Immune effectors required for hepatitis B virus clearance

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 2, 2010, Pages 798-802

  Yang, Priscilla L ^a   Althage, Alana ^a   Chung, Josan ^a   Maier, Holly ^a   Wieland, Stefan ^a   Isogawa, Masanori ^a   Chisari, Francis V ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

HBV clearance; In vivo transfection; Liver; T cell; Viral persistance

Indexed keywords

ALPHA INTERFERON RECEPTOR; BETA INTERFERON RECEPTOR; FAS ANTIGEN; GAMMA INTERFERON; PERFORIN; PLASMID PCMV SB; PLASMID VECTOR; PT MCS HBV1.3; TRANSPOSASE; TUMOR NECROSIS FACTOR RECEPTOR 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DNA TRANSCRIPTION; EFFECTOR CELL; HEPATITIS B VIRUS; IMMUNOHISTOCHEMISTRY; IN VIVO GENE TRANSFER; MOUSE; NATURAL KILLER CELL; NONHUMAN; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; SCID MOUSE; VIRUS GENOME; VIRUS IMMUNITY; VIRUS REPLICATION;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DNA, VIRAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION, VIRAL; GENOME, VIRAL; HEPATITIS B; HEPATITIS B CORE ANTIGENS; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HUMANS; LIVER NEOPLASMS; MICE; MICE, INBRED NOD; MICE, KNOCKOUT; MICE, SCID; TRANSCRIPTION, GENETIC; VIRUS REPLICATION;

ANIMALIA; HEPATITIS B VIRUS; MUS;

EID: 76249097154     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0913498107     Document Type: Article

References (40)

1. Ganem D, Varmus HE (1987) The molecular biology of the hepatitis B viruses. Annu Rev Biochem 56:651-693.
2. Beasley RP, Hwang LY, Lin CC, Chien CS (1981) Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22 707 men in Taiwan. Lancet 2:1129-1133.
3. Chisari FV, Ferrari C (1995) Hepatitis B virus immunopathogenesis. Annu Rev Immunol 13:29-60.
4. Guidotti LG, et al. (1996) Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes. Immunity 4:25-36.
5. Nakamoto Y, Guidotti LG, Pasquetto V, Schreiber RD, Chisari FV (1997) Differential target cell sensitivity to CTL-activated death pathways in hepatitis B virus transgenic mice. J Immunol 158:5692-5697.
6. Franco A, Guidotti LG, Hobbs MV, Pasquetto V, Chisari FV (1997) Pathogenetic effector function of CD4-positive T helper 1 cells in hepatitis B virus transgenic mice. J Immunol 159:2001-2008.
7. Kakimi K, Guidotti LG, Koezuka Y, Chisari FV (2000) Natural killer T cell activation inhibits hepatitis B virus replication in vivo. J Exp Med 192:921-930.
8. Kimura K, Kakimi K, Wieland S, Guidotti LG, Chisari FV (2002) Interleukin-18 inhibits hepatitis B virus replication in the livers of transgenic mice. J Virol 76:10702-10707.
9. Guidotti LG, et al. (1999) Viral clearance without destruction of infected cells during acute HBV infection. Science 284:825-829.
10. Wieland S.F, Spangenberg H.C, Thimme R, Purcell R.H, Chisari F.V. (2004) Expansion and contraction of the hepatitis B virus transcriptional template in infected chimpanzees. Natl Acad Sci USA 101:2129-2134.
11. Thimme R, et al. (2003) CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection. J Virol 77:68-76.
12. Yang PL, Althage A, Chung J, Chisari FV (2002) Hydrodynamic injection of viral DNA: A mouse model of acute hepatitis B virus infection. Proc Natl Acad Sci USA 99: 13825-13830.
13. Burrell CJ, et al. (1984) Correlation between liver histology and markers of hepatitis B virus replication in infected patients: A study by in situ hybridization. Hepatology 4: 20-24.
14. Gowans EJ, Burrell CJ, Jilbert AR, Marmion BP (1985) Cytoplasmic (but not nuclear) hepatitis B virus (HBV) core antigen reflects HBV DNA synthesis at the level of the infected hepatocyte. Intervirology 24:220-225.
15. Quiroga JA, et al. (1987) Identification of different degrees of hepatitis B virus (HBV) replication by serological (HBV-DNAp, HBcAg and HBV-DNA) and histological (HBcAg) methods. Liver 7:169-175.
16. Guidotti LG, Matzke B, Chisari FV (1997) Hepatitis B virus replication is cell cycle independent during liver regeneration in transgenic mice. J Virol 71:4804-4808.
17. Chu CM, Yeh CT, Sheen IS, Liaw YF (1995) Subcellular localization of hepatitis B core antigen in relation to hepatocyte regeneration in chronic hepatitis B. Gastroenterology 109:1926-1932.
18. Asabe S, et al. (2009) The size of the viral inoculum contributes to the outcome of hepatitis B virus infection. J Virol 83:9652-9662.
19. Kuhöber A, et al. (1996) DNA immunization induces antibody and cytotoxic T cell responses to hepatitis B core antigen in H-2b mice. J Immunol 156:3687-3695.
20. Isogawa M, Furuichi Y, Chisari FV (2005) Oscillating CD8(+) T cell effector functions after antigen recognition in the liver. Immunity 23:53-63.
21. Haring JS, Corbin GA, Harty JT (2005) Dynamic regulation of IFN-gamma signaling in antigen-specific CD8+ T cells responding to infection. J Immunol 174:6791-6802.
22. Whitmire JK, Benning N, Whitton JL (2005) Cutting edge: Early IFN-gamma signaling directly enhances primary antiviral CD4+ T cell responses. J Immunol 175:5624-5628.
23. Zhou S, Ou R, Huang L, Moskophidis D (2002) Critical role for perforin-, Fas/FasL-, and TNFR1-mediated cytotoxic pathways in down-regulation of antigen-specific T cells during persistent viral infection. J Virol 76:829-840.
24. Summers J, Mason WS (1982) Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate. Cell 29:403-415.
25. Weiser B, Ganem D, Seeger C, Varmus HE (1983) Closed circular viral DNA and asymmetrical heterogeneous forms in livers from animals infected with ground squirrel hepatitis virus. J Virol 48:1-9.
26. Young LH, Klavinskis LS, Oldstone MB, Young JD (1989) In vivo expression of perforin by CD8+ lymphocytes during an acute viral infection. J Exp Med 169:2159-2171.
27. Abougergi MS, Gidner SJ, Spady DK, Miller BC, Thiele DL (2005) Fas and TNFR1, but not cytolytic granule-dependent mechanisms, mediate clearance of murine liver adenoviral infection. Hepatology 41:97-105.
28. Shultz LD, et al. (1995) Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice. J Immunol 154:180-191.
29. Roder JC (1979) The beige mutation in the mouse. I. A stem cell predetermined impairment in natural killer cell function. J Immunol 123:2168-2173.
30. Adachi M, et al. (1995) Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver.. Nat Genet 11:294-300.
31. Fung-Leung WP, et al. (1991) CD8 is needed for development of cytotoxic T cells but not helper T cells. Cell 65:443-449.
32. Dalton DK, et al. (1993) Multiple defects of immune cell function in mice with disrupted interferon-gamma genes. Science 259:1739-1742.
33. Kägi D, et al. (1994) Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature 369:31-37.
34. Rahemtulla A, et al. (1991) Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4. Nature 353:180-184.
35. Kitamura D, Roes J, Kühn R, Rajewsky K (1991) A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene. Nature 350: 423-426.
36. Pfeffer K, et al. (1993) Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell 73: 457-467.
37. Müller U, et al. (1994) Functional role of type I and type II interferons in antiviral defense. Science 264:1918-1921.
38. Yant SR, et al. (2000) Somatic integration and long-term transgene expression in normal and haemophilic mice using a DNA transposon system. Nat Genet 25:35-41.
39. Guidotti LG, Matzke B, Schaller H, Chisari FV (1995) High-level hepatitis B virus replication in transgenic mice. J Virol 69:6158-6169.
40. Kakimi K, Isogawa M, Chung J, Sette A, Chisari FV (2002) Immunogenicity and tolerogenicity of hepatitis B virus structural and nonstructural proteins: Implications for immunotherapy of persistent viral infections. J Virol 76:8609-8620.