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Volumn 12, Issue 4, 2010, Pages 320-330

Mammalian neutral sphingomyelinases: Regulation and roles in cell signaling responses

Author keywords

Bioactive lipids; Ceramide; Neutral sphingomyelinase; nSMase2; SM; Sphingolipid

Indexed keywords

AMYLOID BETA PROTEIN; CERAMIDE; CYTOKINE; DAUNORUBICIN; NEUTRAL SPHINGOMYELINASE 1; NEUTRAL SPHINGOMYELINASE 2; NEUTRAL SPHINGOMYELINASE 3; PHOSPHODIESTERASE; SPHINGOMYELIN PHOSPHODIESTERASE; UNCLASSIFIED DRUG;

EID: 78649802553     PISSN: 15351084     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12017-010-8120-z     Document Type: Review
Times cited : (136)

References (88)
  • 1
    • 0030595340 scopus 로고    scopus 로고
    • FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinase
    • DOI 10.1016/S0092-8674(00)80169-5
    • S Adam-Klages D Adam K Wiegmann, et al. 1996 FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinase Cell 86 937 947 1:CAS:528:DyaK28XlvV2nsLs%3D 10.1016/S0092-8674(00)80169-5 8808629 (Pubitemid 26336798)
    • (1996) Cell , vol.86 , Issue.6 , pp. 937-947
    • Adam-Klages, S.1    Adam, D.2    Wiegmann, K.3    Struve, S.4    Kolanus, W.5    Schneider-Mergener, J.6    Kronke, M.7
  • 3
    • 66349086742 scopus 로고    scopus 로고
    • Bioactive sphingolipids: Metabolism and function
    • 10.1194/jlr.R800080-JLR200 19017611
    • N Bartke YA Hannun 2009 Bioactive sphingolipids: Metabolism and function Journal of Lipid Research 50 Suppl S91 S96 10.1194/jlr.R800080-JLR200 19017611
    • (2009) Journal of Lipid Research , vol.50 , Issue.SUPPL.
    • Bartke, N.1    Hannun, Y.A.2
  • 5
    • 0036375662 scopus 로고    scopus 로고
    • Mitochondria and ceramide: Intertwined roles in regulation of apoptosis
    • DOI 10.1016/S0065-2571(01)00026-7, PII S0065257101000267
    • H Birbes SE Bawab LM Obeid YA Hannun 2002 Mitochondria and ceramide: Intertwined roles in regulation of apoptosis Advances in Enzyme Regulation 42 113 129 1:CAS:528:DC%2BD3sXoslyjsw%3D%3D 10.1016/S0065-2571(01)00026-7 12123710 (Pubitemid 35033533)
    • (2002) Advances in Enzyme Regulation , vol.42 , pp. 113-129
    • Birbes, H.1    Bawab, S.E.2    Obeid, L.M.3    Hannun, Y.A.4
  • 6
    • 63049093140 scopus 로고    scopus 로고
    • Upregulation of smpd3 via BMP2 stimulation and Runx2
    • 1:CAS:528:DC%2BD1MXjt12gsrk%3D 19250608
    • YM Chae SH Heo JY Kim JM Lee HM Ryoo JY Cho 2009 Upregulation of smpd3 via BMP2 stimulation and Runx2 BMB Reports 42 86 90 1:CAS:528: DC%2BD1MXjt12gsrk%3D 19250608
    • (2009) BMB Reports , vol.42 , pp. 86-90
    • Chae, Y.M.1    Heo, S.H.2    Kim, J.Y.3    Lee, J.M.4    Ryoo, H.M.5    Cho, J.Y.6
  • 7
    • 27844517355 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate and ceramide 1-phosphate: Expanding roles in cell signaling
    • DOI 10.1242/jcs.02637
    • CE Chalfant S Spiegel 2005 Sphingosine 1-phosphate and ceramide 1-phosphate: Expanding roles in cell signaling Journal of Cell Science 118 4605 4612 1:CAS:528:DC%2BD2MXht1CnurzP 10.1242/jcs.02637 16219683 (Pubitemid 41646371)
    • (2005) Journal of Cell Science , vol.118 , Issue.20 , pp. 4605-4612
    • Chalfant, C.E.1    Spiegel, S.2
  • 8
    • 52949108413 scopus 로고    scopus 로고
    • Regulation of neutral sphingomyelinase-2 (nSMase2) by tumor necrosis factor-alpha involves protein kinase C-delta in lung epithelial cells
    • 1:CAS:528:DC%2BD1cXht1Sgtb%2FM 10.1124/mol.108.046250 18653803
    • CJ Clarke JM Guthrie YA Hannun 2008 Regulation of neutral sphingomyelinase-2 (nSMase2) by tumor necrosis factor-alpha involves protein kinase C-delta in lung epithelial cells Molecular Pharmacology 74 1022 1032 1:CAS:528:DC%2BD1cXht1Sgtb%2FM 10.1124/mol.108.046250 18653803
    • (2008) Molecular Pharmacology , vol.74 , pp. 1022-1032
    • Clarke, C.J.1    Guthrie, J.M.2    Hannun, Y.A.3
  • 9
    • 33845292894 scopus 로고    scopus 로고
    • Neutral sphingomyelinases and nSMase2: Bridging the gaps
    • DOI 10.1016/j.bbamem.2006.06.025, PII S000527360600246X, Sphingolipids, Apoptosis and Disease
    • CJ Clarke YA Hannun 2006 Neutral sphingomyelinases and nSMase2: Bridging the gaps Biochimica et Biophysica Acta 1758 1893 1901 1:CAS:528: DC%2BD28Xht12kt7%2FE 10.1016/j.bbamem.2006.06.025 16938269 (Pubitemid 44879364)
    • (2006) Biochimica et Biophysica Acta - Biomembranes , vol.1758 , Issue.12 , pp. 1893-1901
    • Clarke, C.J.1    Hannun, Y.A.2
  • 10
    • 33749009744 scopus 로고    scopus 로고
    • The extended family of neutral sphingomyelinases
    • DOI 10.1021/bi061307z
    • CJ Clarke CF Snook M Tani N Matmati N Marchesini YA Hannun 2006 The extended family of neutral sphingomyelinases Biochemistry 45 11247 11256 1:CAS:528:DC%2BD28XovVaht70%3D 10.1021/bi061307z 16981685 (Pubitemid 44453973)
    • (2006) Biochemistry , vol.45 , Issue.38 , pp. 11247-11256
    • Clarke, C.J.1    Snook, C.F.2    Tani, M.3    Matmati, N.4    Marchesini, N.5    Hannun, Y.A.6
  • 11
    • 33847719144 scopus 로고    scopus 로고
    • Role for neutral sphingomyelinase-2 in tumor necrosis factor α-stimulated expression of vascular cell adhesion molecule-1 (VCAM) and intercellular adhesion molecule-1 (ICAM) in lung epithelial cells: p38 MAPK is an upstream regulator of nSMase2
    • DOI 10.1074/jbc.M609216200
    • CJ Clarke TG Truong YA Hannun 2007 Role for neutral sphingomyelinase-2 in tumor necrosis factor alpha-stimulated expression of vascular cell adhesion molecule-1 (VCAM) and intercellular adhesion molecule-1 (ICAM) in lung epithelial cells: p38 MAPK is an upstream regulator of nSMase2 The Journal of Biological Chemistry 282 1384 1396 1:CAS:528:DC%2BD2sXit1Kruw%3D%3D 10.1074/jbc.M609216200 17085432 (Pubitemid 47076577)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.2 , pp. 1384-1396
    • Clarke, C.J.1    Truong, T.-G.2    Hannun, Y.A.3
  • 12
    • 66049140154 scopus 로고    scopus 로고
    • Activation of neutral sphingomyelinase is involved in acute hypoxic pulmonary vasoconstriction
    • 1:CAS:528:DC%2BD1MXksVaktL0%3D 10.1093/cvr/cvn349 19088082
    • A Cogolludo L Moreno G Frazziano, et al. 2009 Activation of neutral sphingomyelinase is involved in acute hypoxic pulmonary vasoconstriction Cardiovascular Research 82 296 302 1:CAS:528:DC%2BD1MXksVaktL0%3D 10.1093/cvr/cvn349 19088082
    • (2009) Cardiovascular Research , vol.82 , pp. 296-302
    • Cogolludo, A.1    Moreno, L.2    Frazziano, G.3
  • 13
    • 0022830221 scopus 로고
    • Cloning and expression in Escherichia coli and Staphylococcus aureus of the beta-lysin determinant from Staphylococcus aureus: Evidence that bacteriophage conversion of beta-lysin activity is caused by insertional inactivation of the beta-lysin determinant
    • DOI 10.1016/0882-4010(86)90040-9
    • DC Coleman JP Arbuthnott HM Pomeroy TH Birkbeck 1986 Cloning and expression in Escherichia coli and Staphylococcus aureus of the beta-lysin determinant from Staphylococcus aureus: Evidence that bacteriophage conversion of beta-lysin activity is caused by insertional inactivation of the beta-lysin determinant Microbial Pathogenesis 1 549 564 1:CAS:528:DyaL2sXksVyjsw%3D%3D 10.1016/0882-4010(86)90040-9 3334158 (Pubitemid 17222446)
    • (1986) Microbial Pathogenesis , vol.1 , Issue.6 , pp. 549-564
    • Coleman, D.C.1    Arbuthnott, J.P.2    Pomeroy, H.M.3    Birkbeck, T.H.4
  • 14
    • 51049124339 scopus 로고    scopus 로고
    • Neutral sphingomyelinase-3 is a DNA damage and nongenotoxic stress-regulated gene that is deregulated in human malignancies
    • 1:CAS:528:DC%2BD1cXmt1OjsLk%3D 10.1158/1541-7786.MCR-07-2097 18505924
    • CA Corcoran Q He S Ponnusamy B Ogretmen Y Huang MS Sheikh 2008 Neutral sphingomyelinase-3 is a DNA damage and nongenotoxic stress-regulated gene that is deregulated in human malignancies Molecular Cancer Research 6 795 807 1:CAS:528:DC%2BD1cXmt1OjsLk%3D 10.1158/1541-7786.MCR-07-2097 18505924
    • (2008) Molecular Cancer Research , vol.6 , pp. 795-807
    • Corcoran, C.A.1    He, Q.2    Ponnusamy, S.3    Ogretmen, B.4    Huang, Y.5    Sheikh, M.S.6
  • 15
    • 33644819311 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase activation by tumor necrosis factor α through neutral sphingomyelinase 2, sphingosine kinase 1, and sphingosine 1 phosphate receptors: A novel pathway relevant to the pathophysiology of endothelium
    • DOI 10.1161/01.ATV.0000194074.59584.42, PII 0004360520060100000017
    • C De Palma E Meacci C Perrotta P Bruni E Clementi 2006 Endothelial nitric oxide synthase activation by tumor necrosis factor alpha through neutral sphingomyelinase 2, sphingosine kinase 1, and sphingosine 1 phosphate receptors: A novel pathway relevant to the pathophysiology of endothelium Arteriosclerosis, Thrombosis, and Vascular Biology 26 99 105 10.1161/01.ATV.0000194074.59584.42 16269668 (Pubitemid 43732234)
    • (2006) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.26 , Issue.1 , pp. 99-105
    • De Palma, C.1    Meacci, E.2    Perrotta, C.3    Bruni, P.4    Clementi, E.5
  • 16
    • 33646146401 scopus 로고    scopus 로고
    • Alkaline sphingomyelinase: An old enzyme with novel implications
    • 1:CAS:528:DC%2BD28XktVenurY%3D 16631405
    • RD Duan 2006 Alkaline sphingomyelinase: An old enzyme with novel implications Biochimica et Biophysica Acta 1761 281 291 1:CAS:528: DC%2BD28XktVenurY%3D 16631405
    • (2006) Biochimica et Biophysica Acta , vol.1761 , pp. 281-291
    • Duan, R.D.1
  • 17
    • 33748047499 scopus 로고    scopus 로고
    • Bioactive sphingolipids in the modulation of the inflammatory response
    • DOI 10.1016/j.pharmthera.2006.04.004, PII S016372580600060X
    • M El Alwani BX Wu LM Obeid YA Hannun 2006 Bioactive sphingolipids in the modulation of the inflammatory response Pharmacology and Therapeutics 112 171 183 1:CAS:528:DC%2BD28XptFCitrk%3D 10.1016/j.pharmthera.2006.04.004 16759708 (Pubitemid 44301491)
    • (2006) Pharmacology and Therapeutics , vol.112 , Issue.1 , pp. 171-183
    • El Alwani, M.1    Wu, B.X.2    Obeid, L.M.3    Hannun, Y.A.4
  • 18
    • 0033955036 scopus 로고    scopus 로고
    • A neutral magnesium-dependent sphingomyelinase isoform associated with intracellular membranes and reversibly inhibited by reactive oxygen species
    • DOI 10.1074/jbc.275.2.1128
    • AC Fensome F Rodrigues-Lima M Josephs HF Paterson M Katan 2000 A neutral magnesium-dependent sphingomyelinase isoform associated with intracellular membranes and reversibly inhibited by reactive oxygen species The Journal of Biological Chemistry 275 1128 1136 1:CAS:528:DC%2BD3cXntlegsw%3D%3D 10.1074/jbc.275.2.1128 10625655 (Pubitemid 30051163)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.2 , pp. 1128-1136
    • Fensome, A.C.1    Rodrigues-Lima, F.2    Josephs, M.3    Paterson, H.F.4    Katan, M.5
  • 19
    • 33845320488 scopus 로고    scopus 로고
    • Intracellular trafficking of sphingolipids: Relationship to biosynthesis
    • DOI 10.1016/j.bbamem.2006.08.004, PII S0005273606002975, Sphingolipids, Apoptosis and Disease
    • AH Futerman 2006 Intracellular trafficking of sphingolipids: Relationship to biosynthesis Biochimica et Biophysica Acta 1758 1885 1892 1:CAS:528:DC%2BD28Xht12kt7%2FL 10.1016/j.bbamem.2006.08.004 16996025 (Pubitemid 44879366)
    • (2006) Biochimica et Biophysica Acta - Biomembranes , vol.1758 , Issue.12 , pp. 1885-1892
    • Futerman, A.H.1
  • 20
    • 23844555817 scopus 로고    scopus 로고
    • Differential regulation of ceramide in lipid-rich microdomains (rafts): Antagonistic role of palmitoyl:protein thioesterase and neutral sphingomyelinase 2
    • DOI 10.1002/jnr.20549
    • R Goswami M Ahmed J Kilkus T Han SA Dawson G Dawson 2005 Differential regulation of ceramide in lipid-rich microdomains (rafts): Antagonistic role of palmitoyl:protein thioesterase and neutral sphingomyelinase 2 Journal of Neuroscience Research 81 208 217 1:CAS:528:DC%2BD2MXlvFGjs70%3D 10.1002/jnr.20549 15929065 (Pubitemid 41153334)
    • (2005) Journal of Neuroscience Research , vol.81 , Issue.2 , pp. 208-217
    • Goswami, R.1    Ahmed, M.2    Kilkus, J.3    Han, T.4    Dawson, S.A.5    Dawson, G.6
  • 21
    • 28644451007 scopus 로고    scopus 로고
    • Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin
    • 1:CAS:528:DC%2BD2MXht1WqtrjI 10.1038/ncb1313 16227967
    • MO Grimm HS Grimm AJ Patzold, et al. 2005 Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin Nature Cell Biology 7 1118 1123 1:CAS:528:DC%2BD2MXht1WqtrjI 10.1038/ncb1313 16227967
    • (2005) Nature Cell Biology , vol.7 , pp. 1118-1123
    • Grimm, M.O.1    Grimm, H.S.2    Patzold, A.J.3
  • 22
    • 38549152194 scopus 로고    scopus 로고
    • Principles of bioactive lipid signalling: Lessons from sphingolipids
    • DOI 10.1038/nrm2329, PII NRM2329
    • YA Hannun LM Obeid 2008 Principles of bioactive lipid signalling: Lessons from sphingolipids Nature Reviews. Molecular Cell Biology 9 139 150 1:CAS:528:DC%2BD1cXovFOntg%3D%3D 10.1038/nrm2329 18216770 (Pubitemid 351158911)
    • (2008) Nature Reviews Molecular Cell Biology , vol.9 , Issue.2 , pp. 139-150
    • Hannun, Y.A.1    Obeid, L.M.2
  • 25
    • 0029012443 scopus 로고
    • Acid sphingomyelinase deficient mice: A model of types A and B Niemann-Pick disease
    • 1:CAS:528:DyaK2MXms1Kjtbo%3D 10.1038/ng0795-288 7670466
    • K Horinouchi S Erlich DP Perl, et al. 1995 Acid sphingomyelinase deficient mice: A model of types A and B Niemann-Pick disease Nature Genetics 10 288 293 1:CAS:528:DyaK2MXms1Kjtbo%3D 10.1038/ng0795-288 7670466
    • (1995) Nature Genetics , vol.10 , pp. 288-293
    • Horinouchi, K.1    Erlich, S.2    Perl, D.P.3
  • 26
    • 77949321187 scopus 로고    scopus 로고
    • Transcriptional regulation of neutral sphingomyelinase 2 gene expression of a human breast cancer cell line, MCF-7, induced by the anti-cancer drug, daunorubicin
    • 1:CAS:528:DC%2BD1MXhsVajtbnO 19698806
    • H Ito M Murakami A Furuhata, et al. 2009 Transcriptional regulation of neutral sphingomyelinase 2 gene expression of a human breast cancer cell line, MCF-7, induced by the anti-cancer drug, daunorubicin Biochimica et Biophysica Acta 1789 681 690 1:CAS:528:DC%2BD1MXhsVajtbnO 19698806
    • (2009) Biochimica et Biophysica Acta , vol.1789 , pp. 681-690
    • Ito, H.1    Murakami, M.2    Furuhata, A.3
  • 27
    • 58849160520 scopus 로고    scopus 로고
    • Ceramide and neurodegeneration: Susceptibility of neurons and oligodendrocytes to cell damage and death
    • 1:CAS:528:DC%2BD1MXhtlGkt7o%3D 10.1016/j.jns.2008.12.010
    • A Jana EL Hogan K Pahan 2009 Ceramide and neurodegeneration: Susceptibility of neurons and oligodendrocytes to cell damage and death Journal of the Neurological Science 278 5 15 1:CAS:528:DC%2BD1MXhtlGkt7o%3D 10.1016/j.jns.2008.12.010
    • (2009) Journal of the Neurological Science , vol.278 , pp. 5-15
    • Jana, A.1    Hogan, E.L.2    Pahan, K.3
  • 28
    • 10944272619 scopus 로고    scopus 로고
    • Fibrillar amyloid-β peptides kill human primary neurons via NADPH oxidase-mediated activation of neutral sphingomyelinase: Implications for Alzheimer's disease
    • DOI 10.1074/jbc.M404635200
    • A Jana K Pahan 2004 Fibrillar amyloid-beta peptides kill human primary neurons via NADPH oxidase-mediated activation of neutral sphingomyelinase. Implications for Alzheimer's disease The Journal of Biological Chemistry 279 51451 51459 1:CAS:528:DC%2BD2cXhtVaqs73M 10.1074/jbc.M404635200 15452132 (Pubitemid 40017893)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.49 , pp. 51451-51459
    • Jana, A.1    Pahan, K.2
  • 29
    • 34247477204 scopus 로고    scopus 로고
    • Oxidative stress kills human primary oligodendrocytes via neutral sphingomyelinase: Implications for multiple sclerosis
    • 10.1007/s11481-007-9066-2 18040843
    • A Jana K Pahan 2007 Oxidative stress kills human primary oligodendrocytes via neutral sphingomyelinase: Implications for multiple sclerosis Journal of Neuroimmune Pharmacology 2 184 193 10.1007/s11481-007-9066-2 18040843
    • (2007) Journal of Neuroimmune Pharmacology , vol.2 , pp. 184-193
    • Jana, A.1    Pahan, K.2
  • 30
    • 62749184862 scopus 로고    scopus 로고
    • Roles and regulation of secretory and lysosomal acid sphingomyelinase
    • 10.1016/j.cellsig.2009.01.026
    • RW Jenkins D Canals YA Hannun 2009 Roles and regulation of secretory and lysosomal acid sphingomyelinase Cell Signalling 6 836 846 10.1016/j.cellsig. 2009.01.026
    • (2009) Cell Signalling , vol.6 , pp. 836-846
    • Jenkins, R.W.1    Canals, D.2    Hannun, Y.A.3
  • 31
    • 0037032424 scopus 로고    scopus 로고
    • Irreversible inactivation of magnesium-dependent neutral sphingomyelinase 1 (NSM1) by peroxynitrite, a nitric oxide-derived oxidant
    • DOI 10.1016/S0014-5793(02)03551-2, PII S0014579302035512
    • M Josephs M Katan F Rodrigues-Lima 2002 Irreversible inactivation of magnesium-dependent neutral sphingomyelinase 1 (NSM1) by peroxynitrite, a nitric oxide-derived oxidant FEBS Letters 531 329 334 1:CAS:528:DC%2BD38Xotl2msrg%3D 10.1016/S0014-5793(02)03551-2 12417336 (Pubitemid 35341218)
    • (2002) FEBS Letters , vol.531 , Issue.2 , pp. 329-334
    • Josephs, M.1    Katan, M.2    Rodrigues-Lima, F.3
  • 32
    • 14744274499 scopus 로고    scopus 로고
    • Protective effects of S-nitrosoglutathione against amyloid β-peptide neurotoxicity
    • DOI 10.1016/j.freeradbiomed.2004.12.019
    • TC Ju SD Chen CC Liu DI Yang 2005 Protective effects of S-nitrosoglutathione against amyloid beta-peptide neurotoxicity Free Radical Biology and Medicine 38 938 949 1:CAS:528:DC%2BD2MXitVCnsb4%3D 10.1016/j.freeradbiomed.2004.12.019 15749390 (Pubitemid 40326195)
    • (2005) Free Radical Biology and Medicine , vol.38 , Issue.7 , pp. 938-949
    • Ju, T.-C.1    Chen, S.-D.2    Liu, C.-C.3    Yang, D.-I.4
  • 33
    • 0033840568 scopus 로고    scopus 로고
    • Identification of multiple forms of membrane-associated neutral sphingomyelinase in bovine brain
    • DOI 10.1046/j.1471-4159.2000.0751004.x
    • SY Jung JH Suh HJ Park, et al. 2000 Identification of multiple forms of membrane-associated neutral sphingomyelinase in bovine brain Journal of Neurochemistry 75 1004 1014 1:CAS:528:DC%2BD3cXmtFyrsr8%3D 10.1046/j.1471-4159. 2000.0751004.x 10936181 (Pubitemid 30660488)
    • (2000) Journal of Neurochemistry , vol.75 , Issue.3 , pp. 1004-1014
    • Jung, S.Y.1    Suh, J.H.2    Park, H.J.3    Jung, K.M.4    Kim, M.Y.5    Na, D.S.6    Kim, D.K.7
  • 34
    • 4444272893 scopus 로고    scopus 로고
    • Expression of neutral sphingomyelinase-2 (NSMase-2) in primary rat hepatocytes modulates IL-beta-induced JNK activation
    • 1:CAS:528:DC%2BD2cXkslWisbk%3D 15059969
    • AA Karakashian NV Giltiay GM Smith MN Nikolova-Karakashian 2004 Expression of neutral sphingomyelinase-2 (NSMase-2) in primary rat hepatocytes modulates IL-beta-induced JNK activation The Faseb Journal 18 968 970 1:CAS:528:DC%2BD2cXkslWisbk%3D 15059969
    • (2004) The Faseb Journal , vol.18 , pp. 968-970
    • Karakashian, A.A.1    Giltiay, N.V.2    Smith, G.M.3    Nikolova-Karakashian, M.N.4
  • 35
    • 47149105082 scopus 로고    scopus 로고
    • Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias
    • 1:CAS:528:DC%2BD1cXlsVSrsL8%3D 10.1182/blood-2007-10-113068 18299447
    • WJ Kim RA Okimoto LE Purton, et al. 2008 Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias Blood 111 4716 4722 1:CAS:528:DC%2BD1cXlsVSrsL8%3D 10.1182/blood-2007-10-113068 18299447
    • (2008) Blood , vol.111 , pp. 4716-4722
    • Kim, W.J.1    Okimoto, R.A.2    Purton, L.E.3
  • 36
    • 67649252344 scopus 로고    scopus 로고
    • Export and functions of sphingosine-1-phosphate
    • 1:CAS:528:DC%2BD1MXnt1Gntrw%3D 19268560
    • RH Kim K Takabe S Milstien S Spiegel 2009 Export and functions of sphingosine-1-phosphate Biochimica et Biophysica Acta 1791 692 696 1:CAS:528:DC%2BD1MXnt1Gntrw%3D 19268560
    • (2009) Biochimica et Biophysica Acta , vol.1791 , pp. 692-696
    • Kim, R.H.1    Takabe, K.2    Milstien, S.3    Spiegel, S.4
  • 37
    • 42249105215 scopus 로고    scopus 로고
    • The sphingolipid salvage pathway in ceramide metabolism and signaling
    • 1:CAS:528:DC%2BD1cXlsF2rt7s%3D 10.1016/j.cellsig.2007.12.006 18191382
    • K Kitatani J Idkowiak-Baldys YA Hannun 2008 The sphingolipid salvage pathway in ceramide metabolism and signaling Cell Signalling 20 1010 1018 1:CAS:528:DC%2BD1cXlsF2rt7s%3D 10.1016/j.cellsig.2007.12.006 18191382
    • (2008) Cell Signalling , vol.20 , pp. 1010-1018
    • Kitatani, K.1    Idkowiak-Baldys, J.2    Hannun, Y.A.3
  • 39
    • 33744953581 scopus 로고    scopus 로고
    • Novel tumor necrosis factor-responsive mammalian neutral sphingomyelinase-3 is a C-tail-anchored protein
    • DOI 10.1074/jbc.M511306200
    • O Krut K Wiegmann H Kashkar B Yazdanpanah M Kronke 2006 Novel tumor necrosis factor-responsive mammalian neutral sphingomyelinase-3 is a C-tail-anchored protein The Journal of Biological Chemistry 281 13784 13793 1:CAS:528:DC%2BD28Xkt1ymuro%3D 10.1074/jbc.M511306200 16517606 (Pubitemid 43855294)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.19 , pp. 13784-13793
    • Krut, O.1    Wiegmann, K.2    Kashkar, H.3    Yazdanpanah, B.4    Kronke, M.5
  • 40
    • 0347122965 scopus 로고    scopus 로고
    • Amyloid-β peptide induces oligodendrocyte death by activating the neutral sphingomyelinase-ceramide pathway
    • DOI 10.1083/jcb.200307017
    • JT Lee J Xu JM Lee, et al. 2004 Amyloid-beta peptide induces oligodendrocyte death by activating the neutral sphingomyelinase-ceramide pathway The Journal of Cell Biology 164 123 131 1:CAS:528:DC%2BD2cXjs1Cksw%3D%3D 10.1083/jcb.200307017 14709545 (Pubitemid 38082463)
    • (2004) Journal of Cell Biology , vol.164 , Issue.1 , pp. 123-131
    • Lee, J.-T.1    Xu, J.2    Lee, J.-M.3    Ku, G.4    Han, X.5    Yang, D.-I.6    Chen, S.7    Hsu, C.Y.8
  • 41
    • 33646127797 scopus 로고    scopus 로고
    • NSMase2 activation and trafficking are modulated by oxidative stress to induce apoptosis
    • 1:CAS:528:DC%2BD28XktVOqtrY%3D 10.1016/j.bbrc.2006.04.013 16631623
    • M Levy SS Castillo T Goldkorn 2006 nSMase2 activation and trafficking are modulated by oxidative stress to induce apoptosis Biochemical and Biophysical Research Communications 344 900 905 1:CAS:528:DC%2BD28XktVOqtrY%3D 10.1016/j.bbrc.2006.04.013 16631623
    • (2006) Biochemical and Biophysical Research Communications , vol.344 , pp. 900-905
    • Levy, M.1    Castillo, S.S.2    Goldkorn, T.3
  • 42
    • 67650065209 scopus 로고    scopus 로고
    • Neutral sphingomyelinase 2 is activated by cigarette smoke to augment ceramide-induced apoptosis in lung cell death
    • 1:CAS:528:DC%2BD1MXovVKis78%3D 10.1152/ajplung.00031.2009 19395669
    • M Levy E Khan M Careaga T Goldkorn 2009 Neutral sphingomyelinase 2 is activated by cigarette smoke to augment ceramide-induced apoptosis in lung cell death American Journal of Physiology Lung Cellular and Molecular Physiology 297 L125 L133 1:CAS:528:DC%2BD1MXovVKis78%3D 10.1152/ajplung.00031.2009 19395669
    • (2009) American Journal of Physiology Lung Cellular and Molecular Physiology , vol.297
    • Levy, M.1    Khan, E.2    Careaga, M.3    Goldkorn, T.4
  • 43
    • 38349056703 scopus 로고    scopus 로고
    • Confluence induced threonine41/serine45 phospho-beta-catenin dephosphorylation via ceramide-mediated activation of PP1cgamma
    • 1:CAS:528:DC%2BD1cXptlSrtQ%3D%3D 17996206
    • N Marchesini JA Jones YA Hannun 2007 Confluence induced threonine41/serine45 phospho-beta-catenin dephosphorylation via ceramide-mediated activation of PP1cgamma Biochimica et Biophysica Acta 1771 1418 1428 1:CAS:528:DC%2BD1cXptlSrtQ%3D%3D 17996206
    • (2007) Biochimica et Biophysica Acta , vol.1771 , pp. 1418-1428
    • Marchesini, N.1    Jones, J.A.2    Hannun, Y.A.3
  • 44
    • 0038529730 scopus 로고    scopus 로고
    • Biochemical properties of mammalian neutral sphingomyelinase2 and its role in sphingolipid metabolism
    • DOI 10.1074/jbc.M212262200
    • N Marchesini C Luberto YA Hannun 2003 Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism The Journal of Biological Chemistry 278 13775 13783 1:CAS:528:DC%2BD3sXjtVSit70%3D 10.1074/jbc.M212262200 12566438 (Pubitemid 36799914)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.16 , pp. 13775-13783
    • Marchesini, N.1    Luberto, C.2    Hannun, Y.A.3
  • 45
    • 2942532249 scopus 로고    scopus 로고
    • Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells
    • DOI 10.1074/jbc.M313662200
    • N Marchesini W Osta J Bielawski C Luberto LM Obeid YA Hannun 2004 Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells The Journal of Biological Chemistry 279 25101 25111 1:CAS:528:DC%2BD2cXksFyhurs%3D 10.1074/jbc.M313662200 15051724 (Pubitemid 38756759)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.24 , pp. 25101-25111
    • Marchesini, N.1    Osta, W.2    Bielawski, J.3    Luberto, C.4    Obeid, L.M.5    Hannun, Y.A.6
  • 46
    • 50049084765 scopus 로고    scopus 로고
    • Thematic review series: Sphingolipids. ISC1 (inositol phosphosphingolipid-phospholipase C), the yeast homologue of neutral sphingomyelinases
    • 1:CAS:528:DC%2BD1cXltFSltrs%3D 10.1194/jlr.R800004-JLR200 18305313
    • N Matmati YA Hannun 2008 Thematic review series: Sphingolipids. ISC1 (inositol phosphosphingolipid-phospholipase C), the yeast homologue of neutral sphingomyelinases Journal of Lipid Research 49 922 928 1:CAS:528: DC%2BD1cXltFSltrs%3D 10.1194/jlr.R800004-JLR200 18305313
    • (2008) Journal of Lipid Research , vol.49 , pp. 922-928
    • Matmati, N.1    Hannun, Y.A.2
  • 47
    • 78649776491 scopus 로고    scopus 로고
    • Sphingomyelin metabolism at the plasma membrane: Implications for bioactive sphingolipids
    • Milhas, D., Clarke, C. J., & Hannun, Y. A. (2009) Sphingomyelin metabolism at the plasma membrane: Implications for bioactive sphingolipids. The FEBS Letters.
    • (2009) The FEBS Letters
    • Milhas, D.1    Clarke, C.J.2    Hannun, Y.A.3
  • 48
    • 0034759191 scopus 로고    scopus 로고
    • Nuclear localization of neutral sphingomyelinase 1: Biochemical and immunocytochemical analyses
    • Y Mizutani K Tamiya-Koizumi N Nakamura M Kobayashi Y Hirabayashi S Yoshida 2001 Nuclear localization of neutral sphingomyelinase 1: Biochemical and immunocytochemical analyses Journal of Cell Science 114 3727 3736 1:CAS:528:DC%2BD3MXot12nsr4%3D 11707524 (Pubitemid 33041054)
    • (2001) Journal of Cell Science , vol.114 , Issue.20 , pp. 3727-3736
    • Mizutani, Y.1    Tamiya-Koizumi, K.2    Nakamura, N.3    Kobayashi, M.4    Hirabayashi, Y.5    Yoshida, S.6
  • 49
    • 33644977905 scopus 로고    scopus 로고
    • Sphingolipid targets in cancer therapy
    • 1:CAS:528:DC%2BD28XhvVelsrg%3D 10.1158/1535-7163.MCT-05-0420 16505092
    • DE Modrak DV Gold DM Goldenberg 2006 Sphingolipid targets in cancer therapy Molecular Cancer Therapeutics 5 200 208 1:CAS:528:DC%2BD28XhvVelsrg%3D 10.1158/1535-7163.MCT-05-0420 16505092
    • (2006) Molecular Cancer Therapeutics , vol.5 , pp. 200-208
    • Modrak, D.E.1    Gold, D.V.2    Goldenberg, D.M.3
  • 50
    • 34047242070 scopus 로고    scopus 로고
    • Sphingolipids and cell death
    • DOI 10.1007/s10495-007-0721-0, Special Issue on Mitochondria in Apoptosis
    • A Morales H Lee FM Goni R Kolesnick JC Fernandez-Checa 2007 Sphingolipids and cell death Apoptosis 12 923 939 1:CAS:528:DC%2BD2sXksFamtr4%3D 10.1007/s10495-007-0721-0 17294080 (Pubitemid 46653290)
    • (2007) Apoptosis , vol.12 , Issue.5 , pp. 923-939
    • Morales, A.1    Lee, H.2    Goni, F.M.3    Kolesnick, R.4    Fernandez-Checa, J.C.5
  • 52
    • 58149316662 scopus 로고    scopus 로고
    • Role of neutral sphingomyelinases in aging and inflammation
    • 10.1007/978-1-4020-8831-5-18 18751923
    • M Nikolova-Karakashian A Karakashian K Rutkute 2008 Role of neutral sphingomyelinases in aging and inflammation Sub-cellular Biochemistry 49 469 486 10.1007/978-1-4020-8831-5-18 18751923
    • (2008) Sub-cellular Biochemistry , vol.49 , pp. 469-486
    • Nikolova-Karakashian, M.1    Karakashian, A.2    Rutkute, K.3
  • 53
    • 0030795329 scopus 로고    scopus 로고
    • Bimodal regulation of ceramidase by interleukin-1β. Implications for the regulation of cytochrome P450 2C11 (CYP2C11)
    • DOI 10.1074/jbc.272.30.18718
    • M Nikolova-Karakashian ET Morgan C Alexander DC Liotta AH Merrill Jr 1997 Bimodal regulation of ceramidase by interleukin-1beta. Implications for the regulation of cytochrome p450 2C11 The Journal of Biological Chemistry 272 18718 18724 1:CAS:528:DyaK2sXltVSgsbs%3D 10.1074/jbc.272.30.18718 9228043 (Pubitemid 27318216)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.30 , pp. 18718-18724
    • Nikolova-Karakashian, M.1    Morgan, E.T.2    Alexander, C.3    Liotta, D.C.4    Merrill Jr., A.H.5
  • 54
    • 65249147869 scopus 로고    scopus 로고
    • Ceramide and mitochondria in ischemia/reperfusion
    • 1:CAS:528:DC%2BD1MXjtlOhurw%3D 10.1097/FJC.0b013e31819b52d5 19247196
    • SA Novgorodov TI Gudz 2009 Ceramide and mitochondria in ischemia/reperfusion Journal of Cardiovascular Pharmacology 53 198 208 1:CAS:528:DC%2BD1MXjtlOhurw%3D 10.1097/FJC.0b013e31819b52d5 19247196
    • (2009) Journal of Cardiovascular Pharmacology , vol.53 , pp. 198-208
    • Novgorodov, S.A.1    Gudz, T.I.2
  • 55
    • 3543114272 scopus 로고    scopus 로고
    • Biologically active sphingolipids in cancer pathogenesis and treatment
    • B Ogretmen YA Hannun 2004 Biologically active sphingolipids in cancer pathogenesis and treatment Nature Reviews Cancer 4 604 616 1:CAS:528: DC%2BD2cXmtVOhsb4%3D 10.1038/nrc1411 15286740 (Pubitemid 39025055)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.8 , pp. 604-616
    • Ogretmen, B.1    Hannun, Y.A.2
  • 56
    • 0029014350 scopus 로고
    • Acid sphingomyelinase-deficient mice mimic the neurovisceral form of human lysosomal storage disease (Niemann-Pick disease)
    • 1:CAS:528:DyaK2MXms1Kmt74%3D 10.1016/S0092-8674(05)80010-8 7600574
    • B Otterbach W Stoffel 1995 Acid sphingomyelinase-deficient mice mimic the neurovisceral form of human lysosomal storage disease (Niemann-Pick disease) Cell 81 1053 1061 1:CAS:528:DyaK2MXms1Kmt74%3D 10.1016/S0092-8674(05)80010-8 7600574
    • (1995) Cell , vol.81 , pp. 1053-1061
    • Otterbach, B.1    Stoffel, W.2
  • 57
    • 0037203317 scopus 로고    scopus 로고
    • Serine palmitoyltransferase: Role in apoptotic de novo ceramide synthesis and other stress responses
    • 1:CAS:528:DC%2BD3sXivVOqug%3D%3D 12531548
    • DK Perry 2002 Serine palmitoyltransferase: Role in apoptotic de novo ceramide synthesis and other stress responses Biochimica et Biophysica Acta 1585 146 152 1:CAS:528:DC%2BD3sXivVOqug%3D%3D 12531548
    • (2002) Biochimica et Biophysica Acta , vol.1585 , pp. 146-152
    • Perry, D.K.1
  • 58
    • 75749152640 scopus 로고    scopus 로고
    • The Polycomb group protein EED couples TNF receptor 1 to neutral sphingomyelinase
    • 1:CAS:528:DC%2BC3cXhtFyks74%3D 10.1073/pnas.0908486107 20080539
    • S Philipp M Puchert S Adam-Klages, et al. 2010 The Polycomb group protein EED couples TNF receptor 1 to neutral sphingomyelinase Proceedings of the National Academy of Sciences of the United States of America 107 1112 1117 1:CAS:528:DC%2BC3cXhtFyks74%3D 10.1073/pnas.0908486107 20080539
    • (2010) Proceedings of the National Academy of Sciences of the United States of America , vol.107 , pp. 1112-1117
    • Philipp, S.1    Puchert, M.2    Adam-Klages, S.3
  • 59
    • 0037490159 scopus 로고    scopus 로고
    • Ceramide stabilizes β-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid β-peptide biogenesis
    • DOI 10.1074/jbc.M300466200
    • L Puglielli BC Ellis AJ Saunders DM Kovacs 2003 Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis The Journal of Biological Chemistry 278 19777 19783 1:CAS:528:DC%2BD3sXktVaqtrc%3D 10.1074/jbc.M300466200 12649271 (Pubitemid 36799164)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.22 , pp. 19777-19783
    • Puglielli, L.1    Ellis, B.C.2    Saunders, A.J.3    Kovacs, D.M.4
  • 60
    • 0034623231 scopus 로고    scopus 로고
    • Structural requirements for catalysis and membrane targeting of mammalian enzymes with neutral sphingomyelinase and lysophospholipid phospholipase C activities. Analysis by chemical modification and site-directed mutagenesis
    • 1:CAS:528:DC%2BD3cXmsVKktLc%3D 10871611
    • F Rodrigues-Lima AC Fensome M Josephs J Evans RJ Veldman M Katan 2000 Structural requirements for catalysis and membrane targeting of mammalian enzymes with neutral sphingomyelinase and lysophospholipid phospholipase C activities. Analysis by chemical modification and site-directed mutagenesis The Journal of Biological Chemistry 275 28316 28325 1:CAS:528:DC%2BD3cXmsVKktLc%3D 10871611
    • (2000) The Journal of Biological Chemistry , vol.275 , pp. 28316-28325
    • Rodrigues-Lima, F.1    Fensome, A.C.2    Josephs, M.3    Evans, J.4    Veldman, R.J.5    Katan, M.6
  • 61
    • 35848937327 scopus 로고    scopus 로고
    • Regulation of neutral sphingomyelinase-2 by GSH: A new insight to the role of oxidative stress in aging-associated inflammation
    • DOI 10.1194/jlr.M700227-JLR200
    • K Rutkute RH Asmis MN Nikolova-Karakashian 2007 Regulation of neutral sphingomyelinase-2 by GSH: A new insight to the role of oxidative stress in aging-associated inflammation Journal of Lipid Research 48 2443 2452 1:CAS:528:DC%2BD2sXht1Kntr3I 10.1194/jlr.M700227-JLR200 17693623 (Pubitemid 350058755)
    • (2007) Journal of Lipid Research , vol.48 , Issue.11 , pp. 2443-2452
    • Rutkute, K.1    Asmis, R.H.2    Nikolova-Karakashian, M.N.3
  • 62
    • 34547520207 scopus 로고    scopus 로고
    • Aging in rat causes hepatic hyperresposiveness to interleukin-1β which is mediated by neutral sphingomyelinase-2
    • DOI 10.1002/hep.21777
    • K Rutkute AA Karakashian NV Giltiay A Dobierzewska MN Nikolova-Karakashian 2007 Aging in rat causes hepatic hyperresposiveness to interleukin-1beta which is mediated by neutral sphingomyelinase-2 Hepatology 46 1166 1176 1:CAS:528:DC%2BD2sXht1aksrrL 10.1002/hep.21777 17668873 (Pubitemid 350144781)
    • (2007) Hepatology , vol.46 , Issue.4 , pp. 1166-1176
    • Rutkute, K.1    Karakashian, A.A.2    Giltiay, N.V.3    Dobierzewska, A.4    Nikolova-Karakashian, M.N.5
  • 63
    • 0033621471 scopus 로고    scopus 로고
    • Function of the cloned putative neutral sphingomyelinase as lyso- platelet activating factor-phospholipase C
    • DOI 10.1074/jbc.274.53.38131
    • H Sawai N Domae N Nagan YA Hannun 1999 Function of the cloned putative neutral sphingomyelinase as lyso-platelet activating factor-phospholipase C The Journal of Biological Chemistry 274 38131 38139 1:CAS:528:DC%2BD3cXkt1GrsA%3D%3D 10.1074/jbc.274.53.38131 10608884 (Pubitemid 30026885)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.53 , pp. 38131-38139
    • Sawai, H.1    Domae, N.2    Nagan, N.3    Hannun, Y.A.4
  • 64
    • 0034670379 scopus 로고    scopus 로고
    • Identification of ISC1 (YERO19w) as inositol phosphosphingolipid phospholipase C in Saccharomyces cerevisiae
    • DOI 10.1074/jbc.M007721200
    • H Sawai Y Okamoto C Luberto, et al. 2000 Identification of ISC1 (YER019w) as inositol phosphosphingolipid phospholipase C in Saccharomyces cerevisiae The Journal of Biological Chemistry 275 39793 39798 1:CAS:528:DC%2BD3cXptFSrurk%3D 10.1074/jbc.M007721200 11006294 (Pubitemid 32059011)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.50 , pp. 39793-39798
    • Sawai, H.1    Okamoto, Y.2    Luberto, C.3    Mao, C.4    Bielawska, A.5    Domae, N.6    Hannun, Y.A.7
  • 65
    • 0014083339 scopus 로고
    • Sphingomyelinase in normal human spleens and in spleens from subjects with Niemann-Pick disease
    • 1:CAS:528:DyaF2sXktVShurc%3D 4962590
    • PB Schneider EP Kennedy 1967 Sphingomyelinase in normal human spleens and in spleens from subjects with Niemann-Pick disease Journal of Lipid Research 8 202 209 1:CAS:528:DyaF2sXktVShurc%3D 4962590
    • (1967) Journal of Lipid Research , vol.8 , pp. 202-209
    • Schneider, P.B.1    Kennedy, E.P.2
  • 66
    • 35248814255 scopus 로고    scopus 로고
    • The pathogenesis and treatment of acid sphingomyelinase-deficient Niemann-Pick disease
    • DOI 10.1007/s10545-007-0632-9
    • EH Schuchman 2007 The pathogenesis and treatment of acid sphingomyelinase-deficient Niemann-Pick disease Journal of Inherited Metabolic Disease 30 654 663 1:CAS:528:DC%2BD2sXhtFCgsr3N 10.1007/s10545-007-0632-9 17632693 (Pubitemid 47559876)
    • (2007) Journal of Inherited Metabolic Disease , vol.30 , Issue.5 , pp. 654-663
    • Schuchman, E.H.1
  • 67
    • 78649784669 scopus 로고    scopus 로고
    • Osteolytic prostate cancer cells induce the expression of specific cytokines in bone-forming osteoblasts through a Stat3/5-dependent mechanism
    • Schulze, J., Albers, J., Baranowsky, A., et al. (2009). Osteolytic prostate cancer cells induce the expression of specific cytokines in bone-forming osteoblasts through a Stat3/5-dependent mechanism. Bone.
    • (2009) Bone
    • Schulze, J.1    Albers, J.2    Baranowsky, A.3
  • 68
    • 41049100486 scopus 로고    scopus 로고
    • Disruption of retinoic acid receptor alpha reveals the growth promoter face of retinoic acid
    • DOI 10.1371/journal.pone.0000836
    • G Somenzi G Sala S Rossetti M Ren R Ghidoni N Sacchi 2007 Disruption of retinoic acid receptor alpha reveals the growth promoter face of retinoic acid PLoS One 2 e836 10.1371/journal.pone.0000836 17786207 (Pubitemid 351420083)
    • (2007) PLoS ONE , vol.2 , Issue.9
    • Somenzi, G.1    Sala, G.2    Rossetti, S.3    Ren, M.Q.4    Ghidoni, R.5    Sacchi, N.6
  • 69
    • 0032869856 scopus 로고    scopus 로고
    • Functional analysis of acid and neutral sphingomyelinases in vitro and in vivo
    • DOI 10.1016/S0009-3084(99)00079-1, PII S0009308499000791
    • W Stoffel 1999 Functional analysis of acid and neutral sphingomyelinases in vitro and in vivo Chemistry and Physics of Lipids 102 107 121 1:CAS:528:DyaK1MXmt1emtL8%3D 10.1016/S0009-3084(99)00079-1 11001565 (Pubitemid 29438663)
    • (1999) Chemistry and Physics of Lipids , vol.102 , Issue.1-2 , pp. 107-121
    • Stoffel, W.1
  • 71
    • 34547653109 scopus 로고    scopus 로고
    • Neutral sphingomyelinase (SMPD3) deficiency causes a novel form of chondrodysplasia and dwarfism that is rescued by Col2A1-driven smpd3 transgene expression
    • DOI 10.2353/ajpath.2007.061285
    • W Stoffel B Jenke B Holz, et al. 2007 Neutral sphingomyelinase (SMPD3) deficiency causes a novel form of chondrodysplasia and dwarfism that is rescued by Col2A1-driven smpd3 transgene expression American Journal of Pathology 171 153 161 1:CAS:528:DC%2BD2sXosVals70%3D 10.2353/ajpath.2007.061285 17591962 (Pubitemid 47339235)
    • (2007) American Journal of Pathology , vol.171 , Issue.1 , pp. 153-161
    • Stoffel, W.1    Jenke, B.2    Holz, B.3    Binczek, E.4    Gunter, R.H.5    Knifka, J.6    Koebke, J.7    Niehoff, A.8
  • 72
    • 33947363813 scopus 로고    scopus 로고
    • Analysis of membrane topology of neutral sphingomyelinase 2
    • DOI 10.1016/j.febslet.2007.02.046, PII S0014579307002141
    • M Tani YA Hannun 2007 Analysis of membrane topology of neutral sphingomyelinase 2 FEBS Letters 581 1323 1328 1:CAS:528:DC%2BD2sXjsVWnsrc%3D 10.1016/j.febslet.2007.02.046 17349629 (Pubitemid 46452606)
    • (2007) FEBS Letters , vol.581 , Issue.7 , pp. 1323-1328
    • Tani, M.1    Hannun, Y.A.2
  • 73
    • 34248221744 scopus 로고    scopus 로고
    • Neutral sphingomyelinase 2 is palmitoylated on multiple cysteine residues: Role of palmitoylation in subcellular localization
    • DOI 10.1074/jbc.M611249200
    • M Tani YA Hannun 2007 Neutral sphingomyelinase 2 is palmitoylated on multiple cysteine residues. Role of palmitoylation in subcellular localization The Journal of Biological Chemistry 282 10047 10056 1:CAS:528: DC%2BD2sXjtlCisLk%3D 10.1074/jbc.M611249200 17272284 (Pubitemid 47104605)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.13 , pp. 10047-10056
    • Tani, M.1    Hannun, Y.A.2
  • 74
    • 0036839602 scopus 로고    scopus 로고
    • Interaction with factor associated with neutral sphingomyelinase activation, a WD motif-containing protein, identifies receptor for activated C-kinase 1 as a novel component of the signaling pathways of the p55 TNF receptor
    • AE Tcherkasowa S Adam-Klages ML Kruse, et al. 2002 Interaction with factor associated with neutral sphingomyelinase activation, a WD motif-containing protein, identifies receptor for activated C-kinase 1 as a novel component of the signaling pathways of the p55 TNF receptor Journal of Immunology 169 5161 5170 (Pubitemid 35217186)
    • (2002) Journal of Immunology , vol.169 , Issue.9 , pp. 5161-5170
    • Tcherkasowa, A.E.1    Adam-Klages, S.2    Kruse, M.-L.3    Wiegmann, K.4    Mathieu, S.5    Kolanus, W.6    Kronke, M.7    Adam, D.8
  • 75
    • 34147205740 scopus 로고    scopus 로고
    • Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway
    • DOI 10.1128/MCB.01485-06
    • E Tellier A Negre-Salvayre B Bocquet, et al. 2007 Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/ sphingolipid mitogenic pathway Molecular and Cellular Biology 27 2997 3007 1:CAS:528:DC%2BD2sXkt1OgtLo%3D 10.1128/MCB.01485-06 17283058 (Pubitemid 46581313)
    • (2007) Molecular and Cellular Biology , vol.27 , Issue.8 , pp. 2997-3007
    • Tellier, E.1    Negre-Salvayre, A.2    Bocquet, B.3    Itohara, S.4    Hannun, Y.A.5    Salvayre, R.6    Auge, N.7
  • 76
    • 0034811417 scopus 로고    scopus 로고
    • Effect of overexpression of a neutral sphingomyelinase on CD95-induced ceramide production and apoptosis
    • DOI 10.1006/bbrc.2000.4166
    • AD Tepper P Ruurs J Borst WJ van Blitterswijk 2001 Effect of overexpression of a neutral sphingomyelinase on CD95-induced ceramide production and apoptosis Biochemical and Biophysical Research Communications 280 634 639 1:CAS:528:DC%2BD3MXls1aguw%3D%3D 10.1006/bbrc.2000.4166 11162568 (Pubitemid 32924477)
    • (2001) Biochemical and Biophysical Research Communications , vol.280 , Issue.3 , pp. 634-639
    • Tepper, A.D.1    Ruurs, P.2    Borst, J.3    Van Blitterswijk, W.J.4
  • 78
    • 0034102425 scopus 로고    scopus 로고
    • Characterization and subcellular localization of murine and human magnesium-dependent neutral sphingomyelinase
    • DOI 10.1074/jbc.275.8.5710
    • S Tomiuk M Zumbansen W Stoffel 2000 Characterization and subcellular localization of murine and human magnesium-dependent neutral sphingomyelinase The Journal of Biological Chemistry 275 5710 5717 1:CAS:528:DC%2BD3cXhsFKktL0%3D 10.1074/jbc.275.8.5710 10681556 (Pubitemid 30115212)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.8 , pp. 5710-5717
    • Tomiuk, S.1    Zumbansen, M.2    Stoffel, W.3
  • 79
    • 0033577806 scopus 로고    scopus 로고
    • A role for neutral sphingomyelinase-mediated ceramide production in T cell receptor-induced apoptosis and mitogen-activated protein kinase-mediated signal transduction
    • DOI 10.1084/jem.189.10.1581
    • L Tonnetti MC Veri E Bonvini L D'Adamio 1999 A role for neutral sphingomyelinase-mediated ceramide production in T cell receptor-induced apoptosis and mitogen-activated protein kinase-mediated signal transduction The Journal of Experimental Medicine 189 1581 1589 1:CAS:528:DyaK1MXjt1SktbY%3D 10.1084/jem.189.10.1581 10330437 (Pubitemid 29240883)
    • (1999) Journal of Experimental Medicine , vol.189 , Issue.10 , pp. 1581-1589
    • Tonnetti, L.1    Veri, M.-C.2    Bonvini, E.3    D'Adamio, L.4
  • 80
    • 22144463880 scopus 로고    scopus 로고
    • Metabolism and functions of phosphatidylserine
    • DOI 10.1016/j.plipres.2005.05.001, PII S0163782705000214
    • JE Vance R Steenbergen 2005 Metabolism and functions of phosphatidylserine Progress in Lipid Research 44 207 234 1:CAS:528: DC%2BD2MXmt1Srsbo%3D 10.1016/j.plipres.2005.05.001 15979148 (Pubitemid 40973811)
    • (2005) Progress in Lipid Research , vol.44 , Issue.4 , pp. 207-234
    • Vance, J.E.1    Steenbergen, R.2
  • 81
    • 65549128703 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha-induced neutral sphingomyelinase-2 modulates synaptic plasticity by controlling the membrane insertion of NMDA receptors
    • 1:CAS:528:DC%2BD1MXntVCju7g%3D 10.1111/j.1471-4159.2009.06038.x 19476542
    • D Wheeler E Knapp VV Bandaru, et al. 2009 Tumor necrosis factor-alpha-induced neutral sphingomyelinase-2 modulates synaptic plasticity by controlling the membrane insertion of NMDA receptors Journal of Neurochemistry 109 1237 1249 1:CAS:528:DC%2BD1MXntVCju7g%3D 10.1111/j.1471-4159.2009.06038.x 19476542
    • (2009) Journal of Neurochemistry , vol.109 , pp. 1237-1249
    • Wheeler, D.1    Knapp, E.2    Bandaru, V.V.3
  • 82
    • 0942287672 scopus 로고    scopus 로고
    • The role of neutral sphingomyelinase produced ceramide in lipopolysaccharide-mediated expression of inducible nitric oxide synthase
    • DOI 10.1046/j.1471-4159.2003.02165.x
    • JS Won YB Im M Khan AK Singh I Singh 2004 The role of neutral sphingomyelinase produced ceramide in lipopolysaccharide-mediated expression of inducible nitric oxide synthase Journal of Neurochemistry 88 583 593 1:CAS:528:DC%2BD2cXhtVaisbw%3D 10.1046/j.1471-4159.2003.02165.x 14720208 (Pubitemid 38140203)
    • (2004) Journal of Neurochemistry , vol.88 , Issue.3 , pp. 583-593
    • Won, J.-S.1    Im, Y.-B.2    Khan, M.3    Singh, A.K.4    Singh, I.5
  • 83
    • 57649210164 scopus 로고    scopus 로고
    • Identification of Mg2+-dependent neutral sphingomyelinase 1 as a mediator of heat stress-induced ceramide generation and apoptosis
    • 1:CAS:528:DC%2BD1cXht1ynt7bO 10.1074/jbc.M805402200 18678863
    • T Yabu S Imamura M Yamashita T Okazaki 2008 Identification of Mg2+-dependent neutral sphingomyelinase 1 as a mediator of heat stress-induced ceramide generation and apoptosis The Journal of Biological Chemistry 283 29971 29982 1:CAS:528:DC%2BD1cXht1ynt7bO 10.1074/jbc.M805402200 18678863
    • (2008) The Journal of Biological Chemistry , vol.283 , pp. 29971-29982
    • Yabu, T.1    Imamura, S.2    Yamashita, M.3    Okazaki, T.4
  • 84
    • 67749120148 scopus 로고    scopus 로고
    • A novel mitochondrial sphingomyelinase in zebrafish cells
    • 1:CAS:528:DC%2BD1MXos1ensbs%3D 10.1074/jbc.M109.004580 19429680
    • T Yabu A Shimuzu M Yamashita 2009 A novel mitochondrial sphingomyelinase in zebrafish cells The Journal of Biological Chemistry 284 20349 20363 1:CAS:528:DC%2BD1MXos1ensbs%3D 10.1074/jbc.M109.004580 19429680
    • (2009) The Journal of Biological Chemistry , vol.284 , pp. 20349-20363
    • Yabu, T.1    Shimuzu, A.2    Yamashita, M.3
  • 85
    • 0024059792 scopus 로고
    • Nucleotide sequence and expression in Escherichia coli of the gene coding for sphingomyelinase of Bacillus cereus
    • 1:CAS:528:DyaL1MXntVWhtA%3D%3D 10.1111/j.1432-1033.1988.tb14186.x 2841128
    • A Yamada N Tsukagoshi S Udaka, et al. 1988 Nucleotide sequence and expression in Escherichia coli of the gene coding for sphingomyelinase of Bacillus cereus European Journal of Biochemistry 175 213 220 1:CAS:528:DyaL1MXntVWhtA%3D%3D 10.1111/j.1432-1033.1988.tb14186.x 2841128
    • (1988) European Journal of Biochemistry , vol.175 , pp. 213-220
    • Yamada, A.1    Tsukagoshi, N.2    Udaka, S.3
  • 86
    • 4444370898 scopus 로고    scopus 로고
    • Neutral sphingomyelinase activation in endothelial and glial cell death induced by amyloid beta-peptide
    • DOI 10.1016/j.nbd.2004.06.001, PII S0969996104001305
    • DI Yang CH Yeh S Chen J Xu CY Hsu 2004 Neutral sphingomyelinase activation in endothelial and glial cell death induced by amyloid beta-peptide Neurobiology of Disease 17 99 107 1:CAS:528:DC%2BD2cXntlaqsr4%3D 10.1016/j.nbd.2004.06.001 15350970 (Pubitemid 39209317)
    • (2004) Neurobiology of Disease , vol.17 , Issue.1 , pp. 99-107
    • Yang, D.-I.1    Yeh, C.-H.2    Chen, S.3    Xu, J.4    Hsu, C.Y.5
  • 88
    • 0036097252 scopus 로고    scopus 로고
    • Neutral sphingomyelinase 1 deficiency in the mouse causes no lipid storage disease
    • DOI 10.1128/MCB.22.11.3633-3638.2002
    • M Zumbansen W Stoffel 2002 Neutral sphingomyelinase 1 deficiency in the mouse causes no lipid storage disease Molecular and Cellular Biology 22 3633 3638 1:CAS:528:DC%2BD38XjslWlsbs%3D 10.1128/MCB.22.11.3633-3638.2002 11997500 (Pubitemid 34525207)
    • (2002) Molecular and Cellular Biology , vol.22 , Issue.11 , pp. 3633-3638
    • Zumbansen, M.1    Stoffel, W.2


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