T-regulatory cells infected with feline immunodeficiency virus up-regulate programmed death-1 (PD-1)

Veterinary Immunology and Immunopathology

Volumn 143, Issue 3-4, 2011, Pages 307-313

  Achleitner, Andrea ^a   Clark, Mary Ellen ^a   Bienzle, Dorothee ^a  

^a UNIVERSITY OF GUELPH   (Canada)

Author keywords

Cat; CD25; CD274; CD279; FIV; FoxP3; Immunodeficiency; Regulatory T cells

Indexed keywords

BETA ACTIN; MESSENGER RNA; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 RECEPTOR; TRANSCRIPTION FACTOR FOXP3; TYROSINE 3 MONOOXYGENASE;

ARTICLE; CAT; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; FELINE IMMUNODEFICIENCY VIRUS; HOUSEKEEPING GENE; IN VITRO STUDY; LENTIVIRUS INFECTION; LYMPH NODE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

ANIMALS; ANTIGENS, CD274; CATS; CD4-POSITIVE T-LYMPHOCYTES; FELINE ACQUIRED IMMUNODEFICIENCY SYNDROME; FLOW CYTOMETRY; IMMUNODEFICIENCY VIRUS, FELINE; NUCLEIC ACID AMPLIFICATION TECHNIQUES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTES, REGULATORY; UP-REGULATION;

FELINE IMMUNODEFICIENCY VIRUS;

EID: 80052359996     PISSN: 01652427     EISSN: 18732534     Source Type: Journal    
DOI: 10.1016/j.vetimm.2011.06.009     Document Type: Article

References (51)

1. Allan S.E., Crome S.Q., Crellin N.K., Passerini L., Steiner T.S., Bacchetta R., Roncarolo M.G., Levings M.K. Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production. Int. Immunol. 2007, 19(4):345-354.
2. Andersson J., Boasso A., Nilsson J., Zhang R., Shire N.J., Lindback S., Shearer G.M., Chougnet C.A. The prevalence of regulatory T cells in lymphoid tissue is correlated with viral load in HIV-infected patients. J. Immunol. 2005, 174:3143-3147.
3. Barber D.L., Wherry E.J., Masopust D., Zhu B., Allison J.P., Sharpe A.H., Freeman G.J., Ahmed R. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 2006, 439:682-687.
4. Boettler T., et al. T cells with a CD4+CD25+ regulatory phenotype suppress in vitro proliferation of virus-specific CD8+ T cells during chronic hepatitis C virus infection. J. Virol. 2005, 79:7860-7867.
5. Brunkow M.E., Jeffery E.W., Hjerrild K.A., Paeper B., Clark L.B., Yasayko S.A., Wilkinson J.E., Galas D., Ziegler S.F., Ramsdell F. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat. Genet. 2001, 27:68-73.
6. Chen L. Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity. Nat. Rev. Immunol. 2004, 4:336-347.
7. D'Souza M., Fontenot A.P., Mack D.G., Lozupone C., Dillon S., Meditz A., Wilson C.C., Connick E., Palmer B.E. Programmed death 1 expression on HIV-specific CD4+ T cells is driven by viral replication and associated with T cell dysfunction. J. Immunol. 2007, 179:1979-1987.
8. Day C.L., Kaufmann D.E., Kiepiela P., Brown J.A., Moodley E.S., Reddy S., Mackey E.W., Miller J.D., Leslie A.J., et al. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature 2006, 443:350-354.
9. Duttagupta P.A., Boesteanu A.C., Katsikis P.D. Costimulation signals for memory CD8+ T cells during viral infections. Crit. Rev. Immunol. 2009, 29:469-486.
10. Estes J.D., Gordon S.N., Zeng M., Chahroudi A.M., Dunham R.M., Staprans S.I., Reilly C.S., Silvestri G., Haase A.T. Early resolution of acute immune activation and induction of PD-1 in SIV-infected sooty mangabeys distinguishes non-pathogenic from pathogenic infection in rhesus macaques. J. Immunol. 2008, 180:6798-6807.
11. Folkl A., Wen X., Kuczynski E., Clark M.E., Bienzle D. Feline programmed death and its ligand: characterization and changes with feline immunodeficiency virus infection. Vet. Immunol. Immunopathol. 2010, 134(1-2):107-114.
12. Fontenot J.D., Gavin M.A., Rudensky A.Y. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat. Immunol. 2003, 4:330-336.
13. Fontenot J.D., Rasmussen J.P., Williams L.M., Dooley J.L., Farr A.G., Rudensky A.Y. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 2005, 22(3):329-341.
14. Franceschini D., Paroli M., Francavilla V., Videtta M., Morrone S., Labbadia G., Cerino A., Mondelli M.U., Barnaba V. PD-L1 negatively regulates CD4+CD25+Foxp3+ Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV. J. Clin. Invest. 2009, 119(3):551-564.
15. Francisco L.M., Sage P.T., Sharpe A.H. The PD-1 pathway in tolerance and autoimmunity. Immunol. Rev. 2010, 236:219-242.
16. Ginsberg S.D. RNA amplification strategies for small sample populations. Methods 2005, 37(3):229-237.
17. Greenwald R.J., Freeman G.J., Sharpe A.H. The B7 family revisited. Annu. Rev. Immunol. 2005, 23:515-548.
18. Hori S., Nomura T., Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003, 299:1057-1061.
19. Huber S., Schramm C., Lehr H.A., Mann A., Schmitt S., Becker C., Protschka M., Galle P.R., Neurath M.F., Blessing M. Cutting edge: TGF-beta signaling is required for the in vivo expansion and immunosuppressive capacity of regulatory CD4+CD25+T cells. J. Immunol. 2004, 173:6526-6531.
20. Kanwar B., Favre D., McCune J.M. Th17 and regulatory T cells: implications for AIDS pathogenesis. Curr. Opin. HIV AIDS 2010, 5(2):151-157.
21. Keir M.E., Latchman Y.E., Freeman G.J., Sharpe A.H. Programmed death-1 (PD-1): PD-ligand 1 interactions inhibit TCR-mediated positive selection of thymocytes. J. Immunol. 2005, 175:7372-7379.
22. Kessler Y., Helfer-Hungerbuehler A.K., Cattori V., Meli M.L., Zellweger B., Ossent P., Riond B., Reusch C.E., Lutz H., Hofmann-Lehmann R. Quantitative TaqMan real-time PCR assays for gene expression normalisation in feline tissues. BMC Mol. Biol. 2009, 10:106-120.
23. Khattri R., Cox T., Yasayko S.A., Ramsdell F. An essential role for Scurfin in CD4+CD25+T regulatory cells. Nat. Immunol. 2003, 4:337-342.
24. Kinter A.L., et al. CD25(+)CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status. J. Exp. Med. 2004, 200:331-343.
25. Kornfeld C., Ploquin M.J., Pandrea I., Faye A., Onanga R., Apetrei C., Poaty-Mavoungou V., Rouquet P., Estaquier J., Mortara L., Desoutter J.F., Butor C., Le Grand R., Roques P., Simon F., Barre-Sinoussi F., Diop O.M., Muller-Trutwin M.C. Antiinflammatory profiles during primary SIV infection in African green monkeys are associated with protection against AIDS. J. Clin. Invest. 2005, 115:1082-1091.
26. Kroner A., Mehling M., Hemmer B., Rieckmann P., Toyka K.V., Maurer M., Wiendl H. A PD-1 polymorphism is associated with disease progression in multiple sclerosis. Ann. Neurol. 2005, 58:50-57.
27. Mexas A.M., Fogle J.E., Tompkins W.A., Tompkins M.B. CD4 +CD25+ regulatory T cells are infected and activated during acute FIV infection. Vet. Immunol. Immunopathol. 2008, 126:263-272.
28. Morgan M.E., van Bilsen J.H., Bakker A.M., Heemskerk B., Schilham M.W., Hartgers F.C., Elferink B.G., van der Zanden L., de Vries R.R., Huizinga T.W., Ottenhoff T.H., Toes R.E. Expression of FOXP3 mRNA is not confined to CD4+ CD25+ T regulatory cells in humans. Hum. Immunol. 2005, 66(1):13-20.
29. Nielsen C., Hansen D., Husby S., Jacobsen B.B., Lillevang S.T. Association of a putative regulatory polymorphism in the PD-1 gene with susceptibility to type 1 diabetes. Tissue Antigens 2003, 62:492-497.
30. Nielsen C., Laustrup H., Voss A., Junker P., Husby S., Lillevang S.T. A putative regulatory polymorphism in PD-1 is associated with nephropathy in a population-based cohort of systemic lupus erythematosus patients. Lupus 2004, 13(7):510-516.
31. Ohno K., Giotsuka R., Kitamura K., Hasegawa A., Tokunaga T., Honda M. Production of a monoclonal antibody that defines the alpha-subunit of the feline IL-2 receptor. Hybridoma 1992, 11(5):595-605.
32. Okazaki T., Honjo T. The PD-1-PD-L pathway in immunological tolerance. Trends Immunol. 2006, 27:195-201.
33. Pedersen N.C., Ho E.W., Brown M.L., Yamamoto J.K. Isolation of a T-lymphotropic virus from domestic cats with an immunodeficiency-like syndrome. Science 1987, 235:790-793.
34. Pereira L.E., et al. Simian immunodeficiency virus (SIV) infection influences the level and function of regulatory T cells in SIV-infected rhesus macaques but not SIV-infected sooty mangabeys. J. Virol. 2007, 81:4445-4456.
35. Petty C.S., Tompkins M.B., Tompkins W.A. Transforming growth factor-beta/transforming growth factor-betaRII signaling may regulate CD4+ CD25+ T-regulatory cell homeostasis and suppressor function in feline AIDS lentivirus infection. J. Acquir. Immune Defic. Syndr. 2008, 47:148-160.
36. Piconi S., Trabattoni D., Gori A., Parisotto S., Magni C., Meraviglia P., Bandera A., Capetti A., Rizzardini G., Clerici M. Immune activation, apoptosis, and Treg activity are associated with persistently reduced CD4+ T-cell counts during antiretroviral therapy. AIDS 2010, 24(13):1991-2000.
37. Pillai V., Ortega S.B., Wang C.K., Karandikar N.J. Transient regulatory T-cells: a state attained by all activated human T-cells. Clin. Immunol. 2007, 123(1):18-29.
38. Prokunina L., Padyukov L., Bennet A., de Faire U., Wiman B., Prince J., Alfredsson L., Klareskog L., Alarcon-Riquelme M. Association of the PD-1.3A allele of the PDCD1 gene in patients with rheumatoid arthritis negative for rheumatoid factor and the shared epitope. Arthritis Rheum. 2004, 50:1770-1773.
39. Quigley M., Pereyra F., Nilsson B., Porichis F., Fonseca C., Eichbaum Q., Julg B., Jesneck J.L., Brosnahan K., Imam S., Russell K., Toth I., Piechocka-Trocha A., Dolfi D., Angelosanto J., Crawford A., Shin H., Kwon D.S., Zupkosky J., Francisco L., Freeman G.J., Wherry E.J., Kaufmann D.E., Walker B.D., Ebert B., Haining W.N. Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF. Nat. Med. 2010, 16:1147-1151.
40. Reggeti F., Bienzle D. Feline immunodeficiency virus subtypes A, B and C and intersubtype recombinants in Ontario. Can. J. Gen. Virol. 2004, 85:1843-1852.
41. Riley J.L. PD-1 signaling in primary T cells. Immunol. Rev. 2009, 229(1):114-125.
42. Roncador G., Brown P.J., Maestre L., Hue S., Martínez-Torrecuadrada J.L., Ling K.L., Pratap S., Toms C., Fox B.C., Cerundolo V., Powrie F., Banham A.H. Analysis of FOXP3 protein expression in human CD4+ CD25+ regulatory T cells at the single-cell level. Eur. J. Immunol. 2005, 35(6):1681-1691.
43. Sharpe A.H., Wherry E.J., Ahmed R., Freeman G.J. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. Nat. Immunol. 2007, 8:239-245.
44. Suvas S., Azkur A.K., Kim B.S., Kumaraguru U., Rouse B.T. CD4+CD25+ regulatory T cells control the severity of viral immunoinflammatory lesions. J. Immunol. 2004, 172:4123-4132.
45. Suvas S., Kumaraguru U., Pack C.D., Lee S., Rouse B.T. CD4+CD25+T cells regulate virus specific primary and memory CD8+ T cell responses. J. Exp. Med. 2003, 198:889-901.
46. Tran D.Q., Ramsey H., Shevach E.M. Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype. Blood 2007, 110(8):2983-2990.
47. Trautmann L., Janbazian L., Chomont N., Said E.A., Gimmig S., Bessette B., Boulassel M.R., Delwart E., Sepulveda H., et al. Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction. Nat. Med. 2006, 12:1198-1202.
48. Venkatachari N.J., Buchanan W.G., Ayyavoo V. Human immunodeficiency virus HIV-1 infection selectively downregulates PD-1 expression in infected cells and protects the cells from early apoptosis in vitro and in vivo. Virology 2008, 376:140-153.
49. Wang J., Ioan-Facsinay A., van der Voort E.I., Huizinga T.W., Toes R.E. Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells. Eur. J. Immunol. 2007, 37(1):129-138.
50. Weiss L., Donkova-Petrini V., Caccavelli L., Balbo M., Carbonneil C., Levy Y. Human immunodeficiency virus-driven expansion of CD4+CD25+ regulatory T cells, which suppress HIV-specific CD4 T-cell responses in HIV-infected patients. Blood 2004, 104:3249-3256.
51. Zheng S.G., Wang J.H., Stohl W., Kim K.S., Gray J.D., Horwitz D.A. TGF-beta requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4+CD25+ regulatory cells. J. Immunol. 2006, 176:3321-3329.