Hepatitis B virus as a gene delivery vector activating foreign antigenic T cell response that abrogates viral expression in mouse models

Hepatology

Volumn 50, Issue 5, 2009, Pages 1380-1391

  Deng, Qiang ^a,b,d   Mancini Bourgine, Maryline ^a,b   Zhang, Xiaoming ^a,b   Cumont, Marie Christine ^a   Zhu, Ren ^a,b   Lone, Yu Chun ^c   Michel, Marie Louise ^a,b  

^a INSTITUT PASTEUR   (France)

^b INSERM   (France)

^c HÔPITAL PAUL BROUSSE   (France)

^d INSTITUTE PASTEUR OF SHANGHAI   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CORE PROTEIN; EPITOPE; HEPATITIS B SURFACE ANTIGEN; HLA A2 ANTIGEN; HLA DR1 ANTIGEN; PLASMID DNA; RECOMBINANT PROTEIN; VIRUS DNA; VIRUS VECTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; DNA IMMUNIZATION; FLOW CYTOMETRY; HEPATITIS B; HEPATITIS B VIRUS; HISTOLOGY; IMMUNOFLUORESCENCE; IMMUNOTHERAPY; LIVER CELL; LIVER INJURY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SOUTHERN BLOTTING; T LYMPHOCYTE; TRANSGENIC MOUSE; VIRAL GENE DELIVERY SYSTEM; VIRUS CAPSID; VIRUS GENOME; VIRUS RECOMBINANT;

ANIMALS; ANTIGENS; DISEASE MODELS, ANIMAL; EPITOPES; FEMALE; GENE EXPRESSION REGULATION, VIRAL; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HEPATITIS C, CHRONIC; HLA-A2 ANTIGEN; HLA-DR1 ANTIGEN; IMMUNOTHERAPY, ACTIVE; LIVER; MICE; MICE, TRANSGENIC; T-LYMPHOCYTES; VIRUS REPLICATION;

EID: 72949114288     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.23150     Document Type: Article

References (30)

1. Guidotti LG, Chisari FV. Immunobiology and pathogenesis of viral hepatitis. Annu Rev Pathol 2006;1:23-61.
2. Mancini-Bourgine M, Fontaine H, Scott-Algara D, Pol S, Brechot C, Michel ML. Induction or expansion of T-cell responses by a hepatitis B DNA vaccine administered to chronic HBV carriers. HEPATOLOGY 2004; 40:874-882.
3. Pol S, Michel ML. Therapeutic vaccination in chronic hepatitis B virus carriers. Expert Rev Vaccines 2006;5:707-716.
4. Ha SJ, West EE, Araki K, Smith KA, Ahmed R. Manipulating both the inhibitory and stimulatory immune system towards the success of therapeutic vaccination against chronic viral infections. Immunol Rev 2008; 223:317-333.
5. Liu F, Song Y, Liu D. Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA. Gene Ther 1999;6:1258-1266.
6. Yang PL, Althage A, Chung J, Chisari FV. Hydrodynamic injection of viral DNA: a mouse model of acute hepatitis B virus infection. Proc Natl Acad Sci U S A 2002;99:13825-13830.
7. Pajot A, Michel ML, Fazilleau N, Pancre V, Auriault C, Ojcius DM, et al. A mouse model of human adaptive immune functions: HLA-A2.1-/HLADR1-transgenic H-2 class I-/class II-knockout mice. Eur J Immunol 2004; 34:3060-3069.
8. Mancini M, Hadchouel M, Davis HL, Whalen RG, Tiollais P, Michel ML. DNA-mediated immunization in a transgenic mouse model of the hepatitis B surface antigen chronic carrier state. Proc Natl Acad Sci U S A 1996;93:12496-12501.
9. Loirat D, Mancini-Bourgine M, Abastado JP, Michel ML. HBsAg/ HLA-A2 transgenic mice: a model for T cell tolerance to hepatitis B surface antigen in chronic hepatitis B virus infection. Int Immunol 2003;15:1125-1136.
10. Michel ML, Davis HL, Schleef M, Mancini M, Tiollais P, Whalen RG. DNA-mediated immunization to the hepatitis B surface antigen in mice: aspects of the humoral response mimic hepatitis B viral infection in humans. Proc Natl Acad Sci U S A 1995;92:5307-5311.
11. Zhu R, Diem S, Araujo LM, Aumeunier A, Denizeau J, Philadelphe E, et al. The Pro-Th1 cytokine IL-12 enhances IL-4 production by invariant NKT cells: relevance for T cell-mediated hepatitis. J Immunol 2007;178: 5435-5442.
12. Betts MR, Brenchley JM, Price DA, De Rosa SC, Douek DC, Roederer M, et al. Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation. J Immunol Methods 2003; 281:65-78.
13. Sells MA, Zelent AZ, Shvartsman M, Acs G. Replicative intermediates of hepatitis B virus in HepG2 cells that produce infectious virions. J Virol 1988;62:2836-2844.
14. Alexander J, Sidney J, Southwood S, Ruppert J, Oseroff C, Maewal A, et al. Development of high potency universal DR-restricted helper epitopes by modification of high affinity DR-blocking peptides. Immunity 1994;1: 751-761.
15. Bertoletti A, Southwood S, Chesnut R, Sette A, Falco M, Ferrara GB, et al. Molecular features of the hepatitis B virus nucleocapsid T-cell epitope 18-27: interaction with HLA and T-cell receptor. HEPATOLOGY 1997;26: 1027-1034.
16. Seeger C, Mason WS. Hepatitis B virus biology. Microbiol Mol Biol Rev 2000;64:51-68.
17. Scaglioni PP, Melegari M, Wands JR. Posttranscriptional regulation of hepatitis B virus replication by the precore protein. J Virol 1997;71:345-353.
18. Loirat D, Lemonnier FA, Michel ML. Multiepitopic HLA-A*0201- restricted immune response against hepatitis B surface antigen after DNA-based immunization. J Immunol 2000;165:4748-4755.
19. Liu J, Ewald BA, Lynch DM, Nanda A, Sumida SM, Barouch DH. Modulation of DNA vaccine-elicited CD8+ T-lymphocyte epitope immunodominance hierarchies. J Virol 2006;80:11991-11997.
20. Mancini M, Hadchouel M, Tiollais P, Michel ML. Regulation of hepatitis B virus mRNA expression in a hepatitis B surface antigen transgenic mouse model by IFN-gamma-secreting T cells after DNA-based immunization. J Immunol 1998;161:5564-5570.
21. Das A, Hoare M, Davies N, Lopes AR, Dunn C, Kennedy PT, et al. Functional skewing of the global CD8 T cell population in chronic hepatitis B virus infection. J Exp Med 2008;205:2111-2124.
22. Gunther S, Piwon N, Jung A, Iwanska A, Schmitz H, Will H. Enhanced replication contributes to enrichment of hepatitis B virus with a deletion in the core gene. Virology 2000;273:286-299.
23. Guidotti LG, Chisari FV. Noncytolytic control of viral infections by the innate and adaptive immune response. Annu Rev Immunol 2001;19:65-91.
24. Crispe IN. Hepatic T cells and liver tolerance. Nat Rev Immunol 2003;3: 51-62.
25. Bertolino P. Impaired function of dendritic cells translocating the liver sinusoids: a veto effect contributing to intrahepatic tolerance? Eur J Immunol 2008;38:938-941.
26. Dikopoulos N, Jomantaite I, Schirmbeck R, Reimann J. Specific, functional effector/memory CD8+ T cells are found in the liver post-vaccination. J Hepatol 2003;39:910-917.
27. Keating R, Yue W, Rutigliano JA, So J, Olivas E, Thomas PG, et al. Virus-specific CD8+ T cells in the liver: armed and ready to kill. J Immunol 2007;178:2737-2745.
28. Cavanaugh VJ, Guidotti LG, Chisari FV. Inhibition of hepatitis B virus replication during adenovirus and cytomegalovirus infections in transgenic mice. J Virol 1998;72:2630-2637.
29. Pasquetto V, Guidotti LG, Kakimi K, Tsuji M, Chisari FV. Host-virus interactions during malaria infection in hepatitis B virus transgenic mice. J Exp Med 2000;192:529-536.
30. Ladner SK, Otto MJ, Barker CS, Zaifert K, Wang GH, Guo JT, et al. Inducible expression of human hepatitis B virus (HBV) in stably transfected hepatoblastoma cells: a novel system for screening potential inhibitors of HBV replication. Antimicrob Agents Chemother 1997;41:1715-1720.