PD-1 negatively regulates interleukin-12 expression by limiting STAT-1 phosphorylation in monocytes/macrophages duringchronic hepatitis C virus infection

Immunology

Volumn 132, Issue 3, 2011, Pages 421-431

  Ma, Cheng J ^a   Ni, Lei ^a,b   Zhang, Ying ^a   Zhang, C L ^a   Wu, Xiao Y ^a   Atia, Antwan N ^c   Thayer, Penny ^c   Moorman, Jonathan P ^a,c   Yao, Zhi Q ^a,c  

^a East Tennessee State University   (United States)

^b BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Hepatitis C virus infection; Immune regulation; Interleukin 12; Macrophages; Programmed death 1

Indexed keywords

INTERLEUKIN 12; JANUS KINASE; PEGINTERFERON; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 RECEPTOR; RIBAVIRIN; STAT 1 PROTEIN; STAT PROTEIN; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EX VIVO STUDY; FEMALE; FLOW CYTOMETRY; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IMMUNOSURVEILLANCE; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UPREGULATION;

ADULT; AGED; ANTIGENS, CD; APOPTOSIS REGULATORY PROTEINS; CELL SEPARATION; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; GENE EXPRESSION REGULATION; HEPATITIS C, CHRONIC; HUMANS; INTERLEUKIN-12; MACROPHAGES; MALE; MIDDLE AGED; MONOCYTES; PHOSPHORYLATION; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR;

EID: 79251632920     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2010.03382.x     Document Type: Article

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