Transforming growth factor-β1 induces phenotypic modulation of human lung fibroblasts to myofibroblast through a c-Jun-NH2-terminal kinase-dependent pathway

American Journal of Respiratory and Critical Care Medicine

Volumn 163, Issue 1, 2001, Pages 152-157

  Hashimoto, Shu ^a   Gon, Yasuhiro ^a   Takeshita, Ikuko ^a   Matsumoto, Ken ^a   Maruoka, Shuichiro ^a   Horie, Takashi ^a  

^a NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ALPHA ACTIN; CEP 1347; MITOGEN ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FIBROGENESIS; HUMAN; HUMAN CELL; LUNG FIBROBLAST; LUNG FIBROSIS; MYOFIBROBLAST; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; SIGNAL TRANSDUCTION; SMOOTH MUSCLE;

EID: 0035149573     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.163.1.2005069     Document Type: Article

References (35)

1. Current concepts in idiopathic pulmonary fibrosis: A road map for the future
2. Idiopathic pulmonary fibrosis, clinical relevance of pathologic classification
3. Idiopathic pulmonary fibrosis: Diagnosis and treatment, international consensus statement
4. Fibrogenic cytokines and connective tissue production
5. Myofibroblasts and their repair role in lung collagen gene expression during pulmonary fibrosis, a combined immunohistochemical and in situ hybridization study
6. Mechanism of myofibroblast activity and phenotype modulation
7. Rat alveolar myofibroblasts acquire α-smooth muscle actin expression during bleomycin-induced pulmonary fibrosis
8. Lung fibroblast α-smooth muscle actin expression and contractile phenotype in bleomycin-induced pulmonary fibrosis
9. The roles of the myofibroblast in idiopathic pulmonary fibrosis
10. Modulation of myofibroblasts and smooth-muscle phenotype in the lung
11. α-Smooth muscle actin in parenchymal cells of bleomycin-injured rat lung
12. Role of the myofibroblast in pulmonary fibrosis
13. 1 modulates myofibroblastic phenotype of rat palatal fibroblasts in vitro
14. 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis
15. 3) in bleomycin-induced pulmonary fibrosis
16. MAPKs: New JNK expand the group
17. Regulation and function of the JNK subgroup of MAP kinases
18. From receptor to stress-activated MAP kinase
19. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
20. Hyperosmolarity-induced IL-8 expression in human bronchial epithelial cells through p38 MAP kinase
21. Growth factors and mitogen-activated protein kinase
22. Extracellular-regulated kinase 1/2, Jun N-terminal kinase, and c-jun are involved in NF-κB-dependent IL-6 expression in human monocytes
23. p38 mitogen-activated protein kinase and c-Jun-NH2-terminal kinase regulate RANTES production by influenza virus-infected human bronchial epithelial cells
24. Differentiation repertoire of fibroblastic cells; expression of cytoskeletal proteins as marker of phenotype modulation
25. Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway
26. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
27. PD 98059 is a specific inhibitor of the actvation of mitogen-activated protein kinase kinase in vitro and in vivo
28. Osmotic regulation of cytokine synthesis in vitro
29. TGF-β receptor signaling
30. Smads and early developmental signaling by the TGFβ superfamily
31. Evidence for a role of Rho-like GTPase and stress-activated protein kinase/c-Jun-N-terminal kinase (SAPK/JNK) in transforming growth factor β-mediated signaling
32. Activation of p21ras by transforming growth factor β in epithelial cells
33. Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factorβ-induced gene expression
34. TGF-β induces fibronectin synthesis through a c-Jun-N-terminal kinase-dependent, Smad4-independent pathway
35. Pharmacological therapy for idiopathic pulmonary fibrosis