Metabolic master regulators: Sharing information among multiple systems

Trends in Endocrinology and Metabolism

Volumn 23, Issue 12, 2012, Pages 594-601

  Corkey, Barbara E ^a   Shirihai, Orian ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; REACTIVE OXYGEN METABOLITE; SIRTUIN; STEROL REGULATORY ELEMENT BINDING PROTEIN; UNCOUPLING PROTEIN 1;

ARTICLE; BODY WEIGHT; CIRCADIAN RHYTHM; DIABETES MELLITUS; ENERGY BALANCE; FOOD INTAKE; FOOD PREFERENCE; GLUCOSE HOMEOSTASIS; HOMEOSTASIS; HUMAN; INSULIN RELEASE; METABOLIC REGULATION; METABOLOME; MITOCHONDRION; NONHUMAN; OBESITY; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ADIPOSE TISSUE; DIABETES MELLITUS, TYPE 2; FEMALE; HOMEOSTASIS; HUMANS; INSULIN RESISTANCE; LACTIC ACID; LIVER; METABOLOME; MITOCHONDRIA; MODELS, BIOLOGICAL; MUSCLES; NAD; NADP; OBESITY; OXIDATION-REDUCTION; PYRUVIC ACID; SIGNAL TRANSDUCTION;

EID: 84869505294     PISSN: 10432760     EISSN: 18793061     Source Type: Journal    
DOI: 10.1016/j.tem.2012.07.006     Document Type: Article

References (86)

1. Nafziger A.N., et al. Who is maintaining weight in a middle-aged population in Sweden? A longitudinal analysis over 10 years. BMC Public Health 2007, 7:108.
2. Ogden C.L., et al. Prevalence of overweight and obesity in the United States, 1999-2004. JAMA 2006, 295:1549-1555.
3. Rowe G.G., et al. A study in man of cerebral blood flow and cerebral glucose, lactate and pyruvate metabolism before and after eating. J. Clin. Invest. 1959, 38:2154-2158.
4. Dworak M., et al. Intense exercise increases adenosine concentrations in rat brain: implications for a homeostatic sleep drive. Neuroscience 2007, 150:789-795.
5. Jeukendrup A.E. Modulation of carbohydrate and fat utilization by diet, exercise and environment. Biochem. Soc. Trans. 2003, 31:1270-1273.
6. Barter P.J., et al. Diurnal fluctuations in triglyceride, free fatty acids, and insulin during sucrose consumption and insulin infusion in man. J. Clin. Invest. 1971, 50:583-591.
7. Hansen A.P., Johansen K. Diurnal patterns of blood glucose, serum free fatty acids, insulin, glucagon and growth hormone in normals and juvenile diabetics. Diabetologia 1970, 6:27-33.
8. Brown G.C. Control of respiration and atp synthesis in mammalian mitochondria and cells. Biochem. J. 1992, 284:1-13.
9. Speakman J.R., et al. Set points, settling points and some alternative models: Theoretical options to understand how genes and environments combine to regulate body adiposity. Dis. Model Mech. 2011, 4:733-745.
10. Waller A.P., Lindinger M.I. Nutritional aspects of post exercise skeletal muscle glycogen synthesis in horses: a comparative review. Equine Vet. J. 2010, 42:274-281.
11. Maclean P.S., et al. Biology's response to dieting: the impetus for weight regain. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2011, 301:R581-R600.
12. Sims E.A., et al. Experimental obesity in man. A progress report. Isr. J. Med. Sci. 1972, 8:813-814.
13. Sims E.A., et al. Endocrine and metabolic effects of experimental obesity in man. Recent Prog. Horm. Res. 1973, 29:457-496.
14. Gruninger T.R., et al. Molecular signaling involved in regulating feeding and other motivated behaviors. Mol. Neurobiol. 2007, 35:1-20.
15. Batterham R.L., et al. Pyy modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans. Nature 2007, 450:106-109.
16. Stubbs C.O., Lee A.J. The obesity epidemic: both energy intake and physical activity contribute. Med. J. Aust. 2004, 181:489-491.
17. Gillis L.J., et al. Relationship between juvenile obesity, dietary energy and fat intake and physical activity. Int. J. Obes. Relat. Metab. Disord. 2002, 26:458-463.
18. Nordlie R.C., et al. Regulation of glucose production by the liver. Annu. Rev. Nutr. 1999, 19:379-406.
19. Falk B. Effects of thermal stress during rest and exercise in the paediatric population. Sports Med. 1998, 25:221-240.
20. Graber M., Corish D. The electrolytes in hyponatremia. Am. J. Kidney Dis. 1991, 18:527-545.
21. Reaven G.M. Insulin resistance: the link between obesity and cardiovascular disease. Med. Clin. North Am. 2011, 95:875-892.
22. Gallagher E.J., et al. Insulin resistance in obesity as the underlying cause for the metabolic syndrome. Mt. Sinai J. Med. 2010, 77:511-523.
23. Robertson R.P., et al. Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes. Diabetes 2004, 53(Suppl. 1):S119-S124.
24. Wang R.H., et al. Hepatic sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance. J. Clin. Invest. 2011, 121:4477-4490.
25. Savage D.B., et al. Mechanisms of insulin resistance in humans and possible links with inflammation. Hypertension 2005, 45:828-833.
26. Cabrera M.E., et al. A model analysis of lactate accumulation during muscle ischemia. J. Crit. Care 1999, 14:151-163.
27. Cabrera M.E., et al. Lactate metabolism during exercise: analysis by an integrative systems model. Am. J. Physiol. 1999, 277:R1522-R1536.
28. Poggi-Travert F., et al. Metabolic intermediates in lactic acidosis: compounds, samples and interpretation. J. Inherit. Metab. Dis. 1996, 19:478-488.
29. Laffel L. Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes. Diabetes Metab. Res. Rev. 1999, 15:412-426.
30. Gerich J.E., et al. Regulation of pancreatic insulin and glucagon secretion. Annu. Rev. Physiol. 1976, 38:353-388.
31. Reed M.A., et al. Roux-en-y gastric bypass corrects hyperinsulinemia implications for the remission of type 2 diabetes. J. Clin. Endocrinol. Metab. 2011, 96:2525-2531.
32. Saadeh M., et al. Reactive oxygen species stimulate insulin secretion in rat pancreatic islets: studies using mono-oleoyl-glycerol. PLoS ONE 2012, 7:e30200.
33. Bjorndal B., et al. Different adipose depots: their role in the development of metabolic syndrome and mitochondrial response to hypolipidemic agents. J. Obes. 2011, 2011:490650.
34. Mittendorfer B. Origins of metabolic complications in obesity: adipose tissue and free fatty acid trafficking. Curr. Opin. Clin. Nutr. Metab. Care 2011, 14:535-541.
35. Ginsberg H.N., et al. Regulation of plasma triglycerides in insulin resistance and diabetes. Arch. Med. Res. 2005, 36:232-240.
36. Owen O.E., et al. Energy metabolism in feasting and fasting. Adv. Exp. Med. Biol. 1979, 111:169-188.
37. van den Berghe G. The role of the liver in metabolic homeostasis: implications for inborn errors of metabolism. J. Inherit. Metab. Dis. 1991, 14:407-420.
38. Sajan M.P., Farese R.V. Insulin signalling in hepatocytes of humans with type 2 diabetes: excessive production and activity of protein kinase C-iota (PKC-iota) and dependent processes and reversal by PKC-iota inhibitors. Diabetologia 2012, 55:1446-1457.
39. Sajan M.P., et al. Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C-iota. Metabolism 2012, 61:459-469.
40. Woods S.C. Gastrointestinal satiety signals i. An overview of gastrointestinal signals that influence food intake. Am. J. Physiol. Gastrointest. Liver Physiol. 2004, 286:G7-G13.
41. Farooqi I.S., O'Rahilly S. Monogenic human obesity syndromes. Recent Prog. Horm. Res. 2004, 59:409-424.
42. Ishii M., et al. Targeted disruption of gpr7, the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:10540-10545.
43. Jones D.P., et al. Dietary sulfur amino acid effects on fasting plasma cysteine/cystine redox potential in humans. Nutrition 2011, 27:199-205.
44. Hoek J.B., Rydstrom J. Physiological roles of nicotinamide nucleotide transhydrogenase. Biochem. J. 1988, 254:1-10.
45. Murphy M.P. How mitochondria produce reactive oxygen species. Biochem. J. 2009, 417:1-13.
46. Corkey B.E. Banting lecture 2011. Hyperinsulinemia: cause or consequence?. Diabetes 2012, 61:4-13.
47. Divakaruni A.S., Brand M.D. The regulation and physiology of mitochondrial proton leak. Physiology (Bethesda) 2011, 26:192-205.
48. Cahill G.F. Fuel metabolism in starvation. Annu. Rev. Nutr. 2006, 26:1-22.
49. Humphries M.M., et al. The role of energy availability in mammalian hibernation: a cost-benefit approach. Physiol. Biochem. Zool. 2003, 76:165-179.
50. Butler P.J., Woakes A.J. Seasonal hypothermia in a large migrating bird: saving energy for fat deposition?. J. Exp. Biol. 2001, 204:1361-1367.
51. Samovski D., et al. Gating of the mitochondrial permeability transition pore by long chain fatty acyl analogs in vivo. J. Biol. Chem. 2010, 285:6879-6890.
52. Keith S.W., et al. Putative contributors to the secular increase in obesity: exploring the roads less traveled. Int. J. Obes. (Lond.) 2006, 30:1585-1594.
53. Barkley G.S. Factors influencing health behaviors in the National Health and Nutritional Examination survey, III (NHANES III). Soc. Work Health Care 2008, 46:57-79.
54. Elam T.E., Preston R.L. Executive Summary: Fifty Years of Pharmaceutical Technology and its Impact on the Beef We Provide to Consumers 2004, Growth Enhancement Technology Information Team. http://www.feedstuffsfoodlink.com/Media/MediaManager/whitePaper-summary.pdf.
55. US EPA Poultry Production 2012, US Environmental Protection Agency. http://www.epa.gov/oecaagct/ag101/printpoultry.html.
56. Mayer A.M. Historical changes in the mineral content of fruits and vegetables. Br. Food J. 1997, 99:207-211.
57. Vandenberg L.N., et al. Human exposure to bisphenol A (BPA). Reprod. Toxicol. 2007, 24:139-177.
58. Leranth C., et al. Bisphenol A prevents the synaptogenic response to estradiol in hippocampus and prefrontal cortex of ovariectomized nonhuman primates. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:14187-14191.
59. MacLusky N.J., et al. The environmental estrogen bisphenol A inhibits estradiol-induced hippocampal synaptogenesis. Environ. Health Perspect. 2005, 113:675-679.
60. Zaknun D., et al. Potential role of antioxidant food supplements, preservatives and colorants in the pathogenesis of allergy and asthma. Int. Arch. Allergy Immunol. 2012, 157:113-124.
61. Maier E., et al. Food preservatives sodium benzoate and propionic acid and colorant curcumin suppress th1-type immune response in vitro. Food Chem. Toxicol. 2010, 48:1950-1956.
62. Ciardi C., et al. Food additives such as sodium sulphite, sodium benzoate and curcumin inhibit leptin release in lipopolysaccharide-treated murine adipocytes in vitro. Br. J. Nutr. 2012, 107:826-833.
63. Adimora N.J., et al. A model of redox kinetics implicates the thiol proteome in cellular hydrogen peroxide responses. Antioxid. Redox Signal. 2010, 13:731-743.
64. Go Y.M., et al. A key role for mitochondria in endothelial signaling by plasma cysteine/cystine redox potential. Free Radic. Biol. Med. 2010, 48:275-283.
65. Jones D.P. Redox potential of GSH/GSSG couple: Assay and biological significance. Methods Enzymol. 2002, 348:93-112.
66. Moriarty-Craige S.E., Jones D.P. Extracellular thiols and thiol/disulfide redox in metabolism. Annu. Rev. Nutr. 2004, 24:481-509.
67. Fisher-Wellman K.H., Neufer P.D. Linking mitochondrial bioenergetics to insulin resistance via redox biology. Trends Endocrinol. Metab. 2012, 23:142-153.
68. Avogaro A., et al. High blood ketone body concentration in type 2 non-insulin dependent diabetic patients. J. Endocrinol. Invest. 1996, 19:99-105.
69. Ha C.Y., et al. The association of specific metabolites of lipid metabolism with markers of oxidative stress, inflammation and arterial stiffness in men with newly diagnosed type 2 diabetes. Clin. Endocrinol. (Oxf.) 2012, 76:674-682.
70. Wahren J., et al. Turnover and splanchnic metabolism of free fatty acids and ketones in insulin-dependent diabetics at rest and in response to exercise. J. Clin. Invest. 1984, 73:1367-1376.
71. Wang T.J., et al. Metabolite profiles and the risk of developing diabetes. Nat. Med. 2011, 17:448-453.
72. Laferrere B., et al. Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight loss. Sci. Transl. Med. 2011, 3:80re82.
73. Corkey B.E., et al. Regulation of a-ketoisocaproate and a-ketoisovalerate metabolism and their interactions with the citric acid cycle in isolated hepatocytes. Metabolism Clinical Implications of Branched Chain Amino Ketoacids 1981, 119-127. Elsevier. M. Walser, J.R. Williamson (Eds.).
74. Corkey B.E., et al. Regulation of the branched chain alpha-ketoacid pathway in liver. J. Biol. Chem. 1982, 257:9668-9676.
75. Martin-Requero A., et al. Interactions between alpha-ketoisovalerate metabolism and the pathways of gluconeogenesis and urea synthesis in isolated hepatocytes. J. Biol. Chem. 1983, 258:3673-3681.
76. Williamson J.R., et al. Metabolic repercussions of branched chain ketoacid metabolism in liver. Problems and Potential of Branched Chain Amino Acids in Physiology and Medicine 1986, 135-172. Elsevier. R. Odessey (Ed.).
77. Williamson J.R., et al. Interactions between a-ketoisovalerate, propoinate, and fatty acids on gluconeogenesis and ureogenesis in isolated hepatocytes. Metabolism and Clinical Implications of Branched Chain Amino and Ketoacids 1981, 105-117. Elsevier. M. Walser, J.R. Williamson (Eds.).
78. Mulligan J.D., et al. Downregulation of plasma insulin levels and hepatic PPARgamma expression during the first week of caloric restriction in mice. Exp. Gerontol. 2008, 43:146-153.
79. Civelek V.N., et al. Regulation of pancreatic beta-cell mitochondrial metabolism: Influence of ca2+, substrate and adp. Biochem. J. 1996, 318:615-621.
80. Shaw J.H., Wolfe R.R. Influence of beta-hydroxybutyrate infusion on glucose and free fatty acid metabolism in dogs. Am. J. Physiol. 1984, 247:E756-E764.
81. Sherwin R.S., et al. Effect of ketone infusions on amino acid and nitrogen metabolism in man. J. Clin. Invest. 1975, 55:1382-1390.
82. Mendoza J. Circadian clocks: setting time by food. J. Neuroendocrinol. 2007, 19:127-137.
83. Ropero A.B., et al. Bisphenol-a disruption of the endocrine pancreas and blood glucose homeostasis. Int. J. Androl. 2008, 31:194-200.
84. Alonso-Magdalena P., et al. Endocrine disruptors in the etiology of type 2 diabetes mellitus. Nat. Rev. Endocrinol. 2011, 7:346-353.
85. Krawczyk S.A., et al. Reactive oxygen species facilitate translocation of hormone sensitive lipase to the lipid droplet during lipolysis in human differentiated adipocytes. PLoS ONE 2012, 7:e34904.
86. Pedersen P.L. An introduction to the mitochondrial anion carrier family. J. Bioenerg. Biomemb. 1993, 25:431.