2-Deoxy-d-glucose cooperates with arsenic trioxide to induce apoptosis in leukemia cells: Involvement of IGF-1R-regulated Akt/mTOR, MEK/ERK and LKB-1/AMPK signaling pathways

Biochemical Pharmacology

Volumn 84, Issue 12, 2012, Pages 1604-1616

  Estañ, María Cristina ^a   Calviño, Eva ^a   De Blas, Elena ^a   Boyano Adánez, María Del Carmen ^b   Mena, Maria Luz ^c   Gómez Gómez, Milagros ^c   Rial, Eduardo ^a   Aller, Patricio ^a  

^a CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^b UNIVERSITY OF ALCALÁ   (Spain)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

2 Deoxy d glucose; Apoptosis; Arsenic trioxide; Leukemia cells; Protein kinases

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC AGENT; ARSENIC TRIOXIDE; CASPASE 3; CASPASE 9; CYTOCHROME C; DEOXYGLUCOSE; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN BAX; PROTEIN BID; PROTEIN KINASE B; PROTEIN KINASE LKB1; SERINE PROTEINASE OMI; SMALL INTERFERING RNA; SOMATOMEDIN C; X LINKED INHIBITOR OF APOPTOSIS;

APOPTOSIS; ARTICLE; BONE MARROW CELL; CANCER CELL CULTURE; CELL STRAIN HL 60; CONTROLLED STUDY; DRUG EFFICACY; DRUG UPTAKE; HUMAN; HUMAN CELL; LEUKEMIA CELL; MEMBRANE PERMEABILITY; MITOCHONDRION; MYELOID LEUKEMIA; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ADENOSINE TRIPHOSPHATE; APOPTOSIS; ARSENICALS; CELL DIVISION; CELL LINE, TUMOR; DEOXYGLUCOSE; HUMANS; LEUKEMIA; MITOCHONDRIA; OXIDATIVE STRESS; OXIDES; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; RECEPTOR, IGF TYPE 1; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84869223394     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.09.022     Document Type: Article

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