Ligation of B and T lymphocyte attenuator prevents the genesis of experimental cerebral malaria

Journal of Immunology

Volumn 179, Issue 6, 2007, Pages 4093-4100

  Lepenies, Bernd ^a   Pfeffer, Klaus ^b   Hurchla, Michelle A ^c   Murphy, Theresa L ^c   Murphy, Kenneth M ^c   Oetzel, Juliane ^a   Fleischer, Bernhard ^a   Jacobs, Thomas ^a  

^a BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B AND T LYMPHOCYTE ATTENUATOR; INHIBITOR PROTEIN; LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; BLOCKING ANTIBODY; BTLA PROTEIN, MOUSE; HERPESVIRUS ENTRY MEDIATOR; IMMUNOGLOBULIN RECEPTOR; LIGAND; PROTOZOON ANTIBODY; TNFRSF14 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; BRAIN CAPILLARY; BRAIN MALARIA; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL INFILTRATION; CONTROLLED STUDY; FEMALE; HERPES VIRUS; LYMPHOCYTE COUNT; MOUSE; NONHUMAN; PLASMODIUM BERGHEI; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; SPLEEN; T LYMPHOCYTE; UPREGULATION; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; BRAIN; C57BL MOUSE; CELL CULTURE; CELL MOTION; GENETICS; GROWTH, DEVELOPMENT AND AGING; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MALARIA; METABOLISM; MICROCIRCULATION; MOUSE MUTANT; PARASITOLOGY; PATHOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE; VASCULARIZATION;

ANIMALS; ANTIBODIES, BLOCKING; ANTIBODIES, PROTOZOAN; BRAIN; CELL MOVEMENT; CELLS, CULTURED; FEMALE; LIGANDS; LYMPHOCYTE ACTIVATION; MALARIA, CEREBRAL; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROCIRCULATION; PLASMODIUM BERGHEI; RECEPTORS, IMMUNOLOGIC; RECEPTORS, TUMOR NECROSIS FACTOR, MEMBER 14; T-LYMPHOCYTES;

EID: 35748952509     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.179.6.4093     Document Type: Article

References (33)

1. Miller, L. H., D. I. Baruch, K. Marsh, and O. K. Doumbo. 2002. The pathogenic basis of malaria. Nature 415: 673-679.
2. Hearn, J., N. Rayment, D. N. Landon, D. R. Katz, and J. B. de Souza. 2000. Immunopathology of cerebral malaria: morphological evidence of parasite sequestration in murine brain microvasculature. Infect. Immun. 68: 5364-5376.
3. Jennings, V. M., A. A. Lal, and R. L. Hunter. 1998. Evidence for multiple pathologic and protective mechanisms of murine cerebral malaria. Infect. Immun. 66: 5972-5979.
4. + T cells in experimental cerebral malaria. J. Immunol. 169: 6369-6375.
5. Belnoue, E., M. Kayibanda, J. C. Deschemin, M. Viguier, M. Mack, W. A. Kuziel, and L. Renia. 2003. CCR5 deficiency decreases susceptibility to experimental cerebral malaria. Blood 101: 4253-4259.
6. Neill, A. L., and N. H. Hunt. 1992. Pathology of fatal and resolving Plasmodium berghei cerebral malaria in mice. Parasitology 105: 165-175.
7. Finley, R. W., L. J. Mackey, and P. H. Lambert. 1982. Virulent Plasmodium berghei malaria: prolonged survival and decreased cerebral pathology in cell-dependent nude mice. J. Immunol. 129: 2213-2218.
8. + T lymphocytes play a major role in the pathogenesis of murine cerebral malaria. J. Immunol. 137: 2348-2354.
9. Yanez, D. M., D. D. Manning, A. J. Cooley, W. P. Weidanz, and H. C. van der Heyde. 1996. Participation of lymphocyte subpopulations in the pathogenesis of experimental murine cerebral malaria. J. Immunol. 157: 1620-1624.
10. Grau, G. E., G. Bieler, P. Pointaire, S. De Kossodo, F. Tacchini-Cotier, P. Vassalli, P. F. Piguet, and P. H. Lambert. 1990. Significance of cytokine production and adhesion molecules in malarial immunopathology. Immunol. Lett. 25: 189-194.
11. Grau, G. E., L. F. Fajardo, P. F. Piguet, B. Allet, P. H. Lambert, and P. Vassalli. 1987. Tumor necrosis factor (cachectin) as an essential mediator in murine cerebral malaria. Science 237: 1210-1212.
12. Schlotmann, T., I. Waase, C. Julch, U. Klauenberg, B. Muller-Myhsok, M. Dietrich, B. Fleischer, and B. M. Broker. 2000. CD4 αβ T lymphocytes express high levels of the T lymphocyte antigen CTLA-4 (CD152) in acute malaria. J. Infect. Dis. 182: 367-370.
13. Jacobs, T., S. E. Graefe, S. Niknafs, I. Gaworski, and B. Fleischer. 2002. Murine malaria is exacerbated by CTLA-4 blockade. J. Immunol. 169: 2323-2329.
14. Jacobs, T., T. Plate, I. Gaworski, and B. Fleischer. 2004. CTLA-4-dependent mechanisms prevent T cell induced-liver pathology during the erythrocyte stage of Plasmodium berghei malaria. Eur. J. Immunol. 34: 972-980.
15. Watanabe, N., M. Gavrieli, J. R. Sedy, J. Yang, F. Fallarino, S. K. Loftin, M. A. Hurchla, N. Zimmerman, J. Sim, X. Zang, et al. 2003. BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat. Immunol. 4: 670-679.
16. Sedy, J. R., M. Gavrieli, K. G. Potter, M. A. Hurchla, R. C. Lindsley, K. Hildner, S. Scheu, K. Pfeffer, C. F. Ware, T. L. Murphy, and K. M. Murphy. 2005. B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator. Nat. Immunol. 6: 90-98.
17. Schneider, K., K. G. Potter, and C. F. Ware. 2004. Lymphotoxin and LIGHT signaling pathways and target genes. Immunol. Rev. 202: 49-66.
18. Croft, M. 2005. The evolving crosstalk between co-stimulatory and co-inhibitory receptors: HVEM-BTLA. Trends Immunol. 26: 292-294.
19. Chang, Y. H., S. L. Hsieh, Y. Chao, Y. C. Chou, and W. W. Lin. 2005. Proinflammatory effects of LIGHT through HVEM and LTβR interactions in cultured human umbilical vein endothelial cells. J. Biomed. Sci. 12: 363-375.
20. Han, P., O. D. Goularte, K. Rufner, B. Wilkinson, and J. Kaye. 2004. An inhibitory Ig superfamily protein expressed by lymphocytes and APCs is also an early marker of thymocyte positive selection. J. Immunol. 172: 5931-5939.
21. Gavrieli, M., N. Watanabe, S. K. Loftin, T. L. Murphy, and K. M. Murphy. 2003. Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of B and T lymphocyte attenuator required for association with protein tyrosine phosphatases SHP-1 and SHP-2. Biochem. Biophys. Res. Commun. 312: 1236-1243.
22. Deppong, C., T. I. Juehne, M. Hurchla, L. D. Friend, D. D. Shah, C. M. Rose, T. L. Bricker, L. P. Shornick, E. C. Crouch, T. L. Murphy, et al. 2006. Cutting edge: B and T lymphocyte attenuator and programmed death receptor-1 inhibitory receptors are required for termination of acute allergic airway inflammation. J. Immunol. 176: 3909-3913.
23. Tao, R., L. Wang, R. Han, T. Wang, Q. Ye, T. Honjo, T. L. Murphy, K. M. Murphy, and W. W. Hancock. 2005. Differential effects of B and T lymphocyte attenuator and programmed death-1 on acceptance of partially versus fully MHC-mismatched cardiac allografts. J. Immunol. 175: 5774-5782.
24. + T cell-intrinsic homeostasis and memory cell generation. Nat. Immunol. 8: 162-171.
25. Wang, Y., S. K. Subudhi, R. A. Anders, J. Lo, Y. Sun, S. Blink, J. Wang, X. Liu, K. Mink, D. Degrandi, et al. 2005. The role of herpesvirus entry mediator as a negative regulator of T cell-mediated responses. J. Clin. Invest. 115: 711-717.
26. + T cells. J. Immunol. 174: 3377-3385.
27. Grau, G. E., and C. Behr. 1994. T cells and malaria: is Th1 cell activation a prerequisite for pathology? Res. Immunol. 145: 441-454.
28. Grau, G. E., P. Pointaire, P. F. Piguet, C. Vesin, H. Rosen, I. Stamenkovic, F. Takei, and P. Vassalli. 1991. Late administration of monoclonal antibody to leukocyte function-antigen 1 abrogates incipient murine cerebral malaria. Eur. J. Immunol. 21: 2265-2267.
29. Falanga, P. B., and E. C. Butcher. 1991. Late treatment with anti-LFA-1 (CD11a) antibody prevents cerebral malaria in a mouse model. Eur. J. Immunol. 21: 2259-2263.
30. Grau, G. E., K. Frei, P. F. Piguet, A. Fontana, H. Heremans, A. Billiau, P. Vassalli, and P. H. Lambert. 1990. Interleukin 6 production in experimental cerebral malaria: modulation by anticytokine antibodies and possible role in hypergammaglobulinemia. J. Exp. Med. 172: 1505-1508.
31. Lepenies, B., I. Gaworski, S. Tartz, J. Langhorne, B. Fleischer, and T. Jacobs. 2007. CTLA-4 blockade differentially influences the outcome of non-lethal and lethal Plasmodium yoelii infections. Microbes Infect. 9: 687-694.
32. Wang, J., and Y. X. Fu. 2004. The role of LIGHT in T cell-mediated immunity. Immunol. Res. 30: 201-214.
33. Hurchla, M. A., J. R. Sedy, and K. M. Murphy. 2007. Unexpected role of B and T lymphocyte attenuator in sustaining cell survival during chronic allostimulation. J. Immunol. 178: 6073-6082.