A novel CB2 agonist, COR167, potently protects rat brain cortical slices against OGD and reperfusion injury

Pharmacological Research

Volumn 66, Issue 6, 2012, Pages 555-563

  Contartese, Antonella ^a   Valoti, Massimo ^a   Corelli, Federico ^a   Pasquini, Serena ^a   Mugnaini, Claudia ^a   Pessina, Federica ^a   Aldinucci, Carlo ^a   Sgaragli, Giampietro ^a   Frosini, Maria ^a  

^a UNIVERSITY OF SIENA   (Italy)

Author keywords

4 Quinolone 3 carboxylic acid derivatives; Brain slices; Cannabinoids system; CB2 agonist; CB2 inverse agonist; Neuroprotection; Oxygen glucose deprivation and reperfusion

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; 6 IODO 3 (4 METHOXYBENZOYL) 2 METHYL 1 (2 MORPHOLINOETHYL)INDOLE; CARBOXYLIC ACID DERIVATIVE; COR 167; GLUCOSE; GLUTAMIC ACID; GLUTATHIONE; INTERLEUKIN 6; LACTATE DEHYDROGENASE; N (ADAMANTAN 1 YL) 6 ISOPROPYL 4 OXO 1 PENTYL 1,4 DIHYDROQUINOLINE 3 CARBOXAMIDE; NEUROPROTECTIVE AGENT; OXYGEN; SER 601; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN PROTECTION; BRAIN SLICE; CELL DAMAGE; CEREBROSPINAL FLUID; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; MALE; NONHUMAN; OXYGENATION; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN SECRETION; RAT; REPERFUSION INJURY;

ADAMANTANE; ANIMALS; CANNABINOID RECEPTOR AGONISTS; CEREBRAL CORTEX; GLUCOSE; GLUTAMIC ACID; INTERLEUKIN-6; L-LACTATE DEHYDROGENASE; MALE; MOLECULAR STRUCTURE; OXYGEN; QUINOLONES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, CANNABINOID, CB2; REPERFUSION INJURY; TISSUE CULTURE TECHNIQUES; TUMOR NECROSIS FACTOR-ALPHA; WATER;

EID: 84869508479     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2012.08.003     Document Type: Article

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