A longitudinal analysis of innate and adaptive immune profile during hepatic flares in chronic hepatitis B

Journal of Hepatology

Volumn 52, Issue 3, 2010, Pages 330-339

  Tan, Anthony T ^a,d   Koh, Sarene ^a   Goh, Winnie ^a   Zhe, Heng Yee ^e   Gehring, Adam J ^a   Lim, Seng Gee ^d   Bertoletti, Antonio ^a,b,c,d  

^a AGENCY FOR SCIENCE   (Singapore)

^b AGENCY FOR SCIENCE   (Singapore)

^c DUKE NUS MEDICAL SCHOOL   (Singapore)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Chemokines; IL 10; Viral infection

Indexed keywords

ALPHA INTERFERON; CHEMOKINE; CXCL9 CHEMOKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA;

ACUTE HEPATITIS; ADAPTIVE IMMUNITY; ARTICLE; CHRONIC HEPATITIS; CONTROLLED STUDY; DISEASE COURSE; HEPATIC FLARE; HEPATITIS B; HEPATITIS VIRUS; HUMAN; HUMAN CELL; IN VITRO STUDY; INCUBATION TIME; INNATE IMMUNITY; LIVER CELL; LIVER DISEASE; LONGITUDINAL STUDY; MONOCYTE; NATURAL KILLER CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; VIRUS REPLICATION;

ACUTE DISEASE; ADAPTIVE IMMUNITY; CASE-CONTROL STUDIES; CHEMOKINE CXCL10; CHEMOKINE CXCL9; CROSS-SECTIONAL STUDIES; CYTOKINES; HEPATITIS B; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; IMMUNITY, INNATE; KILLER CELLS, NATURAL; LIVER; LONGITUDINAL STUDIES; T-LYMPHOCYTES; T-LYMPHOCYTES, REGULATORY; VIRUS REPLICATION;

EID: 77249098281     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2009.12.015     Document Type: Article

References (38)

1. Dienstag J.L. Hepatitis B virus Infection. N Engl J Med 359 (2008) 1486-1500
2. Perrillo R.P. Acute flares in chronic hepatitis B: the natural and unnatural history of an immunologically mediated liver disease. Gastroenterology 120 (2001) 1009-1022
3. Maruyama T., Iino S., Koike K., Yasuda K., and Milich D.R. Serology of acute exacerbation in chronic hepatitis B virus infection. Gastroenterology 105 4 (1993) 1141-1151
4. Tsai S., Chen M., and Yang P. Acute exacerbation of chronic type B hepatitis are accompanied by increased T cell responses to hepatitis B core and e antigens. Implications for hepatitis B e antigen seroconversion. J Clin Invest 98 (1992) 1185-1194
5. Webster G.J., Reignat S., Brown D., Ogg G.S., Jones L., Seneviratne S.L., et al. Longitudinal analysis of CD8+ T cells specific for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: implications for immunotherapy. J Virol 78 11 (2004) 5707-5719
6. Maini M.K., Boni C., Lee C.K., Larrubia J.R., Reignat S., Ogg G.S., et al. The role of virus-specific CD8+ cells in viral control and liver damage during persistent hepatitis B virus (HBV) infection. J Exp Med 191 (2000) 1269-1280
7. Kakimi K, Lane TE, Wieland S, Asensio VC, Campbell IL, Chisari FV, et al. Blocking chemokine responsive to gamma-2/interferon (IFN)-gamma inducible protein and monokine induced by IFN-gamma activity in vivo reduces the pathogenetic but not the antiviral potential of hepatitis B virus-specific cytotoxic T lymphocytes. J Exp Med 2001;194:1755-66.
8. Sitia G., Isogawa M., Iannacone M., Campbell I.L., Chisari F.V., and Guidotti L.G. MMPs are required for recruitment of antigen-non specific mononuclear cells into the liver by CTLs. J Clin Invest 113 (2004) 1158-1167
9. Iannacone M., Sitia G., Ruggeri Z.M., and Guidotti L.G. HBV pathogenesis in animal models: recent advances on the role of platelets. J Hepatol 46 4 (2007) 719-726
10. Tan A.T., Loggi E., Boni C., Chia A., Gehring A.J., Sastry K.S., et al. Host ethnicity and virus genotype shape the hepatitis B virus-specific T-cell repertoire. J Virol 82 22 (2008) 10986-10997
11. Gehring AJ, Sun D, Kennedy PT, Nolte-'t Hoen E, Lim SG, Wasser S, et al. The level of viral antigen presented by hepatocytes influences CD8 T-cell function. J Virol 2007;81:2940-9.
12. Dienstag J.L. New antiviral agents for viral hepatitis: our cup runneth over but is only half full. Gastroenterology 117 3 (1999) 525
13. Khabar KS, Al-Zoghaibi F, Al-Ahdal MN, Murayama T, Dhalla M, Mukaida N, et al. The alpha chemokine, interleukin 8, inhibits the antiviral action of interferon alpha. J Exp Med 1997;186:1077-85.
14. Kakimi K, Guidotti LG, Koezuka Y, Chisari FV. Natural killer T cell activation inhibits hepatitis B virus replication in vivo. J Exp Med 2000;192:921-30.
15. Dunn C, Brunetto M, Reynolds G, Christophides T, Kennedy PT, Lampertico P, et al. Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage. J Exp Med 2007;204:667-80.
16. Boni C., Fisicaro P., Valdatta C., Amadei B., Di Vincenzo P., Giuberti T., et al. Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection. J Virol 81 8 (2007) 4215-4225
17. Franzese O., Kennedy P.T., Gehring A.J., Gotto J., Williams R., Maini M.K., et al. Modulation of the CD8+-T-cell response by CD4+ CD25+ regulatory T cells in patients with hepatitis B virus infection. J Virol 79 6 (2005) 3322-3328
18. Stoop J.N., van der Molen R.G., Baan C.C., van der Laan L.J., Kuipers E.J., Kusters J.G., et al. Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection. Hepatology 41 4 (2005) 771-778
19. Xu D, Fu J, Jin L, Zhang H, Zhou C, Zou Z, et al. Circulating and liver resident CD4+CD25+ regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B. J Immunol 2006;177:739-47.
20. Borsellino G, Kleinewietfeld M, Di Mitri D, Sternjak A, Diamantini A, Giometto R, et al. Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression. Blood 2007;110:1225-32.
21. Lang K.S., Georgiev P., Recher M., Navarini A.A., Bergthaler A., Heikenwalder M., et al. Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling. J Clin Invest 116 9 (2006) 2456-2463
22. Sitia G, Isogawa M, Kakimi K, Wieland SF, Chisari FV, Guidotti LG. Depletion of neutrophils blocks the recruitment of antigen-nonspecific cells into the liver without affecting the antiviral activity of hepatitis B virus-specific cytotoxic T lymphocytes. Proc Natl Acad Sci USA 2002;99:13717-22.
23. Yang PL, Althage A, Chung J, Chisari FV. Hydrodynamic injection of viral DNA: a mouse model of acute hepatitis B virus infection. Proc Natl Acad Sci USA 2002;99:13825-30.
24. Kakimi K, Lane TE, Chisari FV, Guidotti LG. Cutting edge: Inhibition of hepatitis B virus replication by activated NK T cells does not require inflammatory cell recruitment to the liver. J Immunol 2001;167:6701-5.
25. Biron C. Initial and innate responses to viral infections-pattern setting in immunity or disease. Curr Opin Microbiol 2 (1999) 374-381
26. Fong T.L., Di Bisceglie A.M., Biswas R., Waggoner J.G., Wilson L., Claggett J., et al. High levels of viral replication during acute hepatitis B infection predict progression to chronicity. J Med Virol 43 2 (1994) 155-158
27. Wieland S., and Chisari F.V. Stealth and cunning: hepatitis B and hepatitis C viruses. J Virol 79 (2005) 9369-9380
28. Salazar-Mather T.P., Hamilton T.A., and Biron C.A. A chemokine-to-cytokine-to-chemokine cascade critical in antiviral defense. J Clin Invest 105 7 (2000) 985-993
29. McCaffrey A.P., Fawcett P., Nakai H., McCaffrey R.L., Ehrhardt A., Pham T.T., et al. The host response to adenovirus, helper-dependent adenovirus, and adeno-associated virus in mouse liver. Mol Ther 16 5 (2008) 931-941
30. Wieland S., Thimme R., Purcell R.H., and Chisari F.V. Genomic analysis of the host response to hepatitis B virus infection. Proc Natl Acad Sci USA 101 (2004) 6669-6674
31. Dunn C, Peppa D, Khanna P, Nebbia G, Jones M, Brendish N, et al. Temporal analysis of early immune responses in patients with acute hepatitis B virus infection. Gastroenterology, 2009.
32. Taub DD, Anver M, Oppenheim JJ, Longo DL, Murphy WJ. T lymphocyte recruitment by interleukin-8 (IL-8). IL-8-induced degranulation of neutrophils releases potent chemoattractants for human T lymphocytes both in vitro and in vivo. J Clin Invest 1996;97:1931-41.
33. Taub DD, Longo DL, Murphy WJ. Human interferon-inducible protein-10 induces mononuclear cell infiltration in mice and promotes the migration of human T lymphocytes into the peripheral tissues and human peripheral blood lymphocytes-SCID mice. Blood 1996;87:1423-31.
34. Shields P., Morland C., Salmon M., Qin S., Hubscher S., and Adams D. Chemokine and chemokine receptor interaction provide a mechanism for selective T cell recruitment to specific liver compartments within hepatitis C infected liver. J Immunol 163 (1999) 6236-6243
35. Larrubia J., Calvino M., Benito S., Sanz-de-Villalobos E., Perna C., Pérez-Hornedo J., et al. The role of CCR5/CXCR3 expressing CD8+ cells in liver damage and viral control during persistent hepatitis C virus infection. J Hepatol 47 (2007) 632-641
36. Crane M, Oliver B, Matthews G, Avihingsanon A, Ubolyam S, Markovska V, et al. Immunopathogenesis of hepatic flare in HIV/hepatitis B virus (HBV)-coinfected individuals after the initiation of HBV-active antiretroviral therapy. J Infect Dis 2009;199:974-81.
37. Bone-Larson CL, Hogaboam CM, Evanhoff H, Strieter RM, Kunkel SL. IFN-gamma-inducible protein-10 (CXCL10) is hepatoprotective during acute liver injury through the induction of CXCR2 on hepatocytes. J Immunol 2001;167:7077-83.
38. Hokeness K.L., Deweerd E.S., Munks M.W., Lewis C.A., Gladue R.P., and Salazar-Mather T.P. CXCR3-dependent recruitment of antigen specific T lymphocytes to the liver during murine cytomegalovirus infection. J Virol 81 (2007) 1241-1250