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Volumn 389, Issue 3, 2005, Pages 813-820

Relative contribution of PDX-1, MafA and E47/β2 to the regulation of the human insulin promoter

Author keywords

Diabetes mellitus; Gene transcription; Insulin gene; Islets of Langerhans; PDX 1 (pancreatic duodenal homeobox factor 1)

Indexed keywords

ACETYLATION; ASSAYS; DISEASES; GENES; PROTEINS; TISSUE;

EID: 23644438592     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20041891     Document Type: Article
Times cited : (80)

References (49)
  • 1
    • 0036210550 scopus 로고    scopus 로고
    • Regulation of insulin gene transcription
    • Melloul, D., Marshak, S. and Cerasi, E. (2002) Regulation of insulin gene transcription. Diabetologia 45, 309-326
    • (2002) Diabetologia , vol.45 , pp. 309-326
    • Melloul, D.1    Marshak, S.2    Cerasi, E.3
  • 3
    • 0028941181 scopus 로고
    • Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor
    • Naya, F. J., Stellrecht, C. M. and Tsai, M. J. (1995) Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor. Genes Dev. 9, 1009-1019
    • (1995) Genes Dev. , vol.9 , pp. 1009-1019
    • Naya, F.J.1    Stellrecht, C.M.2    Tsai, M.J.3
  • 4
    • 0030886674 scopus 로고    scopus 로고
    • Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice
    • Naya, F. J., Huang, H. P., Qiu, Y., Mutoh, H., DeMayo, F. J., Leiter, A. B. and Tsai, M. J. (1997) Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice. Genes Dev. 11, 2323-2334
    • (1997) Genes Dev. , vol.11 , pp. 2323-2334
    • Naya, F.J.1    Huang, H.P.2    Qiu, Y.3    Mutoh, H.4    DeMayo, F.J.5    Leiter, A.B.6    Tsai, M.J.7
  • 5
    • 0023477391 scopus 로고
    • A mutational analysis of the insulin gene transcription control region: Expression in β cells is dependent on two related sequences within the enhancer
    • Karlsson, O., Edlund, T., Moss, J. B., Rutter, W. J. and Walker, M. D. (1987) A mutational analysis of the insulin gene transcription control region: expression in β cells is dependent on two related sequences within the enhancer. Proc. Natl. Acad. Sci. U.S.A. 84, 8819-8823
    • (1987) Proc. Natl. Acad. Sci. U.S.A. , vol.84 , pp. 8819-8823
    • Karlsson, O.1    Edlund, T.2    Moss, J.B.3    Rutter, W.J.4    Walker, M.D.5
  • 6
    • 0024328366 scopus 로고
    • Pancreatic β-cell-type-specific expression of the rat insulin II gene is controlled by positive and negative cellular transcriptional elements
    • Whelan, J., Poon, D., Weil, P. A, and Stein, R. (1989) Pancreatic β-cell-type-specific expression of the rat insulin II gene is controlled by positive and negative cellular transcriptional elements. Mol. Cell. Biol. 9, 3253-3259
    • (1989) Mol. Cell. Biol. , vol.9 , pp. 3253-3259
    • Whelan, J.1    Poon, D.2    Weil, P.A.3    Stein, R.4
  • 8
    • 0024454676 scopus 로고
    • A tissue-specific nuclear factor binds to multiple sites in the human insulin-gene enhancer
    • Boam, D. S. and Docherty, K. (1989) A tissue-specific nuclear factor binds to multiple sites in the human insulin-gene enhancer. Biochem. J. 264, 233-239
    • (1989) Biochem. J. , vol.264 , pp. 233-239
    • Boam, D.S.1    Docherty, K.2
  • 9
    • 0027384997 scopus 로고
    • IPF1, a homeodomain-containing transactivator of the insulin gene
    • Ohlsson, H., Karlsson, K. and Edlund, T. (1993) IPF1, a homeodomain-containing transactivator of the insulin gene. EMBO J. 12, 4251-4259
    • (1993) EMBO J. , vol.12 , pp. 4251-4259
    • Ohlsson, H.1    Karlsson, K.2    Edlund, T.3
  • 10
    • 0028314969 scopus 로고
    • IDX-1: A new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene
    • Miller, C. P., McGehee, Jr, B. E. and Habener, J. F. (1994) IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene. EMBO J. 13, 1145-1156
    • (1994) EMBO J. , vol.13 , pp. 1145-1156
    • Miller, C.P.1    McGehee Jr., B.E.2    Habener, J.F.3
  • 11
    • 0027373441 scopus 로고
    • Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells
    • Leonard, J., Peers, B., Johnson, T., Ferreri, K., Lee, S. and Montminy, M. R. (1993) Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells. Mol. Endocrinol. 7, 1275-1283
    • (1993) Mol. Endocrinol. , vol.7 , pp. 1275-1283
    • Leonard, J.1    Peers, B.2    Johnson, T.3    Ferreri, K.4    Lee, S.5    Montminy, M.R.6
  • 12
    • 0030447883 scopus 로고    scopus 로고
    • Purification of the β-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells
    • Marshak, S., Totary, H., Cerasi, E. and Melloul, D. (1996) Purification of the β-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells. Proc. Natl. Acad. Sci. U.S.A. 93, 15057-15062
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 15057-15062
    • Marshak, S.1    Totary, H.2    Cerasi, E.3    Melloul, D.4
  • 13
    • 0034775035 scopus 로고    scopus 로고
    • Pancreatic duodenal homeobox-1, PDX-1, a major regulator of β cell function and identity
    • McKinnon, C. M. and Docherty, K. (2001) Pancreatic duodenal homeobox-1, PDX-1, a major regulator of β cell function and identity. Diabetologia 44, 1203-1214
    • (2001) Diabetologia , vol.44 , pp. 1203-1214
    • McKinnon, C.M.1    Docherty, K.2
  • 14
    • 0028567837 scopus 로고
    • Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1
    • Peers, B., Leonard, J., Sharma, S., Teitelman, G. and Montminy, M. R. (1994) Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1. Mol. Endocrinol. 8, 1798-1806
    • (1994) Mol. Endocrinol. , vol.8 , pp. 1798-1806
    • Peers, B.1    Leonard, J.2    Sharma, S.3    Teitelman, G.4    Montminy, M.R.5
  • 15
    • 0031009805 scopus 로고    scopus 로고
    • Functional characterization of the transactivation properties of the PDX-1 homeodomain protein
    • Peshavaria, M., Henderson, E., Sharma, A., Wright, C. V. and Stein, R. (1997) Functional characterization of the transactivation properties of the PDX-1 homeodomain protein. Mol. Cell. Biol. 17, 3987-3996
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 3987-3996
    • Peshavaria, M.1    Henderson, E.2    Sharma, A.3    Wright, C.V.4    Stein, R.5
  • 16
    • 0034695492 scopus 로고    scopus 로고
    • Transcription factor BETA2 acts cooperatively with E2A and PDX1 to activate the insulin gene promoter
    • Glick, E., Leshkowitz, D. and Walker, M. D. (2000) Transcription factor BETA2 acts cooperatively with E2A and PDX1 to activate the insulin gene promoter. J. Biol. Chem. 275, 2199-2204
    • (2000) J. Biol. Chem. , vol.275 , pp. 2199-2204
    • Glick, E.1    Leshkowitz, D.2    Walker, M.D.3
  • 17
    • 0033962883 scopus 로고    scopus 로고
    • The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter
    • Ohneda, K., Mirmira, R. G., Wang, J., Johnson, J. D. and German, M. S. (2000) The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter. Mol. Cell. Biol. 20, 900-911
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 900-911
    • Ohneda, K.1    Mirmira, R.G.2    Wang, J.3    Johnson, J.D.4    German, M.S.5
  • 18
    • 0028149890 scopus 로고
    • Insulin-promoter-factor 1 is required for pancreas development in mice
    • Jonsson, J., Carlsson, L., Edlund, T. and Edlund, H. (1994) Insulin-promoter-factor 1 is required for pancreas development in mice. Nature (London) 371, 606-609
    • (1994) Nature (London) , vol.371 , pp. 606-609
    • Jonsson, J.1    Carlsson, L.2    Edlund, T.3    Edlund, H.4
  • 20
    • 0037076351 scopus 로고    scopus 로고
    • Identification of β-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA
    • Olbrot, M., Rud, J., Moss, L. G. and Sharma, A. (2002) Identification of β-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA. Proc. Natl. Acad. Sci. U.S.A. 99, 6737-6742
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 6737-6742
    • Olbrot, M.1    Rud, J.2    Moss, L.G.3    Sharma, A.4
  • 21
    • 0041970072 scopus 로고    scopus 로고
    • Members of the large Maf transcription family regulate insulin gene transcription in islet β-cells
    • Matsuoka, T. A., Zhao, L., Artner, I., Jarrett, H. W., Friedman, D., Means, A. and Stein, R. (2003) Members of the large Maf transcription family regulate insulin gene transcription in islet β-cells. Mol. Cell. Biol. 23, 6049-6062
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 6049-6062
    • Matsuoka, T.A.1    Zhao, L.2    Artner, I.3    Jarrett, H.W.4    Friedman, D.5    Means, A.6    Stein, R.7
  • 22
    • 0037147306 scopus 로고    scopus 로고
    • MafA is a glucose-regulated and pancreatic β-cell-specific transcriptional activator for the insulin gene
    • Kataoka, K., Han, S. I., Shioda, S., Hirai, M., Nishizawa, M. and Handa, H. (2002) MafA is a glucose-regulated and pancreatic β-cell-specific transcriptional activator for the insulin gene. J. Biol. Chem. 277, 49903-49910
    • (2002) J. Biol. Chem. , vol.277 , pp. 49903-49910
    • Kataoka, K.1    Han, S.I.2    Shioda, S.3    Hirai, M.4    Nishizawa, M.5    Handa, H.6
  • 23
    • 0344983823 scopus 로고    scopus 로고
    • Mouse MafA, homologue of zebrafish somite Maf 1, contributes to the specific transcriptional activity through the insulin promoter
    • Kajihara, M., Sone, H., Amemiya, M., Katoh, Y., Isogai, M., Shimano, H., Yamada, N. and Takahashi, S. (2003) Mouse MafA, homologue of zebrafish somite Maf 1, contributes to the specific transcriptional activity through the insulin promoter. Biochem. Biophys. Res. Commun. 312, 831-842
    • (2003) Biochem. Biophys. Res. Commun. , vol.312 , pp. 831-842
    • Kajihara, M.1    Sone, H.2    Amemiya, M.3    Katoh, Y.4    Isogai, M.5    Shimano, H.6    Yamada, N.7    Takahashi, S.8
  • 24
    • 1542271011 scopus 로고    scopus 로고
    • Differentially expressed Maf family transcription factors, c-Maf and MafA, activate glucagon and insulin gene expression in pancreatic islet α- and β-cells
    • Kataoka, K., Shioda, S., Ando, K., Sakagami, K., Handa, H. and Yasuda, K. (2004) Differentially expressed Maf family transcription factors, c-Maf and MafA, activate glucagon and insulin gene expression in pancreatic islet α- and β-cells. J. Mol. Endocrinol. 32, 9-20
    • (2004) J. Mol. Endocrinol. , vol.32 , pp. 9-20
    • Kataoka, K.1    Shioda, S.2    Ando, K.3    Sakagami, K.4    Handa, H.5    Yasuda, K.6
  • 25
    • 0011974295 scopus 로고
    • The insulin gene
    • (Ashcroft, F. M. and Ashcroft, S. J., eds.), IRL Press, Oxford
    • Clark, A. R. and Docherty, K. (1992) The insulin gene. In insulin: Molecular Biology to Pathology (Ashcroft, F. M. and Ashcroft, S. J., eds.), pp. 37-63, IRL Press, Oxford
    • (1992) Insulin: Molecular Biology to Pathology , pp. 37-63
    • Clark, A.R.1    Docherty, K.2
  • 26
    • 2542497646 scopus 로고    scopus 로고
    • Identification of a novel PDX-1 binding site in the human insulin gene enhancer
    • Le Lay, J., Matsuoka, T. A., Henderson, E. and Stein, R. (2004) Identification of a novel PDX-1 binding site in the human insulin gene enhancer. J. Biol. Chem. 279, 22228-22235
    • (2004) J. Biol. Chem. , vol.279 , pp. 22228-22235
    • Le Lay, J.1    Matsuoka, T.A.2    Henderson, E.3    Stein, R.4
  • 27
    • 0025349639 scopus 로고
    • Proglucagon processing similar to normal islets in pancreatic α-like cell line derived from transgenic mouse tumor
    • Powers, A. C., Efrat, S., Mojsov, S., Spector, D., Habener, J. F. and Hanahan, D. (1990) Proglucagon processing similar to normal islets in pancreatic α-like cell line derived from transgenic mouse tumor. Diabetes 39, 406-414
    • (1990) Diabetes , vol.39 , pp. 406-414
    • Powers, A.C.1    Efrat, S.2    Mojsov, S.3    Spector, D.4    Habener, J.F.5    Hanahan, D.6
  • 28
    • 0026550830 scopus 로고
    • Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines
    • Asfari, M., Janjic, D., Meda, P., Li, G., Halban, P. A. and Wollheim, C. B. (1992) Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology 130, 167-178
    • (1992) Endocrinology , vol.130 , pp. 167-178
    • Asfari, M.1    Janjic, D.2    Meda, P.3    Li, G.4    Halban, P.A.5    Wollheim, C.B.6
  • 30
    • 0036124978 scopus 로고    scopus 로고
    • Secretion of bioactive human insulin following plasmid-mediated gene transfer to non-neuroendocrine cell lines, primary cultures and rat skeletal muscle in vivo
    • Shaw, J. A., Delday, M. I., Hart, A. W., Docherty, H. M., Maltin, C. A. and Docherty, K. (2002) Secretion of bioactive human insulin following plasmid-mediated gene transfer to non-neuroendocrine cell lines, primary cultures and rat skeletal muscle in vivo. J. Endocrinol. 172, 653-672
    • (2002) J. Endocrinol. , vol.172 , pp. 653-672
    • Shaw, J.A.1    Delday, M.I.2    Hart, A.W.3    Docherty, H.M.4    Maltin, C.A.5    Docherty, K.6
  • 31
    • 0035048253 scopus 로고    scopus 로고
    • Hepatic nuclear factor 1-α directs nucleosomal hyperacetylation to its tissue-specific transcriptional targets
    • Parrizas, M., Maestro, M. A., Boj, S. F., Paniagua, A., Casamitjana, R., Gomis, R., Rivera, F. and Ferrer, J. (2001) Hepatic nuclear factor 1-α directs nucleosomal hyperacetylation to its tissue-specific transcriptional targets. Mol. Cell Biol. 21, 3234-3243
    • (2001) Mol. Cell Biol. , vol.21 , pp. 3234-3243
    • Parrizas, M.1    Maestro, M.A.2    Boj, S.F.3    Paniagua, A.4    Casamitjana, R.5    Gomis, R.6    Rivera, F.7    Ferrer, J.8
  • 33
    • 1542297749 scopus 로고    scopus 로고
    • The MafA transcription factor appears to be responsible for tissue-specific expression of insulin
    • Matsuoka, T. A., Artner, I., Henderson, E., Means, A., Sander, M. and Stein, R. (2004) The MafA transcription factor appears to be responsible for tissue-specific expression of insulin. Proc. Natl. Acad. Sci. U.S.A. 101, 2930-2933
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 2930-2933
    • Matsuoka, T.A.1    Artner, I.2    Henderson, E.3    Means, A.4    Sander, M.5    Stein, R.6
  • 34
    • 0026575428 scopus 로고
    • Jun represses the human insulin promoter activity that depends on multiple cAMP response elements
    • Inagaki, N., Maekawa, T., Sudo, T., Ishii, S., Seino, Y. and Imura, H. (1992) c-Jun represses the human insulin promoter activity that depends on multiple cAMP response elements. Proc. Natl. Acad. Sci. U.S.A. 89, 1045-1049
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 1045-1049
    • Inagaki, N.1    Maekawa, T.2    Sudo, T.3    Ishii, S.4    Seino, Y.5    Imura, H.6
  • 35
    • 0033597915 scopus 로고    scopus 로고
    • The cyclic AMP response element modulator family regulates the insulin gene transcription by interacting with transcription factor IID
    • Inada, A., Someya, Y., Yamada, Y., Ihara, Y., Kubota, A., Ban, N., Watanabe, R., Tsuda, K. and Seino, Y. (1999) The cyclic AMP response element modulator family regulates the insulin gene transcription by interacting with transcription factor IID. J. Biol. Chem. 274, 21095-21103
    • (1999) J. Biol. Chem. , vol.274 , pp. 21095-21103
    • Inada, A.1    Someya, Y.2    Yamada, Y.3    Ihara, Y.4    Kubota, A.5    Ban, N.6    Watanabe, R.7    Tsuda, K.8    Seino, Y.9
  • 36
    • 0025361461 scopus 로고
    • Positive and negative regulation of the human insulin gene by multiple trans-acting factors
    • Boam, D. S., Clark, A. R. and Docherty, K. (1990) Positive and negative regulation of the human insulin gene by multiple trans-acting factors. J. Biol. Chem. 265, 8285-8296
    • (1990) J. Biol. Chem. , vol.265 , pp. 8285-8296
    • Boam, D.S.1    Clark, A.R.2    Docherty, K.3
  • 37
    • 2942595906 scopus 로고    scopus 로고
    • Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose
    • da Silva, G., Rutter, J. and Rutter, G. A. (2004) Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose. Proc. Natl. Acad. Sci. U.S.A. 101, 8319-8324
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 8319-8324
    • Da Silva, G.1    Rutter, J.2    Rutter, G.A.3
  • 38
    • 0026602931 scopus 로고
    • The insulin and islet amyloid polypeptide genes contain similar cell-specific promoter elements that bind identical β-cell nuclear complexes
    • German, M. S., Moss, L. G., Wang, J. and Rutter, W. J. (1992) The insulin and islet amyloid polypeptide genes contain similar cell-specific promoter elements that bind identical β-cell nuclear complexes. Mol. Cell. Biol. 12, 1777-1788
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 1777-1788
    • German, M.S.1    Moss, L.G.2    Wang, J.3    Rutter, W.J.4
  • 39
    • 0038607422 scopus 로고    scopus 로고
    • Covalent histone modifications underlie the developmental regulation of insulin gene transcription in pancreatic β cells
    • Chakrabarti, S. K., Francis, J., Ziesmann, S. M., Garmey, J. C. and Mirmira, R. G. (2003) Covalent histone modifications underlie the developmental regulation of insulin gene transcription in pancreatic β cells. J. Biol. Chem. 278, 23617-23623
    • (2003) J. Biol. Chem. , vol.278 , pp. 23617-23623
    • Chakrabarti, S.K.1    Francis, J.2    Ziesmann, S.M.3    Garmey, J.C.4    Mirmira, R.G.5
  • 40
    • 0036134978 scopus 로고    scopus 로고
    • Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47
    • Qiu, Y., Guo, M., Huang, S. and Stein, R. (2002) Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47. Mol. Cell. Biol. 22, 412-420
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 412-420
    • Qiu, Y.1    Guo, M.2    Huang, S.3    Stein, R.4
  • 41
  • 43
    • 0035986888 scopus 로고    scopus 로고
    • Evolution of transcription factor binding sites in Mammalian gene regulatory regions: Conservation and turnover
    • Dermitzakis, E. T. and Clark, A. G. (2002) Evolution of transcription factor binding sites in Mammalian gene regulatory regions: conservation and turnover. Mol. Biol. Evol. 19, 1114-1121
    • (2002) Mol. Biol. Evol. , vol.19 , pp. 1114-1121
    • Dermitzakis, E.T.1    Clark, A.G.2
  • 44
    • 0035808433 scopus 로고    scopus 로고
    • Transcription factors recognizing overlapping C1-A2 binding sites positively regulate insulin gene expression
    • Harrington, R. H. and Sharma, A. (2001) Transcription factors recognizing overlapping C1-A2 binding sites positively regulate insulin gene expression. J. Biol. Chem. 276, 104-113
    • (2001) J. Biol. Chem. , vol.276 , pp. 104-113
    • Harrington, R.H.1    Sharma, A.2
  • 45
    • 15744393397 scopus 로고    scopus 로고
    • The islet β-cell-enriched MafA activator is a key regulator of insulin gene transcription
    • Zhao, L., Guo, M., Matsuoka, T. A., Hagman, D. K., Parazzoli, S. D., Poitout, V. and Stein, R. (2005) The islet β-cell-enriched MafA activator is a key regulator of insulin gene transcription. J. Biol. Chem. 280, 11887-11894
    • (2005) J. Biol. Chem. , vol.280 , pp. 11887-11894
    • Zhao, L.1    Guo, M.2    Matsuoka, T.A.3    Hagman, D.K.4    Parazzoli, S.D.5    Poitout, V.6    Stein, R.7
  • 46
    • 0023850112 scopus 로고
    • Cooperativity of the glucocorticoid receptor and the CACCC-box binding factor
    • Schule, R., Muller, M., Otsuka-Murakami, H. and Renkawitz, R. (1988) Cooperativity of the glucocorticoid receptor and the CACCC-box binding factor. Nature (London) 332, 87-90
    • (1988) Nature (London) , vol.332 , pp. 87-90
    • Schule, R.1    Muller, M.2    Otsuka-Murakami, H.3    Renkawitz, R.4
  • 47
    • 0026052256 scopus 로고
    • Structure-function analysis of the rat prolactin promoter: Phasing requirements of proximal cell-specific elements
    • Harvey, C., Jackson, S. M., Siddiqui, S. K. and Gutierrez-Hartmann, A. (1991) Structure-function analysis of the rat prolactin promoter: phasing requirements of proximal cell-specific elements. Mol. Endocrinol. 5, 836-843
    • (1991) Mol. Endocrinol. , vol.5 , pp. 836-843
    • Harvey, C.1    Jackson, S.M.2    Siddiqui, S.K.3    Gutierrez-Hartmann, A.4
  • 48
    • 0029812704 scopus 로고    scopus 로고
    • Induction of insulin and islet amyloid polypeptide production in pancreatic islet glucagonoma cells by insulin promoter factor 1
    • Serup, P., Jensen, J., Andersen, F. G., Jorgensen, M. C., Blume, N., Holst, J. J. and Madsen, O. D. (1996) Induction of insulin and islet amyloid polypeptide production in pancreatic islet glucagonoma cells by insulin promoter factor 1. Proc. Natl. Acad. Sci. U.S.A. 93, 9015-9020
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 9015-9020
    • Serup, P.1    Jensen, J.2    Andersen, F.G.3    Jorgensen, M.C.4    Blume, N.5    Holst, J.J.6    Madsen, O.D.7
  • 49
    • 0037458120 scopus 로고    scopus 로고
    • Experimental conversion of liver to pancreas
    • Horb, M. E., Shen, C. N., Tosh, D. and Slack, J. M. (2003) Experimental conversion of liver to pancreas. Curr. Biol. 13, 105-115
    • (2003) Curr. Biol. , vol.13 , pp. 105-115
    • Horb, M.E.1    Shen, C.N.2    Tosh, D.3    Slack, J.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.