Contrary effects of sphingosine-1-phosphate on expression of α-smooth muscle actin in transforming growth factor β1-stimulated lung fibroblasts

European Journal of Pharmacology

Volumn 696, Issue 1-3, 2012, Pages 120-129

  Kawashima, Tatsuo ^a   Yamazaki, Risa ^b   Matsuzawa, Yasuo ^a   Yamaura, Erika ^b   Takabatake, Mamoru ^b   Otake, Sho ^b   Ikawa, Yuta ^b   Nakamura, Hiroyuki ^b   Fujino, Hiromichi ^b   Murayama, Toshihiko ^b  

^a TOHO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b CHIBA UNIVERSITY   (Japan)

Author keywords

Smooth muscle actin; Cyclooxygenase; HFL1 cells; Sphingosine 1 phosphate; TGF 1

Indexed keywords

3,3' (1,4 PHENYLENE)BIS[N [4 (4,5 DIHYDRO 1H IMIDAZOL 2 YL)PHENYL]ACRYLAMIDE]; ALPHA SMOOTH MUSCLE ACTIN; CYCLOOXYGENASE 2; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; IMIPRAMINE; MESSENGER RNA; PERTUSSIS TOXIN; PROSTAGLANDIN E RECEPTOR 2; PROSTAGLANDIN E2; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE KINASE; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME SPECIFICITY; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; LUNG FIBROBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; RNA ANALYSIS; SIGNAL TRANSDUCTION; UPREGULATION;

ACTINS; ARACHIDONIC ACID; CELL LINE; CYCLIC AMP; CYCLOOXYGENASE 2; DINOPROSTONE; FIBROBLASTS; HUMANS; LUNG; LYSOPHOSPHOLIPIDS; RECEPTORS, LYSOSPHINGOLIPID; RNA, MESSENGER; SPHINGOSINE; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84869095680     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.09.038     Document Type: Article

References (58)

1. S.E. Alvarez, K.B. Harikumar, N.C. Hait, J. Allegood, G.M. Strub, E.Y. Kim, M. Maceyka, H. Jiang, C. Luo, T. Kordula, S. Milstien, and S. Spiegel Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2 Nature 465 2010 1084 1088
2. 2 G protein-coupled receptor J. Biol. Chem. 278 2003 32841 32851 (Pubitemid 37055726)
3. K.A. Becker, J. Riethmüller, A. Lüth, G. Döring, B. Kleuser, and E. Gulbins Acid sphingomyelinase inhibitors normalize pulmonary ceramide and inflammation in cystic fibrosis Am. J. Respir. Cell. Mol. Biol. 42 2010 716 724
4. A. Billich, and P. Ettmayer Fluorescence-based assay of sphingosine kinases Anal. Biochem. 326 2004 114 119 (Pubitemid 38177490)
5. A. Billich, F. Bornancin, D. Mechtcheriakova, F. Natt, D. Huesken, and T. Baumruker Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: function in cell survival and IL-1β and TNF-α induced production of inflammatory mediators Cell. Signal. 17 2005 1203 1217 (Pubitemid 40982611)
6. S. Bu, M. Yamanaka, H. Pei, A. Bielawska, J. Bielawski, Y.A. Hannun, L. Obeid, and M. Trojanowska Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts FASEB J. 20 2006 184 186 (Pubitemid 43100508)
7. F. Cencetti, C. Bernacchioni, P. Nincheri, C. Donati, and P. Bruni Transforming growth factor-β1 induces transdifferentiation of myoblasts into myofibroblasts via up-regulation of sphingosine kinase-1/S1P3 axis Mol. Biol. Cell 21 2010 1111 1124
8. A. Charruyer, S. Grazide, C. Bezombes, S. Müller, G. Laurent, and J.P. Jaffrézou UV-C light induces raft-associated acid sphingomyelinase and JNK activation and translocation independently on a nuclear signal J. Biol. Chem. 280 2005 19196 19204 (Pubitemid 41379626)
9. 2α activation induced by S1P is mediated by the S1P3 receptor in lung epithelial cells Am. J. Physiol. Lung Cell. Mol. Physiol. 295 2008 L326 L335
10. B.C. Chen, H.M. Chang, M.J. Hsu, C.M. Shih, Y.H. Chiu, W.T. Chiu, and C.H. Lin Peptidoglycan induces cyclooxygenase-2 expression in macrophages by activating the neutral sphingomyelinase-ceramide pathway J. Biol. Chem. 284 2009 20562 20573
11. J. Chun, T. Hla, K.R. Lynch, S. Spiegel, and W.H. Moolenaar International union of basic and clinical pharmacology. LXXVIII. Lysophospholipid receptor nomenclature Pharmacol. Rev. 62 2010 579 587
12. M.D. Davis, J.J. Clemens, T.L. Macdonald, and K.R. Lynch Sphingosine 1-phosphate analogs as receptor antagonists J. Biol. Chem. 280 2005 9833 9841 (Pubitemid 40395829)
13. R. Dhami, X. He, and E.H. Schuchman Acid sphingomylinase deficiency attenuates bleomycin-induced lung inflammation and fibrosis in mice Cell. Physiol. Biochem. 26 2010 749 760
14. C. Donati, F. Cencetti, C. De Palma, E. Rapizzi, S. Brunelli, G. Cossu, E. Clementi, and P. Bruni TGFβ protects mesoangioblasts from apoptosis via sphingosine kinase-1 regulation Cell. Signal. 21 2009 228 236
15. S. Filosto, W. Fry, A.A. Knowlton, and T. Goldkorn Neutral sphingomyelinase 2 (nSMase2) is a phosphoprotein regulated by calcineurin (PP2B) J. Biol. Chem. 285 2010 10213 102222
16. K.J. French, R.S. Schrecengost, B.D. Lee, Y. Zhuang, S.N. Smith, J.L. Eberly, J.K. Yun, and C.D. Smith Discovery and evaluation of inhibitors of human sphingosine kinase Cancer Res. 63 2003 5962 5969 (Pubitemid 37187498)
17. H. Fujino, X.B. Chen, J.W. Regan, and T. Murayama Indomethacin decreases EP2 prostanoid receptor expression in colon cancer cells Biochem. Biophys. Res. Commun. 359 2007 568 573 (Pubitemid 46898989)
18. N. Gellings Lowe, J.S. Swaney, K.M. Moreno, and R.A. Sabbadini Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor-β-stimulated collagen production by cardiac fibroblasts Cardiovasc. Res. 82 2009 303 312
19. 2 production by lung fibroblasts Am. J. Respir. Cell Mol. Biol. 30 2004 91 100 (Pubitemid 38085263)
20. 1 agonist that does not require S1P-like headgroup interactions Mol. Pharmacol. 74 2008 1308 1318
21. C. Han, A.J. Demetris, Y. Liu, J.H. Shelhamer, and T. Wu Transforming growth factor-β (TGF-β) activates cytosolic phospholipase A2α(cPLA2α)-mediated prostaglandin E2 (PGE)2/EP1 and peroxisome proliferator-activated receptor-γ (PPAR-γ)/Smad signaling pathways in human liver cancer cells J. Biol. Chem. 279 2004 44344 44354
22. K.A. Harvey, C.N. Paranavitana, G.P. Zaloga, and R.A. Siddiqui Diverse signaling pathways regulate fibroblast differentiation and transformation through Rho kinase activation J. Cell. Physiol. 211 2007 353 363 (Pubitemid 46580089)
23. 2 receptor Am. J. Respir. Cell Mol. Biol. 39 2008 356 363
24. 2-terminal kinase-dependent pathway Am. J. Respir. Crit. Care Med. 163 2001 152 157 (Pubitemid 32095266)
25. X. He, N. Okino, R. Dhami, A. Dagan, S. Gatt, H. Schulze, K. Sandhoff, and E.H. Schuchman Purification and characterization of recombinant, human acid ceramidase J. Biol. Chem. 278 2003 32978 32986
26. B. Hu, Z. Wu, and S.H. Phan Smad3 mediates transforming growth factor-β-induced α-smooth muscle actin expression Am. J. Respir. Cell Mol. Biol. 29 2003 397 404 (Pubitemid 37093999)
27. T. Kato, H. Fujino, S. Oyama, T. Kawashima, and T. Murayama Indomethacin induces cellular morphological changes and migration via epithelial-mesenchymal transition in A549 human lung cancer cells: a novel cyclooxygenase-inhibition- independent effect Biochem. Pharmacol. 82 2011 1781 1791
28. 12 specifically regulates COX-2 induction by sphingosine 1-phosphate J. Biol. Chem. 282 2007 1938 1947 2007
29. M. Kiriyama, F. Ushikubi, T. Kobayashi, M. Hirata, Y. Sugimoto, and S. Narumiya Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells Br. J. Pharmacol. 122 1997 217 224 (Pubitemid 27397191)
30. P.J. Koelink, L.J. Hawinkels, E. Wiercinska, C.F. Sier, P. ten Dijke, C.B. Lamers, D.W. Hommes, and H.W. Verspaget 5-Aminosalicylic acid inhibits TGF-β1 signaling in colorectal cancer cells Cancer Lett. 287 2010 82 90
31. Y. Koide, T. Hasegawa, A. Takahashi, A. Endo, N. Mochizuki, M. Nakagawa, and A. Nishida Development of novel EDG3 antagonists using a 3D database search and their structure-activity relationships J. Med. Chem. 45 2002 4629 4638
32. 2 inhibits fibroblast to myofibroblast transition via E. prostanoid receptor 2 signaling and cyclic adenosine monophosphate elevation Am. J. Respir. Cell Mol. Biol. 29 2003 537 544 (Pubitemid 37357704)
33. Y. Kono, T. Nishiuma, Y. Nishimura, Y. Kotani, T. Okada, S. Nakamura, and M. Yokoyama Sphingosine kinase 1 regulates differentiation of human and mouse lung fibroblasts mediated by TGFβ1 Am. J. Respir. Cell Mol. Biol. 37 2007 395 404 (Pubitemid 47502714)
34. A.A. Kulkarni, T.H. Thatcher, K.C. Olsen, S.B. Maggirwar, R.P. Phipps, and P.J. Sime PPAR-γ ligands repress TGFβ-induced myofibroblast differentiation by targeting the PI3K/Akt pathway: implications for therapy of fibrosis PloS ONE 6 1 2011 e15909
35. A. Leask, and D.J. Abraham TGF-β signaling and the fibrotic response FASEB J. 18 2004 816 827
36. 2 inhibits human lung fibroblast chemotaxis through disparate actions on different E-prostanoid receptors Am. J. Respir. Cell Mol. Biol. 44 2011 99 107
37. X. Liu, R.J. Kelm Jr.; and A.R. Strauch Transforming growth factor β1-mediated activation of the smooth muscle α-actin gene in human pulmonary myofibroblasts is inhibited by tumor necrosis factor-α via mitogen-activated protein kinase kinase 1-dependent induction of the Egr-1 transcriptional repressor Mol. Biol. Cell 20 2009 2174 2185
38. F. Liu, J.D. Mih, B.S. Shea, A.T. Kho, A.S. Sharif, A.M. Tager, and D.J. Tschumperlin Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression J. Cell Biol. 190 2010 693 706
39. C. Luberto, D.F. Hassler, P. Signorelli, Y. Okamoto, H. Sawai, E. Boros, D.J. Hazen-Martin, L.M. Obeid, Y.A. Hannun, and G.K. Smith Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase J. Biol. Chem. 277 2002 41128 41139 (Pubitemid 35215704)
40. Y. Matsuzawa, T. Kawashima, R. Yamazaki, E. Yamaura, T. Makiyama, H. Fujino, and T. Murayama Inhibitory effects of clinical reagents having anti-oxidative activity on transforming growth factor-β1-induced expression of α-smooth muscle actin in human fetal lung fibroblasts J. Toxicol. Sci. 36 2011 733 740
41. A.V. Miller, S.E. Alvarez, S. Spiegel, and D.A. Lebman Sphingosine kinases and sphingosine-1-phosphate are critical for transforming growth factor β-induced extracellular signal-regulated kinase 1 and 2 activation and promotion of migration and invasion of esophageal cancer cells Mol. Cell. Biol. 28 2008 4142 4151 (Pubitemid 351812997)
42. H. Nakamura, S. Wakita, A. Suganami, Y. Tamura, K. Hanada, and T. Murayama Modulation of the activity of cytosolic phospholipase A2α (cPLA2α) by cellular sphingolipids and inhibition of cPLA2α by sphingomyelin J. Lipid. Res. 51 2010 720 728
43. 2α receptor signaling facilitates bleomycin-induced pulmonary fibrosis independently of transforming growth factor-β Nat. Med. 15 2009 1426 1430
44. T. Ohama, M. Okada, T. Murata, D.L. Brautigan, M. Hori, and H. Ozaki Sphingosine-1-phosphate enhances IL-1β-induced COX-2 expression in mouse intestinal subepithelial myofibroblats Am. J. Physiol. Gastrointest. Liver Physiol. 295 2008 G766 G775
45. 2 production in response to TNF-α FASEB J. 17 2003 1411 1421 (Pubitemid 36939148)
46. R.A. Rahimi, and E.B. Leof TGF-β signaling: a tale of two responses J. Cell. Biochem. 102 2007 593 608 (Pubitemid 47557414)
47. S. Ren, C. Xin, J. Pfeilschifter, and A. Huwiler A novel mode of actin of the putative sphingosine kinase inhibitor 2-(p-hydroxyanilino)-4-(p- chlorophenyl) thiazole (SKI II): induction of lysosomal sphingosine kinase 1 degradation Cell. Physiol. Biochem. 26 2010 97 104
48. 2+ release functional assays: re-assessment of the pharmacology of VPC24191 and VPC23019 Br. J. Pharmacol. 167 2012 868 880
49. H. Rosen, P.J. Gonzalez-Cabrera, M.G. Sanna, and S. Brown Sphingosine 1-phosphate receptor signaling Annu. Rev. Biochem. 78 2009 743 768
50. M. Sato, M. Markiewicz, M. Yamanaka, A. Bielawska, C. Mao, L.M. Obeid, Y.A. Hannun, and M. Trojanowska Modulation of transforming growth factor-β (TGF-β) signaling by endogenous sphingolipid mediators J. Biol. Chem. 278 2003 9276 9282 (Pubitemid 36800411)
51. C.J. Scotton, and R.C. Chambers Molecular targets in pulmonary fibrosis: the myofibroblast in focus Chest 132 2007 1311 1321 (Pubitemid 47621009)
52. F.D. Testai, M.A. Landek, and G. Dawson Regulation of sphingomyelinases in cells of the oligodendrocyte lineage J. Neurosci. Res. 75 2004 66 74 (Pubitemid 38049407)
53. Y. Urata, Y. Nishimura, T. Hirase, and M. Yokoyama Sphingosine 1-phosphate induces alpha-smooth muscle actin expression in lung fibroblasts via Rho-kinase Kobe J. Med. Sci. 51 2005 17 27
54. B.X. Wu, C.J. Clarke, and Y.A. Hannun Mammalian neutral sphingomyelinases: regulation and roles in cell signaling responses Neuromolecular Med. 12 2010 320 330
55. C. Xin, S. Ren, B. Kleuser, S. Shabahang, W. Eberhardt, H. Radeke, M. Schäfer-Korting, J. Pfeilschifter, and A. Huwiler Sphingosine 1-phosphate cross-activates the Smad signaling cascade and mimics transforming growth factor-β-induced cell responses J. Biol. Chem. 279 2004 35255 35262 (Pubitemid 39100522)
56. M. Yamanaka, D. Shegogue, H. Pei, S. Bu, A. Bielawska, J. Bielawski, B. Pettus, Y.A. Hannun, L. Obeid, and M. Trojanowska Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-β and mediates TIMP-1 up-regulation J. Biol. Chem. 279 2004 53994 54001 (Pubitemid 40053131)
57. 2 production J. Biol. Chem. 281 2006 24695 24703 (Pubitemid 44274243)
58. B. Zhang, H. Tomura, A. Kuwabara, T. Kimura, S. Miura, K. Noda, F. Okajima, and K. Saku Correlation of high density lipoprotein (HLD)-associated sphingosine 1-phosphate with serum levels of HDL-cholesterol and apolipoproteins Atherosclerosis 178 2005 199 205 (Pubitemid 39600834)