Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease

Journal of Clinical Oncology

Volumn 28, Issue 18, 2010, Pages 3061-3068

  Paugh, Barbara S ^a   Qu, Chunxu ^a   Jones, Chris ^a   Liu, Zhaoli ^a   Adamowicz Brice, Martyna ^a   Zhang, Junyuan ^a   Bax, Dorine A ^a   Coyle, Beth ^a   Barrow, Jennifer ^a   Hargrave, Darren ^a   Lowe, James ^a   Gajjar, Amar ^a   Zhao, Wei ^a   Broniscer, Alberto ^a   Ellison, David W ^a   Grundy, Richard G ^a   Baker, Suzanne J ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; TUMOR MARKER;

ARTICLE; CANCER GENETICS; CHILDHOOD CANCER; CHROMOSOME 1Q; CHROMOSOME 7; GENE; GENE AMPLIFICATION; GENE EXPRESSION; GENE FREQUENCY; GENE MUTATION; GENETIC ANALYSIS; GLIOBLASTOMA; GLIOMA; HIGH GRADE GLIOMA; HUMAN; HUMAN TISSUE; IDH1 GENE; MAJOR CLINICAL STUDY; MICROARRAY ANALYSIS; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; ADOLESCENT; ADULT; BRAIN TUMOR; CHILD; CHROMOSOME 1; COMPARATIVE STUDY; DNA MICROARRAY; GENE EXPRESSION PROFILING; GENETICS; INFANT; PATHOLOGY; PRESCHOOL CHILD; PROGNOSIS; SKULL IRRADIATION;

ADOLESCENT; ADULT; BRAIN NEOPLASMS; CHILD; CHILD, PRESCHOOL; CHROMOSOMES, HUMAN, PAIR 1; CRANIAL IRRADIATION; GENE EXPRESSION PROFILING; GLIOMA; HUMANS; INFANT; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROGNOSIS; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 77954596239     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2009.26.7252     Document Type: Article

References (55)

1. Broniscer A, Gajjar A: Supratentorial highgrade astrocytoma and diffuse brainstem glioma: Two challenges for the pediatric oncologist. Oncologist 9:197-206, 2004 (Pubitemid 38452119)
2. Broniscer A, Baker SJ, West AN, et al: Clinical and molecular characteristics of malignant transformation of low-grade glioma in children. J Clin Oncol 25:682-689, 2007 (Pubitemid 350002924)
3. Furnari FB, Fenton T, Bachoo RM, et al: Malignant astrocytic glioma: Genetics, biology, and paths to treatment. Genes Dev 21:2683-2710, 2007 (Pubitemid 350070717)
4. Bredel M, Bredel C, Juric D, et al: High-resolution genome-wide mapping of genetic alterations in human glial brain tumors. Cancer Res 65:4088-4096, 2005 (Pubitemid 40775645)
5. Kotliarov Y, Steed ME, Christopher N, et al: High-resolution global genomic survey of 178 gliomas reveals novel regions of copy number alteration and allelic imbalances. Cancer Res 66:9428-9436, 2006 (Pubitemid 44623639)
6. Maher EA, Brennan C, Wen PY, et al: Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct molecular and clinical secondary glioblastoma entities. Cancer Res 66:11502-11513, 2006 (Pubitemid 46009984)
7. Nigro JM, Misra A, Zhang L, et al: Integrated array-comparative genomic hybridization and expression array profiles identify clinically relevant molecular subtypes of glioblastoma. Cancer Res 65:1678-1686, 2005 (Pubitemid 40478592)
8. Liang Y, Diehn M, Watson N, et al: Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme. Proc Natl Acad Sci U S A 102:5814-5819, 2005 (Pubitemid 40559642)
9. Phillips HS, Kharbanda S, Chen R, et al: Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell 9:157-173, 2006 (Pubitemid 43357943)
10. Rich JN, Hans C, Jones B, et al: Gene expression profiling and genetic markers in glioblastoma survival. Cancer Res 65:4051-4058, 2005 (Pubitemid 40775641)
11. Ruano Y, Mollejo M, Ribalta T, et al: Identification of novel candidate target genes in amplicons of glioblastoma multiforme tumors detected by expression and CGH microarray profiling. Mol Cancer 5:39, 2006
12. Parsons DW, Jones S, Zhang X, et al: An integrated genomic analysis of human glioblastoma multiforme. Science 321:1807-1812, 2008
13. Cancer Genome Atlas Research Network: Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455:1061-1068, 2008
14. Pollack IF, Finkelstein SD, Burnham J, et al: Age and TP53 mutation frequency in childhood malignant gliomas: Results in a multi-institutional cohort. Cancer Res 61:7404-7407, 2001 (Pubitemid 32995024)
15. Newcomb EW, Alonso M, Sung T, et al: Incidence of p14ARF gene deletion in high-grade adult and pediatric astrocytomas. Hum Pathol 31:115-119, 2000 (Pubitemid 30054396)
16. Gallia GL, Rand V, Siu IM, et al: PIK3CA gene mutations in pediatric and adult glioblastoma multiforme. Mol Cancer Res 4:709-714, 2006 (Pubitemid 44683311)
17. Pollack IF, Hamilton RL, James CD, et al: Rarity of PTEN deletions and EGFR amplification in malignant gliomas of childhood: Results from the Children's Cancer Group 945 cohort. J Neurosurg 105:418-424, 2006 (Pubitemid 44954773)
18. Faury D, Nantel A, Dunn SE, et al: Molecular profiling identifies prognostic subgroups of pediatric glioblastoma and shows increased YB-1 expression in tumors. J Clin Oncol 25:1196-1208, 2007 (Pubitemid 46640565)
19. Rickert CH, Strater R, Kaatsch P, et al: Pediatric high-grade astrocytomas show chromosomal imbalances distinct from adult cases. Am J Pathol 158:1525-1532, 2001 (Pubitemid 32281316)
20. Wong KK, Tsang YT, Chang YM, et al: Genome-wide allelic imbalance analysis of pediatric gliomas by single nucleotide polymorphic allele array. Cancer Res 66:11172-11178, 2006 (Pubitemid 46009944)
21. Torchia EC, Boyd K, Rehg JE, et al: EWS/FLI-1 induces rapid onset of myeloid/erythroid leukemia in mice. Mol Cell Biol 27:7918-7934, 2007 (Pubitemid 350086425)
22. Beroukhim R, Getz G, Nghiemphu L, et al: Assessing the significance of chromosomal aberrations in cancer: Methodology and application to glioma. Proc Natl Acad Sci U S A 104:20007-20012, 2007
23. Veeriah S, Brennan C, Meng S, et al: The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers. Proc Natl Acad Sci U S A 106:9435-9440, 2009
24. Solomon DA, Kim JS, Cronin JC, et al: Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanoma. Cancer Res 68:10300-10306, 2008
25. Ichimura K, Pearson DM, Kocialkowski S, et al: IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas. Neuro Oncol 11:341-347, 2009
26. Balss J, Meyer J, Mueller W, et al: Analysis of the IDH1 codon 132 mutation in brain tumors. Acta Neuropathol 116:597-602, 2008
27. Watanabe T, Nobusawa S, Kleihues P, et al: IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas. Am J Pathol 174:1149-1153, 2009
28. Yan H, Parsons DW, Jin G, et al: IDH1 and IDH2 mutations in gliomas. N Engl J Med 360:765-773, 2009
29. Solomon DA, Kim JS, Ressom HW, et al: Sample type bias in the analysis of cancer genomes. Cancer Res 69:5630-5633, 2009
30. Sanders RP, Kocak M, Burger PC, et al: High-grade astrocytoma in very young children. Pediatr Blood Cancer 49:888-893, 2007 (Pubitemid 350022440)
31. Lee Y, Scheck AC, Cloughesy TF, et al: Gene expression analysis of glioblastomas identifies the major molecular basis for the prognostic benefit of younger age. BMC Med Genomics 1:52, 2008
32. Dyer S, Prebble E, Davison V, et al: Genomic imbalances in pediatric intracranial ependymomas define clinically relevant groups. Am J Pathol 161:2133-2141, 2002 (Pubitemid 35434859)
33. Carter M, Nicholson J, Ross F, et al: Genetic abnormalities detected in ependymomas by comparative genomic hybridisation. Br J Cancer 86:929-939, 2002 (Pubitemid 34271030)
34. Li M, Lee KF, Lu Y, et al: Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors. Cancer Cell 16:533-546, 2009
35. Ferreira BI, Alonso J, Carrillo J, et al: Array CGH and gene-expression profiling reveals distinct genomic instability patterns associated with DNA repair and cell-cycle checkpoint pathways in Ewing's sarcoma. Oncogene 27:2084-2090, 2008 (Pubitemid 351442743)
36. Natrajan R, Williams RD, Hing SN, et al: Array CGH profiling of favourable histology Wilms tumours reveals novel gains and losses associated with relapse. J Pathol 210:49-58, 2006 (Pubitemid 44288180)
37. Bardelli A, Cahill DP, Lederer G, et al: Carcinogen-specific induction of genetic instability. Proc Natl Acad Sci U S A 98:5770-5775, 2001 (Pubitemid 32435717)
38. Radtke I, Mullighan CG, Ishii M, et al: Genomic analysis reveals few genetic alterations in pediatric acute myeloid leukemia. Proc Natl Acad Sci U S A 106:12944-12949, 2009
39. Mendrzyk F, Korshunov A, Benner A, et al: Identification of gains on 1q and epidermal growth factor receptor overexpression as independent prognostic markers in intracranial ependymoma. Clin Cancer Res 12:2070-2079, 2006
40. Roberts P, Burchill SA, Brownhill S, et al: Ploidy and karyotype complexity are powerful prognostic indicators in the Ewing's sarcoma family of tumors: A study by the United Kingdom Cancer Cytogenetics and the Children's Cancer and Leukaemia Group. Genes Chromosomes Cancer 47:207-220, 2008 (Pubitemid 351162852)
41. Hattinger CM, Potschger U, Tarkkanen M, et al: Prognostic impact of chromosomal aberrations in Ewing tumours. Br J Cancer 86:1763-1769, 2002 (Pubitemid 34712921)
42. Hing S, Lu YJ, Summersgill B, et al: Gain of 1q is associated with adverse outcome in favorable histology Wilms' tumors. Am J Pathol 158:393-398, 2001 (Pubitemid 32158602)
43. Clifford SC, O'Toole K, Ellison DW: Chromosome 1q gain is not associated with a poor outcome in childhood medulloblastoma: Requirements for the validation of potential prognostic biomarkers. Cell Cycle 8:787, 2009
44. Thorarinsdottir HK, Santi M, McCarter R, et al: Protein expression of platelet-derived growth factor receptor correlates with malignant histology and PTEN with survival in childhood gliomas. Clin Cancer Res 14:3386-3394, 2008
45. Bredel M, Pollack IF, Hamilton RL, et al: Epidermal growth factor receptor expression and gene amplification in high-grade non-brainstem gliomas of childhood. Clin Cancer Res 5:1786-1792, 1999 (Pubitemid 29334460)
46. Khatua S, Peterson KM, Brown KM, et al: Overexpression of the EGFR/FKBP12/HIF-2alpha pathway identified in childhood astrocytomas by angiogenesis gene profiling. Cancer Res 63:1865-1870, 2003
47. Jackson EL, Garcia-Verdugo JM, Gil-Perotin S, et al: PDGFR alpha-positive B cells are neural stem cells in the adult SVZ that form glioma-like growths in response to increased PDGF signaling. Neuron 51:187-199, 2006 (Pubitemid 44063617)
48. Burrows RC, Wancio D, Levitt P, et al: Response diversity and the timing of progenitor cell maturation are regulated by developmental changes in EGFR expression in the cortex. Neuron 19:251-267, 1997 (Pubitemid 27374226)
49. Sun Y, Goderie SK, Temple S: Asymmetric distribution of EGFR receptor during mitosis generates diverse CNS progenitor cells. Neuron 45:873-886, 2005 (Pubitemid 40395266)
50. Tchougounova E, Kastemar M, Brasater D, et al: Loss of Arf causes tumor progression of PDGFB-induced oligodendroglioma. Oncogene 26:6289-6296, 2007 (Pubitemid 47462106)
51. Dai C, Celestino JC, Okada Y, et al: PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo. Genes Dev 15:1913-1925, 2001
52. Lindberg N, Kastemar M, Olofsson T, et al: Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma. Oncogene 28:2266-2275, 2009
53. Ding H, Shannon P, Lau N, et al: Oligodendrogliomas result from the expression of an activated mutant epidermal growth factor receptor in a RAS transgenic mouse astrocytoma model. Cancer Res 63:1106-1113, 2003 (Pubitemid 36278445)
54. Holland EC, Hively WP, DePinho RA, et al: A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice. Genes Dev 12:3675-3685, 1998 (Pubitemid 29019648)
55. Walter AW, Hancock ML, Pui CH, et al: Secondary brain tumors in children treated for acute lymphoblastic leukemia at St Jude Children's Research Hospital. J Clin Oncol 16:3761-3767, 1998 (Pubitemid 29001527)