Environmental Enrichment Produces a Behavioral Phenotype Mediated by Low Cyclic Adenosine Monophosphate Response Element Binding (CREB) Activity in the Nucleus Accumbens

Biological Psychiatry

Volumn 67, Issue 1, 2010, Pages 28-35

  Green, Thomas A ^a   Alibhai, Imran N ^a   Roybal, C Nathaniel ^b   Winstanley, Catharine A ^a   Theobald, David E H ^a   Birnbaum, Shari G ^a   Graham, Ami R ^a   Unterberg, Stephen ^a   Graham, Danielle L ^a   Vialou, Vincent ^a   Bass, Caroline E ^c   Terwilliger, Ernest F ^c   Bardo, Michael T ^d   Nestler, Eric J ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^d UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Addiction; anxiety; craving; depression; differential rearing; drug abuse; drug addiction; forced swim test; incentive sensitization; relapse; salience

Indexed keywords

COCAINE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; SHORT HAIRPIN RNA; VIRUS VECTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANXIETY; ARTICLE; BEHAVIOR; BRAIN REGION; CONTROLLED STUDY; DEPRESSION; DRUG SELF ADMINISTRATION; ENVIRONMENTAL ENRICHMENT; MALE; NONHUMAN; NUCLEUS ACCUMBENS; PHENOTYPE; PLACE PREFERENCE; PRIORITY JOURNAL; RAT; REINFORCEMENT; REWARD;

ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; ANXIETY; BEHAVIOR, ANIMAL; BEHAVIORAL SYMPTOMS; BRAIN-DERIVED NEUROTROPHIC FACTOR; COCAINE; CONDITIONING, OPERANT; CREB-BINDING PROTEIN; DEPRESSION; DISEASE MODELS, ANIMAL; DOPAMINE UPTAKE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENT; FOOD PREFERENCES; MALE; NUCLEUS ACCUMBENS; PHENOTYPE; RATS; RATS, SPRAGUE-DAWLEY; REINFORCEMENT SCHEDULE; RNA, MESSENGER; RNA, SMALL INTERFERING; SELF ADMINISTRATION;

EID: 71349086128     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2009.06.022     Document Type: Article

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