Expression of Reg and cytokeratin 20 during ductal cell differentiation and proliferation in a mouse model of autoimmune diabetes

European Journal of Endocrinology

Volumn 141, Issue 6, 1999, Pages 644-652

  Anastasi, Emanuela ^b   Ponte, Eleonora ^c   Gradini, Roberto ^a   Bulotta, Angela ^c   Sale, Patrizio ^a   Tiberti, Claudio ^c   Okamoto, Hiroshi ^c   Dotta, Francesco ^c   Di Mario, Umberto ^c  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b DEM Foundation   (Italy)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKERATIN 20; GLUCOSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL REGENERATION; CONTROLLED STUDY; DIABETES MELLITUS; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; INSULITIS; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; STREPTOZOCIN DIABETES;

EID: 0033375401     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.0.1410644     Document Type: Article

References (28)

1. Logotheopoulos J. Islet regeneration and neogenesis. In Handbook of Physiology, Section 7, Endocrinology, Vol.1 pp 67-76. Eds DF Steiner & N Freinkel N. Washington: American Physiological Society, 1972.
2. Hellestrom C, Andersson A & Gunnarsson R. Regeneration of islet cells. Acta Endocrinologica 1996 83 (Suppl 205) 145-158.
3. Brockenbrough JS, Weir GC & Bonner-Weir S. Discordance of exocrine and endocrine growth after 90% pancreatectomy in rats. Diabetes 1988 37 232-236.
4. Bonner-Weir S, Baxter LA, Schuppin GT & Smith F. A second pathway for regeneration of adult exocrine and endocrine pancreas: a possible recapitulation of embryonic development. Diabetes 1993 2 1715-1720.
5. Sarvetnick NE & Gu D. Regeneration of pancreatic endocrine cells in interferon-gamma transgenic mice. Advances in Experimental Medicine and Biology 1992 321 85-89.
6. Wang RN, Klöppel G & Bouwens L. Duct-to-islet cell differentiation and islet growth in the pancreas of duct-ligated adult rats. Diabetologia 1995 38 1405-1411.
7. Yonemura Y, Takashima T, Miwa K, Miyazaki I, Yamamoto H & Okamoto H. Amelioration of diabetes mellitus in partially depancreatised rats by poly(ADP-ribose) synthetase inhibitors. Diabetes 1984 33 401-404.
8. Terazono K, Yamamoto H, Takasawa S, Shiga K, Yonemura Y, Tochino Y & Okamoto H. A novel gene activated in regenerating islet. Journal of Biological Chemistry 1988 263 2111-2114.
9. Francis PJ, Southgate JL, Wilkin TJ & Bone AJ. Expression of an islet regenerating (reg) gene in isolated rat islet: effects of nutrient and non-nutrient growth factors. Diabetologia 1992 35 258-242.
10. Miyaura C, Ling C & Appel M. Expression of reg gene/PSP, a pancreatic exocrine gene: relationship to changes in islet beta-cell mass. Molecular Endocrinology 1991 5 226-254.
11. Terazono K, Uchiyama Y, Ide M, Watanabe T, Yonekura H, Yamamoto H & Okamoto H. Expression of reg protein in rat regenerating islet and its co-localization with insulin in the beta cell secretory granules. Diabetologia 1991 33 250-252.
12. Moll R, Franke WW & Schiller DL The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells. Cell 1982 31 11-24.
13. Franke WW, Jahn L & Knapp AC Cytokeratins and desmosomal proteins in certain epithelioid and nonepithelial cells. In Cytoskeletal Proteins in Tumor Diagnosis. pp 151-172. Eds M Osborn & K Webber. Cold Spring Harbor:Cold Spring Harbor Laboratories, 1989.
14. Bouwens L, Wang RN, De Blay E, Pipeleers DG & Klöppel G. Cytokeratins as markers of ductal cell differentiation and islet neogenesis in the neonatal rat pancreas. Diabetes 1994 43 1279-1283.
15. Wang RN, Bouwens L & Klöppel G. Beta-cell growth in adolescent and adult rats treated with streptozotocin during the neonatal period. Diabetologia 1996 39 548-557.
16. O'Reilly LA, Gu D, Sarvetnick N, Edlund H, Phillips JM, Fulford T & Cooke A. α-Cell neogenesis in an animal model of IDDM. Diabetes 1997 46 599-606.
17. Like AA & Rossini AA. Streptozotocin-induced pancreatic insulitis: a new model of diabetes mellitus. Science 1976 193 415-417.
18. Gu D, Lee M, Krahl T & Sarvrtnick N. Transitional cells in the regenerating pancreas. Development 1994 120 1873-1881.
19. De Fazio A, Leary JA, Heley DW & Tattersall MHN Immunohistochemical detection of proliferating cells in vivo. Journal of Histochemistry and Cytochemistry 1987 5 571-577.
20. Gu D & Sarvetnik N. Epithelial cell proliferation and islet neogenesis in IFN-g transgenic mice. Development 1993 118 33-46.
21. Mosmann TR. Cytokines, is there biological meaning? Current Opinion in Immunology 1991 3 311-314.
22. Baeza NJ, Moriscot CI, Renaud WP, Okamoto H, Figarella CG & Vialettes BH. Pancreatic regenerating gene overexpression in the nonobese diabetic mouse during active diabetogenesis. Diabetes 1996 33 67-70.
23. Bone A, Banister SH & Zhan S. Islet cell defence and repair mechanisms in insulin-dependent diabetes: a role for the pancreatic regenerating (reg) gene. Biochemistry Society Transactions 1994 22 37-41.
24. Gross DJ, Weiss L, Reibstein I, van den Brand J, Okamoto H, Clark A & Slavin S. Amelioration of diabetes in nonobese-diabetic mice with advanced disease by linomide-induced immuno-regulation combined with Reg protein treatment. Endocrinology 1998 139 2369-2374.
25. Wang RN, Bouwens L & Klöppel G. Beta-cell growth in adolescent and adult rats treated with streptozotocin during the neonatal period. Diabetologia 1996 39 548-557.
26. Wang TC, Bonner-Weir S, Oates PS, Chulak MB Simon B, Merlino GT, Schmidt E & Brand S. Pancreatic gastrin stimulates islet differentiation of transforming growth factor α-induced ductular precursor cells. Journal of Clinical Investigation 1993 92 1349-1356.
27. Wang RN, Rehfeld JF, Nielsen FC & Klöppel G. Expression of gastrin and transforming growth factor-α during duct to islet cell differentiation in the pancreas of duct-ligated adult rats. Diabetologia 1997 40 887-893.
28. Vinik A, Rafaeloff R, Pittenger G, Rosenberg L & Duguid W. Induction of pancreatic islet neogenesis. Hormone and Metabolic Research 1997 29 278-293 (Symposium report).