Evidence of undiscovered cell regulatory mechanisms: Phosphoproteins and protein kinases in mitochondria

Cellular and Molecular Life Sciences

Volumn 59, Issue 2, 2002, Pages 213-219

  Thomson, M ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Apoptosis; GTP binding proteins; Mitochondria; Phosphoprotein; Placenta; Protein kinase; Steroidogenesis

Indexed keywords

2 OXOACID DEHYDROGENASE; CYCLIC AMP DEPENDENT PROTEIN KINASE; PHOSPHOPROTEIN; PROTEIN KINASE; PROTEIN KINASE C DELTA; PYRUVATE DEHYDROGENASE; STRESS ACTIVATED PROTEIN KINASE;

APOPTOSIS; ENZYME ACTIVITY; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REVIEW; STEROIDOGENESIS;

ANIMALS; APOPTOSIS; CELL RESPIRATION; CYCLIC AMP-DEPENDENT PROTEIN KINASES; EVOLUTION; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MODELS, BIOLOGICAL; MONOMERIC GTP-BINDING PROTEINS; PHOSPHOPROTEINS; PROTEIN KINASES; STEROIDS;

EID: 0036183196     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00018-002-8417-7     Document Type: Review

References (77)

1. Protein phosphorylation and signal transduction
2. Phosphorylated proteins as physiological effectors
3. Molecular and cellular mechanisms used in the acute phase of stimulated steroidogenesis
4. StAR protein and the regulation of steroid hormone biosynthesis
5. Signalling through scaffold, anchoring, and adaptor proteins
6. Alpha-keto acid dehydrogenase complexes. X. Regulation of the activity of the pyruvate dehydrogenase complex from beef kidney mitochondria by phosphorylation and dephosphorylation
7. Endogenous protein phosphorylation in rat brain mitochondria: Occurrence of a novel ATP-dependent form of the autophosphorylated enzyme succinyl-CoA synthetase
8. The effects of glucagon, phenylephrine and insulin on the phosphorylation of cytoplasmic, mitochondrial and membrane-bound proteins of intact liver cells from starved rats
9. Role of pyruvate dehydrogenase in lactate production in exercising human skeletal muscle
10. Control of pyruvate dehydrogenase kinase gene expression
11. Isoenzymes of pyruvate dehydrogenase phosphatase: DNA-derived amino acid sequences, expression, and regulation
12. A new family of protein kinases - The mitochondrial protein kinases
13. Studies on the regulation of the mitochondrial alpha-ketoacid dehydrogenase complexes and their kinases
14. Nutritional control of branched chain alpha-ketoacid dehydrogenase in rat hepatocytes
15. Primary structure of pyruvate dehydrogenase kinase establishes a new family of eukaryotic protein kinases
16. Branched-chain alpha-ketoacid dehydrogenase kinase: Molecular cloning, expression, and sequence similarity with histidine protein kinases
17. NMR structure of the histidine kinase domain of the E. coli osmosensor EnvZ
18. Pyruvate dehydrogenase kinase from Arabidopsis thaliana: A protein histidine kinase that phosphorylates serine residues
19. An essential role of Glu-243 and His-239 in the phosphotransfer reaction catalyzed by pyruvate dehydrogenase kinase
20. Evidence that pyruvate dehydrogenase kinase belongs to the ATPase/kinase superfamily
21. Tetrameric assembly and conservation in the ATP-binding domain of rat branched-chain alpha-ketoacid dehydrogenase kinase
22. Evidence for cyclic AMP-dependent protein kinase activity in isolated guinea pig and rat liver mitochondria
23. The cAMP-dependent protein kinases and cAMP signal transduction
24. A cyclic 3′,5′-AMP-stimulated protein kinase from cardiac muscle
25. Dynamics of the distribution of cyclic AMP-dependent protein kinase in living cells
26. The biological functions of A-kinase anchor proteins
27. Cyclic AMP-dependent protein kinase in mitochondria and cytosol from different-sized follicles and corpora lutea of porcine ovaries
28. cAMP-dependent protein kinase isozymes with preference for histone H2B as substrate in mitochondria of bovine heart
29. cAMP-dependent protein kinase activity in yeast mitochondria
30. Differential localization of two isoforms of the regulatory subunit RII alpha of cAMP-dependent protein kinase in human sperm: Biochemical and cytochemical study
31. The origin of eukaryotes: The difference between prokaryotic and eukaryotic cells
32. Subcellular distribution of the R-subunits of cAMP-dependent protein kinase in LS-174T human colon carcinoma
33. Protein phosphorylation in mitochondria from human placenta
34. cAMP-dependent protein kinase and phosphoproteins in mammalian mitochondria: An extension of the cAMP-mediated intracellular signal transduction
35. Phosphorylation of mitochondrial telomere binding protein of Candida parapsilosis by cAMP-dependent protein kinase
36. AKAPs: From structure to function
37. D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain
38. Cloning and mitochondrial localization of full-length D-AKAP2, a protein kinase A anchoring protein
39. Organelle-specific targeting of protein kinase AII (PKAII): Molecular and in situ characterization of murine A kinase anchor proteins that recruit regulatory subunits of PKAII to the cytoplasmic surface of mitochondria
40. Characterization of S-AKAP84, a novel developmentally regulated A kinase anchor protein of male germ cells
41. Molecular characterization of AKAP149, a novel A kinase anchor protein with a KH domain
42. GTP-binding proteins in mitochondria of human placenta identified as G alpha i and Ran
43. Phosphorylation of mitochondrial proteins in isolated porcine ovarian follicles after treatment with luteinizing hormone
44. Protein phosphorylation in yeast mitochondria: cAMP-dependence, submitochondrial localization and substrates of mitochondrial protein kinases
45. Characterization of proteins phosphorylated by the cAMP-dependent protein kinase of bovine heart mitochondria
46. Phosphorylation of mitochondrial proteins in bovine heart: Characterization of kinases and substrates
47. Isoform-specific localization of A-RAF in mitochondria
48. Protein kinase Cδ targets mitochondria, alters mitochondrial membrane potential, and induces apoptosis in normal and neoplastic keratinocytes when overexpressed by an adenoviral vector
49. Translocation of SAPK/JNK to mitochondria and interaction with Bcl-x(L) in response to DNA damage
50. Molecular mechanisms of apoptosis induced by cytotoxic chemicals
51. Induction of the apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
52. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
53. Apoptotic and necrotic cell death induced by death domain receptors
54. The Bcl-2 protein family: Arbiters of cell survival
55. Bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes
56. Overexpression of Bcl2 blocks TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in human lung cancer cells
57. Induction of bcl-2 expression by Epstein-Barr-virus latent membrane protein-1 protects infected B-cells from programmed cell-death
58. Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A
59. JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
60. Coordinated regulation of radioadaptive response by protein kinase C and p38 mitogen-activated protein kinase
61. GTP-binding proteins in adrenocortical mitochondria
62. Partial characterization of mitochondrial G proteins in adrenal cells
63. Studies on ACTH action on perfused bovine adrenals: Site of action of ACTH corticosteroidogenesis
64. Acute adrenocorticotropic hormone stimulation of adrenal corticosteroidogenesis
65. Regulation of steroid hormone biosynthesis: Identification of precursors of a phosphoprotein targeted to the mitochondrion in stimulated rat adrenal cortex cells
66. Acute stimulation of steroidogenesis in corpus luteum and adrenal cortex by peptide hormones
67. The purification cloning and expression of a novel luteneinizing hormone-induced mitochondrial protein in mouse Leydig MA-10 cells
68. Targeted disruption of the peripheral-type benzodiazepine receptor gene inhibits steroidogenesis in the R2C Leydig tumor cell line
69. Unveiling the mechanism of action and regulation of the steroidogenic acute regulatory protein
70. The molecular structure of mitochondrial contact sites. Their role in regulation of energy metabolism and permeability transition
71. What are GTP-binding proteins doing in mitochondria?
72. Phosphorylation of steroidogenic acute regulatory protein (StAR) modulates its steroidogenic activity
73. Cyclic AMP-dependent protein kinase in rat adrenal mitochondrial fraction - Studies on the mechanism of ACTH action
74. Placental steroid biosynthesis in primate pregnancy
75. The mitochondrial import machinery for preproteins
76. Mitochondrial protein phosphorylation: Lessons from yeasts
77. Small GTP-binding proteins