; ARTICLE; ASTHMA; BRONCHUS BIOPSY; CONTROLLED STUDY; DISEASE SEVERITY; DRUG MEGADOSE; FEMALE; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; GENE FREQUENCY; GENETIC VARIABILITY; HUMAN; IMMUNOHISTOCHEMISTRY; LUNG ALVEOLUS EPITHELIUM; LUNG ALVEOLUS MACROPHAGE; LUNG FUNCTION; LUNG LAVAGE; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RESPIRATORY EPITHELIUM; RESPIRATORY TRACT ALLERGY; SINGLE NUCLEOTIDE POLYMORPHISM; SMOOTH MUSCLE; VASCULAR ENDOTHELIUM;

EID: 84864485029     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2012.03.018     Document Type: Article

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