Effect of ursodeoxycholic acid on methionine adenosyltransferase activity and hepatic glutathione metabolism rats

Gut

Volumn 50, Issue 5, 2002, Pages 701-706

  Rodriguez Ortigosa C M ^a   Cincu, R N ^a   Sanz, S ^a   Ruiz, F ^a   Quiroga, J ^a   Prieto, J ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BILE SALT; DEOXYCHOLIC ACID; GAMMA GLUTAMYLTRANSFERASE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; METHIONINE; METHIONINE ADENOSYLTRANSFERASE; TAUROCHOLIC ACID; URSODEOXYCHOLIC ACID;

ANIMAL TISSUE; ARTICLE; BILIARY EXCRETION; BIOSYNTHESIS; ENZYME ACTIVITY; GENE EXPRESSION; GLUTATHIONE METABOLISM; ISOLATED LIVER; LIVER METABOLISM; LIVER PERFUSION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BILE; GLUTATHIONE; ISOENZYMES; LIVER; MALE; METHIONINE ADENOSYLTRANSFERASE; ORGAN CULTURE TECHNIQUES; RATS; RATS, WISTAR; URSODEOXYCHOLIC ACID;

EID: 0036109728     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.50.5.701     Document Type: Article

References (45)

1. Glutathione as a primary osmotic driving force in hepatic bile formation
2. Detoxication: Deconjugation and hydrolysis
3. Glutathione metabolism and its role in hepatotoxicity
4. Endogenous glutathione conjugates: Occurrence and biological functions
5. Regulation of gamma-glutamylcysteine synthetase by nonallosteric feedback inhibition by glutathione
6. S-adenosylmethionine: A new intermediate formed enzymatically from L-methionine and adenosine-triphosphate
7. Biochemical methylation: Selected aspects
8. S-adenosylmethionine and the liver
9. Modulation of rat liver S-adenosylmethionine synthetase activity by glutathione
10. Nitric oxide inactivates rat hepatic methionine adenosyltransferase in vivo by S-nitrosylation
11. In vivo regulation by glutathione of methionine adenosyltransferase S-nitrosylation in rat liver
12. Consensus nomenclature for the mammalian methionine adenosyltransferase genes and gene products
13. 4-stimulated choleresis in isolated rat liver
14. The isolated perfused rat liver: Conceptual and practical considerations
15. Rapid oxidation in vitro of endogenous and exogenous glutathione in bile of rats
16. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues
17. Glutathione biosynthesis; γ-glutamylcysteine synthetase from rat kidney
18. An improved pyrogallol red-molybdate method for determining total urinary protein
19. S-adenosyl-L-methionine synthetase and phospholipid methyltransferase are inhibited in human cirrhosis
20. Purification and comparison of two forms of S-adenosyl-L-methionine synthetase from rat liver
21. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
22. Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose
23. Analysis of the 5′ non-coding region of rat liver S-adenosylmethionine synthetase mRNA and comparison of the Mr deduced from the cDNA sequence and the purified enzyme
24. Cloning and characterization of inducible nitric oxide synthase from mouse macrophages
25. Molecular cloning of a gene sequence regulated by nerve growth factor
26. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding
27. Site-directed mutagenesis of rat liver S-adenosylmethionine synthetase - Identification of a cysteine residue critical for the oligomeric state
28. Biochemical and ultrastructural evaluation of isolated rat liver systems perfused with a hemoglobin-free medium
29. Regulation of rat liver S-adenosylmethionine synthetase during septic shock: Role of nitric oxide
30. Interaction of liver methionine adenosyltransferase with hydroxyl radical
31. Bile acid secretion, bile flow and biliary lipid secretion in humans
32. Role of hepatic γ-glutamyltransferase in the degradation of circulating glutathione: Studies in the intact guinea pig perfused liver
33. Effects of bile acids and their glycine conjugates on γ-glutamyl transpeptidase
34. Modulation of gamma-glutamyl transpeptidase activity by bile acids
35. Inhibition of glutathione synthesis in the liver leads to S-adenosyl-L-methionine synthetase reduction
36. Ursodeoxycholic acid protects hepatocytes against oxidative injury via induction of antioxidants
37. Adsorption of mixtures of bile salt taurine conjugates to lecithin- cholesterol membranes: Implications for bile salt toxicity and cytoprotection
38. Ursodeoxycholic acid in cholestasis: Potential mechanisms of action and therapeutic applications
39. S-adenosylmethionine protects against acetaminophen hepatotoxicity in two mouse models
40. Review article: S-adenosyl-L-methionine - A new therapeutic agent in liver disease?
41. Protective role of S-adenosyl-L-methionine on liver injury induced by D-galactosamine in rats
42. +-ATPase, membrane fluidity, and bile flow in rats with ethinyl estradiol-induced cholestasis
43. Effects of S-adenosylmethionine on lipid peroxidation and liver fibrogenesis in carbon tetrachloride-induced cirrhosis
44. 4: A study with isolated and perfused rat liver