Mechanism of action of inhibition of allergic immune responses by a novel antedrug TLR7 agonist

Journal of Immunology

Volumn 189, Issue 11, 2012, Pages 5194-5205

  Matsui, Hiroyuki ^a   Tomizawa, Hideyuki ^a   Eiho, Kazuo ^a   Kashiwazaki, Yasuo ^a   Edwards, Susan ^b   Biffen, Mark ^b   Bell, John P ^b   Bahl, Ashwani ^b   Leishman, Andrew J ^b   Murray, Clare M ^b   Takaku, Haruo ^a   Ueda, Yutaka ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^b ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIALLERGIC AGENT; AZ 12441970; CYTOKINE; ESTERASE; INTERFERON; TOLL LIKE RECEPTOR 7 AGONIST; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG;

ALLERGIC AIRWAY INFLAMMATION; ALLERGY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; CELL SUBPOPULATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG EXPOSURE; DRUG MECHANISM; DRUG METABOLISM; EOSINOPHILIA; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOREGULATION; IMMUNOSUPPRESSIVE TREATMENT; IN VIVO STUDY; MOUSE; NONHUMAN; PLASMACYTOID DENDRITIC CELL; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SPLEEN CELL; TH1 CELL; TH2 CELL; TREATMENT DURATION;

ADMINISTRATION, TOPICAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; B-LYMPHOCYTES; CELL LINE; CELL MOVEMENT; DENDRITIC CELLS; EOSINOPHILIA; GENES, REPORTER; HUMANS; IMMUNITY, INNATE; INTERFERON TYPE I; MICE; PRODRUGS; RATS; RESPIRATORY HYPERSENSITIVITY; RESPIRATORY SYSTEM; SIGNAL TRANSDUCTION; SPLEEN; TH2 CELLS; TOLL-LIKE RECEPTOR 7;

EID: 84869746281     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1101331     Document Type: Article

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