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Volumn 61, Issue 12, 2012, Pages 1754-1764

Innate and adaptive immune responses in chronic hepatitis B virus infections: Towards restoration of immune control of viral infection

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; GAMMA INTERFERON; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B VIRUS POLYMERASE; HEPATITIS B VIRUS X PROTEIN; HEPATITIS B(E) ANTIGEN; INTERFERON; INTERFERON REGULATORY FACTOR; MITOCHONDRIAL ANTIVIRAL SIGNALLING PROTEIN; PATTERN RECOGNITION RECEPTOR; PROTEIN DDX3; RETINOIC ACID INDUCIBLE PROTEIN I; STAT PROTEIN; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VIRUS DNA; VIRUS ENZYME;

EID: 84868702241     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2011-301073     Document Type: Review
Times cited : (395)

References (120)
  • 1
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • DOI 10.1016/j.cell.2006.02.015, PII S0092867406001905
    • Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell 2006;124:783-801. (Pubitemid 43261452)
    • (2006) Cell , vol.124 , Issue.4 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 2
    • 77957353047 scopus 로고    scopus 로고
    • The host-pathogen interaction during HBV infection: Immunological controversies
    • Bertoletti A, Maini MK, Ferrari C. The host-pathogen interaction during HBV infection: immunological controversies. Antiviral Ther 2010;15:15-24.
    • (2010) Antiviral Ther , vol.15 , pp. 15-24
    • Bertoletti, A.1    Maini, M.K.2    Ferrari, C.3
  • 3
    • 22544481160 scopus 로고    scopus 로고
    • Stealth and cunning: Hepatitis B and hepatitis C viruses
    • DOI 10.1128/JVI.79.15.9369-9380.2005
    • Wieland S, Chisari FV. Stealth and cunning: hepatitis B and hepatitis C viruses. J Virol 2005;79:9369-80. (Pubitemid 41022281)
    • (2005) Journal of Virology , vol.79 , Issue.15 , pp. 9369-9380
    • Wieland, S.F.1    Chisari, F.V.2
  • 4
    • 0038461904 scopus 로고    scopus 로고
    • Kinetics of the immune response during HBV and HCV infection
    • DOI 10.1053/jhep.2003.50310
    • Bertoletti A, Ferrari C. Kinetics of the immune response during HBV and HCV infection. Hepatology 2003;38:4-13. (Pubitemid 36775788)
    • (2003) Hepatology , vol.38 , Issue.1 , pp. 4-13
    • Bertoletti, A.1    Ferrari, C.2
  • 6
    • 59849105037 scopus 로고    scopus 로고
    • Persistence of the hepatitis B virus covalently closed circular DNA in HepaRG human hepatocyte-like cells
    • Hantz O, Parent R, Durantel D, et al. Persistence of the hepatitis B virus covalently closed circular DNA in HepaRG human hepatocyte-like cells. J Gen Virol 2009;90 :127-35.
    • (2009) J Gen Virol , vol.90 , pp. 127-135
    • Hantz, O.1    Parent, R.2    Durantel, D.3
  • 7
    • 0028809476 scopus 로고
    • The woodchuck: An animal model for hepatitis B virus infection in man
    • Roggendorf M, Tolle TK. The woodchuck: an animal model for hepatitis B virus infection in man. Intervirology 1995;38:100-12.
    • (1995) Intervirology , vol.38 , pp. 100-112
    • Roggendorf, M.1    Tolle, T.K.2
  • 8
    • 50149117189 scopus 로고    scopus 로고
    • Intrahepatic expression of genes affiliated with innate and adaptive immune responses immediately after invasion and during acute infection with woodchuck hepadnavirus
    • Guy CS, Mulrooney-Cousins PM, Churchill ND, et al. Intrahepatic expression of genes affiliated with innate and adaptive immune responses immediately after invasion and during acute infection with woodchuck hepadnavirus. J Virol 2008;82:8579-91.
    • (2008) J Virol , vol.82 , pp. 8579-8591
    • Guy, C.S.1    Mulrooney-Cousins, P.M.2    Churchill, N.D.3
  • 10
    • 64049116643 scopus 로고    scopus 로고
    • Induction of a striking systemic cytokine cascade prior to peak in acute human immunodeficiency virus type 1 infection, in contrast to more modest and delayed responses in acute hepatitis B and C virus infections
    • Stacey AR, Norris PJ, Qin L, et al. Induction of a striking systemic cytokine cascade prior to peak in acute human immunodeficiency virus type 1 infection, in contrast to more modest and delayed responses in acute hepatitis B and C virus infections. J Virol 2009;83:3719-33.
    • (2009) J Virol , vol.83 , pp. 3719-3733
    • Stacey, A.R.1    Norris, P.J.2    Qin, L.3
  • 11
    • 70349435373 scopus 로고    scopus 로고
    • Temporal analysis of early immune responses in patients with acute hepatitis B virus infection
    • Dunn C, Peppa D, Khanna P, et al. Temporal analysis of early immune responses in patients with acute hepatitis B virus infection. Gastroenterology 2009;137 :1289-300.
    • (2009) Gastroenterology , vol.137 , pp. 1289-1300
    • Dunn, C.1    Peppa, D.2    Khanna, P.3
  • 14
    • 73149120044 scopus 로고    scopus 로고
    • Innate response to hepatitis B virus infection: Observations challenging the concept of a stealth virus
    • Durantel D, Zoulim F. Innate response to hepatitis B virus infection: observations challenging the concept of a stealth virus. Hepatology 2009;50:1692-5.
    • (2009) Hepatology , vol.50 , pp. 1692-1695
    • Durantel, D.1    Zoulim, F.2
  • 15
    • 73449093499 scopus 로고    scopus 로고
    • Control of hepatitis B virus replication by innate response of HepaRG cells
    • Lucifora J, Durantel D, Testoni B, et al. Control of hepatitis B virus replication by innate response of HepaRG cells. Hepatology 2010;51:63-72.
    • (2010) Hepatology , vol.51 , pp. 63-72
    • Lucifora, J.1    Durantel, D.2    Testoni, B.3
  • 16
    • 73149094329 scopus 로고    scopus 로고
    • Not Interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection
    • Hösel M, Quasdorff M, Wiegmann K, et al. Not Interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection. Hepatology 2009;50:1773-82.
    • (2009) Hepatology , vol.50 , pp. 1773-1782
    • Hösel, M.1    Quasdorff, M.2    Wiegmann, K.3
  • 17
    • 79956155368 scopus 로고    scopus 로고
    • Innate DNA sensing moves to the nucleus
    • Unterholzner L, Bowie AG. Innate DNA sensing moves to the nucleus. Cell Host Microbe 2011;9:351-3.
    • (2011) Cell Host Microbe , vol.9 , pp. 351-353
    • Unterholzner, L.1    Bowie, A.G.2
  • 18
    • 70349298402 scopus 로고    scopus 로고
    • The size of the viral inoculum contributes to the outcome of hepatitis B virus infection
    • Asabe S, Wieland SF, Chattopadhyay PK, et al. The size of the viral inoculum contributes to the outcome of hepatitis B virus infection. J Virol 2009;83:9652-62.
    • (2009) J Virol , vol.83 , pp. 9652-9662
    • Asabe, S.1    Wieland, S.F.2    Chattopadhyay, P.K.3
  • 19
    • 0032738688 scopus 로고    scopus 로고
    • Persistence of infectious hepadnavirus in the offspring of woodchuck mothers recovered from viral hepatitis
    • Coffin CS, Michalak TI. Persistence of infectious hepadnavirus in the offspring of woodchuck mothers recovered from viral hepatitis. J Clin Invest 1999;104:203-12.
    • (1999) J Clin Invest , vol.104 , pp. 203-212
    • Coffin, C.S.1    Michalak, T.I.2
  • 20
    • 79958127932 scopus 로고    scopus 로고
    • Hepatitis B virus limits response of human hepatocytes to interferon - A in chimeric Mice
    • Lütgehetmann M, Bornscheuer T, Volz T, et al. Hepatitis B virus limits response of human hepatocytes to interferon - a in chimeric Mice. Gastroenterology 2011;140:2074-83.
    • (2011) Gastroenterology , vol.140 , pp. 2074-2083
    • Lütgehetmann, M.1    Bornscheuer, T.2    Volz, T.3
  • 22
    • 79956061094 scopus 로고    scopus 로고
    • IF I16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection
    • Kerur N, Veettil M, Sharma-Walia N, et al. IF I16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection. Cell Host Microbe 2011;9:363-75.
    • (2011) Cell Host Microbe , vol.9 , pp. 363-375
    • Kerur, N.1    Veettil, M.2    Sharma-Walia, N.3
  • 23
    • 77955381494 scopus 로고    scopus 로고
    • Hepatitis B virus polymerase blocks pattern recognition receptor signalling via interaction with DDX3: Implications for immune evasion
    • Published Online First: 15 July 2010. doi:e1000986
    • Wang H, Ryu WS. Hepatitis B virus polymerase blocks pattern recognition receptor signalling via interaction with DDX3: implications for immune evasion. PloS Pathog. Published Online First: 15 July 2010. doi:e1000986.
    • PloS Pathog
    • Wang, H.1    Ryu, W.S.2
  • 24
    • 77955290279 scopus 로고    scopus 로고
    • Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKepsilon and DDX3
    • Yu S, Chen J, Wu M, et al. Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKepsilon and DDX3. J Gen Virol 2010;91:2080-90.
    • (2010) J Gen Virol , vol.91 , pp. 2080-2090
    • Yu, S.1    Chen, J.2    Wu, M.3
  • 25
    • 77955496554 scopus 로고    scopus 로고
    • The hepatitis B virus X protein disrupts innate immunity by downregulating mitochondrial antiviral signalling protein
    • Wei C, Ni C, Song T, et al. The hepatitis B virus X protein disrupts innate immunity by downregulating mitochondrial antiviral signalling protein. J Immunol 2010;185:1158-68.
    • (2010) J Immunol , vol.185 , pp. 1158-1168
    • Wei, C.1    Ni, C.2    Song, T.3
  • 26
    • 78650645590 scopus 로고    scopus 로고
    • Hepatitis B virus regulatory HBx protein binds to adaptor protein IPS-1 and inhibits the activation of beta interferon
    • Kumar M, Jung SY, Hodgson AJ, et al. Hepatitis B virus regulatory HBx protein binds to adaptor protein IPS-1 and inhibits the activation of beta interferon. J Virol 2011;85:987-95.
    • (2011) J Virol , vol.85 , pp. 987-995
    • Kumar, M.1    Jung, S.Y.2    Hodgson, A.J.3
  • 27
    • 77957679632 scopus 로고    scopus 로고
    • Hepatitis B virus X protein suppresses virus-triggered IRF3 activation and IFN-beta induction by disrupting the VISA-associated complex
    • Wang X, Li Y, Mao A, et al. Hepatitis B virus X protein suppresses virus-triggered IRF3 activation and IFN-beta induction by disrupting the VISA-associated complex. Cell Mol Immunol 2010;7:341-8.
    • (2010) Cell Mol Immunol , vol.7 , pp. 341-348
    • Wang, X.1    Li, Y.2    Mao, A.3
  • 29
    • 36749058339 scopus 로고    scopus 로고
    • Hepatitis B virus polymerase inhibits the interferon-inducible MyD88 promoter by blocking nuclear translocation of Stat1
    • DOI 10.1099/vir.0.82959-0
    • Wu M, Xu Y, Lin S, et al. Hepatitis B virus polymerase inhibits the interferon-inducible MyD88 promoter by blocking nuclear translocation of Stat1. J Gen Virol 2007;88:3260-9. (Pubitemid 350201835)
    • (2007) Journal of General Virology , vol.88 , Issue.12 , pp. 3260-3269
    • Wu, M.1    Xu, Y.2    Lin, S.3    Zhang, X.4    Xiang, L.5    Yuan, Z.6
  • 32
    • 67651148539 scopus 로고    scopus 로고
    • Hepatitis B and C virus coinfection: A novel model system reveals the absence of direct viral interference
    • Bellecave P, Gouttenoire J, Gajer M, et al. Hepatitis B and C virus coinfection: a novel model system reveals the absence of direct viral interference. Hepatology 2009;50:46-55.
    • (2009) Hepatology , vol.50 , pp. 46-55
    • Bellecave, P.1    Gouttenoire, J.2    Gajer, M.3
  • 33
    • 84984585800 scopus 로고    scopus 로고
    • Peginterferon alfa-2a plus ribavirin for the treatment of dual chronic infection with hepatitis B and C viruses
    • Liu CJ, Chuang WL, Lee CM, et al. Peginterferon alfa-2a plus ribavirin for the treatment of dual chronic infection with hepatitis B and C viruses. Gastroenterology 2009;136:496-504.
    • (2009) Gastroenterology , vol.136 , pp. 496-504
    • Liu, C.J.1    Chuang, W.L.2    Lee, C.M.3
  • 34
    • 65449117568 scopus 로고    scopus 로고
    • Hepatitis B virus suppresses toll-like receptor-mediated innate immune responses in murine parenchymal and nonparenchymal liver cells
    • Wu J, Meng Z, Jiang M, et al. Hepatitis B virus suppresses toll-like receptor-mediated innate immune responses in murine parenchymal and nonparenchymal liver cells. Hepatology 2009;49:1132-40.
    • (2009) Hepatology , vol.49 , pp. 1132-1140
    • Wu, J.1    Meng, Z.2    Jiang, M.3
  • 36
    • 59749098686 scopus 로고    scopus 로고
    • A mechanism to explain the selection of the hepatitis e antigen-negative mutant during chronic hepatitis B virus infection
    • Frelin L, Wahlström T, Tucker AE, et al. A mechanism to explain the selection of the hepatitis e antigen-negative mutant during chronic hepatitis B virus infection. J Virol 2009;83:1379-92.
    • (2009) J Virol , vol.83 , pp. 1379-1392
    • Frelin, L.1    Wahlström, T.2    Tucker, A.E.3
  • 37
    • 0035424543 scopus 로고    scopus 로고
    • NK cells and NKT cells in innate defense against viral infections
    • DOI 10.1016/S0952-7915(00)00241-7
    • Biron CA, Brossay L. NK cells and NKT cells in innate defense against viral infections. Curr Opin Immunol 2001;13:458-64. (Pubitemid 32728479)
    • (2001) Current Opinion in Immunology , vol.13 , Issue.4 , pp. 458-464
    • Biron, C.A.1    Brossay, L.2
  • 39
    • 0033617583 scopus 로고    scopus 로고
    • Viral clearance without destruction of infected cells during acute HBV infection
    • DOI 10.1126/science.284.5415.825
    • Guidotti LG, Rochford R, Chung J, et al. Viral clearance without destruction of infected cells during acute HBV infection. Science 1999;284:825-9. (Pubitemid 29291352)
    • (1999) Science , vol.284 , Issue.5415 , pp. 825-829
    • Guidotti, L.G.1    Rochford, R.2    Chung, J.3    Shapiro, M.4    Purcell, R.5    Chisari, F.V.6
  • 41
    • 0033754682 scopus 로고    scopus 로고
    • Incubation phase of acute hepatitis B in man: Dynamic of cellular immune mechanisms
    • Webster G, Reignat S, Maini M, et al. Incubation phase of acute hepatitis B in man: dynamic of cellular immune mechanisms. Hepatology 2000;32:1117-24.
    • (2000) Hepatology , vol.32 , pp. 1117-1124
    • Webster, G.1    Reignat, S.2    Maini, M.3
  • 42
    • 67349186530 scopus 로고    scopus 로고
    • Early kinetics of innate and adaptive immune responses during hepatitis B virus infection
    • Fisicaro P, Valdatta C, Boni C, et al. Early kinetics of innate and adaptive immune responses during hepatitis B virus infection. Gut 2009;58:974-82.
    • (2009) Gut , vol.58 , pp. 974-982
    • Fisicaro, P.1    Valdatta, C.2    Boni, C.3
  • 44
    • 69249113887 scopus 로고    scopus 로고
    • Natural killer cell functional dichotomy in chronic hepatitis B and chronic hepatitis C virus infections
    • Oliviero B, Varchetta S, Paudice E, et al. Natural killer cell functional dichotomy in chronic hepatitis B and chronic hepatitis C virus infections. Gastroenterology 2009;137:1151-60.
    • (2009) Gastroenterology , vol.137 , pp. 1151-1160
    • Oliviero, B.1    Varchetta, S.2    Paudice, E.3
  • 45
    • 78651225310 scopus 로고    scopus 로고
    • Blockade of immunosuppressive cytokines restores NK cell antiviral function in chronic hepatitis B virus infection
    • Peppa D, Micco L, Javaid A, et al. Blockade of immunosuppressive cytokines restores NK cell antiviral function in chronic hepatitis B virus infection. Plos Pathog 2010;6:e1001227.
    • (2010) Plos Pathog , vol.6
    • Peppa, D.1    Micco, L.2    Javaid, A.3
  • 46
    • 78751482977 scopus 로고    scopus 로고
    • Hypercytolytic activity of hepatic natural killer cells correlates with liver injury in chronic hepatitis B patients
    • Zhang Z, Zhang S, Zou Z, et al. Hypercytolytic activity of hepatic natural killer cells correlates with liver injury in chronic hepatitis B patients. Hepatology 2011;53:73-85.
    • (2011) Hepatology , vol.53 , pp. 73-85
    • Zhang, Z.1    Zhang, S.2    Zou, Z.3
  • 47
    • 77951861128 scopus 로고    scopus 로고
    • Interferon-alpha-induced TRAIL on natural killer cells is associated with control of hepatitis C virus infection
    • Stegmann KA, Björkström NK, Veber H, et al. Interferon-alpha-induced TRAIL on natural killer cells is associated with control of hepatitis C virus infection. Gastroenterology 2010;138:1885-97.
    • (2010) Gastroenterology , vol.138 , pp. 1885-1897
    • Stegmann, K.A.1    Björkström, N.K.2    Veber, H.3
  • 49
    • 77249098281 scopus 로고    scopus 로고
    • A longitudinal analysis of innate and adaptive immune profile during hepatic flares in chronic hepatitis B
    • Tan AT, Koh S, Goh W, et al. A longitudinal analysis of innate and adaptive immune profile during hepatic flares in chronic hepatitis B. J Hepatol 2010; 52:330-9.
    • (2010) J Hepatol , vol.52 , pp. 330-339
    • Tan, A.T.1    Koh, S.2    Goh, W.3
  • 50
    • 18744399291 scopus 로고    scopus 로고
    • Toll-like receptor signaling inhibits hepatitis B virus replication in vivo
    • DOI 10.1128/JVI.79.11.7269-7272.2005
    • Isogawa M, Robek MD, Furuichi Y, et al. Toll-like receptor signaling inhibits hepatitis B virus replication in vivo. J Virol 2005;79:7269-72. (Pubitemid 40677357)
    • (2005) Journal of Virology , vol.79 , Issue.11 , pp. 7269-7272
    • Isogawa, M.1    Robek, M.D.2    Furuichi, Y.3    Chisari, F.V.4
  • 51
    • 58149517671 scopus 로고    scopus 로고
    • Activation of pattern recognition receptor-mediated innate immunity inhibits the replication of hepatitis B virus in human hepatocyte-derived cells
    • Guo H, Jiang D, Ma D, et al. Activation of pattern recognition receptor-mediated innate immunity inhibits the replication of hepatitis B virus in human hepatocyte-derived cells. J Virol 2009;83:847-58.
    • (2009) J Virol , vol.83 , pp. 847-858
    • Guo, H.1    Jiang, D.2    Ma, D.3
  • 52
    • 81355129949 scopus 로고    scopus 로고
    • Anti-viral efficacy and induction of an antibody response against surface antigen with the TLR7 agonist GS-9620 in the woodchuck model of chronic HBV infection
    • Abstract 1114
    • Menne S, Tennant BC, Liu KH, et al. Anti-viral efficacy and induction of an antibody response against surface antigen with the TLR7 agonist GS-9620 in the woodchuck model of chronic HBV infection. J Hepatol 2011;54(Suppl 1):S441. Abstract 1114.
    • (2011) J Hepatol , vol.54 , Issue.SUPPL. 1
    • Menne, S.1    Tennant, B.C.2    Liu, K.H.3
  • 53
    • 84862896269 scopus 로고    scopus 로고
    • Therapeutic efficacy of the TLR7 agonist GS-9620 for HBV chronic infection in chimpanzees
    • Lanford RE, Guerra B, Chavez DC, et al. Therapeutic efficacy of the TLR7 agonist GS-9620 for HBV chronic infection in chimpanzees. J Hepatol 2011;54:S45.
    • (2011) J Hepatol , vol.54
    • Lanford, R.E.1    Guerra, B.2    Chavez, D.C.3
  • 55
    • 79551697736 scopus 로고    scopus 로고
    • Targeting hepatitis B virus-infected cells with a T-cell receptor like antibody
    • Sastry KS, Too CT, Kaur K, et al. Targeting hepatitis B virus-infected cells with a T-cell receptor like antibody. J Virol 2011;85:1935-42.
    • (2011) J Virol , vol.85 , pp. 1935-1942
    • Sastry, K.S.1    Too, C.T.2    Kaur, K.3
  • 56
    • 0035794317 scopus 로고    scopus 로고
    • Kinetics of acute hepatitis B virus infection in humans
    • Whalley SA, Murray JM, Brown D, et al. Kinetics of acute hepatitis B virus infection in humans. J Exp Med 2001;193:847-54.
    • (2001) J Exp Med , vol.193 , pp. 847-854
    • Whalley, S.A.1    Murray, J.M.2    Brown, D.3
  • 57
    • 14944375587 scopus 로고    scopus 로고
    • Immunology of hepatitis B virus and hepatitis C virus infection
    • DOI 10.1038/nri1573
    • Rehermann B, Nascimbeni M. Immunology of hepatitis B virus and hepatitis C virus infection. Nat Rev Immunol 2005;5:215-29. (Pubitemid 40364823)
    • (2005) Nature Reviews Immunology , vol.5 , Issue.3 , pp. 215-229
    • Rehermann, B.1    Nascimbeni, M.2
  • 58
    • 33645729182 scopus 로고    scopus 로고
    • Immunobiology and pathogenesis of viral hepatitis
    • Guidotti LG, Chisari FV. Immunobiology and pathogenesis of viral hepatitis. Annu Rev Pathol 2006;1:23-61.
    • (2006) Annu Rev Pathol , vol.1 , pp. 23-61
    • Guidotti, L.G.1    Chisari, F.V.2
  • 59
    • 33845864424 scopus 로고    scopus 로고
    • Treatment with HMGB1 inhibitors diminishes CTL-induced liver disease in HBV transgenic mice
    • DOI 10.1189/jlb.0306173
    • Sitia G, Iannacone M, Muller S, et al. Treatment with HMGB1 inhibitors diminishes CTL-induced liver disease in HBV transgenic mice. J Leukoc Biol 2007;81:100-7. (Pubitemid 46021258)
    • (2007) Journal of Leukocyte Biology , vol.81 , Issue.1 , pp. 100-107
    • Sitia, G.1    Iannacone, M.2    Muller, S.3    Bianchi, M.E.4    Guidotti, L.G.5
  • 62
    • 33947095580 scopus 로고    scopus 로고
    • HBV pathogenesis in animal models: Recent advances on the role of platelets
    • DOI 10.1016/j.jhep.2007.01.007, PII S016882780700044X
    • Iannacone M, Sitia G, Ruggeri ZM, et al. HBV pathogenesis in animal models: recent advances on the role of platelets. J Hepatol 2007;46:719-26. (Pubitemid 46400149)
    • (2007) Journal of Hepatology , vol.46 , Issue.4 , pp. 719-726
    • Iannacone, M.1    Sitia, G.2    Ruggeri, Z.M.3    Guidotti, L.G.4
  • 63
    • 2442684151 scopus 로고    scopus 로고
    • Memory CD8 T-cell differentiation during viral infection
    • DOI 10.1128/JVI.78.11.5535-5545.2004
    • Wherry EJ, Ahmed R. Memory CD8 T-cell differentiation during viral infection. J Virol 2004;78:5535-45. (Pubitemid 38661640)
    • (2004) Journal of Virology , vol.78 , Issue.11 , pp. 5535-5545
    • Wherry, E.J.1    Ahmed, R.2
  • 66
    • 33645220927 scopus 로고    scopus 로고
    • Expression of the interleukin-7 receptor alpha chain (CD127) on virus-specific CD8+ T cells identifies functionally and phenotypically defined memory T cells during acute resolving hepatitis B virus infection
    • Boettler T, Panther E, Bengsch B, et al. Expression of the interleukin-7 receptor alpha chain (CD127) on virus-specific CD8+ T cells identifies functionally and phenotypically defined memory T cells during acute resolving hepatitis B virus infection. J Virol 2006;80:3532-40.
    • (2006) J Virol , vol.80 , pp. 3532-3540
    • Boettler, T.1    Panther, E.2    Bengsch, B.3
  • 67
    • 84919679159 scopus 로고    scopus 로고
    • Contribution of herpesvirus specific CD8 T cells to anti-viral T cell response in humans
    • Published Online First: 19 August 2011. doi:e1001051
    • Sandalova E, Laccabue D, Boni C, et al. Contribution of herpesvirus specific CD8 T cells to anti-viral T cell response in humans. PLoS Pathog. Published Online First: 19 August 2011. doi:e1001051.
    • PLoS Pathog
    • Sandalova, E.1    Laccabue, D.2    Boni, C.3
  • 68
    • 0018077149 scopus 로고
    • Regulation of human lymphocyte function by a soluble extract from normal human liver
    • Chisari FV. Regulation of human lymphocyte function by a soluble extract from normal human liver. J Immunol 1978;121:1279-86. (Pubitemid 9033516)
    • (1978) Journal of Immunology , vol.121 , Issue.4 , pp. 1279-1286
    • Chisari, F.V.1
  • 69
    • 51049123791 scopus 로고    scopus 로고
    • Functional skewing of the global CD8 T cell population in chronic hepatitis B virus infection
    • Das A, Hoare M, Davies N, et al. Functional skewing of the global CD8 T cell population in chronic hepatitis B virus infection. J Exp Med 2008;205:2111-24.
    • (2008) J Exp Med , vol.205 , pp. 2111-2124
    • Das, A.1    Hoare, M.2    Davies, N.3
  • 70
    • 79958081170 scopus 로고    scopus 로고
    • Virus-induced transient immune suppression and the inhibition of T cell proliferation by type I interferon
    • Marshall HD, Urban SL, Welsh RM. Virus-induced transient immune suppression and the inhibition of T cell proliferation by type I interferon. J Virol 2011;85:5929-39.
    • (2011) J Virol , vol.85 , pp. 5929-5939
    • Marshall, H.D.1    Urban, S.L.2    Welsh, R.M.3
  • 71
    • 2442682870 scopus 로고    scopus 로고
    • + T cells specific for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: Implications for immunotherapy
    • DOI 10.1128/JVI.78.11.5707-5719.2004
    • Webster GJ, Reignat S, Brown D, et al. Longitudinal analysis of CD8+ T cells specific for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: implications for immunotherapy. J Virol 2004;78:5707-19. (Pubitemid 38661658)
    • (2004) Journal of Virology , vol.78 , Issue.11 , pp. 5707-5719
    • Webster, G.J.M.1    Reignat, S.2    Brown, D.3    Ogg, G.S.4    Jones, L.5    Seneviratne, S.L.6    Williams, R.7    Dusheiko, G.8    Bertoletti, A.9
  • 73
    • 75149117314 scopus 로고    scopus 로고
    • Antiviral intrahepatic Tcell responses can be restored by blocking programmed death-1 pathway in chronic hepatitis B
    • Fisicaro P, Valdatta C, Massari M, et al. Antiviral intrahepatic Tcell responses can be restored by blocking programmed death-1 pathway in chronic hepatitis B. Gastroenterology 2010;138:682-93.
    • (2010) Gastroenterology , vol.138 , pp. 682-693
    • Fisicaro, P.1    Valdatta, C.2    Massari, M.3
  • 74
    • 2642674430 scopus 로고    scopus 로고
    • + T lymphocytes but fail to promote survival
    • DOI 10.1002/(SICI)1521-4141(199801)28:01<221::AID-IMMU221>3.0.CO;2- F
    • Bertolino P, Trescol-Biémont MC, Rabourdin-Combe C. Hepatocytes induce functional activation of naïve CD8 T lymphocytes but fail to promote survival. Eur J Immunol 1998;28:221-36. (Pubitemid 28048293)
    • (1998) European Journal of Immunology , vol.28 , Issue.1 , pp. 221-236
    • Bertolino, P.1    Trescol-Biemont, M.-C.2    Rabourdin-Combe, C.3
  • 75
    • 4944245002 scopus 로고    scopus 로고
    • The site of primary T cell activation is a determinant of the balance between intrahepatic tolerance and immunity
    • DOI 10.1172/JCI200421593
    • Bowen DG, Zen M, Holz L, et al. The site of primary T cell activation is a determinant of the balance between intrahepatic tolerance and immunity. J Clin Invest 2004;114:701-12. (Pubitemid 39578761)
    • (2004) Journal of Clinical Investigation , vol.114 , Issue.5 , pp. 701-712
    • Bowen, D.G.1    Zen, M.2    Holz, L.3    Davis, T.4    McCaughan, G.W.5    Bertolino, P.6
  • 76
    • 78751576088 scopus 로고    scopus 로고
    • Liver antigen presenting cells
    • Crispe IN. Liver antigen presenting cells. J Hepatol 2011;54:357-65.
    • (2011) J Hepatol , vol.54 , pp. 357-365
    • Crispe, I.N.1
  • 77
    • 79959555074 scopus 로고    scopus 로고
    • Murine hepatic stellate cells Veto CD8 T cell activation by a CD54-dependent mechanism
    • Schildberg FA, Wojtalla A, Siegmund SV, et al. Murine hepatic stellate cells Veto CD8 T cell activation by a CD54-dependent mechanism. Hepatology 2011:54:262-72.
    • (2011) Hepatology , vol.54 , pp. 262-272
    • Schildberg, F.A.1    Wojtalla, A.2    Siegmund, S.V.3
  • 78
    • 79955112364 scopus 로고    scopus 로고
    • Role of the coinhibitory receptor cytotoxic T lymphocyte antigen-4 on apoptosis-Prone CD8 T cells in persistent hepatitis B virus infection
    • Schurich A, Khanna P, Lopes AR, et al. Role of the coinhibitory receptor cytotoxic T lymphocyte antigen-4 on apoptosis-Prone CD8 T cells in persistent hepatitis B virus infection. Hepatology 2011;53:1494-50.
    • (2011) Hepatology , vol.53 , pp. 1494-1550
    • Schurich, A.1    Khanna, P.2    Lopes, A.R.3
  • 79
    • 78649625973 scopus 로고    scopus 로고
    • The immunoregulatory role of CD244 in chronic hepatitis B infection and its inhibitory potential on virus-specific CD8+ T-cell function
    • Raziorrouh B, Schraut W, Gerlach T, et al. The immunoregulatory role of CD244 in chronic hepatitis B infection and its inhibitory potential on virus-specific CD8+ T-cell function. Hepatology 2010; 52:1934-47.
    • (2010) Hepatology , vol.52 , pp. 1934-1947
    • Raziorrouh, B.1    Schraut, W.2    Gerlach, T.3
  • 80
    • 76249097154 scopus 로고    scopus 로고
    • Immune effectors required for hepatitis B virus clearance
    • Yang PL, Althage A, Chung J, et al. Immune effectors required for hepatitis B virus clearance. Proc Natl Acad Sci U S A 2010;107:798-802.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 798-802
    • Yang, P.L.1    Althage, A.2    Chung, J.3
  • 81
    • 77649220954 scopus 로고    scopus 로고
    • Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells
    • O'Shea JJ, Paul E. Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells. Science 2010;327:1098-102.
    • (2010) Science , vol.327 , pp. 1098-1102
    • O'Shea, J.J.1    Paul, E.2
  • 82
    • 35348983341 scopus 로고    scopus 로고
    • Interleukin-22 but Not Interleukin-17 Provides Protection to Hepatocytes during Acute Liver Inflammation
    • DOI 10.1016/j.immuni.2007.07.023, PII S1074761307004426
    • Zenewicz LA, Yancopoulos GD, Valenzuela DM, et al. Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. Immunity 2007;27:647-59. (Pubitemid 47615503)
    • (2007) Immunity , vol.27 , Issue.4 , pp. 647-659
    • Zenewicz, L.A.1    Yancopoulos, G.D.2    Valenzuela, D.M.3    Murphy, A.J.4    Karow, M.5    Flavell, R.A.6
  • 83
    • 0032697042 scopus 로고    scopus 로고
    • An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response
    • Chiaramonte MG, Donaldson DD, Cheever AW, et al. An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2edominated inflammatory response. J Clin Invest 1999;104:777-85. (Pubitemid 29536363)
    • (1999) Journal of Clinical Investigation , vol.104 , Issue.6 , pp. 777-785
    • Chiaramonte, M.G.1    Donaldson, D.D.2    Cheever, A.W.3    Wynn, T.A.4
  • 84
    • 33846600414 scopus 로고    scopus 로고
    • + regulatory T cells with chronic activity and viral clearance in patients with hepatitis B
    • DOI 10.1093/intimm/dxl130
    • Yang G, Liu A, Xie Q, et al. Association of CD4+CD25+Foxp3+ regulatory T cells with chronic activity and viral clearance in patients with hepatitis B. Int Immunol 2007;19:133-40. (Pubitemid 46179008)
    • (2007) International Immunology , vol.19 , Issue.2 , pp. 133-140
    • Yang, G.1    Liu, A.2    Xie, Q.3    Guo, T.B.4    Wan, B.5    Zhou, B.6    Zhang, J.Z.7
  • 85
    • 73449125874 scopus 로고    scopus 로고
    • Interleukin-17-producing CD4(+) T cells increase with severity of liver damage in patients with chronic hepatitis B
    • Zhang J, Zhang Z, Lin F, et al. Interleukin-17-producing CD4(+) T cells increase with severity of liver damage in patients with chronic hepatitis B. Hepatology 2010;51:81-91.
    • (2010) Hepatology , vol.51 , pp. 81-91
    • Zhang, J.1    Zhang, Z.2    Lin, F.3
  • 87
    • 84863726312 scopus 로고    scopus 로고
    • IL-22 and non-ELR-CXC chemokine expression in chronic hepatitis B virus infected liver
    • Published Online First: 27 Sep 2011. doi:10.1038/icb.2011.79
    • Xiang X, Gui H, King NJ, et al. IL-22 and non-ELR-CXC chemokine expression in chronic hepatitis B virus infected liver. Immunol Cell Biol. Published Online First: 27 Sep 2011. doi:10.1038/icb.2011.79. http://www.ncbi.nlm.nih.gov/pubmed/21946664
    • Immunol Cell Biol
    • Xiang, X.1    Gui, H.2    King, N.J.3
  • 88
    • 77649253219 scopus 로고    scopus 로고
    • Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties
    • Billerbeck E, Kang YH, Walker L, et al. Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties. Proc Natl Acad Sci U S A 2010;107:3066-11.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 3066-3111
    • Billerbeck, E.1    Kang, Y.H.2    Walker, L.3
  • 91
    • 80054847781 scopus 로고    scopus 로고
    • A proinflammatory role for interleukin-22 in the immune response to hepatitis B virus
    • Published Online First: 25 June 2011. doi:10.1053/j.gastro.2011.06.051
    • Zhang Y, Cobleigh M, Lian J, et al. A proinflammatory role for interleukin-22 in the immune response to hepatitis B virus. Gastroenterology. Published Online First: 25 June 2011. doi:10.1053/j.gastro.2011.06.051.
    • Gastroenterology
    • Zhang, Y.1    Cobleigh, M.2    Lian, J.3
  • 92
    • 80051875146 scopus 로고    scopus 로고
    • Licensing virus-specific T cells to secrete the neutrophil attracting chemokine CXCL-8 during hepatitis B virus infection
    • Gehring A, Koh S, Chia A, et al. Licensing virus-specific T cells to secrete the neutrophil attracting chemokine CXCL-8 during hepatitis B virus infection. PloS One 2011;6:-23330.
    • (2011) PloS One , vol.6 , pp. 23330
    • Gehring, A.1    Koh, S.2    Chia, A.3
  • 93
    • 79959382649 scopus 로고    scopus 로고
    • Interleukin-8 is activated in patients with chronic liver diseases and associated with hepatic macrophage accumulation in human liver fibrosis
    • Zimmermann HW, Seidler S, Gassler N, et al. Interleukin-8 is activated in patients with chronic liver diseases and associated with hepatic macrophage accumulation in human liver fibrosis. PLoS One 2011;6:-21381.
    • (2011) PLoS One , vol.6 , pp. 21381
    • Zimmermann, H.W.1    Seidler, S.2    Gassler, N.3
  • 95
    • 21644453108 scopus 로고    scopus 로고
    • Low CD8 T-cell proliferative potential and high viral load limit the effectiveness of therapeutic vaccination
    • DOI 10.1128/JVI.79.14.8960-8968.2005
    • Wherry EJ, Blattman JN, Ahmed R. Low CD8 T-cell proliferative potential and high viral load limit the effectiveness of therapeutic vaccination. J Virol 2005;79:8960-8. (Pubitemid 40934807)
    • (2005) Journal of Virology , vol.79 , Issue.14 , pp. 8960-8968
    • Wherry, E.J.1    Blattman, J.N.2    Ahmed, R.3
  • 96
    • 77956852144 scopus 로고    scopus 로고
    • Comparison of immune restoration in early versus late alpha interferon therapy against hepatitis C virus
    • Abdel-Hakeem MS, Bédard N, Badr G, et al. Comparison of immune restoration in early versus late alpha interferon therapy against hepatitis C virus. J Virol 2010;84:10429-35.
    • (2010) J Virol , vol.84 , pp. 10429-10435
    • Abdel-Hakeem, M.S.1    Bédard, N.2    Badr, G.3
  • 98
    • 61749093304 scopus 로고    scopus 로고
    • In-vitro use of autologous dendritic cells improves detection of T cell responses to hepatitis B virus (HBV) antigens
    • Carotenuto P, Artsen A, Niesters HG, et al. In-vitro use of autologous dendritic cells improves detection of T cell responses to hepatitis B virus (HBV) antigens. J Med Virol 2009;81:332-9.
    • (2009) J Med Virol , vol.81 , pp. 332-339
    • Carotenuto, P.1    Artsen, A.2    Niesters, H.G.3
  • 99
    • 79551710362 scopus 로고    scopus 로고
    • Immune and viral profile from tolerance to hepatitis B surface antigen clearance: A longitudinal study of vertically hepatitis B virus-infected children on combined therapy
    • Carey I, D'Antiga L, Bansal S, et al. Immune and viral profile from tolerance to hepatitis B surface antigen clearance: a longitudinal study of vertically hepatitis B virus-infected children on combined therapy. J Virol 2011;85:2416-28.
    • (2011) J Virol , vol.85 , pp. 2416-2428
    • Carey, I.1    D'Antiga, L.2    Bansal, S.3
  • 105
    • 77953259508 scopus 로고    scopus 로고
    • TGF-beta to the rescue
    • Shevach EM. TGF-beta to the rescue. Immunity 2010;32:585-7.
    • (2010) Immunity , vol.32 , pp. 585-587
    • Shevach, E.M.1
  • 106
    • 65549136983 scopus 로고    scopus 로고
    • Mechanisms of foxp3+ T regulatory cell-mediated suppression
    • Shevach EM. Mechanisms of foxp3+ T regulatory cell-mediated suppression. Immunity 2009;30:636-45.
    • (2009) Immunity , vol.30 , pp. 636-645
    • Shevach, E.M.1
  • 108
    • 79958840661 scopus 로고    scopus 로고
    • Engineering virus-specific T cells that target HBV infected hepatocytes and hepatocellular carcinoma cell lines
    • Gehring AJ, Xue SA, Ho ZZ, et al. Engineering virus-specific T cells that target HBV infected hepatocytes and hepatocellular carcinoma cell lines. J Hepatol 2011;55:103-10.
    • (2011) J Hepatol , vol.55 , pp. 103-110
    • Gehring, A.J.1    Xue, S.A.2    Ho, Z.Z.3
  • 109
    • 72949114288 scopus 로고    scopus 로고
    • Hepatitis B virus as a gene delivery vector activating foreign antigenic T cell response that abrogates viral expression in mouse models
    • Deng Q, Mancini-Bourgine M, Zhang X, et al. Hepatitis B virus as a gene delivery vector activating foreign antigenic T cell response that abrogates viral expression in mouse models. Hepatology 2009;50:1380.
    • (2009) Hepatology , vol.50 , pp. 1380
    • Deng, Q.1    Mancini-Bourgine, M.2    Zhang, X.3
  • 110
    • 77949655584 scopus 로고    scopus 로고
    • The molecular basis of the failed immune response in chronic HBV: Therapeutic implications
    • Maini MK, Schurich A. The molecular basis of the failed immune response in chronic HBV: therapeutic implications. J Hepatol 2010;52:616-19.
    • (2010) J Hepatol , vol.52 , pp. 616-619
    • Maini, M.K.1    Schurich, A.2
  • 111
    • 65349153714 scopus 로고    scopus 로고
    • Immune regulation by 4-1BB and 4-1BBL: Complexities and challenges
    • Wang C, Lin GH, McPherson AJ, et al. Immune regulation by 4-1BB and 4-1BBL: complexities and challenges. Immunol Rev 2009;229:192-215.
    • (2009) Immunol Rev , vol.229 , pp. 192-215
    • Wang, C.1    Lin, G.H.2    McPherson, A.J.3
  • 112
    • 79952220107 scopus 로고    scopus 로고
    • IL-21 is pivotal in determining age-dependent effectiveness of immune responses in a mouse model of human hepatitis B
    • Publicover J, Goodsell A, Nishimura S, et al. IL-21 is pivotal in determining age-dependent effectiveness of immune responses in a mouse model of human hepatitis B. J Clin Invest 2011;121:1154-62.
    • (2011) J Clin Invest , vol.121 , pp. 1154-1162
    • Publicover, J.1    Goodsell, A.2    Nishimura, S.3
  • 113
    • 70449698040 scopus 로고    scopus 로고
    • Therapeutic vaccination and novel strategies to treat chronic HBV infection
    • Bertoletti A, Gehring A. Therapeutic vaccination and novel strategies to treat chronic HBV infection. Expert Rev Gastroenterol Hepatol 2009; 3:561-9.
    • (2009) Expert Rev Gastroenterol Hepatol , vol.3 , pp. 561-569
    • Bertoletti, A.1    Gehring, A.2
  • 115
    • 70149114880 scopus 로고    scopus 로고
    • Gene therapy with mouse and human T cell receptor mediates cancer regression and targets normal tissue expressing cognate antigens
    • Johnson LA, Morgan RA, Dudley ME, et al. Gene therapy with mouse and human T cell receptor mediates cancer regression and targets normal tissue expressing cognate antigens. Blood 2009;114:535.
    • (2009) Blood , vol.114 , pp. 535
    • Johnson, L.A.1    Morgan, R.A.2    Dudley, M.E.3
  • 116
    • 66149125213 scopus 로고    scopus 로고
    • Efficacy of hepatitis B vaccine against antiviral drug-resistant hepatitis B virus mutants in the chimpanzee model
    • Kamili S, Sozzi V, Thompson G, et al. Efficacy of hepatitis B vaccine against antiviral drug-resistant hepatitis B virus mutants in the chimpanzee model. Hepatology 2009;49:1483-91.
    • (2009) Hepatology , vol.49 , pp. 1483-1491
    • Kamili, S.1    Sozzi, V.2    Thompson, G.3
  • 117
    • 0026088152 scopus 로고
    • Reactivation of hepatitis B virus replication in patients receiving cytotoxic therapy. Report of a prospective study
    • Lok AS, Liang RH, Chiu EK, et al. Reactivation of hepatitis B virus replication in patients receiving cytotoxic therapy. Report of a prospective study. Gastroenterology 1991;100:182-8.
    • (1991) Gastroenterology , vol.100 , pp. 182-188
    • Lok, A.S.1    Liang, R.H.2    Chiu, E.K.3
  • 119
    • 0032008570 scopus 로고    scopus 로고
    • Use of famciclovir to prevent HPV reactivation in HBsAg-positive recipients after allogeneic bone marrow transplantation
    • DOI 10.1016/S0168-8278(98)80307-3
    • Lau GK, Liang R, Wu PC, et al. Use of famciclovir to prevent HBV reactivation in HBsAg-positive recipients after allogeneic bone marrow transplantation. J Hepatol 1998;28:359-68. (Pubitemid 28133537)
    • (1998) Journal of Hepatology , vol.28 , Issue.3 , pp. 359-368
    • Lau, G.K.K.1    Liang, R.2    Wu, P.C.3    Lee, C.K.4    Lim, W.L.5    Au, W.Y.6
  • 120
    • 0037100514 scopus 로고    scopus 로고
    • Lamivudine therapy for prevention of immunosuppressive-induced hepatitis B virus reactivation in hepatitis B surface antigen carriers
    • DOI 10.1182/blood.V100.2.391
    • Shibolet O, Ilan Y, Gillis S, et al. Lamivudine therapy for prevention of immunosuppressive-induced hepatitis B virus reactivation in hepatitis B surface antigen carriers. Blood 2002;100:391-6. (Pubitemid 34761098)
    • (2002) Blood , vol.100 , Issue.2 , pp. 391-396
    • Shibolet, O.1    Ilan, Y.2    Gillis, S.3    Hubert, A.4    Shouval, D.5    Safadi, R.6


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