Chronic exposure to leucine in vitro induces β-cell dysfunction in INS-1E cells and mouse islets

Journal of Endocrinology

Volumn 215, Issue 1, 2012, Pages 79-88

  Liu, Zhenping ^a,c   Jeppesen, Per Bendix ^a   Gregersen, Søren ^a   Larsen, Lotte Bach ^b   Hermansen, Kjeld ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b DANISH INSTITUTE OF AGRICULTURAL SCIENCES   (Denmark)

^c 309TH HOSPITAL OF PLA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; COLLAPSIN RESPONSE MEDIATOR PROTEIN 2; CYTOCHROME C OXIDASE; GLUCOSE; HOMEODOMAIN PROTEIN; LEUCINE; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; MEVALONIC ACID; PROTEASOME; RAN PROTEIN; TRIACYLGLYCEROL;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ISOLATION; CELL MIGRATION; CELL STIMULATION; CELL TRANSPORT; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; IN VITRO STUDY; INCUBATION TIME; INSULIN RELEASE; INSULIN SENSITIVITY; LONG TERM EXPOSURE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE PHOSPHORYLATION; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; APOPTOSIS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; FEMALE; GENE EXPRESSION REGULATION; GLUCOSE; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; LEUCINE; MICE; PANCREATIC DISEASES; PROTEOMICS; TIME FACTORS;

EID: 84869213450     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1530/JOE-12-0148     Document Type: Article

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