Food preservatives sodium benzoate and propionic acid and colorant curcumin suppress Th1-type immune response in vitro

Food and Chemical Toxicology

Volumn 48, Issue 7, 2010, Pages 1950-1956

  Maier, Elisabeth ^a   Kurz, Katharina ^b   Jenny, Marcel ^a   Schennach, Harald ^c   Ueberall, Florian ^a   Fuchs, Dietmar ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^c UNIVERSITY HOSPITAL INNSBRUCK   (Austria)

Author keywords

Food colorant; Food preservative; Immunomodulation; Indoleamine 2,3 dioxygenase (IDO); Neopterin

Indexed keywords

BENZOIC ACID; CURCUMIN; FOOD PRESERVATIVE; PROPIONIC ACID;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IMMUNE RESPONSE; IMMUNOMODULATION; IMMUNOREGULATION; IN VITRO STUDY; PERIPHERAL BLOOD MONONUCLEAR CELL; TH1 CELL; TH2 CELL;

CELL SURVIVAL; CELLS, CULTURED; CURCUMIN; FOOD COLORING AGENTS; FOOD PRESERVATIVES; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; MITOGENS; PROPIONIC ACIDS; SODIUM BENZOATE; TH1 CELLS;

EID: 77953536537     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2010.04.042     Document Type: Article

References (47)

1. Aggarwal B.B., Shishodia S., Takada Y., Banerjee S., Newman R.A., Bueso-Ramos C.E., Price J.E. Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice. Clin. Cancer Res. 2005, 11:7490-7498.
2. Aggarwal S., Ichikawa H., Takada Y., Sandur S.K., Shishodia S., Aggarwal B.B. Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IκBα kinase and Akt activation. Mol. Pharmacol. 2006, 69:195-206.
3. Allan K., Kelly F.J., Devereux G. Antioxidants and allergic disease: a case of too little or too much?. Clin. Exp. Allergy 2009, 40:370-380.
4. Andersen A. Final report on the safety assessment of benzaldehyde. Int. J. Toxicol. 2006, 25(Suppl. 1):11-27.
5. Bengmark S. Curcumin, an atoxic antioxidant and natural NFkappaB, cyclooxygenase-2, lipooxygenase, and inducible nitric oxide synthase inhibitor: a shield against acute and chronic diseases. J. Parent. Nutr. 2006, 30:45-51.
6. Billiau A., Heremans H., Vermeire K., Matthys P. Immunomodulatory properties of interferon-gamma. Ann. NY Acad. Sci. 1998, 856:22-32.
7. Bischoff S., Crowe S.E. Gastrointestinal food allergy: new insights into pathophysiology and clinical perspectives. Gastroenterology 2005, 128:1089-1113.
8. Brandacher G., Schroecksnadel K., Winkler C., Margreiter R., Fuchs D. Antitumoral activity of interferon-γ involved in impaired immune function in cancer patients. Curr. Drug Metab. 2006, 7:599-612.
9. Chainani-Wu N.J. Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa). Altern. Complement. Med. 2003, 9:161-168.
10. Diplock A.T., Charleux J.L., Crozier-Willi G., Kok F.J., Rice-Evans C., Roberfroid M., Stahl W., Viña-Ribes J.Br. Functional food science and defence against reactive oxidative species. J. Nutr. 1998, 80(Suppl. 1):S77-S112.
11. Grammer T.B., Fuchs D., Böhm B.O., Winkelmann B.R., Maerz W. Neopterin as a predictor of total and cardiovascular mortality in individuals undergoing angiography (The Ludwigshafen Risk and Cardiovascular Health Study). Clin. Chem. 2009, 55:115-146.
12. Halliwell B., Rafter J., Jenner A. Health promotion by flavonoids, tocopherols, tocotrienols, and other phenols: direct or indirect effects? Antioxidants or not?. Am. J. Clin. Nutr. 2005, 81:268S-276S.
13. Harrison P.T. Propionic acid and the phenomenon of rodent forestomach tumorigenesis: a review. Food Chem. Toxicol. 1992, 30:333-340.
14. Kositz C., Schroecksnadel K., Grander G., Schennach H., Kofler H., Fuchs D. Serum tryptophan concentration in patients predicts outcome of specific immunotherapy with pollen extracts. Int. Arch. Allergy Immunol. 2008, 147:35-40.
15. Lizaso M.T., Moneo I., García B.E., Acero S., Quirce S., Tabar A.I. Identification of allergens involved in occupational asthma due to carmine dye. Ann. Allergy Asthma Immunol. 2000, 84:549-552.
16. McCall M.R., Frei B. Can antioxidant vitamins materially reduce oxidative damage in humans?. Free Radic. Biol. Med. 1999, 26:1034-1053.
17. Murr C., Fuith L.C., Widner B., Wirleitner B., Baier-Bitterlich G., Fuchs D. Increased neopterin concentrations in patients with cancer: indicator of oxidative stress?. Anticancer Res. 1999, 19:1721-1728.
18. Murr C., Widner B., Wirleitner B., Fuchs D. Neopterin as a marker for immune system activation. Curr. Drug Metab. 2002, 3:175-287.
19. Murr C., Schroecksnadel K., Winkler C., Ledochowski M., Fuchs D. Antioxidants may increase the probability of developing allergic diseases and asthma. Med. Hypotheses 2005, 64:973-977.
20. Murr C., Talasz H., Artner-Dworzak E., Schroecksnadel K., Fiegl M., Fuchs D., Denz H.A. Inverse association between serum selenium concentrations and parameters of immune activation in patients with cardiac disorders. Clin. Chem. Lab. Med. 2007, 45:1224-1228.
21. Murr C., Schroecksnadel K., Winklhofer-Roob B.M., Mangge H., Böhm B.O., Winkelmann B.R., Maerz W., Fuchs D. Inverse association between serum concentrations of neopterin and antioxidants in patients with and without angiographic coronary artery disease. Atherosclerosis 2009, 202:543-549.
22. Nair B. Final report on the safety assessment of benzyl alcohol, benzoic acid, and sodium benzoate. Int. J. Toxicol. 2001, 20(Suppl. 3):23-50.
23. Neurauter G., Wirleitner B., Schroecksnadel K., Schennach H., Fuchs D. Wine and grape juice modulate interferon-γ-induced neopterin production and tryptophan degradation in human PBMC. Pteridines 2004, 15:1-9.
24. Parke D.V., Lewis D.F. Safety aspects of food preservatives. Food Addit. Contam. 1992, 9:561-577.
25. Quiles J.L., Mesa M.D., Ramirez-Tortosa C.L., Aguilera C.M., Battino M., Gil A., Ramirez-Tortosa M.C. Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits. Arterioscler. Thromb. Vasc. Biol. 2002, 22:1225-1231.
26. Raitala A., Karjalainen J., Oja S.S., Kosunen T.U., Hurme M. Indoleamine 2,3-dioxygenase (IDO) activity is lower in atopic than in non-atopic individuals and is enhanced by environmental factors protecting from atopy. Mol. Immunol. 2006, 43:1054-1056.
27. Romagnani S. Immunologic influences on allergy and the TH1/TH2 balance. J. Allergy Clin. Immunol. 2004, 113:395-400.
28. Schroecksnadel K., Winkler C., Wirleitner B., Schennach H., Fuchs D. Aspirin downregulates tryptophan degradation in stimulated human peripheral blood mononuclear cells in vitro. Clin. Exp. Immunol. 2005, 140:41-45.
29. Schroecksnadel K., Wirleitner B., Winkler C., Fuchs D. Monitoring tryptophan metabolism in chronic immune activation. Clin. Chim. Acta 2006, 364:82-90.
30. Schroecksnadel K., Fischer B., Schennach H., Weiss G., Fuchs D. Antioxidants down-regulate Th1-type immune response in vitro. Drug Metab. Lett. 2007, 1:166-171.
31. Sonin L., Patterson R. Metabisulfite challenge in patients with idiopathic anaphylaxis. J. Allergy Clin. Immunol. 1985, 75:67-69.
32. Strachan D.P. Hay fever, hygiene and household size. Brit. Med. J. 1989, 299:1259-1260.
33. Sucher R., Schroecksnadel K., Weiss G., Margreiter R., Fuchs D., Brandacher G. Neopterin, a prognostic marker in human malignancies. Cancer Lett. 2010, 287:13-22.
34. Tan P.H., Sagoo P., Chan C., Yates J.B., Campbell J., Beutelspacher S.C., Foxwell B.M., Lombardi G., George A.J. Inhibition of NF-kappa B and oxidative pathways in human dendritic cells by antioxidative vitamins generates regulatory T cells. J. Immunol. 2005, 174:7633-7644.
35. Taylor M.W., Feng G.S. Relationship between interferon-gamma, indoleamine 2,3-dioxygenase, and tryptophan catabolism. FASEB J. 1991, 5:2516-2522.
36. Vally H., Misso N.L., Madan V. Clinical effects of sulphite additives. Clin. Exp. Allergy 2009, 39:1643-1651.
37. Weiss G., Murr C., Zoller H., Haun M., Widner B., Ludescher C., Fuchs D. Modulation of neopterin formation and tryptophan degradation by Th1- and Th2-derived cytokines in human monocytic cells. Clin. Exp. Immunol. 1999, 116:435-440.
38. Widner B., Werner E.R., Schennach H., Wachter H., Fuchs D. Simultaneous measurement of serum tryptophan and kynurenine by HPLC. Clin. Chem. 1997, 43:2424-2426.
39. Wilson B.G., Bahna S.L. Adverse reactions to food additives. Ann. Allergy Asthma Immunol. 2005, 95:499-507.
40. Winkler C., Wirleitner B., Schroecksnadel K., Schennach H., Fuchs D. In vitro effects of beet root juice on stimulated and unstimulated peripheral blood mononuclear cells. Am. J. Biochem. Biotechnol. 2005, 1:180-185.
41. Winkler C., Frick B., Schroecksnadel K., Schennach H., Fuchs D. Food preservatives sodium sulfite and sorbic acid suppress mitogen-stimulated peripheral blood mononuclear cells. Food Chem. Toxicol. 2006, 44:2003-2007.
42. Winkler C., Wirleitner B., Schroecksnadel K., Schennach H., Fuchs D. Beer downregulates activated peripheral blood mononuclear cells in vitro. Int. Immunopharmacol. 2006, 6:390-395.
43. Winkler C., Schroecksnadel K., Schennach H., Fuchs D. Vitamin C and E suppress mitogen-stimulated peripheral blood mononuclear cells in vitro. Int. Arch. Allergy Immunol. 2007, 142:127-132.
44. Wirleitner B., Schroecksnadel K., Winkler C., Schennach H., Fuchs D. Resveratrol suppresses interferon-gamma-induced biochemical pathways in human peripheral blood mononuclear cells in vitro. Immunol. Lett. 2005, 100:159-163.
45. Wirleitner B., Wirleitner B., Winkler C., Fuchs D. Neopterin in HIV infection. Mol. Immunol. 2005, 42:183-194.
46. Zhang S.Y., Boisson-Dupuis S., Chapgier A., Yang K., Bustamante J., Puel A., Picard C., Abel L., Jouanguy E., Casanova J.L. Inborn errors of interferon (IFN)-mediated immunity in humans: insights into the respective roles of IFN-alpha/beta, IFN-gamma, and IFN-lambda in host defense. Immunol. Rev. 2008, 226:29-40.
47. Zvetkova E., Wirleitner B., Tram N.T., Schennach H., Fuchs D. Aqueous extracts of Crinum latifolium (L.) and Camellia sinensis show immunomodulatory properties in human peripheral blood mononuclear cells. Int. Immunopharmacol. 2001, 1:2143-2150.