Effects of long-term ursodeoxycholate administration on expression levels of secretory low-molecular-weight phospholipases A2 and mucin genes in gallbladders and biliary composition in patients with multiple cholesterol stones

Hepatology

Volumn 28, Issue 2, 1998, Pages 302-313

  Kano, Masahito ^a   Shoda, Junichi ^a   Irimura, Tatsuro ^b   Ueda, Tetsuya ^c   Iwasaki, Ryu ^c   Urasaki, Tetsuya ^d   Kawauchi, Yasushi ^d   Asano, Toru ^a   Matsuzaki, Yasushi ^a   Tanaka, Naomi ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c Mitsubishi Kagaku Bio Clin Labs   (Japan)

^d ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; COMPLEMENTARY DNA; MUCIN; PHOSPHOLIPASE A1; RNA; URSODEOXYCHOLIC ACID;

ARTICLE; CHOLELITHIASIS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; GALLSTONE; GALLSTONE FORMATION; GENE EXPRESSION; HUMAN; HUMAN TISSUE; INFLAMMATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ARACHIDONIC ACID; BILE; CHOLAGOGUES AND CHOLERETICS; CHOLELITHIASIS; CHOLESTEROL; GALLBLADDER; GENE EXPRESSION; HUMANS; LIPIDS; MOLECULAR WEIGHT; MUCINS; PHOSPHOLIPASES A; TIME FACTORS; URSODEOXYCHOLIC ACID;

EID: 7344246553     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510280204     Document Type: Article

References (14)

1. Afdhal NH, Smith BE Current concepts on the pathogenesis of gallstones. Viewpoints in Digestive Disease 1990;22:13-18.
2. Sedaghat A, Grundy SM. Cholesterol crystals and the formation of cholesterol gallstones. N Engl J Med 1980;302:1274-1277.
3. 1-acid glycoprotein do not contribute to the cholesterol crystallization promoting effect of concanavalin A-binding biliary protein. HEPATOLOGY 1994;20:626-632.
4. Offner GD, Gong D, Àfdahl NH. Identification of a 130-kilodalton human biliary concanavalin A binding protein as aminopeptidase N. Gastroenterology 1994;106:755-762.
5. Kibe A, Holzbach RT, LaRusso NF, Mao SJT. Inhibition of cholesterol crystal formation by apoproteins in supersaturated model bile. Science 1984;225:514-516.
6. Juvonen T, Niemela J, Mäkelä J, Kairaluoma MI. Characteristics of symptomatic gallbladder disease in patients with either solitary or multiple cholesterol gallstones. Hepatogastroenterology 1994;41:263-266.
7. Villanova N, Bazzoli F, Taroni F, Frabboni R, Mazzella G, Festi D, Barbara L. Gallstone recurrence after successful oral bile acid treatment: a 12-year follow-up study and evaluation of long-term postdissolution treatment. Gastroenterology 1989;97:726-731.
8. Jungst D, Lang T, von Ritter C, Pratschke E, Paumgartner G. Cholesterol nucleation time in gallbladder bile of patients with solitary or multiple cholesterol gallstones. HEPATOLOGY 1992;15:804-808.
9. Afdhal NH, Niu N, Gantz D, Small D, Smith BE Bovine gallbladder mucin accelerates cholesterol monohydrate crystal growth in model bile. Gastroenterology 1993;104:1515-1523.
10. Levy PF, Smith BF, LaMont JT. Human gallbladder mucin accelerates nucleation of cholesterol in artificial bile. Gastroenterology 1984;87:270-275.
11. Kim YS, Gun JR Jr. Diversity of mucin genes, structure, function, and expression. Gastroenterology 1995;109:999-1013.
12. Offner GD, Nunes DP, Zang F, McAnneny DB, Afdhal NH. Alterations in gallbladder mucin gene expression in patients with cholesterol gallstones. Gastroenterology 1996;110:A1282.
13. Seilhamer JJ, Pruzanski W, Vadas P, PLant S, Miller JA, Kloss J, Johnson LK. Cloning and recombinant expression of phospholipase A2 present in rheumatoid arthritic synovial fluid. J Biol Chem 1989;264:5335-5338.
14. Shoda J, Ueda T, Ikegami T, Matsuzaki Y, Satoh S, Kano M, Matsuura K, et al. Increased biliary group II phospholipase A2 and altered gallbladder bile in patients with multiple cholesterol stones. Gastroenterology 1997;112:2036-2047.