Porcine CTLA4-Ig prolong islet xenografts in rats by downregulating the direct pathway of T-cell activation

Xenotransplantation

Volumn 18, Issue 1, 2011, Pages 40-45

  Zhai, Chao ^a   Yu, Liang ^a   Zhu, Haitao ^a   Tian, Min ^a   Xiaogang, Zhang ^a   Bo, Wang ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

dendritic cell; direct pathway; islet; xenotransplantation

Indexed keywords

ABATACEPT; ALPHA INTERFERON; INTERLEUKIN 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL TRANSPLANTATION; CLINICAL ASSESSMENT; CONTROLLED STUDY; DIABETES MELLITUS; DONOR; GENETIC TRANSFECTION; GRAFT FAILURE; GRAFT RECIPIENT; GRAFT REJECTION; GRAFT SURVIVAL; HUMAN; KIDNEY CAPSULE; NONHUMAN; PANCREAS ISLET CELL; PANCREAS TRANSPLANTATION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; RECEPTOR DOWN REGULATION; SURVIVAL; T LYMPHOCYTE ACTIVATION; XENOGRAFT;

ANIMALS; DIABETES MELLITUS; GRAFT SURVIVAL; HUMANS; IMMUNOCONJUGATES; IMMUNOSUPPRESSIVE AGENTS; ISLETS OF LANGERHANS TRANSPLANTATION; LYMPHOCYTE ACTIVATION; RATS; RATS, SPRAGUE-DAWLEY; SUS SCROFA; T-LYMPHOCYTES; TRANSPLANTATION, HETEROLOGOUS;

EID: 79952019458     PISSN: 0908665X     EISSN: 13993089     Source Type: Journal    
DOI: 10.1111/j.1399-3089.2011.00627.x     Document Type: Article

References (22)

1. Cardona K, Korbutt GS, Milas Z, et al. Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways. Nat Med 2006; 12: 304-306. (Pubitemid 43355077)
2. Hering BJ, Wijkstrom M, Graham ML, et al. Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates. Nat Med 2006; 12: 301-303. (Pubitemid 43355076)
3. Tonomura N, Shimizu A, Wang S, et al. Pig islet xenograft rejection in a mouse model with an established human immune system. Xenotransplantation 2008; 15: 129-135. (Pubitemid 351601117)
4. Pierson RN III, Dorling A, Ayares D, et al. Current status of xenotransplantation and prospects for clinical application. Xenotransplantation 2009; 16: 263-280.
5. Clarkson MR, Sayegh MH,. T-cell costimulatory pathways in allograft rejection and tolerance. Transplantation 2005; 80: 555-563. (Pubitemid 41377737)
6. Mirenda V, Golshayan D, Read J, et al. Lechler achieving permanent survival of islet xenografts by independent manipulation of direct and indirect T-cell responses. Diabetes 2005; 54: 1048-1055. (Pubitemid 40446318)
7. Smith KM, Garside P, Mcneil RC, Brewer JM., Analysis of costimulatory molecule expression on antigen -specific T and B cells during the induction of adjuvant induced Th1 and Th2 type responses. Vaccine 2006; 24: 3335-3343.
8. Jen KY, Jain VV, Makani S, Finn PW,. Immunomodulation of allergic responses by targeting co-stimulatory molecules. Curr Opin Allergy Clin Immunol 2006; 6: 489-494. (Pubitemid 44714165)
9. Guo L, Fujino M, Kimura H, et al. Simultaneous blockade of co-stimulatory signals, CD28 and ICOS, induced a stable tolerance in rat heart transplantation. Transpl Immunol 2003; 12: 41-48. (Pubitemid 37321504)
10. Salomon B, Bluestone JA,. Complexities of CD28/B7: CTLA-4 co-stimulatory pathways in autoimmunity and transplantation. Annu Rev Immunol 2001; 19: 225-252. (Pubitemid 32368035)
11. Slavik JM, Hutchcroft JE, Bierer BE., CD28/CTLA-4 and CD80/CD86 families: signaling and function. Immunol Res 1999; 19: 1-24. (Pubitemid 29248709)
12. Garapati VP, Lefranc MP,. IMGT Colliers de Perles and IgSF domain standardization for T cell costimulatory activatory (CD28, ICOS) and inhibitory (CTLA4, PDCD1 and BTLA) receptors. Dev Comp Immunol 2007; 31: 1050-1072. (Pubitemid 47103213)
13. Ma Y, Lin BR, Lin B, et al. Pharmacokinetics of CTLA4Ig fusion protein in healthy volunteers and patients with rheumatoid arthritis. Acta Pharmacol Sin 2009; 30: 364-371.
14. Graca L,. CTLA4Ig and the therapeutic potential of T cell co-stimulation blockade. Acta Reumatol Port 2008; 33: 267-276.
15. Kvist M, Kanje M, Ekberg H, Corbascio M, Dahlin LB., Costimulation blockade in transplantation of nerve allografts: long-term effects. J Peripher Nerv Syst 2008; 13: 200-207.
16. Greene JL, Leytze GM, Emswiler J, et al. Covalent dimerization of CD28/CTLA-4 and oligomerization of CD80/CD86 regulate T cell costimulatory interactions. J Biol Chem 1996; 271: 26762-26771. (Pubitemid 26359085)
17. Vaughan AN, Malde P, Rogers NJ, Jackson IM, Lechler RI, Dorling A,. Porcine CTLA4-Ig lacks a MYPPPY motif, binds inefficiently to human B7 and specifically suppresses human CD4+ T-cell response costimulated by pig but not human B7. J Immunol 2000; 165: 3175-3181.
18. Min T, Yi L, Chao Z, et al. Superiority of visipaque (Iodixanol)- controlled density gradient over Ficoll-400 in adult porcine islet purification. Transplant Proc 2010; 42: 1825-18290.
19. Tian M, Lv Y, Zhai C, et al. pCTLA-Ig gene-modified porcine immature dendritic cells inhibit the proliferation of xenogenetic spleen cells. Chin J Cell Mol Immunol 2010; 26: 434-437.
20. Koulmanda M, Laufer TM, Auchincloss H Jr, Smith RN,. Prolonged survival of fetal pig islet xenografts in mice lacking the capacity for an indirect response. Xenotransplantation 2004; 11: 525-530. (Pubitemid 39423075)
21. Dorling A, Lombardi G, Binns R, Lechler RI,. Detection of primary direct and indirect human anti-porcine T-cell responses using a porcine dendritic cell population. Eur J Immunol 1996; 26: 1378-1387. (Pubitemid 26001076)
22. Yang D-F, Qiu W-H, Zhu H-F, et al. CTLA4-Ig-modified dendritic cells inhibit lymphocyte-mediated alloimmune responses and prolong the islet graft survival in mice. Transpl Immunol 2008; 19: 197-201.