Curcumin stimulates reactive oxygen species production and potentiates apoptosis induction by the antitumor drugs arsenic trioxide and lonidamine in human myeloid leukemia cell lines

Journal of Pharmacology and Experimental Therapeutics

Volumn 335, Issue 1, 2010, Pages 114-123

  Sánchez, Yolanda ^a   Simón, Gloria P ^a   Calviño, Eva ^a   De Blas, Elena ^a   Aller, Patricio ^a  

^a CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 METHOXYESTRADIOL; 2 MORPHOLINO 8 PHENYLCHROMONE; ACETYLCYSTEINE; ARSENIC TRIOXIDE; CASPASE 3; CASPASE 9; CISPLATIN; CURCUMIN; CYTOCHROME C; GLUTATHIONE; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LONIDAMINE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BAX; PROTEIN BID; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; SUPEROXIDE; UO 126; X LINKED INHIBITOR OF APOPTOSIS; ANTINEOPLASTIC AGENT; APOPTOSIS REGULATORY PROTEIN; INDAZOLE DERIVATIVE; ORGANOARSENIC DERIVATIVE; OXIDE; OXIDIZING AGENT; PROTEIN KINASE; PROTEIN KINASE B; PROTEIN KINASE INHIBITOR;

APOPTOSIS; ARTICLE; CELL STRAIN HL 60; CELL STRAIN U937; CELL VIABILITY; DRUG EFFECT; DRUG POTENTIATION; ENZYME PHOSPHORYLATION; ENZYME RELEASE; FLOW CYTOMETRY; GEL MOBILITY SHIFT ASSAY; IMMUNOBLOTTING; LEUKEMIA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL SURVIVAL; DRUG EFFECTS; GENETICS; HL 60 CELL LINE; HUMAN; MEMBRANE POTENTIAL; METABOLISM; MITOCHONDRION; U937 CELL LINE; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; ARSENICALS; BLOTTING, WESTERN; CELL SURVIVAL; CURCUMIN; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FLOW CYTOMETRY; GLUTATHIONE; HL-60 CELLS; HUMANS; INDAZOLES; MEMBRANE POTENTIALS; MITOCHONDRIA; OXIDANTS; OXIDES; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; U937 CELLS;

EID: 77957236923     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.110.168344     Document Type: Article

References (39)

1. Amadori S, Fenaux P, Ludwig H, O'dwyer M, and Sanz M (2005) Use of arsenic trioxide in haematological malignancies: insight into the clinical development of a novel agent. Curr Med Res Opin 21:403-411.
2. Anand P, Kunnumakkara AB, Newman RA, and Aggarwal BB (2007) Bioavailability of curcumin: problems and promises. Mol Pharm 4:807-818.
3. Anand P, Sundaram C, Jhurani S, Kunnumakkara AB, and Aggarwal BB (2008) Curcumin and cancer: an "old-age" disease with an "age-old" solution. Cancer Lett 267:133-164.
4. Basile V, Ferrari E, Lazzari S, Belluti S, Pignedoli F, and Imbriano C (2009) Curcumin derivatives: molecular basis of their anti-cancer activity. Biochem Pharmacol 78:1305-1315.
5. Chan WH, Wu HY, and Chang WH (2006) Dosage effects of curcumin on cell death types in a human osteoblast cell line. Food Chem Toxicol 44:1362-1371.
6. Chanvorachote P, Pongrakhananon V, Wannachaiyasit S, Luanpitpong S, Rojanasakul Y, and Nimmannit U (2009) Curcumin sensitizes lung cancer cells to cisplatin-induced apoptosis through superoxide anion-mediated Bcl-2 degradation. Cancer Invest 27:624-635.
7. Dai J, Weinberg RS, Waxman S, and Jing Y (1999) Malignant cells can be sensitized to undergo growth inhibition and apoptosis by arsenic trioxide through modulation of the glutathione redox system. Blood 93:268-277. (Pubitemid 29019412)
8. Di Cosimo S, Ferretti G, Papaldo P, Carlini P, Fabi A, and Cognetti F (2003) Lonidamine: efficacy and safety in clinical trials for the treatment of solid tumors. Drugs Today 39:157-174. (Pubitemid 36514356)
9. Fantin VR and Leder P (2006) Mitochondriotoxic compounds for cancer therapy. Oncogene 25:4787-4797.
10. Fernández C, Ramos AM, Sancho P, Amrán D, de Blas E, and Aller P (2004) 12-O-tetradecanoylphorbol-13-acetate may both potentiate and decrease the generation of apoptosis by the antileukemic agent arsenic trioxide in human promonocytic cells. Regulation by extracellular signal-regulated protein kinases and glutathione. J Biol Chem 279:3877-3884.
11. Galán A, García-Bermejo ML, Troyano A, Vilaboa NE, de Blas E, Kazanietz MG, and Aller P (2000) Stimulation of p38 mitogen-activated protein kinase is an early regulatory event for the cadmium-induced apoptosis in human promonocytic cells. J Biol Chem 275:11418-11424.
12. Galati G, Sabzevari O, Wilson JX, and O'Brien PJ (2002) Prooxidant activity and cellular effects of the phenoxyl radicals of dietary flavonoids and other polyphenolics. Toxicology 177:91-104.
13. Huang P, Feng L, Oldham EA, Keating MJ, and Plunkett W (2000) Superoxide dismutase as a target for the selective killing of cancer cells. Nature 407:390-395.
14. Javvadi P, Segan AT, Tuttle SW, and Koumenis C (2008) The chemopreventive agent curcumin is a potent radiosensitizer of human cervical tumor cells via increased reactive oxygen species production and overactivation of the mitogen-activated protein kinase pathway. Mol Pharmacol 73:1491-1501.
15. Jing Y, Dai J, Chalmers-Redman RM, Tatton WG, and Waxman S (1999) Arsenic trioxide selectively induces acute promyelocytic leukemia cell apoptosis via a hydrogen peroxide-dependent pathway. Blood 94:2102-2111.
16. Kikuchi H, Kuribayashi F, Kiwaki N, and Nakayama T (2010) Curcumin dramatically enhances retinoic acid-induced superoxide generating activity via accumulation of p47-phox and p67-phox protein in U937 cells. Biochem Biophys Res Commun 395:61-65.
17. Kurata S (2000) Selective activation of p38 MAPK cascade and mitotic arrest caused by low level oxidative stress. J Biol Chem 275:23413-23416.
18. Lau AT, Wang Y, and Chiu JF (2008) Reactive oxygen species: current knowledge and applications in cancer research and therapeutic. J Cell Biochem 104:657-667.
19. Ligeret H, Barthelemy S, Zini R, Tillement JP, Labidalle S, and Morin D (2004) Effects of curcumin and curcumin derivatives on mitochondrial permeability transition pore. Free Radic Biol Med 36:919-929.
20. Limtrakul P (2007) Curcumin as chemosensitizer. Adv Exp Med Biol 595:269-300.
21. Lin JK (2007) Molecular targets of curcumin. Adv Exp Med Biol 595:227-243.
22. Miller WH Jr, Schipper HM, Lee JS, Singer J, and Waxman S (2002) Mechanisms of action of arsenic trioxide. Cancer Res 62:3893-3903.
23. Mukherjee S, Roy M, Dey S, and Bhattacharya RK (2007) A mechanistic approach for modulation of arsenic toxicity in human lymphocytes by curcumin, an active constituent of medicinal herb Curcuma longa Linn. J Clin Biochem Nutr 41:32-42.
24. Navarro-Antolín J, Redondo-Horcajo M, Zaragoza C, Alvarez-Barrientos A, Fernández AP, León-Gómez E, Rodrigo J, and Lamas S (2007) Role of peroxynitrite in endothelial damage mediated by cyclosporine A. Free Radic Biol Med 42:394-403.
25. Nonn L, Duong D, and Peehl DM (2007) Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase- 5 in prostate cells. Carcinogenesis 28:1188-1196.
26. Notarbartolo M, Poma P, Perri D, Dusonchet L, Cervello M, and D'Alessandro N (2005) Antitumor effects of curcumin, alone or in combination with cisplatin or doxorubicin, on human hepatic cancer cells. Analysis of their possible relationship to changes in NF-kB activation levels and in IAP gene expression. Cancer Lett 224:53-65.
27. Ramos AM, Fernández C, Amrán D, Sancho P, de Blas E, and Aller P (2005) Pharmacologic inhibitors of PI3K/Akt potentiate the apoptotic action of the antileukemic drug arsenic trioxide via glutathione depletion and increased peroxide accumulation in myeloid leukemia cells. Blood 105:4013-4020.
28. Reuter S, Eifes S, Dicato M, Aggarwal BB, and Diederich M (2008) Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells. Biochem Pharmacol 76:1340-1351.
29. Roy M, Sinha D, Mukherjee S, Paul S, and Bhattacharya RK (2008) Protective effect of dietary phytochemicals against arsenite induced genotoxicity in mammalian V79 cells. Indian J Exp Biol 46:690-697.
30. Salvi M, Brunati AM, Clari G, and Toninello A. Brunati AM, Clari G, and Toninello A (2002) Interaction of genistein with the mitochondrial electron transport chain results in opening of the membrane transition pore. Biochim Biophys Acta 1556: 187-196.
31. Sánchez Y, Amrán D, Fernández C, de Blas E, and Aller P (2008) Genistein selectively potentiates arsenic trioxide-induced apoptosis in human leukemia cells via reactive oxygen species generation and activation of reactive oxygen speciesinducible protein kinases (p38-MAPK, AMPK). Int J Cancer 123:1205-1214.
32. Solary E, Bettaieb A, Dubrez-Daloz L, and Corcos L (2003) Mitochondria as a target for inducing death of malignant hematopoietic cells. Leuk Lymphoma 44:563-574.
33. Troyano A, Fernández C, Sancho P, de Blas E, and Aller P (2001) Effect of glutathione depletion on antitumor drug toxicity (apoptosis and necrosis) in U-937 human promonocytic cells. The role of intracellular oxidation. J Biol Chem 276:47107-47115.
34. Troyano A, Sancho P, Fernández C, de Blas E, Bernardi P, and Aller P (2003) The selection between apoptosis and necrosis is differentially regulated in hydrogen peroxide-treated and glutathione-depleted human promonocytic cells. Cell Death Differ 10:889-898.
35. Wang WZ, Cheng J, Luo J, and Zhuang SM (2008) Abrogation of G2/M arrest sensitizes curcumin-resistant hepatoma cells to apoptosis. FEBS Lett 582:2689-2695.
36. Wang ZY and Chen Z (2008) Acute promyelocytic leukemia: from highly fatal to highly curable. Blood 111:2505-2515.
37. Woo JH, Kim YH, Choi YJ, Kim DG, Lee KS, Bae JH, Min DS, Chang JS, Jeong YJ, Lee YH, et al. (2003) Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, downregulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt. Carcinogenesis 24:1199-1208.
38. Yi J, Gao F, Shi G, Li H, Wang Z, Shi X, and Tang X (2002) The inherent cellular level of reactive oxygen species: one of the mechanisms determining apoptotic susceptibility of leukemic cells to arsenic trioxide. Apoptosis 7:209-215. (Pubitemid 34633460)
39. Yadav RS, Sankhwar ML, Shukla RK, Chandra R, Pant AB, Islam F, and Khanna VK (2009) Attenuation of arsenic neurotoxicity by curcumin in rats. Toxicol Appl Pharmacol 240:367-376.