Neuroplasticity in addiction: Cellular and transcriptional perspectives

Frontiers in Molecular Neuroscience

Volumn , Issue OCTOBER 2012, 2012, Pages

  Madsen, Heather B ^a   Brown, Robyn M ^a   Lawrence, Andrew J ^a,b  

^a FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Addiction; CREB; DeltafosB; DNA methylation; Epigenetics; Histone modification; Micrornas; Plasticity

Indexed keywords

ACETYLCYSTEINE; ALCOHOL; AMPA RECEPTOR; COCAINE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DNA METHYLTRANSFERASE 3A; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 3; METHAMPHETAMINE; METHYL CPG BINDING PROTEIN 2; MICRORNA; MICRORNA 212; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; UNCLASSIFIED DRUG;

DISEASE MODEL; DNA METHYLATION; DOPAMINERGIC NERVE CELL; DRUG DEPENDENCE; DRUG WITHDRAWAL; EPIGENETICS; EXCITATORY SYNAPSE; GABAERGIC TRANSMISSION; GENETIC TRANSCRIPTION; HISTONE MODIFICATION; HUMAN; INHIBITORY SYNAPSE; INSTRUMENTAL CONDITIONING; LEARNING DISORDER; LOCOMOTOR SENSITIZATION; LONG TERM DEPRESSION; LONG TERM POTENTIATION; MEMORY DISORDER; MOLECULAR DYNAMICS; NERVE CELL PLASTICITY; NERVE CHARACTERISTICS AND FUNCTIONS; NEUROPATHOLOGY; NEUROPATHY; NONHUMAN; NUCLEUS ACCUMBENS; PLACE PREFERENCE; REINFORCEMENT; REVIEW; SENSITIZATION; SYNAPSE; SYNAPSE POTENTIATION; VENTRAL TEGMENTUM;

EID: 84868159255     PISSN: 16625099     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnmol.2012.00099     Document Type: Review

References (205)

1. Abraham, W.C., and Bear, M.F. (1996). Metaplasticity: the plasticity of synaptic plasticity. Trends in Neurosciences 19, 126-130.
2. Ahmed, S.H. (2011). The science of making drug-addicted animals. Neuroscience.
3. Ahmed, S.H., and Koob, G.F. (1998). Transition from moderate to excessive drug intake: change in hedonic set point. Science 282, 298-300.
4. Amen, S.L., Piacentine, L.B., Ahmad, M.E., Li, S.-J., Mantsch, J.R., Risinger, R.C., and Baker, D.A. (2011). Repeated N-acetyl cysteine reduces cocaine seeking in rodents and craving in cocaine-dependent humans. Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology 36, 871-878.
5. Argilli, E., Sibley, D.R., Malenka, R.C., England, P.M., and Bonci, A. (2008). Mechanism and time course of cocaine-induced long-term potentiation in the ventral tegmental area. The Journal of neuroscience: the official journal of the Society for Neuroscience 28, 9092-9100.
6. Arias, J., Alberts, A.S., Brindle, P., Claret, F.X., Smeal, T., Karin, M., Feramisco, J., and Montminy, M. (1994). Activation of cAMP and mitogen responsive genes relies on a common nuclear factor. Nature 370, 226-229.
7. Backstrom, P., and Hyytia, P. (2004). Ionotropic glutamate receptor antagonists modulate cue- induced reinstatement of ethanol-seeking behavior. Alcoholism, Clinical and Experimental Research 28, 558-565.
8. Bannister, A.J., and Kouzarides, T. (1996). The CBP co-activator is a histone acetyltransferase. Nature 384, 641-643.
9. Bardo, M.T., and Bevins, R.A. (2000). Conditioned place preference: what does it add to our preclinical understanding of drug reward? Psychopharmacology 153, 31-43.
10. Barrot, M., Olivier, J.D.A., Perrotti, L.I., Dileone, R.J., Berton, O., Eisch, A.J., Impey, S., Storm, D.R., Neve, R.L., Yin, J.C., Zachariou, V., and Nestler, E.J. (2002). CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli. Proceedings of the National Academy of Sciences of the United States of America 99, 11435-11440.
11. Bartel, D.P. (2004). MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116, 281-297.
12. Bellone, C., and Luscher, C. (2006). Cocaine triggered AMPA receptor redistribution is reversed in vivo by mGluR-dependent long-term depression. Nature Neuroscience 9, 636-641.
13. Benwell, M.E.M., and Balfour, D.J.K. (1992). The effects of acute and repeated nicotine treatment on nucleus-accumbens dopamine and locomotor-activity. British Journal of Pharmacology 105, 849-856.
14. Berger, S.L. (2007). The complex language of chromatin regulation during transcription. Nature 447, 407-412.
15. Beyer, C.E., Stafford, D., Lesage, M.G., Glowa, J.R., and Steketee, J.D. (2001). Repeated exposure to inhaled toluene induces behavioral and neurochemical cross-sensitization to cocaine in rats. Psychopharmacology 154, 198-204.
16. Bibb, J.A., Chen, J., Taylor, J.R., Svenningsson, P., Nishi, A., Snyder, G.L., Yan, Z., Sagawa, Z.K., Ouimet, C.C., Nairn, A.C., Nestler, E.J., and Greengard, P. (2001). Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5. Nature 410, 376-380.
17. Bliss, T.V., and Lomo, T. (1973). Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J Physiol 232, 331-356.
18. Bonci, A., and Malenka, R.C. (1999). Properties and plasticity of excitatory synapses on dopaminergic and GABAergic cells in the ventral tegmental area. Journal of Neuroscience 19, 3723-3730.
19. Borgland, S.L., Malenka, R.C., and Bonci, A. (2004). Acute and chronic cocaine-induced potentiation of synaptic strength in the ventral tegmental area: electrophysiological and behavioral correlates in individual rats. Journal of Neuroscience 24, 7482-7490.
20. Borgland, S.L., Taha, S.A., Sarti, F., Fields, H.L., and Bonci, A. (2006). Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine. Neuron 49, 589-601.
21. Boudreau, A.C., Reimers, J.M., Milovanovic, M., and Wolf, M.E. (2007). Cell surface AMPA receptors in the rat nucleus accumbens increase during cocaine withdrawal but internalize after cocaine challenge in association with altered activation of mitogen-activated protein kinases. Journal of Neuroscience 27, 10621-10635.
22. Boudreau, A.C., and Wolf, M.E. (2005). Behavioral sensitization to cocaine is associated with increased AMPA receptor surface expression in the nucleus accumbens. Journal of Neuroscience 25, 9144-9151.
23. Brebner, K., Wong, T.P., Liu, L., Liu, Y., Campsall, P., Gray, S., Phelps, L., Phillips, A.G., and Wang, Y.T. (2005). Nucleus accumbens long-term depression and the expression of behavioral sensitization. Science 310, 1340-1343.
24. Bredy, T.W., Sun, Y.E., and Kobor, M.S. (2010). How the epigenome contributes to the development of psychiatric disorders. Developmental Psychobiology 52, 331-342.
25. Bredy, T.W., Wu, H., Crego, C., Zellhoefer, J., Sun, Y.E., and Barad, M. (2007). Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear. Learning & memory (Cold Spring Harbor, N.Y.) 14, 268-276.
26. Brown, M.T.C., Bellone, C., Mameli, M., Labouebe, G., Bocklisch, C., Balland, B., Dahan, L., Lujan, R., Deisseroth, K., and Luscher, C. (2010). Drug-driven AMPA receptor redistribution mimicked by selective dopamine neuron stimulation. PLoS One 5, e15870.
27. Brunzell, D.H., Mineur, Y.S., Neve, R.L., and Picciotto, M.R. (2009). Nucleus accumbens CREB activity is necessary for nicotine conditioned place preference. Neuropsychopharmacology 34, 1993-2001.
28. Cadoni, C., Pisanu, A., Solinas, M., Acquas, E., and Di Chiara, G. (2001). Behavioural sensitization after repeated exposure to Delta 9-tetrahydrocannabinol and cross-sensitization with morphine. Psychopharmacology 158, 259-266.
29. Cajal, S.R. (1894). La fine structure des centres nerveux. Proc R Soc Lond B Bio 55, 444-468.
30. Carlezon, W.A., Jr., Boundy, V.A., Haile, C.N., Lane, S.B., Kalb, R.G., Neve, R.L., and Nestler, E.J. (1997). Sensitization to morphine induced by viral-mediated gene transfer. Science (New York, N.Y.) 277, 812-814.
31. Carlezon, W.A., Jr., and Nestler, E.J. (2002). Elevated levels of GluR1 in the midbrain: a trigger for sensitization to drugs of abuse? Trends in Neurosciences 25, 610-615.
32. Carlezon, W.A., Jr., Thome, J., Olson, V.G., Lane-Ladd, S.B., Brodkin, E.S., Hiroi, N., Duman, R.S., Neve, R.L., and Nestler, E.J. (1998). Regulation of cocaine reward by CREB. Science 282, 2272-2275.
33. Cha-Molstad, H., Keller, D.M., Yochum, G.S., Impey, S., and Goodman, R.H. (2004). Cell-type-specific binding of the transcription factor CREB to the cAMP-response element. Proceedings of the National Academy of Sciences of the United States of America 101, 13572-13577.
34. Chao, J., and Nestler, E.J. (2004). Molecular neurobiology of drug addiction. Annual Review of Medicine 55, 113-132.
35. Chen, B.T., Bowers, M.S., Martin, M., Hopf, F.W., Guillory, A.M., Carelli, R.M., Chou, J.K., and Bonci, A. (2008). Cocaine but not natural reward self-administration nor passive cocaine infusion produces persistent LTP in the VTA. Neuron 59, 288-297.
36. Choe, E.S., Chung, K.T., Mao, L., and Wang, J.Q. (2002). Amphetamine increases phosphorylation of extracellular signal-regulated kinase and transcription factors in the rat striatum via group I metabotropic glutamate receptors. Neuropsychopharmacology 27, 565-575.
37. Choi, K.H., Whisler, K., Graham, D.L., and Self, D.W. (2006). Antisense-induced reduction in nucleus accumbens cyclic AMP response element binding protein attenuates cocaine reinforcement. Neuroscience 137, 373-383.
38. Citri, A., and Malenka, R.C. (2008). Synaptic plasticity: multiple forms, functions, and mechanisms. Neuropsychopharmacology 33, 18-41.
39. Colby, C.R., Whisler, K., Steffen, C., Nestler, E.J., and Self, D.W. (2003). Striatal cell type-specific overexpression of DeltaFosB enhances incentive for cocaine. Journal of Neuroscience 23, 2488-2493.
40. Conrad, K.L., Tseng, K.Y., Uejima, J.L., Reimers, J.M., Heng, L.-J., Shaham, Y., Marinelli, M., and Wolf, M.E. (2008). Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving. Nature 454, 118-121.
41. Cornish, J.L., and Kalivas, P.W. (2000). Glutamate transmission in the nucleus accumbens mediates relapse in cocaine addiction. Journal of Neuroscience 20, RC89.
42. Crombag, H.S., and Shaham, Y. (2002). Renewal of drug seeking by contextual cues after prolonged extinction in rats. Behavioral Neuroscience 116, 169-173.
43. Cunningham, C.L., and Noble, D. (1992). Conditioned activation induced by ethanol - role in sensitization and conditioned place preference. Pharmacology, Biochemistry and Behavior 43, 307-313.
44. Denu, J.M. (2005). The Sir 2 family of protein deacetylases. Current Opinion in Chemical Biology 9, 431-440.
45. Deroche-Gamonet, V., Belin, D., and Piazza, P.V. (2004). Evidence for addiction-like behavior in the rat. Science 305, 1014-1017.
46. Dewit, H., and Stewart, J. (1981). Reinstatement of cocaine-reinforced responding in the rat. Psychopharmacology 75, 134-143.
47. Di Chiara, G., and Imperato, A. (1988). Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proceedings of the National Academy of Sciences of the United States of America 85, 5274-5278.
48. Dobi, A., Seabold, G.K., Christensen, C.H., Bock, R., and Alvarez, V.A. (2011). Cocaine-induced plasticity in the nucleus accumbens is cell specific and develops without prolonged withdrawal. The Journal of neuroscience: the official journal of the Society for Neuroscience 31, 1895-1904.
49. Dong, Y., Green, T., Saal, D., Marie, H., Neve, R., Nestler, E.J., and Malenka, R.C. (2006). CREB modulates excitability of nucleus accumbens neurons. Nature Neuroscience 9, 475-477.
50. Dong, Y., Saal, D., Thomas, M., Faust, R., Bonci, A., Robinson, T., and Malenka, R.C. (2004). Cocaine-induced potentiation of synaptic strength in dopamine neurons: behavioral correlates in GluRA(-/-) mice. Proceedings of the National Academy of Sciences of the United States of America 101, 14282-14287.
51. Dumont, E.C., Mark, G.P., Mader, S., and Williams, J.T. (2005). Self-administration enhances excitatory synaptic transmission in the bed nucleus of the stria terminalis. Nature Neuroscience 8, 413-414.
52. Engblom, D., Bilbao, A., Sanchis-Segura, C., Dahan, L., Perreau-Lenz, S., Balland, B., Parkitna, J.R., Lujan, R., Halbout, B., Mameli, M., Parlato, R., Sprengel, R., Luscher, C., Schutz, G., and Spanagel, R. (2008). Glutamate receptors on dopamine neurons control the persistence of cocaine seeking. Neuron 59, 497-508.
53. Erb, S., Shaham, Y., and Stewart, J. (1996). Stress reinstates cocaine-seeking behavior after prolonged extinction and a drug-free period. Psychopharmacology 128, 408-412.
54. Faleiro, L.J., Jones, S., and Kauer, J.A. (2004). Rapid synaptic plasticity of glutamatergic synapses on dopamine neurons in the ventral tegmental area in response to acute amphetamine injection. Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology 29, 2115-2125.
55. Famous, K.R., Kumaresan, V., Sadri-Vakili, G., Schmidt, H.D., Mierke, D.F., Cha, J.-H.J., and Pierce, R.C. (2008). Phosphorylation-dependent trafficking of GluR2-containing AMPA receptors in the nucleus accumbens plays a critical role in the reinstatement of cocaine seeking. Journal of Neuroscience 28, 11061-11070.
56. Fasano, S., Pittenger, C., and Brambilla, R. (2009). Inhibition of CREB activity in the dorsal portion of the striatum potentiates behavioral responses to drugs of abuse. Front Behav Neurosci 3, 29.
57. Ferrario, C.R., Li, X., Wang, X., Reimers, J.M., Uejima, J.L., and Wolf, M.E. (2010). The role of glutamate receptor redistribution in locomotor sensitization to cocaine. Neuropsychopharmacology 35, 818-833.
58. Fu, Y., Pollandt, S., Liu, J., Krishnan, B., Genzer, K., Orozco-Cabal, L., Gallagher, J.P., and Shinnick-Gallagher, P. (2007). Long-term potentiation (LTP) in the central amygdala (CeA) is enhanced after prolonged withdrawal from chronic cocaine and requires CRF1 receptors. Journal of Neurophysiology 97, 937-941.
59. Gao, M., Jin, Y., Yang, K., Zhang, D., Lukas, R.J., and Wu, J. (2010). Mechanisms involved in systemic nicotine-induced glutamatergic synaptic plasticity on dopamine neurons in the ventral tegmental area. The Journal of neuroscience: the official journal of the Society for Neuroscience 30, 13814-13825.
60. Geisler, S., and Wise, R.A. (2008). Functional implications of glutamatergic projections to the ventral tegmental area. Reviews in the Neurosciences 19, 227-244.
61. Goldman, D., Oroszi, G., and Ducci, F. (2005). The genetics of addictions: uncovering the genes. Nature reviews. Genetics 6, 521-532.
62. Good, C.H., and Lupica, C.R. (2010). Afferent-specific AMPA receptor subunit composition and regulation of synaptic plasticity in midbrain dopamine neurons by abused drugs. The Journal of neuroscience: the official journal of the Society for Neuroscience 30, 7900-7909.
63. Graham, D.L., Edwards, S., Bachtell, R.K., Dileone, R.J., Rios, M., and Self, D.W. (2007). Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse. Nature Neuroscience 10, 1029-1037.
64. Graybiel, A.M., Moratalla, R., and Robertson, H.A. (1990). Amphetamine and cocaine induce drug-specific activation of the c-fos gene in striosome-matrix compartments and limbic subdivisions of the striatum. Proceedings of the National Academy of Sciences of the United States of America 87, 6912-6916.
65. Green, T.A., Alibhai, I.N., Roybal, C.N., Winstanley, C.A., Theobald, D.E.H., Birnbaum, S.G., Graham, A.R., Unterberg, S., Graham, D.L., Vialou, V., Bass, C.E., Terwilliger, E.F., Bardo, M.T., and Nestler, E.J. (2010). Environmental enrichment produces a behavioral phenotype mediated by low cyclic adenosine monophosphate response element binding (CREB) activity in the nucleus accumbens. Biological Psychiatry 67, 28-35.
66. Grillner, P., and Mercuri, N.B. (2002). Intrinsic membrane properties and synaptic inputs regulating the firing activity of the dopamine neurons. Behavioural Brain Research 130, 149-169.
67. Grimm, J.W., Lu, L., Hayashi, T., Hope, B.T., Su, T.-P., and Shaham, Y. (2003). Time-dependent increases in brain-derived neurotrophic factor protein levels within the mesolimbic dopamine system after withdrawal from cocaine: implications for incubation of cocaine craving. Journal of Neuroscience 23, 742-747.
68. Guan, Y.-Z., and Ye, J.-H. (2010). Ethanol blocks long-term potentiation of GABAergic synapses in the ventral tegmental area involving mu-opioid receptors. Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology 35, 1841-1849.
69. Ho, S.-Y., Chen, C.-H., Liu, T.-H., Chang, H.-F., and Liou, J.-C. (2012). Protein kinase mzeta is necessary for cocaine-induced synaptic potentiation in the ventral tegmental area. Biological Psychiatry 71, 706-713.
70. Hollander, J.A., Im, H.-I., Amelio, A.L., Kocerha, J., Bali, P., Lu, Q., Willoughby, D., Wahlestedt, C., Conkright, M.D., and Kenny, P.J. (2010). Striatal microRNA controls cocaine intake through CREB signalling. Nature 466, 197-202.
71. Hope, B., Kosofsky, B., Hyman, S.E., and Nestler, E.J. (1992). Regulation of immediate early gene expression and AP-1 binding in the rat nucleus accumbens by chronic cocaine. Proceedings of the National Academy of Sciences of the United States of America 89, 5764-5768.
72. Hope, B.T., Nye, H.E., Kelz, M.B., Self, D.W., Iadarola, M.J., Nakabeppu, Y., Duman, R.S., and Nestler, E.J. (1994). Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments. Neuron 13, 1235-1244.
73. Horger, B.A., Iyasere, C.A., Berhow, M.T., Messer, C.J., Nestler, E.J., and Taylor, J.R. (1999). Enhancement of locomotor activity and conditioned reward to cocaine by brain-derived neurotrophic factor. Journal of Neuroscience 19, 4110-4122.
74. Huang, Y.H., Lin, Y., Mu, P., Lee, B.R., Brown, T.E., Wayman, G., Marie, H., Liu, W., Yan, Z., Sorg, B.A., Schluter, O.M., Zukin, R.S., and Dong, Y. (2009). In vivo cocaine experience generates silent synapses. Neuron 63, 40-47.
75. Hyman, S.E. (2005). Addiction: a disease of learning and memory. The American journal of psychiatry 162, 1414-1422.
76. Hyman, S.E., Malenka, R.C., and Nestler, E.J. (2006). Neural mechanisms of addiction: the role of reward-related learning and memory. Annual Review of Neuroscience 29, 565-598.
77. Im, H.-I., Hollander, J.A., Bali, P., and Kenny, P.J. (2010). MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212. Nature Neuroscience 13, 1120-1127.
78. Isaac, J.T., Nicoll, R.A., and Malenka, R.C. (1995). Evidence for silent synapses: implications for the expression of LTP. Neuron 15, 427-434.
79. Isaac, J.T.R., Ashby, M.C., and Mcbain, C.J. (2007). The role of the GluR2 subunit in AMPA receptor function and synaptic plasticity. Neuron 54, 859-871.
80. Itzhak, Y., and Martin, J.L. (1999). Effects of cocaine, nicotine, dizocipline and alcohol on mice locomotor activity: cocaine-alcohol cross-sensitization involves upregulation of striatal dopamine transporter binding sites. Brain Research 818, 204-211.
81. Jeanes, Z.M., Buske, T.R., and Morrisett, R.A. (2011). In vivo chronic intermittent ethanol exposure reverses the polarity of synaptic plasticity in the nucleus accumbens shell. The Journal of pharmacology and experimental therapeutics 336, 155-164.
82. Jing, L., Luo, J., Zhang, M., Qin, W.-J., Li, Y.-L., Liu, Q., Wang, Y.-T., Lawrence, A.J., and Liang, J.-H. (2011). Effect of the histone deacetylase inhibitors on behavioural sensitization to a single morphine exposure in mice. Neuroscience Letters 494, 169-173.
83. Kalivas, P.W. (2009). The glutamate homeostasis hypothesis of addiction. Nat Rev Neurosci 10, 561-572.
84. Kalivas, P.W., and Duffy, P. (1987). Sensitization to repeated morphine injection in the rat - possible involvement of A10 dopamine neurons. Journal of Pharmacology and Experimental Therapeutics 241, 204-212.
85. Kalivas, P.W., Lalumiere, R.T., Knackstedt, L., and Shen, H. (2009). Glutamate transmission in addiction. Neuropharmacology 56 Suppl 1, 169-173.
86. Kalivas, P.W., and O'brien, C. (2008). Drug addiction as a pathology of staged neuroplasticity. Neuropsychopharmacology 33, 166-180.
87. Kalivas, P.W., Volkow, N., and Seamans, J. (2005). Unmanageable motivation in addiction: a pathology in prefrontal-accumbens glutamate transmission. Neuron 45, 647-650.
88. Kandel, D. (1975). Stages in adolescent involvement in drug-use. Science 190, 912-914.
89. Kandel, D.B., Yamaguchi, K., and Chen, K. (1992). Stages of progression in drug involvement from adolescence to adulthood - further evidence for the gateway theory. Journal of Studies on Alcohol 53, 447-457.
90. Kandel, E.R. (2001). The molecular biology of memory storage: a dialogue between genes and synapses. Science (New York, N.Y.) 294, 1030-1038.
91. Kano, T., Suzuki, Y., Shibuya, M., Kiuchi, K., and Hagiwara, M. (1995). Cocaine-induced CREB phosphorylation and c-Fos expression are suppressed in Parkinsonism model mice. Neuroreport 6, 2197-2200.
92. Kao, J.-H., Huang, E.Y.-K., and Tao, P.-L. (2011). NR2B subunit of NMDA receptor at nucleus accumbens is involved in morphine rewarding effect by siRNA study. Drug and Alcohol Dependence 118, 366-374.
93. Kasanetz, F., Deroche-Gamonet, V., Berson, N., Balado, E., Lafourcade, M., Manzoni, O., and Piazza, P.V. (2010). Transition to addiction is associated with a persistent impairment in synaptic plasticity. Science 328, 1709-1712.
94. Kauer, J.A., and Malenka, R.C. (2007). Synaptic plasticity and addiction. Nat Rev Neurosci 8, 844-858.
95. Kelley, A.E. (2004). Ventral striatal control of appetitive motivation: role in ingestive behavior and reward-related learning. Neuroscience and Biobehavioral Reviews 27, 765-776.
96. Kelz, M.B., Chen, J., Carlezon, W.A., Jr., Whisler, K., Gilden, L., Beckmann, A.M., Steffen, C., Zhang, Y.J., Marotti, L., Self, D.W., Tkatch, T., Baranauskas, G., Surmeier, D.J., Neve, R.L., Duman, R.S., Picciotto, M.R., and Nestler, E.J. (1999). Expression of the transcription factor deltaFosB in the brain controls sensitivity to cocaine. Nature 401, 272-276.
97. Kendler, K.S., Myers, J., and Prescott, C.A. (2007). Specificity of genetic and environmental risk factors for symptoms of cannabis, cocaine, alcohol, caffeine, and nicotine dependence. Archives of General Psychiatry 64, 1313-1320.
98. Konradi, C., Cole, R.L., Heckers, S., and Hyman, S.E. (1994). Amphetamine regulates gene expression in rat striatum via transcription factor CREB. Journal of Neuroscience 14, 5623-5634.
99. Kourrich, S., Rothwell, P.E., Klug, J.R., and Thomas, M.J. (2007). Cocaine experience controls bidirectional synaptic plasticity in the nucleus accumbens. Journal of Neuroscience 27, 7921-7928.
100. Kouzarides, T. (2007). Chromatin modifications and their function. Cell 128, 693-705.
101. Kumar, A., Choi, K.-H., Renthal, W., Tsankova, N.M., Theobald, D.E.H., Truong, H.-T., Russo, S.J., Laplant, Q., Sasaki, T.S., Whistler, K.N., Neve, R.L., Self, D.W., and Nestler, E.J. (2005). Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum. Neuron 48, 303-314.
102. Lalumiere, R.T., and Kalivas, P.W. (2008). Glutamate release in the nucleus accumbens core is necessary for heroin seeking. Journal of Neuroscience 28, 3170-3177.
103. Lammel, S., Ion, D.I., Roeper, J., and Malenka, R.C. (2011). Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli. Neuron 70, 855-862.
104. Laplant, Q., Vialou, V., Covington, H.E., 3rd, Dumitriu, D., Feng, J., Warren, B.L., Maze, I., Dietz, D.M., Watts, E.L., Iniguez, S.D., Koo, J.W., Mouzon, E., Renthal, W., Hollis, F., Wang, H., Noonan, M.A., Ren, Y., Eisch, A.J., Bolanos, C.A., Kabbaj, M., Xiao, G., Neve, R.L., Hurd, Y.L., Oosting, R.S., Fan, G., Morrison, J.H., and Nestler, E.J. (2010). Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. Nature Neuroscience 13, 1137-1143.
105. Larson, E.B., Graham, D.L., Arzaga, R.R., Buzin, N., Webb, J., Green, T.A., Bass, C.E., Neve, R.L., Terwilliger, E.F., Nestler, E.J., and Self, D.W. (2011). Overexpression of CREB in the nucleus accumbens shell increases cocaine reinforcement in self-administering rats. Journal of Neuroscience 31, 16447-16457.
106. Lattal, K.M., Barrett, R.M., and Wood, M.A. (2007). Systemic or intrahippocampal delivery of histone deacetylase inhibitors facilitates fear extinction. Behavioral Neuroscience 121, 1125-1131.
107. Le Moal, M., and Simon, H. (1991). Mesocorticolimbic dopaminergic network: functional and regulatory roles. Physiological Reviews 71, 155-234.
108. Letchworth, S.R., Nader, M.A., Smith, H.R., Friedman, D.P., and Porrino, L.J. (2001). Progression of changes in dopamine transporter binding site density as a result of cocaine self-administration in rhesus monkeys. Journal of Neuroscience 21, 2799-2807.
109. Levine, A., Huang, Y., Drisaldi, B., Griffin, E.A., Jr., Pollak, D.D., Xu, S., Yin, D., Schaffran, C., Kandel, D.B., and Kandel, E.R. (2011). Molecular mechanism for a gateway drug: epigenetic changes initiated by nicotine prime gene expression by cocaine. Science translational medicine 3, 107 ra109.
110. Levine, A.A., Guan, Z., Barco, A., Xu, S., Kandel, E.R., and Schwartz, J.H. (2005). CREB-binding protein controls response to cocaine by acetylating histones at the fosB promoter in the mouse striatum. Proceedings of the National Academy of Sciences of the United States of America 102, 19186-19191.
111. Liu, Q.-S., Pu, L., and Poo, M.-M. (2005). Repeated cocaine exposure in vivo facilitates LTP induction in midbrain dopamine neurons. Nature 437, 1027-1031.
112. Loidl, P. (1994). Histone acetylation: facts and questions. Chromosoma 103, 441-449.
113. Luger, K., Mader, A.W., Richmond, R.K., Sargent, D.F., and Richmond, T.J. (1997). Crystal structure of the nucleosome core particle at 2.8 A resolution. Nature 389, 251-260.
114. Luscher, C., and Malenka, R.C. (2011). Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling. Neuron 69, 650-663.
115. Luu, P., and Malenka, R.C. (2008). Spike timing-dependent long-term potentiation in ventral tegmental area dopamine cells requires PKC. Journal of Neurophysiology 100, 533-538.
116. Madsen, H.B., Navaratnarajah, S., Farrugia, J., Djouma, E., Ehrlich, M., Mantamadiotis, T., Van Deursen, J., and Lawrence, A.J. (2012). CREB1 and CREB-binding protein in striatal medium spiny neurons regulate behavioural responses to psychostimulants. Psychopharmacology 219, 699-713.
117. Malenka, R.C., and Bear, M.F. (2004). LTP and LTD: an embarrassment of riches. Neuron 44, 5-21.
118. Malvaez, M., Mhillaj, E., Matheos, D.P., Palmery, M., and Wood, M.A. (2011). CBP in the nucleus accumbens regulates cocaine-induced histone acetylation and is critical for cocaine-associated behaviors. Journal of Neuroscience 31, 16941-16948.
119. Malvaez, M., Sanchis-Segura, C., Vo, D., Lattal, K.M., and Wood, M.A. (2010). Modulation of Chromatin Modification Facilitates Extinction of Cocaine-Induced Conditioned Place Preference. Biological Psychiatry 67, 36-43.
120. Mameli, M., Balland, B., Lujan, R., and Luscher, C. (2007). Rapid synthesis and synaptic insertion of GluR2 for mGluR-LTD in the ventral tegmental area. Science 317, 530-533.
121. Mameli, M., Bellone, C., Brown, M.T.C., and Luscher, C. (2011). Cocaine inverts rules for synaptic plasticity of glutamate transmission in the ventral tegmental area. Nature Neuroscience 14, 414-416.
122. Mameli, M., Halbout, B., Creton, C., Engblom, D., Parkitna, J.R., Spanagel, R., and Luscher, C. (2009). Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc. Nature Neuroscience 12, 1036-1041.
123. Mao, D., Gallagher, K., and Mcgehee, D.S. (2011). Nicotine potentiation of excitatory inputs to ventral tegmental area dopamine neurons. The Journal of neuroscience: the official journal of the Society for Neuroscience 31, 6710-6720.
124. Martin, M., Chen, B.T., Hopf, F.W., Bowers, M.S., and Bonci, A. (2006). Cocaine self-administration selectively abolishes LTD in the core of the nucleus accumbens. Nature Neuroscience 9, 868-869.
125. Mayr, B., and Montminy, M. (2001). Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol 2, 599-609.
126. Maze, I., Covington, H.E., 3rd, Dietz, D.M., Laplant, Q., Renthal, W., Russo, S.J., Mechanic, M., Mouzon, E., Neve, R.L., Haggarty, S.J., Ren, Y., Sampath, S.C., Hurd, Y.L., Greengard, P., Tarakhovsky, A., Schaefer, A., and Nestler, E.J. (2010). Essential role of the histone methyltransferase G9a in cocaine-induced plasticity. Science 327, 213-216.
127. Maze, I., Feng, J., Wilkinson, M.B., Sun, H., Shen, L., and Nestler, E.J. (2011). Cocaine dynamically regulates heterochromatin and repetitive element unsilencing in nucleus accumbens. Proceedings of the National Academy of Sciences of the United States of America 108, 3035-3040.
128. Maze, I., and Nestler, E.J. (2011). The epigenetic landscape of addiction. Annals of the New York Academy of Sciences 1216, 99-113.
129. Mcclung, C.A., and Nestler, E.J. (2003). Regulation of gene expression and cocaine reward by CREB and DeltaFosB. Nature Neuroscience 6, 1208-1215.
130. Mccutcheon, J.E., Wang, X., Tseng, K.Y., Wolf, M.E., and Marinelli, M. (2011). Calcium-permeable AMPA receptors are present in nucleus accumbens synapses after prolonged withdrawal from cocaine self-administration but not experimenter-administered cocaine. The Journal of neuroscience: the official journal of the Society for Neuroscience 31, 5737-5743.
131. Mcdaid, J., Graham, M.P., and Napier, T.C. (2006). Methamphetamine-induced sensitization differentially alters pCREB and DeltaFosB throughout the limbic circuit of the mammalian brain. Molecular Pharmacology 70, 2064-2074.
132. Mcfarland, K., Lapish, C.C., and Kalivas, P.W. (2003). Prefrontal glutamate release into the core of the nucleus accumbens mediates cocaine-induced reinstatement of drug-seeking behavior. Journal of Neuroscience 23, 3531-3537.
133. Mcpherson, C.S., Mantamadiotis, T., Tan, S.-S., and Lawrence, A.J. (2010). Deletion of CREB1 from the dorsal telencephalon reduces motivational properties of cocaine. Cerebral Cortex 20, 941-952.
134. Mcquown, S.C., and Wood, M.A. (2010). Epigenetic regulation in substance use disorders. Curr Psychiatry Rep 12, 145-153.
135. Meil, W.M., and See, R.E. (1996). Conditioned cued recovery of responding following prolonged withdrawal from self-administered cocaine in rats: an animal model of relapse. Behavioural Pharmacology 7, 754-763.
136. Melis, M., Camarini, R., Ungless, M.A., and Bonci, A. (2002). Long-lasting potentiation of GABAergic synapses in dopamine neurons after a single in vivo ethanol exposure. The Journal of neuroscience: the official journal of the Society for Neuroscience 22, 2074-2082.
137. Mitchell, P.J., and Tjian, R. (1989). Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. Science (New York, N.Y.) 245, 371-378.
138. Morgan, J.I., and Curran, T. (1995). Immediate-early genes: ten years on. Trends in Neurosciences 18, 66-67.
139. Moussawi, K., Pacchioni, A., Moran, M., Olive, M.F., Gass, J.T., Lavin, A., and Kalivas, P.W. (2009). N-Acetylcysteine reverses cocaine-induced metaplasticity. Nature Neuroscience 12, 182-189.
140. Moussawi, K., Zhou, W., Shen, H., Reichel, C.M., See, R.E., Carr, D.B., and Kalivas, P.W. (2011). Reversing cocaine-induced synaptic potentiation provides enduring protection from relapse. Proceedings of the National Academy of Sciences of the United States of America 108, 385-390.
141. Mueller, D., and Stewart, J. (2000). Cocaine-induced conditioned place preference: reinstatement by priming injections of cocaine after extinction. Behavioural Brain Research 115, 39-47.
142. Muller, D.L., and Unterwald, E.M. (2005). D1 dopamine receptors modulate deltaFosB induction in rat striatum after intermittent morphine administration. Journal of Pharmacology and Experimental Therapeutics 314, 148-154.
143. Myers, K.M., and Davis, M. (2002). Behavioral and neural analysis of extinction. Neuron 36, 567-584.
144. Nan, X., Ng, H.H., Johnson, C.A., Laherty, C.D., Turner, B.M., Eisenman, R.N., and Bird, A. (1998). Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393, 386-389.
145. Nestler, E.J. (2008). Review. Transcriptional mechanisms of addiction: role of DeltaFosB. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 363, 3245-3255.
146. Niehaus, J.L., Murali, M., and Kauer, J.A. (2010). Drugs of abuse and stress impair LTP at inhibitory synapses in the ventral tegmental area. European Journal of Neuroscience 32, 108-117.
147. Nugent, F.S., Penick, E.C., and Kauer, J.A. (2007). Opioids block long-term potentiation of inhibitory synapses. Nature 446, 1086-1090.
148. Nye, H.E., Hope, B.T., Kelz, M.B., Iadarola, M., and Nestler, E.J. (1995). Pharmacological studies of the regulation of chronic FOS-related antigen induction by cocaine in the striatum and nucleus accumbens. Journal of Pharmacology and Experimental Therapeutics 275, 1671-1680.
149. Nye, H.E., and Nestler, E.J. (1996). Induction of chronic Fos-related antigens in rat brain by chronic morphine administration. Molecular Pharmacology 49, 636-645.
150. O'brien, C.P. (1997). A range of research-based pharmacotherapies for addiction. Science 278, 66-70.
151. O'brien, C.P., Childress, A.R., Ehrman, R., and Robbins, S.J. (1998). Conditioning factors in drug abuse: can they explain compulsion? Journal of Psychopharmacology 12, 15-22.
152. Padgett, C.L., Lalive, A.L., Tan, K.R., Terunuma, M., Munoz, M.B., Pangalos, M.N., Martinez-Hernandez, J., Watanabe, M., Moss, S.J., Lujan, R., Luscher, C., and Slesinger, P.A. (2012). Methamphetamine-evoked depression of GABA(B) receptor signaling in GABA neurons of the VTA. Neuron 73, 978-989.
153. Pan, B., Hillard, C.J., and Liu, Q.-S. (2008). Endocannabinoid signaling mediates cocaine-induced inhibitory synaptic plasticity in midbrain dopamine neurons. Journal of Neuroscience 28, 1385-1397.
154. Pan, B., Zhong, P., Sun, D., and Liu, Q.-S. (2011). Extracellular signal-regulated kinase signaling in the ventral tegmental area mediates cocaine-induced synaptic plasticity and rewarding effects. Journal of Neuroscience 31, 11244-11255.
155. Pascoli, V., Turiault, M., and Luscher, C. (2012). Reversal of cocaine-evoked synaptic potentiation resets drug-induced adaptive behaviour. Nature 481, 71-75.
156. Peakman, M.C., Colby, C., Perrotti, L.I., Tekumalla, P., Carle, T., Ulery, P., Chao, J., Duman, C., Steffen, C., Monteggia, L., Allen, M.R., Stock, J.L., Duman, R.S., Mcneish, J.D., Barrot, M., Self, D.W., Nestler, E.J., and Schaeffer, E. (2003). Inducible, brain region-specific expression of a dominant negative mutant of c-Jun in transgenic mice decreases sensitivity to cocaine. Brain Research 970, 73-86.
157. Pich, E.M., Pagliusi, S.R., Tessari, M., Talabot-Ayer, D., Hooft Van Huijsduijnen, R., and Chiamulera, C. (1997). Common neural substrates for the addictive properties of nicotine and cocaine. Science 275, 83-86.
158. Ping, A., Xi, J., Prasad, B.M., Wang, M.-H., and Kruzich, P.J. (2008). Contributions of nucleus accumbens core and shell GluR1 containing AMPA receptors in AMPA- and cocaine-primed reinstatement of cocaine-seeking behavior. Brain Research 1215, 173-182.
159. Pliakas, A.M., Carlson, R.R., Neve, R.L., Konradi, C., Nestler, E.J., and Carlezon, W.A., Jr. (2001). Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated cAMP response element-binding protein expression in nucleus accumbens. Journal of Neuroscience 21, 7397-7403.
160. Porrino, L.J., Lyons, D., Smith, H.R., Daunais, J.B., and Nader, M.A. (2004). Cocaine self-administration produces a progressive involvement of limbic, association, and sensorimotor striatal domains. Journal of Neuroscience 24, 3554-3562.
161. Pulipparacharuvil, S., Renthal, W., Hale, C.F., Taniguchi, M., Xiao, G., Kumar, A., Russo, S.J., Sikder, D., Dewey, C.M., Davis, M.M., Greengard, P., Nairn, A.C., Nestler, E.J., and Cowan, C.W. (2008). Cocaine regulates MEF2 to control synaptic and behavioral plasticity. Neuron 59, 621-633.
162. Renthal, W., Kumar, A., Xiao, G., Wilkinson, M., Covington, H.E., 3rd, Maze, I., Sikder, D., Robison, A.J., Laplant, Q., Dietz, D.M., Russo, S.J., Vialou, V., Chakravarty, S., Kodadek, T.J., Stack, A., Kabbaj, M., and Nestler, E.J. (2009). Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins. Neuron 62, 335-348.
163. Renthal, W., Maze, I., Krishnan, V., Covington, H.E., 3rd, Xiao, G., Kumar, A., Russo, S.J., Graham, A., Tsankova, N., Kippin, T.E., Kerstetter, K.A., Neve, R.L., Haggarty, S.J., Mckinsey, T.A., Bassel-Duby, R., Olson, E.N., and Nestler, E.J. (2007). Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. Neuron 56, 517-529.
164. Renthal, W., and Nestler, E.J. (2008). Epigenetic mechanisms in drug addiction. Trends in Molecular Medicine 14, 341-350.
165. Rice, J.C., and Allis, C.D. (2001). Histone methylation versus histone acetylation: new insights into epigenetic regulation. Current Opinion in Cell Biology 13, 263-273.
166. Robinson, T.E., Jurson, P.A., Bennett, J.A., and Bentgen, K.M. (1988). Persistent sensitization of dopamine neurotransmission in ventral striatum (nucleus accumbens) produced by prior experience with (+)-amphetamine - a microdialysis study in freely moving rats. Brain Research 462, 211-222.
167. Robison, A.J., and Nestler, E.J. (2011). Transcriptional and epigenetic mechanisms of addiction. Nat Rev Neurosci 12, 623-637.
168. Romieu, P., Host, L., Gobaille, S., Sandner, G., Aunis, D., and Zwiller, J. (2008). Histone deacetylase inhibitors decrease cocaine but not sucrose self-administration in rats. Journal of Neuroscience 28, 9342-9348.
169. Russo, S.J., Wilkinson, M.B., Mazei-Robison, M.S., Dietz, D.M., Maze, I., Krishnan, V., Renthal, W., Graham, A., Birnbaum, S.G., Green, T.A., Robison, B., Lesselyong, A., Perrotti, L.I., Bolanos, C.A., Kumar, A., Clark, M.S., Neumaier, J.F., Neve, R.L., Bhakar, A.L., Barker, P.A., and Nestler, E.J. (2009). Nuclear factor kappa B signaling regulates neuronal morphology and cocaine reward. The Journal of neuroscience: the official journal of the Society for Neuroscience 29, 3529-3537.
170. Saal, D., Dong, Y., Bonci, A., and Malenka, R.C. (2003). Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neurons. Neuron 37, 577-582.
171. Sanchez, C.J., and Sorg, B.A. (2001). Conditioned fear stimuli reinstate cocaine-induced conditioned place preference. Brain Research 908, 86-92.
172. Sanchis-Segura, C., Lopez-Atalaya, J.P., and Barco, A. (2009). Selective boosting of transcriptional and behavioral responses to drugs of abuse by histone deacetylase inhibition. Neuropsychopharmacology 34, 2642-2654.
173. Schilstrom, B., Yaka, R., Argilli, E., Suvarna, N., Schumann, J., Chen, B.T., Carman, M., Singh, V., Mailliard, W.S., Ron, D., and Bonci, A. (2006). Cocaine enhances NMDA receptor-mediated currents in ventral tegmental area cells via dopamine D5 receptor-dependent redistribution of NMDA receptors. The Journal of neuroscience: the official journal of the Society for Neuroscience 26, 8549-8558.
174. Schumann, J., Matzner, H., Michaeli, A., and Yaka, R. (2009). NR2A/B-containing NMDA receptors mediate cocaine-induced synaptic plasticity in the VTA and cocaine psychomotor sensitization. Neuroscience Letters 461, 159-162.
175. Shaham, Y., and Stewart, J. (1995). Stress reinstates heroin-seeking in drug-free animals: an effect mimicking heroin, not withdrawal. Psychopharmacology 119, 334-341.
176. Shen, H.-W., Toda, S., Moussawi, K., Bouknight, A., Zahm, D.S., and Kalivas, P.W. (2009). Altered dendritic spine plasticity in cocaine-withdrawn rats. The Journal of neuroscience: the official journal of the Society for Neuroscience 29, 2876-2884.
177. Shen, H., Moussawi, K., Zhou, W., Toda, S., and Kalivas, P.W. (2011). Heroin relapse requires long-term potentiation-like plasticity mediated by NMDA2b-containing receptors. Proceedings of the National Academy of Sciences of the United States of America 108, 19407-19412.
178. Shepard, J.D., Bossert, J.M., Liu, S.Y., and Shaham, Y. (2004). The anxiogenic drug yohimbine reinstates methamphetamine seeking in a rat model of drug relapse. Biological Psychiatry 55, 1082-1089.
179. Shuster, L., Yu, G., and Bates, A. (1977). Sensitization to cocaine stimulation in mice. Psychopharmacology 52, 185-190.
180. Steketee, J.D. (2003). Neurotransmitter systems of the medial prefrontal cortex: potential role in sensitization to psychostimulants. Brain Research Reviews 41, 203-228.
181. Stolzenberg, D.S., Grant, P.A., and Bekiranov, S. (2011). Epigenetic methodologies for behavioral scientists. Hormones and Behavior 59, 407-416.
182. Strahl, B.D., and Allis, C.D. (2000). The language of covalent histone modifications. Nature 403, 41-45.
183. Stuber, G.D., Klanker, M., De Ridder, B., Bowers, M.S., Joosten, R.N., Feenstra, M.G., and Bonci, A. (2008). Reward-predictive cues enhance excitatory synaptic strength onto midbrain dopamine neurons. Science 321, 1690-1692.
184. Sun, J., Wang, L., Jiang, B., Hui, B., Lv, Z., and Ma, L. (2008). The effects of sodium butyrate, an inhibitor of histone deacetylase, on the cocaine- and sucrose-maintained self-administration in rats. Neuroscience Letters 441, 72-76.
185. Tan, K.R., Brown, M., Labouebe, G., Yvon, C., Creton, C., Fritschy, J.-M., Rudolph, U., and Luscher, C. (2010). Neural bases for addictive properties of benzodiazepines. Nature 463, 769-774.
186. Taniguchi, M., Carreira, M.B., Smith, L.N., Zirlin, B.C., Neve, R.L., and Cowan, C.W. (2012). Histone deacetylase 5 limits cocaine reward through cAMP-induced nuclear import. Neuron 73, 108-120.
187. Taverna, S.D., Li, H., Ruthenburg, A.J., Allis, C.D., and Patel, D.J. (2007). How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers. Nature Structural & Molecular Biology 14, 1025-1040.
188. Thomas, M.J., Beurrier, C., Bonci, A., and Malenka, R.C. (2001). Long-term depression in the nucleus accumbens: a neural correlate of behavioral sensitization to cocaine. Nature Neuroscience 4, 1217-1223.
189. Thomas, M.J., Kalivas, P.W., and Shaham, Y. (2008). Neuroplasticity in the mesolimbic dopamine system and cocaine addiction. British Journal of Pharmacology 154, 327-342.
190. Tiffany, S.T., and Drobes, D.J. (1990). Imagery and smoking urges: the manipulation of affective content. Addictive Behaviors 15, 531-539.
191. Tzschentke, T.M. (1998). Measuring reward with the conditioned place preference paradigm: a comprehensive review of drug effects, recent progress and new issues. Progress in Neurobiology 56, 613-672.
192. Ungless, M.A., Whistler, J.L., Malenka, R.C., and Bonci, A. (2001). Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons. Nature 411, 583-587.
193. Van Den Oever, M.C., Goriounova, N.A., Li, K.W., Van Der Schors, R.C., Binnekade, R., Schoffelmeer, A.N.M., Mansvelder, H.D., Smit, A.B., Spijker, S., and De Vries, T.J. (2008). Prefrontal cortex AMPA receptor plasticity is crucial for cue-induced relapse to heroin-seeking. Nature Neuroscience 11, 1053-1058.
194. Vanderschuren, L.J.M.J., and Everitt, B.J. (2004). Drug seeking becomes compulsive after prolonged cocaine self-administration. Science 305, 1017-1019.
195. Vezina, P., and Stewart, J. (1990). Amphetamine administered to the ventral tegmental area but not to the nucleus accumbens sensitizes rats to systemic morphine: lack of conditioned effects. Brain Research 516, 99-106.
196. Vo, N., Klein, M.E., Varlamova, O., Keller, D.M., Yamamoto, T., Goodman, R.H., and Impey, S. (2005). A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis. Proceedings of the National Academy of Sciences of the United States of America 102, 16426-16431.
197. Walters, C.L., and Blendy, J.A. (2001). Different requirements for cAMP response element binding protein in positive and negative reinforcing properties of drugs of abuse. Journal of Neuroscience 21, 9438-9444.
198. Wang, J., Fang, Q., Liu, Z., and Lu, L. (2006). Region-specific effects of brain corticotropin-releasing factor receptor type 1 blockade on footshock-stress- or drug-priming-induced reinstatement of morphine conditioned place preference in rats. Psychopharmacology 185, 19-28.
199. Weiss, F., Maldonado-Vlaar, C.S., Parsons, L.H., Kerr, T.M., Smith, D.L., and Ben-Shahar, O. (2000). Control of cocaine-seeking behavior by drug-associated stimuli in rats: effects on recovery of extinguished operant-responding and extracellular dopamine levels in amygdala and nucleus accumbens. Proceedings of the National Academy of Sciences of the United States of America 97, 4321-4326.
200. Wikler, A., and Pescor, F.T. (1967). Classical conditioning of a morphine abstinence phenomenon, reinforcement of opioid-drinking behavior and relapse in morphine-addicted rats. Psychopharmacologia 10, 255-284.
201. Wolf, M.E., and Tseng, K.Y. (2012). Calcium-permeable AMPA receptors in the VTA and nucleus accumbens after cocaine exposure: when, how, and why? Frontiers in molecular neuroscience 5, 72.
202. Wu, X., Shi, M., Wei, C., Yang, M., Liu, Y., Liu, Z., Zhang, X., and Ren, W. (2012). Potentiation of synaptic strength and intrinsic excitability in the nucleus accumbens after 10 days of morphine withdrawal. Journal of Neuroscience Research 90, 1270-1283.
203. Young, S.T., Porrino, L.J., and Iadarola, M.J. (1991). Cocaine induces striatal c-fos-immunoreactive proteins via dopaminergic D1 receptors. Proceedings of the National Academy of Sciences of the United States of America 88, 1291-1295.
204. Zachariou, V., Bolanos, C.A., Selley, D.E., Theobald, D., Cassidy, M.P., Kelz, M.B., Shaw-Lutchman, T., Berton, O., Sim-Selley, L.J., Dileone, R.J., Kumar, A., and Nestler, E.J. (2006). An essential role for DeltaFosB in the nucleus accumbens in morphine action. Nature Neuroscience 9, 205-211.
205. Zweifel, L.S., Argilli, E., Bonci, A., and Palmiter, R.D. (2008). Role of NMDA receptors in dopamine neurons for plasticity and addictive behaviors. Neuron 59, 486-496.