Molecular mechanisms of the diabetogenic effects of arsenic inhibition of insulin signaling by arsenite and methylarsonous acid

Environmental Health Perspectives

Volumn 115, Issue 5, 2007, Pages 734-742

  Paul, David S ^a   Harmon, Anne W ^a   Devesa, Vicenta ^b   Thomas, David J ^c   Stýblo, Miroslav ^a,b  

^a IL   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Arsenic; Diabetes; Glucose uptake; PDK 1; PKB Akt

Indexed keywords

ARSENIC DERIVATIVE; ARSENIC TRIOXIDE; INSULIN; METHYLARSENOUS ACID; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 PHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ADIPOCYTE; ARTICLE; CATALYSIS; CONTROLLED STUDY; DIABETES MELLITUS; DIABETOGENESIS; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL HEALTH; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SYNTHESIS; GLUCOSE TRANSPORT; HEALTH HAZARD; HUMAN; HUMAN CELL; IMPAIRED GLUCOSE TOLERANCE; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3T3 CELLS; ADIPOCYTES; ANIMALS; ARSENICALS; ARSENITES; DIABETES MELLITUS; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; IMMUNOBLOTTING; INSULIN; MICE; MICROSCOPY, FLUORESCENCE; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION;

EID: 34249060044     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.9867     Document Type: Article

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