메뉴 건너뛰기




Volumn 8, Issue 10, 2012, Pages 1420-1430

Immunotherapies: The blockade of inhibitory signals

Author keywords

BTLA; CTLA 4; Immunotherapy; Inhibitory receptors; PD 1

Indexed keywords

ABATACEPT; ANTIBODY CONJUGATE; BTLA PROTEIN, MOUSE; CD274 PROTEIN, MOUSE; CD28 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DIFFERENTIATION ANTIGEN; HERPESVIRUS ENTRY MEDIATOR; IMMUNOGLOBULIN RECEPTOR; IMMUNOSUPPRESSIVE AGENT; PD 1 ANTIGEN, MOUSE; PD-1 ANTIGEN, MOUSE; PROGRAMMED DEATH 1 LIGAND 1;

EID: 84869787349     PISSN: 14492288     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijbs.5273     Document Type: Review
Times cited : (25)

References (102)
  • 2
    • 0031888608 scopus 로고    scopus 로고
    • Immunological ignorance of silent antigens as an explanation of tumor evasion
    • Chen L. Immunological ignorance of silent antigens as an explanation of tumor evasion. Immunol Today. 1998; 19: 27-30.
    • (1998) Immunol Today , vol.19 , pp. 27-30
    • Chen, L.1
  • 3
    • 0035056017 scopus 로고    scopus 로고
    • CTLA-4-mediated inhibition of T cell responses: Mechanisms and manipulation in tumor immunother-apy
    • Chambers CA, Kuhns MS, Egen JG, et al. CTLA-4-mediated inhibition of T cell responses: mechanisms and manipulation in tumor immunother-apy. Annu Rev Immunol. 2001; 19: 565-594.
    • (2001) Annu Rev Immunol , vol.19 , pp. 565-594
    • Chambers, C.A.1    Kuhns, M.S.2    Egen, J.G.3
  • 4
    • 76549084610 scopus 로고    scopus 로고
    • Dual function of CTLA-4 in regulatory T cells and conventional T cells to prevent multiorgan autoim-munity
    • Jain N, Nguyen H, Chambers C, et al. Dual function of CTLA-4 in regulatory T cells and conventional T cells to prevent multiorgan autoim-munity. PANS. 2010; 107: 1524-1528.
    • (2010) PANS , vol.107 , pp. 1524-1528
    • Jain, N.1    Nguyen, H.2    Chambers, C.3
  • 5
    • 0029953858 scopus 로고    scopus 로고
    • CTLA-4 ligation blocks CD-28-dependent T cell activation
    • Walunas TL, Bakker CY, Bluestone JA. CTLA-4 ligation blocks CD-28-dependent T cell activation. J Exp Med. 1996; 183: 2541-2550.
    • (1996) J Exp Med , vol.183 , pp. 2541-2550
    • Walunas, T.L.1    Bakker, C.Y.2    Bluestone, J.A.3
  • 6
    • 0028484545 scopus 로고
    • CTLA-4 can function as a negative regulator of T cell activation
    • Walunas TL, Lenschow DJ, Bakker CY, et al. CTLA-4 can function as a negative regulator of T cell activation. J Immunol. 1994; 1: 405-413.
    • (1994) J Immunol , vol.1 , pp. 405-413
    • Walunas, T.L.1    Lenschow, D.J.2    Bakker, C.Y.3
  • 7
    • 0035056017 scopus 로고    scopus 로고
    • CTLA-4-mediated inhibition in regulation of T cell responses: Mechanisms and manipulation in tumor immunotherapy
    • Chambers CA, Kuhns MS, Egen JG, et al. CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy. Annu Rev Immunol, 2001; 19: 565-594.
    • (2001) Annu Rev Immunol , vol.19 , pp. 565-594
    • Chambers, C.A.1    Kuhns, M.S.2    Egen, J.G.3
  • 8
    • 0142259712 scopus 로고    scopus 로고
    • Unifying concepts in CD28, ICOS and CTLA-4 co-receptor signaling
    • Rudd CE, Schneider H. Unifying concepts in CD28, ICOS and CTLA-4 co-receptor signaling. Nature Rev Immunol. 2003; 3: 544-556.
    • (2003) Nature Rev Immunol , vol.3 , pp. 544-556
    • Rudd, C.E.1    Schneider, H.2
  • 9
    • 0035059417 scopus 로고    scopus 로고
    • Complexities of CD28/B7: CTLA-4 co-stimulatory pathways in autoimmunity and transplantation
    • Salomon B, Bluestone JA. Complexities of CD28/B7: CTLA-4 co-stimulatory pathways in autoimmunity and transplantation. Annu Rev Immunol. 2001; 19: 225-252.
    • (2001) Annu Rev Immunol , vol.19 , pp. 225-252
    • Salomon, B.1    Bluestone, J.A.2
  • 12
    • 0028999041 scopus 로고
    • Long-term inhibition of murine experimental autoimmune encephalomyelitis using CTLA-4-Fc supports a key role for CD28 costimulation
    • Cross AH, Girard TJ, Giacoletto KS, et al. Long-term inhibition of murine experimental autoimmune encephalomyelitis using CTLA-4-Fc supports a key role for CD28 costimulation. J Clin Invest. 1995; 95: 2783-2789.
    • (1995) J Clin Invest , vol.95 , pp. 2783-2789
    • Cross, A.H.1    Girard, T.J.2    Giacoletto, K.S.3
  • 13
    • 0029162499 scopus 로고
    • Collagen-induced arthritis in the BB rat. Prevention of disease by treatment with CTLA-4-Ig
    • Knoerzer DB, Karr RW, Schwartz BD, et al. Collagen-induced arthritis in the BB rat. Prevention of disease by treatment with CTLA-4-Ig. J Clin Invest. 1995; 96: 987-993.
    • (1995) J Clin Invest , vol.96 , pp. 987-993
    • Knoerzer, D.B.1    Karr, R.W.2    Schwartz, B.D.3
  • 14
    • 33745291091 scopus 로고    scopus 로고
    • Effects of abatacept in patients with methotrexate-resistant active rheumatoid arthritis: A randomized trial
    • Kremer JM, Genant HK, Moreland LW, et al. Effects of abatacept in patients with methotrexate-resistant active rheumatoid arthritis: a randomized trial. Ann Intern Med. 2006; 144: 865-876.
    • (2006) Ann Intern Med , vol.144 , pp. 865-876
    • Kremer, J.M.1    Genant, H.K.2    Moreland, L.W.3
  • 15
    • 0028483990 scopus 로고
    • Treatment of murine lupus with CTLA4Ig
    • Finck BK, Linsley PS, Wofsy D. Treatment of murine lupus with CTLA4Ig. Science. 1994; 265: 1225-1227.
    • (1994) Science , vol.265 , pp. 1225-1227
    • Finck, B.K.1    Linsley, P.S.2    Wofsy, D.3
  • 16
    • 0036156303 scopus 로고    scopus 로고
    • Anti-CD28 monoclonal antibody therapy prevents chronic rejection of renal allografts in rat
    • Laskowski IA, Pratschke J, Wilhelm MJ, et al. Anti-CD28 monoclonal antibody therapy prevents chronic rejection of renal allografts in rat. J Am Soc Nephrol. 2002; 13: 519-527.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 519-527
    • Laskowski, I.A.1    Pratschke, J.2    Wilhelm, M.J.3
  • 17
    • 0037181623 scopus 로고    scopus 로고
    • Mechanisms of targeting CD28 by a signaling monoclonal antibody in acute and chronic allografts rejection
    • Dong VM, Yuan X, Coito AJ, et al. Mechanisms of targeting CD28 by a signaling monoclonal antibody in acute and chronic allografts rejection. Transplantation. 2002; 73: 1310-1317.
    • (2002) Transplantation , vol.73 , pp. 1310-1317
    • Dong, V.M.1    Yuan, X.2    Coito, A.J.3
  • 18
    • 40049105939 scopus 로고    scopus 로고
    • Anti-cd28 antibodies modify regulatory mechanisms and reinforce tolerance in CD40Ig-treated heart allograft recipients
    • Guillonneau C, Séveno C, Dugast AS, et al. Anti-cd28 antibodies modify regulatory mechanisms and reinforce tolerance in CD40Ig-treated heart allograft recipients. J Immunol. 2007; 179: 8164-8171.
    • (2007) J Immunol , vol.179 , pp. 8164-8171
    • Guillonneau, C.1    Séveno, C.2    Dugast, A.S.3
  • 19
    • 33845432336 scopus 로고    scopus 로고
    • Combination of donor-specific blood transfusion with anti-CD28 antibody synergizes to prolong graft survival in rat liver transplantation
    • Urakami H, Ostanin DV, Hunig T, et al. Combination of donor-specific blood transfusion with anti-CD28 antibody synergizes to prolong graft survival in rat liver transplantation. Transplant Proc. 2006; 38: 3244-3246.
    • (2006) Transplant Proc , vol.38 , pp. 3244-3246
    • Urakami, H.1    Ostanin, D.V.2    Hunig, T.3
  • 20
    • 0034192104 scopus 로고    scopus 로고
    • CD28-specific antibody prevents graft-versus-host disease in mice
    • Yu XZ, Bidwell SJ, Martin PJ, et al. CD28-specific antibody prevents graft-versus-host disease in mice. J Immunol. 2000; 164: 4564-4568.
    • (2000) J Immunol , vol.164 , pp. 4564-4568
    • Yu, X.Z.1    Bidwell, S.J.2    Martin, P.J.3
  • 21
    • 85047693292 scopus 로고    scopus 로고
    • CD28 ligation induces transplantation tolerance by IFN-gamma-dependent depletion of T cells that recognize alloantigens
    • Yu XZ, Albert MH, Martin PJ, et al. CD28 ligation induces transplantation tolerance by IFN-gamma-dependent depletion of T cells that recognize alloantigens. J Clin Invest. 2004; 113: 1624-1630.
    • (2004) J Clin Invest , vol.113 , pp. 1624-1630
    • Yu, X.Z.1    Albert, M.H.2    Martin, P.J.3
  • 22
    • 0033557295 scopus 로고    scopus 로고
    • Prolonged allograft survival but no tolerance infuction by modulation CD28 antibody JJ319 after high-responder rat heart transplantation
    • Dengler TJ, Szabo G, Sido B, et al. Prolonged allograft survival but no tolerance infuction by modulation CD28 antibody JJ319 after high-responder rat heart transplantation. Transplantation. 1999; 67: 392-398.
    • (1999) Transplantation , vol.67 , pp. 392-398
    • Dengler, T.J.1    Szabo, G.2    Sido, B.3
  • 23
    • 0028365181 scopus 로고
    • Transplantation tolerance induced by CTLA-4-Ig
    • Pearson TC, Alexander DZ, Winn KJ, et al. Transplantation tolerance induced by CTLA-4-Ig. Transplantation. 1994; 57: 1701-1706.
    • (1994) Transplantation , vol.57 , pp. 1701-1706
    • Pearson, T.C.1    Alexander, D.Z.2    Winn, K.J.3
  • 24
    • 79952019458 scopus 로고    scopus 로고
    • Porcine CTLA-4-Ig prolong islet xenografts in rats by downregulating the direct pathway of T-cell activation
    • Zhai C, Yu L, Zhu H, et al. Porcine CTLA-4-Ig prolong islet xenografts in rats by downregulating the direct pathway of T-cell activation. Xeno-transplantation. 2011; 18: 40-45.
    • (2011) Xeno-transplantation , vol.18 , pp. 40-45
    • Zhai, C.1    Yu, L.2    Zhu, H.3
  • 25
    • 80555126845 scopus 로고    scopus 로고
    • CTLA-4-Ig therapy diminishes the frequency but enhances the function of Treg cells in patients with Rheumatoid Arthritis
    • Álvarez-Quiroga C, Abud-Mendoza C, Doníz-Padilla L, et al. CTLA-4-Ig therapy diminishes the frequency but enhances the function of Treg cells in patients with Rheumatoid Arthritis. J. Clin. Immunol. 2011; 31: 588-595.
    • (2011) J. Clin. Immunol , vol.31 , pp. 588-595
    • Álvarez-Quiroga, C.1    Abud-Mendoza, C.2    Doníz-Padilla, L.3
  • 26
    • 0029947568 scopus 로고    scopus 로고
    • Enhancement of antitumor immunity by CTLA-4 blockade
    • Leach DR, Krummel MF, Allison JP. Enhancement of antitumor immunity by CTLA-4 blockade. Science. 1996; 271: 1734-1736.
    • (1996) Science , vol.271 , pp. 1734-1736
    • Leach, D.R.1    Krummel, M.F.2    Allison, J.P.3
  • 27
    • 33644659256 scopus 로고    scopus 로고
    • Principles and use of an-ti-CTLA-4 antibody in human cancer immunothearpy
    • Peggs KS, Quezada SA, Korma AJ, et al. Principles and use of an-ti-CTLA-4 antibody in human cancer immunothearpy. Curr Opin Immunol. 2006; 18: 206-213.
    • (2006) Curr Opin Immunol , vol.18 , pp. 206-213
    • Peggs, K.S.1    Quezada, S.A.2    Korma, A.J.3
  • 28
    • 68149155982 scopus 로고    scopus 로고
    • Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor anctivity of anti-CTLA-4 antibodies
    • Peggs KS, Quezada SA, Chambers CA, et al. Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor anctivity of anti-CTLA-4 antibodies. J Exp Med. 2009; 206: 1717-1725.
    • (2009) J Exp Med , vol.206 , pp. 1717-1725
    • Peggs, K.S.1    Quezada, S.A.2    Chambers, C.A.3
  • 29
    • 0032404099 scopus 로고    scopus 로고
    • Realization of the therapeutic potential of CTLA-4 blockade in low-dose chemotherapy-treated tumor-beating mice
    • Mokyr MB, Kalinichenko T, Gorelik L, et al. Realization of the therapeutic potential of CTLA-4 blockade in low-dose chemotherapy-treated tumor-beating mice. Cancer Res. 1998; 58: 5301-5304.
    • (1998) Cancer Res , vol.58 , pp. 5301-5304
    • Mokyr, M.B.1    Kalinichenko, T.2    Gorelik, L.3
  • 30
    • 12244252335 scopus 로고    scopus 로고
    • Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer
    • Demaria S, Kawashima N, Yang AM, et al. Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer. Clin Cancer Res. 2005; 11: 728-734.
    • (2005) Clin Cancer Res , vol.11 , pp. 728-734
    • Demaria, S.1    Kawashima, N.2    Yang, A.M.3
  • 31
    • 0035903324 scopus 로고    scopus 로고
    • Synergism of cytotoxic T lymphocyte-associated T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses
    • Sutmuller RPM, van Duivenvoorde LM, van Elsas A, et al. Synergism of cytotoxic T lymphocyte-associated T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses. J Exp Med. 2001; 194: 823-832.
    • (2001) J Exp Med , vol.194 , pp. 823-832
    • Sutmuller, R.P.M.1    van Duivenvoorde, L.M.2    van Elsas, A.3
  • 32
    • 79961102493 scopus 로고    scopus 로고
    • Synergistic effects of CTLA-4 blockade with tremelimumab and elimination of regulatory T lymphocytes in vitro and in vivo
    • Suarez N, Alfaro C, Dubrot J, et al. Synergistic effects of CTLA-4 blockade with tremelimumab and elimination of regulatory T lymphocytes in vitro and in vivo. Int J Cancer. 2011; 129: 374-386.
    • (2011) Int J Cancer , vol.129 , pp. 374-386
    • Suarez, N.1    Alfaro, C.2    Dubrot, J.3
  • 33
    • 0038745486 scopus 로고    scopus 로고
    • Generation of antitumor immunity by cytotoxic T lymphocyte epitope peptide vaccination, CpG-oligodeoxynucleotide adjuvant, and CTLA-4 blockade
    • Davila E, Kennedy R, Celis E. Generation of antitumor immunity by cytotoxic T lymphocyte epitope peptide vaccination, CpG-oligodeoxynucleotide adjuvant, and CTLA-4 blockade. Cancer Res. 2003; 63: 3281-3288.
    • (2003) Cancer Res , vol.63 , pp. 3281-3288
    • Davila, E.1    Kennedy, R.2    Celis, E.3
  • 34
    • 77749279776 scopus 로고    scopus 로고
    • PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and my-eloid cells within B16 melanoma tumors
    • Curran MA, Montalvo W, Yagita H, et al. PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and my-eloid cells within B16 melanoma tumors. PANS. 2010; 107: 4275-4280.
    • (2010) PANS , vol.107 , pp. 4275-4280
    • Curran, M.A.1    Montalvo, W.2    Yagita, H.3
  • 35
    • 79955785050 scopus 로고    scopus 로고
    • Combination CTLA-4 blockade and 4-1BB activation enhances tumor rejection by increasing T cell infiltration, proliferation and cytokine production
    • Curran MA, Kim M, Montalvo W, et al. Combination CTLA-4 blockade and 4-1BB activation enhances tumor rejection by increasing T cell infiltration, proliferation and cytokine production. PLoS ONE. 2011; 6: 1-11.
    • (2011) PLoS ONE , vol.6 , pp. 1-11
    • Curran, M.A.1    Kim, M.2    Montalvo, W.3
  • 36
    • 20044395957 scopus 로고    scopus 로고
    • Autoimmunity in a phase I trial of a fully human anti-CTLA-4 monoclonal antibody with multiple peptides and Montanide ISA 51 for patients with resected stages III/IV melanoma
    • Sanderson K, Scotland R, Lee P, et al. Autoimmunity in a phase I trial of a fully human anti-CTLA-4 monoclonal antibody with multiple peptides and Montanide ISA 51 for patients with resected stages III/IV melanoma. J Clin Oncol. 2005; 23: 741-750.
    • (2005) J Clin Oncol , vol.23 , pp. 741-750
    • Sanderson, K.1    Scotland, R.2    Lee, P.3
  • 37
    • 0038153907 scopus 로고    scopus 로고
    • Cancer regression and autoim-munity induced by cytotoxic T lymphocyte-associated antigen antigen 4 blockade in patients with metastatic melanoma
    • Phan GQ, Yang JC, Aherry RM, et al. Cancer regression and autoim-munity induced by cytotoxic T lymphocyte-associated antigen antigen 4 blockade in patients with metastatic melanoma. Proc Natl Acad Sci. 2003; 100: 8371-8377.
    • (2003) Proc Natl Acad Sci , vol.100 , pp. 8371-8377
    • Phan, G.Q.1    Yang, J.C.2    Aherry, R.M.3
  • 38
    • 79953300714 scopus 로고    scopus 로고
    • Anti-CTLA-4 antibody-induced Guillain-Barré syndrome in a melanoma patient
    • Wilgenhof S, Neyns B. Anti-CTLA-4 antibody-induced Guillain-Barré syndrome in a melanoma patient. Ann Oncol. 2011; 22: 991-993.
    • (2011) Ann Oncol , vol.22 , pp. 991-993
    • Wilgenhof, S.1    Neyns, B.2
  • 39
    • 8344267742 scopus 로고    scopus 로고
    • A phase II, randomized multi-center study of MDX-010 alone or in combination with dacarbazine (DTIC) in stage IV metastatic malignant melanoma
    • Hersh EM, Weber J, Powderly J, et al. A phase II, randomized multi-center study of MDX-010 alone or in combination with dacarbazine (DTIC) in stage IV metastatic malignant melanoma. J Clin Oncol. 2004; 22: s7511.
    • (2004) J Clin Oncol , vol.22
    • Hersh, E.M.1    Weber, J.2    Powderly, J.3
  • 40
    • 0344341626 scopus 로고    scopus 로고
    • Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients
    • Hodi FS, Mihm MC, Soiffer RJ, et al. Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients. Pron Natl Acad Sci. 2003; 100: 4712-4717.
    • (2003) Pron Natl Acad Sci , vol.100 , pp. 4712-4717
    • Hodi, F.S.1    Mihm, M.C.2    Soiffer, R.J.3
  • 41
    • 79960895501 scopus 로고    scopus 로고
    • + T cells in prevaccinated patients with melanoma: Three cases
    • + T cells in prevaccinated patients with melanoma: three cases. Cancer Immunol Immunother. 2011; 60: 1137-1146.
    • (2011) Cancer Immunol Immunother , vol.60 , pp. 1137-1146
    • Yuan, J.1    Ginsberg, B.2    Page, D.3
  • 42
    • 0031905627 scopus 로고    scopus 로고
    • Normal responsiveness of CTLA-4-deficient anti-viral cytotoxic T cells
    • Bachmann MF, Waterhouse P, Speiser DE, et al. Normal responsiveness of CTLA-4-deficient anti-viral cytotoxic T cells. J Immunol. 1998; 160: 95-100.
    • (1998) J Immunol , vol.160 , pp. 95-100
    • Bachmann, M.F.1    Waterhouse, P.2    Speiser, D.E.3
  • 43
    • 32544459770 scopus 로고    scopus 로고
    • Restoring function in exhausted CD8 T cells during chronic viral infection
    • Barber DL, Wherry EJ, Masopust D, et al. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature. 2006; 439: 682-687.
    • (2006) Nature , vol.439 , pp. 682-687
    • Barber, D.L.1    Wherry, E.J.2    Masopust, D.3
  • 44
    • 0037040351 scopus 로고    scopus 로고
    • CTLA-4 upregulated during HIV infection: Association with anergy and possible target for therapeutic intervention
    • Leng Q, Bentwich Z, Magen E, et al. CTLA-4 upregulated during HIV infection: association with anergy and possible target for therapeutic intervention. Aids. 2002; 16: 519-529.
    • (2002) Aids , vol.16 , pp. 519-529
    • Leng, Q.1    Bentwich, Z.2    Magen, E.3
  • 45
    • 34548680261 scopus 로고    scopus 로고
    • + T cells correlates with disease progression and defines a reversible immune dysfunction
    • + T cells correlates with disease progression and defines a reversible immune dysfunction. Nat Immunol. 2007; 8: 1246-1254.
    • (2007) Nat Immunol , vol.8 , pp. 1246-1254
    • Kaufmann, D.E.1    Kavanagh, D.G.2    Pereyra, F.3
  • 46
    • 79960928006 scopus 로고    scopus 로고
    • Aberrant production of soluble co-stimulatory molecules CTLA-4 and CD28 in patients with chronic hepatitis B
    • Cao J, Zhang L, Huang S, et al. Aberrant production of soluble co-stimulatory molecules CTLA-4 and CD28 in patients with chronic hepatitis B. Microb Pathog. 2011; 51: 262-267.
    • (2011) Microb Pathog , vol.51 , pp. 262-267
    • Cao, J.1    Zhang, L.2    Huang, S.3
  • 47
    • 0026700235 scopus 로고
    • Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death
    • Ishida Y, Agata Y, Shibahara K, et al. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J.1992; 11: 3887-3895.
    • (1992) EMBO J , vol.11 , pp. 3887-3895
    • Ishida, Y.1    Agata, Y.2    Shibahara, K.3
  • 48
    • 0033180181 scopus 로고    scopus 로고
    • Develpoment of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM mo-tif-carring immunoreceptor
    • Nishimura H, Nose M, Hiai H, et al. Develpoment of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM mo-tif-carring immunoreceptor. Immunity. 1999; 11: 141-151.
    • (1999) Immunity , vol.11 , pp. 141-151
    • Nishimura, H.1    Nose, M.2    Hiai, H.3
  • 49
    • 0035846991 scopus 로고    scopus 로고
    • Autoimmune dilated cardio-myopathy in PD-1 receptor-deficient mice
    • Nishimura H, Okazaki T, Tanaka Y, et al. Autoimmune dilated cardio-myopathy in PD-1 receptor-deficient mice. Science. 2001; 291: 319-322.
    • (2001) Science , vol.291 , pp. 319-322
    • Nishimura, H.1    Okazaki, T.2    Tanaka, Y.3
  • 50
    • 79960950244 scopus 로고    scopus 로고
    • Programmed death (PD)-1-dificient mice are extremely sentitive to murine hepatitis virus strain-3 (MHV-3) infection
    • Chen Y, Wu S, Guo G, et al. Programmed death (PD)-1-dificient mice are extremely sentitive to murine hepatitis virus strain-3 (MHV-3) infection. PLoS Pathog. 2011; 7: e1001347.
    • (2011) PLoS Pathog , vol.7
    • Chen, Y.1    Wu, S.2    Guo, G.3
  • 51
    • 80052359996 scopus 로고    scopus 로고
    • T-regulatory cells infected with immunodeficiency virus up-regulate programmed death-1(PD-1)
    • Achleiner A, Clark ME, Bienzle D. T-regulatory cells infected with immunodeficiency virus up-regulate programmed death-1(PD-1). Vet Immunol Immunopathol. 2011; 143: 307-313.
    • (2011) Vet Immunol Immunopathol , vol.143 , pp. 307-313
    • Achleiner, A.1    Clark, M.E.2    Bienzle, D.3
  • 52
    • 78651367729 scopus 로고    scopus 로고
    • Intrahepatic levels of PD-1/PD-L1 correlate with liver inflammation in chronic hepatitis B
    • Chen J, Wang XM, Wu XJ, et al. Intrahepatic levels of PD-1/PD-L1 correlate with liver inflammation in chronic hepatitis B. Inflamm Res. 2011; 60: 47-53.
    • (2011) Inflamm Res , vol.60 , pp. 47-53
    • Chen, J.1    Wang, X.M.2    Wu, X.J.3
  • 54
    • 80052365815 scopus 로고    scopus 로고
    • Upregulation of circulating PD-L1/PD-1 is associated with poor post-cryoablation prognosis in patients with HBV-related hepatocellular carcinoma
    • Zeng Z, Shi F, Zhou L, et al. Upregulation of circulating PD-L1/PD-1 is associated with poor post-cryoablation prognosis in patients with HBV-related hepatocellular carcinoma. PLoS One. 2011; 6(9): e23621.
    • (2011) PLoS One , vol.6 , Issue.9
    • Zeng, Z.1    Shi, F.2    Zhou, L.3
  • 55
    • 78650621479 scopus 로고    scopus 로고
    • + T cell apoptosis and postoperative recurrence in hepatocellular carcinoma patients
    • + T cell apoptosis and postoperative recurrence in hepatocellular carcinoma patients. Int J Cancer. 2011; 128: 887-896.
    • (2011) Int J Cancer , vol.128 , pp. 887-896
    • Shi, F.1    Shi, M.2    Zeng, Z.3
  • 56
    • 79959765108 scopus 로고    scopus 로고
    • Enhanced programmed death 1 (PD-1) and PD-1 ligand (PD-L1) expression in patients with actinic cheilitis and oral squamous cell carcinoma
    • Malaspina TS, Gasparoto TH, Costa MR, et al. Enhanced programmed death 1 (PD-1) and PD-1 ligand (PD-L1) expression in patients with actinic cheilitis and oral squamous cell carcinoma. Cancer Immunol Im-munother. 2011; 60: 965-974.
    • (2011) Cancer Immunol Im-munother , vol.60 , pp. 965-974
    • Malaspina, T.S.1    Gasparoto, T.H.2    Costa, M.R.3
  • 58
    • 33751094550 scopus 로고    scopus 로고
    • Programmed Death-1 Gene Polymorphisms in Patients With Systemic Lupus Erythematosus in Taiwan
    • Wang SC, Chen YJ, Ou TT, et al. Programmed Death-1 Gene Polymorphisms in Patients With Systemic Lupus Erythematosus in Taiwan. J Clin Immunol. 2006; 26: 506-511.
    • (2006) J Clin Immunol , vol.26 , pp. 506-511
    • Wang, S.C.1    Chen, Y.J.2    Ou, T.T.3
  • 59
    • 77954220941 scopus 로고    scopus 로고
    • The Programmed Death1/Programmed Death Ligand 1 Inhibitory Pathway Is Up-Regulated in Rheumatoid Synovium and Regulates Peripheral T Cell Responses in Human and Murine Arthritis
    • Raptopoulou AP, Bertsias G, Makrygiannakis D, et al. The Programmed Death1/Programmed Death Ligand 1 Inhibitory Pathway Is Up-Regulated in Rheumatoid Synovium and Regulates Peripheral T Cell Responses in Human and Murine Arthritis. Arthritis Rheum. 2010; 62: 1870-1880.
    • (2010) Arthritis Rheum , vol.62 , pp. 1870-1880
    • Raptopoulou, A.P.1    Bertsias, G.2    Makrygiannakis, D.3
  • 60
    • 33947097389 scopus 로고    scopus 로고
    • PD-1 gene haplotype is associated with the development of type diabetes I mellitus in Japanese children
    • Ni R, Ihara K, Miyako K, et al. PD-1 gene haplotype is associated with the development of type diabetes I mellitus in Japanese children. Hum Genet. 2007; 121: 223-232.
    • (2007) Hum Genet , vol.121 , pp. 223-232
    • Ni, R.1    Ihara, K.2    Miyako, K.3
  • 61
    • 32044445824 scopus 로고    scopus 로고
    • Delivering PD-1 inhibitory signal concomitant with blocking ICOS costimulation supresses lupus-like syndrome in autoimmune BXSB mice
    • Ding H, Wu X, Wu J, et al. Delivering PD-1 inhibitory signal concomitant with blocking ICOS costimulation supresses lupus-like syndrome in autoimmune BXSB mice. Clin Immunol. 2006; 118: 258-267.
    • (2006) Clin Immunol , vol.118 , pp. 258-267
    • Ding, H.1    Wu, X.2    Wu, J.3
  • 62
    • 13544259967 scopus 로고    scopus 로고
    • Prevention of experiment autoimmune encephalomyelitis by transfer of embryonic stem cell-derived dendritic cells expressing myelin oligodendrocyte glycoprotein peptide along with TRAIL or programmed death-1 ligand
    • Hirata S, Senju S, Matsuyoshi H, et al. Prevention of experiment autoimmune encephalomyelitis by transfer of embryonic stem cell-derived dendritic cells expressing myelin oligodendrocyte glycoprotein peptide along with TRAIL or programmed death-1 ligand. J Immunol. 2005; 174: 1888-1897.
    • (2005) J Immunol , vol.174 , pp. 1888-1897
    • Hirata, S.1    Senju, S.2    Matsuyoshi, H.3
  • 63
    • 4444355857 scopus 로고    scopus 로고
    • Interferon-beta enhances monocyte and dendritic cell expression of B7-H1 (PD-L1), a strong inhibitor of autologous T-cell activation: Relevance for the immune modu-latory effect in multiple sclerosis
    • Schreiner B, Mitsdoerffer M, Kieseier BC, et al. Interferon-beta enhances monocyte and dendritic cell expression of B7-H1 (PD-L1), a strong inhibitor of autologous T-cell activation: relevance for the immune modu-latory effect in multiple sclerosis. J Neuroimmunol. 2004; 155: 172-182.
    • (2004) J Neuroimmunol , vol.155 , pp. 172-182
    • Schreiner, B.1    Mitsdoerffer, M.2    Kieseier, B.C.3
  • 64
    • 78149491097 scopus 로고    scopus 로고
    • Blockade of programmed death -1 pathway rescues the effector function of tumor-infiltrating T cells and enhances the antitumor efficacy of lentivector immunization
    • Zhou Q, Xiao H, Liu Y, et al. Blockade of programmed death -1 pathway rescues the effector function of tumor-infiltrating T cells and enhances the antitumor efficacy of lentivector immunization. J Immuno. 2010; 185: 5082-5092.
    • (2010) J Immuno , vol.185 , pp. 5082-5092
    • Zhou, Q.1    Xiao, H.2    Liu, Y.3
  • 65
    • 79960732805 scopus 로고    scopus 로고
    • Combination of lentivector immunization and low-dose chemotherapy of PD-1/PD-L1 blocking primes self-reactive T cells and induces anti-tumor immunity
    • Sierro SR, Donda A, Perret R, et al. Combination of lentivector immunization and low-dose chemotherapy of PD-1/PD-L1 blocking primes self-reactive T cells and induces anti-tumor immunity. Eur J Immunol. 2011; 41: 2217-2228.
    • (2011) Eur J Immunol , vol.41 , pp. 2217-2228
    • Sierro, S.R.1    Donda, A.2    Perret, R.3
  • 66
    • 34848900497 scopus 로고    scopus 로고
    • Programmed death-1 blockade enhances expansion and functional capacity of human melanoma antigen-specific CTLs
    • Wong RM, Scotland RR, Lau RL, et al. Programmed death-1 blockade enhances expansion and functional capacity of human melanoma antigen-specific CTLs. Int Immunol. 2007; 19: 1223-1234.
    • (2007) Int Immunol , vol.19 , pp. 1223-1234
    • Wong, R.M.1    Scotland, R.R.2    Lau, R.L.3
  • 67
    • 77953229315 scopus 로고    scopus 로고
    • RNA interference targeting programmed death receptor-1 improves immune function of tumor-specific T cells
    • Borkner L, Kaiser A, van de Kasteele W, et al. RNA interference targeting programmed death receptor-1 improves immune function of tumor-specific T cells. Cancer Immunol Immunother. 2010; 59: 1173-1183.
    • (2010) Cancer Immunol Immunother , vol.59 , pp. 1173-1183
    • Borkner, L.1    Kaiser, A.2    van de Kasteele, W.3
  • 68
    • 79957574865 scopus 로고    scopus 로고
    • The negative costimu-latory molecule PD-1 modulates the balance between immunity and tolerance via miR-21
    • Iliopoulos D, Kavousanaki M, Ioannou M, et al. The negative costimu-latory molecule PD-1 modulates the balance between immunity and tolerance via miR-21. Eur J Immunol. 2011; 41: 1754-1763.
    • (2011) Eur J Immunol , vol.41 , pp. 1754-1763
    • Iliopoulos, D.1    Kavousanaki, M.2    Ioannou, M.3
  • 69
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of an-ti-PD-1 antibody in patients with advanced cancer
    • Brahmer JR, Tykodi SS, Chow LQM, et al. Safety and activity of an-ti-PD-1 antibody in patients with advanced cancer. N Engl J Med. 2012; 366: 2455-2465.
    • (2012) N Engl J Med , vol.366 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.M.3
  • 70
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-L1 antibody in cancer
    • Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-L1 antibody in cancer. N Engl J Med. 2012; 366: 2443-2454.
    • (2012) N Engl J Med , vol.366 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 71
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune immunotherapy
    • Pardoll DM. The blockade of immune immunotherapy. Nat Rev Cancer. 2012; 12: 252-264.
    • (2012) Nat Rev Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 72
    • 33748947326 scopus 로고    scopus 로고
    • PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
    • Day CL, Kaufmann DE, Kiepiela P, et al. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature. 2006; 443: 350-354.
    • (2006) Nature , vol.443 , pp. 350-354
    • Day, C.L.1    Kaufmann, D.E.2    Kiepiela, P.3
  • 73
    • 79251632920 scopus 로고    scopus 로고
    • PD-1 negatively regulates interleukin-12 expression by limiting STAT-1 phosphorylation in mono-cytes/macrophages during chronic hepatitis C virus infection
    • Ma CJ, Ni L, Zhang Y, et al. PD-1 negatively regulates interleukin-12 expression by limiting STAT-1 phosphorylation in mono-cytes/macrophages during chronic hepatitis C virus infection. Immunology. 2010; 132: 421-431.
    • (2010) Immunology , vol.132 , pp. 421-431
    • Ma, C.J.1    Ni, L.2    Zhang, Y.3
  • 74
    • 57849168934 scopus 로고    scopus 로고
    • + t Cell exhaustion during chronic viral infection by multiple inhibitory receptors
    • + t Cell exhaustion during chronic viral infection by multiple inhibitory receptors. Nat Immunol. 2009; 10: 29-37.
    • (2009) Nat Immunol , vol.10 , pp. 29-37
    • Blackburn, S.D.1    Shin, H.2    Haining, W.N.3
  • 75
    • 33644558718 scopus 로고    scopus 로고
    • Expression of B7-H1 on gastric epithelial cells: Its potential role in regulating T cells during Helicobacter pylori infection
    • Das S, Suarez G, Beswick EJ, et al. Expression of B7-H1 on gastric epithelial cells: its potential role in regulating T cells during Helicobacter pylori infection. J Immunol. 2006; 176: 3000-3009.
    • (2006) J Immunol , vol.176 , pp. 3000-3009
    • Das, S.1    Suarez, G.2    Beswick, E.J.3
  • 76
    • 3142750528 scopus 로고    scopus 로고
    • Schistosoma mansoni worms induce anergy of T cells via selective up-regulation of programmed death ligand 1 on macrophages
    • Smith P, Walsh CM, Mangan NE, et al. Schistosoma mansoni worms induce anergy of T cells via selective up-regulation of programmed death ligand 1 on macrophages. J Immunol. 2004; 173: 1240-1248.
    • (2004) J Immunol , vol.173 , pp. 1240-1248
    • Smith, P.1    Walsh, C.M.2    Mangan, N.E.3
  • 77
    • 84871066174 scopus 로고    scopus 로고
    • Lack of programmed cell death receptor (PD)-1 leads to improved survival in a murine model of indirect acute lung injury
    • Monaghan SF, Thakkar RK, Chung CS, et al. Lack of programmed cell death receptor (PD)-1 leads to improved survival in a murine model of indirect acute lung injury. J Am Coll Surg. 2010; 211: s52.
    • (2010) J Am Coll Surg , vol.211
    • Monaghan, S.F.1    Thakkar, R.K.2    Chung, C.S.3
  • 78
    • 77955710639 scopus 로고    scopus 로고
    • PD-1 on immature and PD-1 ligands on migratory human langerhans cells regulate antigen-presenting cell activity
    • Peña-Cruz V, McDonough SM, Diaz-Griffero F, et al. PD-1 on immature and PD-1 ligands on migratory human langerhans cells regulate antigen-presenting cell activity. J Invest Dermatol. 2010; 130: 2222-2230.
    • (2010) J Invest Dermatol , vol.130 , pp. 2222-2230
    • Peña-Cruz, V.1    McDonough, S.M.2    Diaz-Griffero, F.3
  • 79
    • 0036884356 scopus 로고    scopus 로고
    • Programmed death-1 targeting can promote allograft survival
    • Özkaynak E, Wang L, Goodear A, et al. Programmed death-1 targeting can promote allograft survival. J Immunol. 2002; 169: 6546-6553.
    • (2002) J Immunol , vol.169 , pp. 6546-6553
    • Özkaynak, E.1    Wang, L.2    Goodear, A.3
  • 80
    • 0041845131 scopus 로고    scopus 로고
    • Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism
    • Blazar BR, Carreno BM, Panoskaltsis-Mortari A, et al. Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism. J Immunol. 2003; 171: 1272-1277.
    • (2003) J Immunol , vol.171 , pp. 1272-1277
    • Blazar, B.R.1    Carreno, B.M.2    Panoskaltsis-Mortari, A.3
  • 81
    • 0141433189 scopus 로고    scopus 로고
    • Stimulating PD-1-negtive signals concurrent with blocking CD154 co-stimulation induces long-term islet allograft survival
    • Gao W, Demirci G, Strom TB, et al. Stimulating PD-1-negtive signals concurrent with blocking CD154 co-stimulation induces long-term islet allograft survival. Transplantation. 2003; 76: 994-999.
    • (2003) Transplantation , vol.76 , pp. 994-999
    • Gao, W.1    Demirci, G.2    Strom, T.B.3
  • 82
    • 33845487130 scopus 로고    scopus 로고
    • Costimulatory reseptors in jawed vertebrates: Conserved CD28, odd CTLA-4 and multiple BTLAs
    • Bernard D, Hansen JD, Pasquier LD, et al. Costimulatory reseptors in jawed vertebrates: conserved CD28, odd CTLA-4 and multiple BTLAs. Dew Comp Immunol. 2007; 31: 255-271.
    • (2007) Dew Comp Immunol , vol.31 , pp. 255-271
    • Bernard, D.1    Hansen, J.D.2    Pasquier, L.D.3
  • 83
    • 33646856912 scopus 로고    scopus 로고
    • B and T lymphocyte attenuator-mediated signal transduction provides a potent inhibitory signal to primary human CD4 T cells that can be initiated by multiple phosphotyrosine motifs
    • Chemnitz JM, Lanfranco AR, Braunstein I, et al. B and T lymphocyte attenuator-mediated signal transduction provides a potent inhibitory signal to primary human CD4 T cells that can be initiated by multiple phosphotyrosine motifs. J Immunol. 2006; 176: 6603-6614.
    • (2006) J Immunol , vol.176 , pp. 6603-6614
    • Chemnitz, J.M.1    Lanfranco, A.R.2    Braunstein, I.3
  • 84
    • 12844268068 scopus 로고    scopus 로고
    • A co-receptor interaction between the CD28 and TNF receptor family members B and T lymphocyte attenuator and herpesvirus entry mediator
    • Gonzalez LC, Loyet KM, Calemine-Fenaux J, et al. A co-receptor interaction between the CD28 and TNF receptor family members B and T lymphocyte attenuator and herpesvirus entry mediator. PNAS USA. 2005; 102: 1116-1121.
    • (2005) PNAS USA , vol.102 , pp. 1116-1121
    • Gonzalez, L.C.1    Loyet, K.M.2    Calemine-Fenaux, J.3
  • 85
    • 0037810670 scopus 로고    scopus 로고
    • BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1
    • Watanabe N, Gavrieli M, Sedy JR, et al. BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat Immunol. 2003; 4: 670-679.
    • (2003) Nat Immunol , vol.4 , pp. 670-679
    • Watanabe, N.1    Gavrieli, M.2    Sedy, J.R.3
  • 86
    • 28244498658 scopus 로고    scopus 로고
    • Attenuationg lymphocyte activity-the crystal structure of the BTLA-HVEM complex
    • Compaan DM, Gonzalez LC, Tom I, et al. Attenuationg lymphocyte activity-the crystal structure of the BTLA-HVEM complex. J Biol Chem. 2005; 280: 39552-39561.
    • (2005) J Biol Chem , vol.280 , pp. 39552-39561
    • Compaan, D.M.1    Gonzalez, L.C.2    Tom, I.3
  • 87
    • 33846479499 scopus 로고    scopus 로고
    • + T cell intrinsic homeostasis and memory cell generation
    • + T cell intrinsic homeostasis and memory cell generation. Nat Immunol. 2007; 8: 162-171.
    • (2007) Nat Immunol , vol.8 , pp. 162-171
    • Krieg, C.1    Boyman, O.2    Fu, Y.X.3
  • 88
    • 19944433635 scopus 로고    scopus 로고
    • B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirous entry mediator
    • Sedy JR, Gavrieli M, Potter KG, et al. B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirous entry mediator. Nat Immunol. 2005; 6: 90-98.
    • (2005) Nat Immunol , vol.6 , pp. 90-98
    • Sedy, J.R.1    Gavrieli, M.2    Potter, K.G.3
  • 90
    • 34248171932 scopus 로고    scopus 로고
    • Unexpected role of B and T lymphocyte attenuator in sustaining cell survival during chronic allostimu-lation
    • Hurchla MA, Sedy JR, Murphy KM. Unexpected role of B and T lymphocyte attenuator in sustaining cell survival during chronic allostimu-lation. J Immunol. 2007; 178: 6073-6082.
    • (2007) J Immunol , vol.178 , pp. 6073-6082
    • Hurchla, M.A.1    Sedy, J.R.2    Murphy, K.M.3
  • 91
    • 33845413240 scopus 로고    scopus 로고
    • Association of a BTLA gene polymorphism with the risk of rheumatoid arthritis
    • Lin SC, Kuo CC, Chan CH. Association of a BTLA gene polymorphism with the risk of rheumatoid arthritis. J Biomed Sci. 2006; 13: 853-860.
    • (2006) J Biomed Sci , vol.13 , pp. 853-860
    • Lin, S.C.1    Kuo, C.C.2    Chan, C.H.3
  • 92
    • 74849138078 scopus 로고    scopus 로고
    • Association of a BTLA gene polymorphism with the risk of malignant breast cancer in Chinese women of Hei-longjiang Province
    • Fu Z, Li D, Jiang W, et al. Association of a BTLA gene polymorphism with the risk of malignant breast cancer in Chinese women of Hei-longjiang Province. Breast Cancer Res Treat. 2010; 120: 195-202.
    • (2010) Breast Cancer Res Treat , vol.120 , pp. 195-202
    • Fu, Z.1    Li, D.2    Jiang, W.3
  • 93
    • 20044389839 scopus 로고    scopus 로고
    • The role of herpesvirus entry mediator as a negative regulator of T cell-mediated responses
    • Wang Y, Subudhi SK, Anders RA, et al. The role of herpesvirus entry mediator as a negative regulator of T cell-mediated responses. J Clin Invest. 2005; 115: 711-717.
    • (2005) J Clin Invest , vol.115 , pp. 711-717
    • Wang, Y.1    Subudhi, S.K.2    Anders, R.A.3
  • 94
    • 33845413240 scopus 로고    scopus 로고
    • Association of a BTLA gene polymorphism with the risk of rheumatoid arthritis
    • Lin SC, Kuo CC, Chan CH. Association of a BTLA gene polymorphism with the risk of rheumatoid arthritis. J Biomed Sci. 2006; 13: 853-860.
    • (2006) J Biomed Sci , vol.13 , pp. 853-860
    • Lin, S.C.1    Kuo, C.C.2    Chan, C.H.3
  • 95
    • 49449113696 scopus 로고    scopus 로고
    • Development of autoimmune hepatitis-like disease and autoantibody production to nuclear antigens in mice lacking B and T lymphocyte attenuator (BTLA)
    • Oya Y, Watanabe N, Owada T, et al. Development of autoimmune hepatitis-like disease and autoantibody production to nuclear antigens in mice lacking B and T lymphocyte attenuator (BTLA). Arthritis Rheum. 2008; 58: 2498-2510.
    • (2008) Arthritis Rheum , vol.58 , pp. 2498-2510
    • Oya, Y.1    Watanabe, N.2    Owada, T.3
  • 96
    • 79955491348 scopus 로고    scopus 로고
    • Lack of B and T lymphocyte attenuator exacerbates autoimmune disorders and induces Fas-independent liver injury in MRL-Ipr/lpr mice
    • Oya Y, Watanabe N, Kobayashi Y, et al. Lack of B and T lymphocyte attenuator exacerbates autoimmune disorders and induces Fas-independent liver injury in MRL-Ipr/lpr mice. Int Immunol. 2011; 23: 335-344.
    • (2011) Int Immunol , vol.23 , pp. 335-344
    • Oya, Y.1    Watanabe, N.2    Kobayashi, Y.3
  • 97
    • 64849105620 scopus 로고    scopus 로고
    • Herpesvirus Entry Mediator-Ig Treatment during Immunization Aggravates Rheumatoid Arthritis in the Collagen-Induced Arthritis Model
    • Pierer M, Schulz A, Rossol M, et al. Herpesvirus Entry Mediator-Ig Treatment during Immunization Aggravates Rheumatoid Arthritis in the Collagen-Induced Arthritis Model. J Immunol. 2009; 182: 3139-3145.
    • (2009) J Immunol , vol.182 , pp. 3139-3145
    • Pierer, M.1    Schulz, A.2    Rossol, M.3
  • 98
    • 74949125667 scopus 로고    scopus 로고
    • + T cells that can be partially reversed by vaccination
    • + T cells that can be partially reversed by vaccination. J Clin Invest. 2010; 120: 157-167.
    • (2010) J Clin Invest , vol.120 , pp. 157-167
    • Derré, L.1    Rivals, J.P.2    Jandus, C.3
  • 99
    • 35748952509 scopus 로고    scopus 로고
    • Ligation of B and T Lymphocyte Attenuator Prevents the Genesis of Experimental Cerebral Malaria
    • Lepenies B, Pfeffer K, Hurchla MA, et al. Ligation of B and T Lymphocyte Attenuator Prevents the Genesis of Experimental Cerebral Malaria. J Immunol. 2007; 179: 4093-4100.
    • (2007) J Immunol , vol.179 , pp. 4093-4100
    • Lepenies, B.1    Pfeffer, K.2    Hurchla, M.A.3
  • 100
    • 27144557202 scopus 로고    scopus 로고
    • Differential Effects of B and T Lymphocyte Attenuator and Programmed Death-1 on Acceptance of Partially versus Fully MHC-Mismatched Cardiac Allografts
    • Tao R, Wang L, Han R, et al. Differential Effects of B and T Lymphocyte Attenuator and Programmed Death-1 on Acceptance of Partially versus Fully MHC-Mismatched Cardiac Allografts. J Immunol. 2005; 175: 5774-5782.
    • (2005) J Immunol , vol.175 , pp. 5774-5782
    • Tao, R.1    Wang, L.2    Han, R.3
  • 101
    • 0038658878 scopus 로고    scopus 로고
    • LIGHT-HVEM signaling and the regulation of T cell-mediated immunity
    • Granger SW, Rickert S. LIGHT-HVEM signaling and the regulation of T cell-mediated immunity. Cytokine Growth Factor Rev. 2003; 14: 289-296.
    • (2003) Cytokine Growth Factor Rev , vol.14 , pp. 289-296
    • Granger, S.W.1    Rickert, S.2
  • 102
    • 35748968456 scopus 로고    scopus 로고
    • Combined Coinhibitory and Costimulatory Modulation with Anti-BTLA and CTLA4Ig Facilitated Tolerance in Murine Islet Allografts
    • Truong W, Plester JC, Hancock WW, et al. Combined Coinhibitory and Costimulatory Modulation with Anti-BTLA and CTLA4Ig Facilitated Tolerance in Murine Islet Allografts. Am J Transplant. 2007; 7: 2663-2674.
    • (2007) Am J Transplant , vol.7 , pp. 2663-2674
    • Truong, W.1    Plester, J.C.2    Hancock, W.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.