Indomethacin induces cellular morphological change and migration via epithelial-mesenchymal transition in A549 human lung cancer cells: A novel cyclooxygenase-inhibition-independent effect

Biochemical Pharmacology

Volumn 82, Issue 11, 2011, Pages 1781-1791

  Kato, Tomoko ^a   Fujino, Hiromichi ^a   Oyama, Satomi ^a   Kawashima, Tatsuo ^b   Murayama, Toshihiko ^a  

^a CHIBA UNIVERSITY   (Japan)

^b TOHO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

E cadherin; EMT; Indomethacin; MMP 9; NSCLC

Indexed keywords

ACETYLSALICYLIC ACID; ACTIN; COLLAGEN TYPE 4; CYCLOOXYGENASE 2; DICLOFENAC; GELATINASE B; INDOMETACIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROSTAGLANDIN E2; SULINDAC; TROGLITAZONE; UVOMORULIN;

ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL GROWTH; CELL MIGRATION; CELL MOTILITY; CELL SHAPE; CELL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; REGULATORY MECHANISM; STRESS FIBER;

ANTICARCINOGENIC AGENTS; ASPIRIN; CADHERINS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CHROMANS; COLLAGEN TYPE IV; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; DICLOFENAC; DINOPROSTONE; EPITHELIAL-MESENCHYMAL TRANSITION; HUMANS; INDOMETHACIN; LUNG NEOPLASMS; MATRIX METALLOPROTEINASE 9; PPAR GAMMA; THIAZOLIDINEDIONES;

EID: 80255125999     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.07.096     Document Type: Article

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