CB1 and CB2 cannabinoid receptors differentially regulate the production of reactive oxygen species by macrophages

Cardiovascular Research

Volumn 84, Issue 3, 2009, Pages 378-386

  Han, Ki Hoon ^a   Lim, Sunny ^a   Ryu, Jewon ^a   Lee, Cheol Whan ^a   Kim, Yuna ^a   Kang, Ju Hee ^a   Kang, Soon Suk ^a   Ahn, Yeong Ki ^a   Park, Chan Sik ^a   Kim, Jae Joong ^a  

^a University of Ulsan College of Medicine   (South Korea)

Author keywords

CB1 receptor; CB2 receptor; Cytokines; Macrophages; Rap1; Reactive oxygen species (ROS)

Indexed keywords

CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CD36 ANTIGEN; CD68 ANTIGEN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; PHORBOL 13 ACETATE 12 MYRISTATE; RAP1 PROTEIN; RAS PROTEIN; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; ATHEROMA; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; INFLAMMATION; MONOCYTE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR UPREGULATION; REGULATORY MECHANISM;

ANIMALS; CELL LINE; CELLS, CULTURED; CHEMOKINE CCL2; CYTOKINES; HUMANS; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, ANIMAL; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RAP1 GTP-BINDING PROTEINS; REACTIVE OXYGEN SPECIES; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 70849114191     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvp240     Document Type: Article

References (30)

1. Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation 2002;105:1135-1143.
2. Valente AJ, Rozek MM, Sprague EA, Schwartz CJ. Mechanisms of intimal monocyte-macrophage recruitment. A special role for monocyte chemo-tactic protein-1. Circulation 1992;86:III20-III25.
3. Pacher P, Batkai S, Kunos G. The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev 2006;58:389-462.
4. Klein TW, Newton C, Larsen K, Lu L, Perkins I, Nong L et al. The canna-binoid system and immune modulation. J Leukoc Biol 2003;74:486-496.
5. Ghosh S, Preet A, Groopman JE, Ganju RK. Cannabinoid receptor CB2 modulates the CXCL12/CXCR4-mediated chemotaxis of T lymphocytes. Mol Immunol 2006;43:2169-2179.
6. Coopman K, Smith LD, Wright KL, Ward SD. Temporal variation in CB2R levels following T lymphocyte activation: evidence that cannabinoids modulate CXCL12-induced chemotaxis. Int Immunopharmacol 2007;7: 360-371.
7. Steffens S, Veillard NR, Arnaud C, Pelli G, Burger F, Staub C et al. Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice. Nature 2005;434:782-786.
8. Rajesh M, Mukhopadhyay P, Hasko G, Huffman JW, Mackie K, Pacher P. CB2 cannabinoid receptor agonists attenuate TNF-alpha-induced human vascular smooth muscle cell proliferation and migration. Br J Pharmacol 2008;153:347-357.
9. Rajesh M, Mukhopadhyay P, Batkai S, Hasko G, Liaudet L, Huffman JW et al. CB2-receptor stimulation attenuates TNF-alpha-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion. Am J Physiol Heart Circ Physiol 2007;293:H2210-H2218.
10. Steffens S, Mach F. Cannabinoid receptors in atherosclerosis. Curr Opin Lipidol 2006;17:519-526.
11. Dol-Gleizes F, Paumelle R, Visentin V, Marés AM, Desitter P, Hennuyer N et al. Rimonabant, a selective cannabinoid CB1 receptor antagonist, inhibits atherosclerosis in LDL receptor deficient mice. Arterioscl Thromb Vasc Biol 2009;29:12-18.
12. Moon EY, Pyo S. Elicited peritoneal lipopolysaccharide stimulates Epac1-mediated Rap1/NF-kappaB pathway in Raw 264.7 murine macrophages. Immunol Lett 2007;110:121-125.
13. Siegmund SV, Qian T, de Minicis S, Harvey-White J, Kunos G, Vinod KY et al. The endocannabinoid 2-arachidonoyl glycerol induces death of hepatic stellate cells via mitochondrial reactive oxygen species. FASEB J 2007;21:2798-2806.
14. Jaramillo M, Olivier M. Hydrogen peroxide induces murine macrophage chemokine gene transcription via extracellular single-regulated kinase and cyclic adenosine 50-monophosphate(cAMP)-dependent pathways: Involvement of Nf-kB, activator protein 1, and cAMP response element binding protein. J Immunol 2002;169:7026-7038.
15. Remans PH, Wijbrandts CA, Sanders ME, Toes RE, Breedveld FC, Tak PP et al. CTLA-4IG suppresses reactive oxygen species by preventing synovial adherent cell-induced inactivation of Rap1, a Ras family GTPASE mediator of oxidative stress in rheumatoid arthritis T cells. Arthritis Rheum 2006;54:3135-3143.
16. Remans PH, Gringhuis SI, van Laar JM, Sanders ME, Papendrecht-van der Voort EA, Zwartkruis FJ et al. Rap1 signaling is required for suppression of Ras-generated reactive oxygen species and protection against oxidative stress in T lymphocytes. J Immunol 2004;173:920-931.
17. He JC, Gomes I, Nguyen T, Jayaram G, Ram PT, Devi LA et al. The G alpha(o/i)-coupled cannabinoid receptor-mediated neurite outgrowth involves Rap regulation of Src and Stat3. J Biol Chem 2005;280: 33426-33434.
18. Montecucco F, Burger F, Steffens S. CB2 cannabinoid receptor agonist JWH-015 modulates human monocyte migration through defined intra-cellular signaling pathways. Am J Physiol Heart Circ Physiol 2008;294: H1145-H1155.
19. Raborn ES, Marciano-Cabral F, Buckley NE, Martin BR, Cabral GA. The can-nabinoid delta-9-tetrahydrocannabinol mediates inhibition of macro-phage chemotaxis to RANTES/CCL5: linkage to the CB2 receptor. J Neuroimmune Pharmacol 2008;3:117-129.
20. Sugamura K, Sugiyama S, Nozaki T, Matsuzawa Y, Izumiya Y, Miyata K et al. Activated endocannabinoid system in coronary artery disease and antiinflammatory effects of cannabinoid 1 receptor blockade on macro-phages. Circulation 2008;119:28-36.
21. Nong L, Newton C, Cheng Q, Friedman H, Roth MD, Klein TW. Altered can-nabinoid receptor mRNA expression in peripheral blood mononuclear cells from marijuana smokers. J Neuroimmunol 2002;127:169-176.
22. Noel B, Ruf I, Panizzon RG. Cannabis arteritis. J Am Acad Dermatol 2008; 58:S65-S67.
23. Torres M, Forman HJ. Redox signaling and the MAP kinase pathways. Bio-factors 2003;17:287-296.
24. Sanchez C, Galve-Roperh I, Rueda D, Guzman M. Involvement of sphingomyelin hydrolysis and the mitogen-activated protein kinase cascade in the Delta9-tetrahydrocannabinol-induced stimulation of glucose metabolism in primary astrocytes. Mol Pharmacol 1998;54: 834-843.
25. Derkinderen P, Ledent C, Parmentier M, Girault JA. Cannabinoids activate p38 mitogen-activated protein kinases through CB1 receptors in hippocampus. J Neurochem 2001;77:957-960.
26. Zhang J, Chen C. Endocannabinoid 2-arachidonoylglycerol protects neurons by limiting COX-2 elevation. J Biol Chem 2008;283: 22601-22611.
27. Jordan JD, Carey KD, Stork PJ, Iyengar R. Modulation of rap activity by direct interaction of Galpha(o) with Rap1 GTPase-activating protein. J Biol Chem 1999;274:21507-21510.
28. Sugiura T, Waku K. 2-Arachidonoylglycerol and the cannabinoid receptors. Chem Phys Lipids 2000;108:89-106.
29. Jiang LS, Pu J, Han ZH, Hu LH, He B. Role of activated endocannabinoid system in regulation of cellular cholesterol metabolism in macrophages. Cardiovasc Res 2009; Epub ahead.
30. Nissen SE, Nicholls SJ, Wolski K, Rodes-cabau J, Cannon CP, Deanfield JE et al. Effect of rimonabant on progression of atherosclerosis in patients with abdominal obesity and coronary artery disease: the STRADIVARIUS randomized controlled trial. JAMA 2008;299:1547-1560.