Redox regulation of the epigenetic landscape in Cancer: A role for metabolic reprogramming in remodeling the epigenome

Free Radical Biology and Medicine

Volumn 53, Issue 11, 2012, Pages 2178-2187

  Hitchler, Michael J ^a   Domann, Frederick E ^b  

^a KAISER PERMANENTE MEDICAL CENTER   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

Anaplerotic metabolite; Demethylation; Epigenetic progenitor; Free radicals; Glycolysis; Warburg effect

Indexed keywords

2 OXOGLUTARIC ACID; ACETYL COENZYME A; CARBON; HISTONE; NICOTINAMIDE ADENINE DINUCLEOTIDE; S ADENOSYLMETHIONINE;

DEMETHYLATION; EPIGENETICS; HISTONE ACETYLATION; HUMAN; METHYLATION; NEOPLASM; NUCLEAR REPROGRAMMING; OXIDATION; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROSTATE CANCER; REVIEW;

ACETYLATION; ANIMALS; CARBOHYDRATE METABOLISM; EPIGENESIS, GENETIC; EPIGENOMICS; GENOME, HUMAN; HISTONES; HUMANS; METHYLATION; NEOPLASMS; OXIDATION-REDUCTION; PROTEIN PROCESSING, POST-TRANSLATIONAL;

EID: 84868706939     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.09.028     Document Type: Review

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