Engineering virus-specific T cells that target HBV infected hepatocytes and hepatocellular carcinoma cell lines

Journal of Hepatology

Volumn 55, Issue 1, 2011, Pages 103-110

  Gehring, Adam J ^a   Xue, Shao An ^b   Ho, Zi Zong ^a   Teoh, Denise ^a   Ruedl, Christiane ^c   Chia, Adeline ^a   Koh, Sarene ^a,d   Lim, Seng Gee ^e   Maini, Mala K ^f   Stauss, Hans ^b   Bertoletti, Antonio ^a,e,g  

^a AGENCY FOR SCIENCE   (Singapore)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^c NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^d KAROLINSKA INSTITUTE   (Sweden)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^f UNIVERSITY COLLEGE LONDON   (United Kingdom)

^g DUKE NUS MEDICAL SCHOOL   (Singapore)

Author keywords

Hepatitis B virus; Hepatocellular carcinoma; Immunotherapy; T cell receptor gene transfer

Indexed keywords

GAMMA INTERFERON; HEPATITIS B ANTIGEN; INTERLEUKIN 2; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; VIRUS ANTIGEN; VIRUS DNA; VIRUS VECTOR;

ARTICLE; CANCER CELL CULTURE; CELL SURFACE; CELLULAR IMMUNITY; CONTROLLED STUDY; GENE TRANSFER; HEPATITIS B; HUMAN; HUMAN CELL; LIVER CELL; LIVER CELL CARCINOMA; MOLECULAR CLONING; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; STAINING; VIRUS DNA CELL DNA INTERACTION;

CARCINOMA, HEPATOCELLULAR; CELL LINE; CELL LINE, TUMOR; GENE EXPRESSION; GENETIC ENGINEERING; GENETIC VECTORS; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HLA-A2 ANTIGEN; HUMANS; IMMUNITY, CELLULAR; LIVER NEOPLASMS; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES; TRANSDUCTION, GENETIC;

EID: 79958840661     PISSN: 01688278     EISSN: 01688278     Source Type: Journal    
DOI: 10.1016/j.jhep.2010.10.025     Document Type: Article

References (35)

1. A. Bertoletti, and A.J. Gehring The immune response during hepatitis B virus infection J Gen Virol 87 2006 1439 1449 (Pubitemid 43827198)
2. D. Ganem, and A.M. Prince Hepatitis B virus infection-natural history and clinical consequences N Engl J Med 350 2004 1118 1129 (Pubitemid 38298992)
3. J. Bruix, L. Boix, M. Sala, and J.M. Llovet Focus on hepatocellular carcinoma Cancer Cell 5 2004 215 219 (Pubitemid 38402113)
4. J.M. Llovet, and J. Bruix Novel advancements in the management of hepatocellular carcinoma in 2008 J Hepatol 48 2008 S20 S37
5. J.M. Llovet, A. Burroughs, and J. Bruix Hepatocellular carcinoma Lancet 362 2003 1907 1917 (Pubitemid 37518510)
6. Y. Ilan, A. Nagler, R. Adler, R. Tur-Kaspa, S. Slavin, and D. Shouval Ablation of persistent hepatitis B by bone marrow transplantation from a hepatitis B-immune donor Gastroenterology 104 1993 1818 1821 (Pubitemid 23235477)
7. G.K. Lau, A.S. Lok, R.H. Liang, C.L. Lai, E.K. Chiu, and Y.L. Lau Clearance of hepatitis B surface antigen after bone marrow transplantation: role of adoptive immunity transfer Hepatology 25 1997 1497 1501 (Pubitemid 27250775)
8. E. Loggi, F. Bihl, J.V. Chisholm 3rd, M. Biselli, A. Bontadini, and G. Vitale Anti-HBs re-seroconversion after liver transplantation in a patient with past HBV infection receiving a HBsAg positive graft J Hepatol 50 2009 625 630
9. + T Cells in Xenografted Nude Mice J Immunol 170 2003 1183 1190 (Pubitemid 36139481)
10. A.J. Gehring, Z.Z. Ho, A.T. Tan, M.O. Aung, K.H. Lee, and K.C. Tan Profile of tumor antigen-specific CD8 T cells in patients with hepatitis B virus-related hepatocellular carcinoma Gastroenterology 137 2009 682 690
11. C. Boni, A. Penna, A. Bertoletti, V. Lamonaca, I. Rapti, and G. Missale Transient restoration of anti-viral T cell responses induced by lamivudine therapy in chronic hepatitis B J Hepatol 39 2003 595 605 (Pubitemid 37204661)
12. A. Craxi, G. Antonucci, and C. Camma Treatment options in HBV J Hepatol 44 2006 S77 S83
13. C.M. Lo, C.L. Liu, S.C. Chan, G.K. Lau, and S.T. Fan Failure of hepatitis B vaccination in patients receiving lamivudine prophylaxis after liver transplantation for chronic hepatitis B J Hepatol 43 2005 283 287 (Pubitemid 40956881)
14. S. Pol, B. Nalpas, F. Driss, M.L. Michel, P. Tiollais, and J. Denis Efficacy and limitations of a specific immunotherapy in chronic hepatitis B J Hepatol 34 2001 917 921 (Pubitemid 32595193)
15. P. Vandepapeliere, G.K. Lau, G. Leroux-Roels, Y. Horsmans, E. Gane, and T. Tawandee Therapeutic vaccination of chronic hepatitis B patients with virus suppression by antiviral therapy: a randomized, controlled study of co-administration of HBsAg/AS02 candidate vaccine and lamivudine Vaccine 25 2007 8585 8597 (Pubitemid 350192039)
16. C.H. June Adoptive T cell therapy for cancer in the clinic J Clin Invest 117 2007 1466 1476 (Pubitemid 46871329)
17. D. Sun, and M. Nassal Stable HepG2- and Huh7-based human hepatoma cell lines for efficient regulated expression of infectious hepatitis B virus J Hepatol 45 2006 636 645 (Pubitemid 44466664)
18. T. Manigold, and V. Racanelli T-cell regulation by CD4 regulatory T cells during hepatitis B and C virus infections: facts and controversies Lancet Infect Dis 7 2007 804 813 (Pubitemid 350152043)
19. A. Das, M. Hoare, N. Davies, A.R. Lopes, C. Dunn, and P.T. Kennedy Functional skewing of the global CD8 T cell population in chronic hepatitis B virus infection J Exp Med 205 2008 2111 2124
20. L. Chen, Z. Zhang, W. Chen, Z. Zhang, Y. Li, and M. Shi B7-H1 up-regulation on myeloid dendritic cells significantly suppresses T cell immune function in patients with chronic hepatitis B J Immunol 178 2007 6634 6641 (Pubitemid 46717448)
21. R.G. van der Molen, D. Sprengers, R.S. Binda, E.C. de Jong, H.G. Niesters, and J.G. Kusters Functional impairment of myeloid and plasmacytoid dendritic cells of patients with chronic hepatitis B Hepatology [Baltimore, MD] 40 2004 738 746 (Pubitemid 39265597)
22. J.J. Alexander, E.M. Bey, E.W. Geddes, and G. Lecatsas Establishment of a continuously growing cell line from primary carcinoma of the liver S Afr Med J 50 1976 2124 2128 (Pubitemid 8004296)
23. G.M. MacNab, J.J. Alexander, G. Lecatsas, E.M. Bey, and J.M. Urbanowicz Hepatitis B surface antigen produced by a human hepatoma cell line Br J Cancer 34 1976 509 515
24. E.M. Twist, H.F. Clark, D.P. Aden, B.B. Knowles, and S.A. Plotkin Integration pattern of hepatitis B virus DNA sequences in human hepatoma cell lines J Virol 37 1981 239 243 (Pubitemid 11174593)
25. D. Shouval, D.A. Shafritz, V.R. Zurawski Jr., K.J. Isselbacher, and J.R. Wands Immunotherapy in nude mice of human hepatoma using monoclonal antibodies against hepatitis B virus Nature 298 1982 567 569 (Pubitemid 12038658)
26. F. Bohne, M. Chmielewski, G. Ebert, K. Wiegmann, T. Kurschner, and A. Schulze T cells redirected against hepatitis B virus surface proteins eliminate infected hepatocytes Gastroenterology 134 2008 239 247 (Pubitemid 350309333)
27. M.H. Heemskerk, R.S. Hagedoorn, M.A. van der Hoorn, L.T. van der Veken, M. Hoogeboom, and M.G. Kester Efficiency of T-cell receptor expression in dual-specific T cells is controlled by the intrinsic qualities of the TCR chains within the TCR-CD3 complex Blood 109 2007 235 243 (Pubitemid 46053064)
28. S. Thomas, S.A. Xue, M. Cesco-Gaspere, E. San Jose, D.P. Hart, and V. Wong Targeting the Wilms tumor antigen 1 by TCR gene transfer: TCR variants improve tetramer binding but not the function of gene modified human T cells J Immunol 179 2007 5803 5810
29. G.M. Bendle, C. Linnemann, A.I. Hooijkaas, L. Bies, M.A. de Witte, and A. Jorritsma Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy Nature Med 16 2010 565 570 [561p. following 570]
30. C.J. Cohen, Y. Zhao, Z. Zheng, S.A. Rosenberg, and R.A. Morgan Enhanced antitumor activity of murine-human hybrid T-cell receptor (TCR) in human lymphocytes is associated with improved pairing and TCR/CD3 stability Cancer Res 66 2006 8878 8886 (Pubitemid 44449206)
31. J. Kuball, M.L. Dossett, M. Wolfl, W.Y. Ho, R.H. Voss, and C. Fowler Facilitating matched pairing and expression of TCR chains introduced into human T cells Blood 109 2007 2331 2338 (Pubitemid 46425872)
32. C. Brechot, C. Pourcel, A. Louise, B. Rain, and P. Tiollais Presence of integrated hepatitis B virus DNA sequences in cellular DNA of human hepatocellular carcinoma Nature 286 1980 533 535 (Pubitemid 10017698)
33. D.A. Shafritz, D. Shouval, H.I. Sherman, S.J. Hadziyannis, and M.C. Kew Integration of hepatitis B virus DNA into the genome of liver cells in chronic liver disease and hepatocellular carcinoma. Studies in percutaneous liver biopsies and post-mortem tissue specimens N Engl J Med 305 1981 1067 1073 (Pubitemid 12234831)
34. M. Ziemer, P. Garcia, Y. Shaul, and W.J. Rutter Sequence of hepatitis B virus DNA incorporated into the genome of a human hepatoma cell line J Virol 53 1985 885 892 (Pubitemid 15173297)
35. L.A. Johnson, R.A. Morgan, M.E. Dudley, L. Cassard, J.C. Yang, and M.S. Hughes Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen Blood 114 2009 535 546