The covalent modification and regulation of TLR8 in HEK-293 cells stimulated with imidazoquinoline agonists

Biochemical Journal

Volumn 409, Issue 1, 2008, Pages 275-287

  Rajagopal, Raj ^a   Waller, Andrew S ^a   Mendoza, James D ^a   Wightman, Paul D ^a  

^a 3M COMPANY   (United States)

Author keywords

Covalent modification; Immune response modifier; Toll like receptor (TLR); Toll interleukin 1 receptor (TIR) domain; Tyrosine phosphorylation; Ubiquitination

Indexed keywords

COVALENT MODIFICATION; IMMUNE RESPONSE MODIFIER; MOLECULAR PATTERNS;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MOLECULAR MASS; PATHOGENS; PEPTIDES; PHOSPHORYLATION;

CELLS;

IMIDAZOQUINOLINE AGONIST; IMIDAZOQUINOLINE DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUCIFERASE; PHENYLALANINE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN TYROSINE KINASE INHIBITOR; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; UNCLASSIFIED DRUG; IMIDAZOLE DERIVATIVE; PEPTIDE; QUINOLINE; QUINOLINE DERIVATIVE; RNA; TLR8 PROTEIN, HUMAN; TYROSINE; UBIQUITIN;

ARTICLE; CELL STRAIN HEK293; COVALENT BOND; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EMBRYO; IMMUNE RESPONSE; KIDNEY CELL; MASS SPECTROMETRY; MOLECULAR WEIGHT; MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA VIRUS; TANDEM MASS SPECTROMETRY; AMINO ACID SEQUENCE; CELL LINE; CHEMISTRY; DRUG POTENTIATION; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN MOTIF; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

MAMMALIA;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; CELL LINE; HUMANS; IMIDAZOLES; MAP KINASE SIGNALING SYSTEM; MOLECULAR SEQUENCE DATA; NF-KAPPA B; PEPTIDES; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; QUINOLINES; RNA; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 8; TYROSINE; UBIQUITIN;

EID: 38149021578     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20070519     Document Type: Article

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