Inducible, brain region-specific expression of a dominant negative mutant of c-Jun in transgenic mice decreases sensitivity to cocaine

Brain Research

Volumn 970, Issue 1-2, 2003, Pages 73-86

  Peakman, M C ^a,b   Colby, C ^b   Perrotti, L I ^c   Tekumalla, P ^b   Carle, T ^c   Ulery, P ^c   Chao, J ^b,c   Duman, C ^b   Steffen, C ^b,c   Monteggia, L ^b,c   Allen, M R ^a   Stock, J L ^a   Duman, R S ^b   McNeish, J D ^a   Barrot, M ^b,c   Self, D W ^b,c   Nestler, E J ^b,c,d   Schaeffer, E ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Cdk5; Drug addiction; GluR2; NF B; Nucleus accumbens; Tetracycline; Transgenic mouse; FosB

Indexed keywords

AMPA RECEPTOR; COCAINE; CYCLIN DEPENDENT KINASE 5; GLUTAMATE RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MUTANT PROTEIN; PROTEIN C JUN; PROTEIN FOS; PROTEIN SUBUNIT; TETRACYCLINE; TRANSCRIPTION FACTOR AP 1;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CONTROLLED STUDY; CORPUS STRIATUM; GENE CONTROL; LOCOMOTION; MALE; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; NUCLEUS ACCUMBENS; PLACE PREFERENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RAT; SENSITIZATION; TRANSGENIC MOUSE;

EID: 0347928858     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(03)02230-3     Document Type: Article

References (55)

1. Ang E., Chen J.S., Zagouras P., Magna H., Holland J., Schaeffer E., Nestler E.J. Induction of NFκB in nucleus accumbens by chronic cocaine administration. J. Neurochem. 79:2001;221-224.
2. Angulo J.A., McEwen B.S. Molecular aspects of neuropeptide regulation and function in the corpus striatum and nucleus accumbens. Brain Res. Rev. 19:1994;1-28.
3. Berke J.D., Hyman S.E. Addiction, dopamine, and the molecular mechanisms of memory. Neuron. 25:2000;515-532.
4. Bibb J.A., Chen J.S., Taylor J.R., Svenningsson P., Nishi A., Snyder G.L., Yan Z., Sagawa Z.K., Ouimet C.C., Nairn A.C., Nestler E.J., Greengard P.P. Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5. Nature. 410:2001;376-380.
5. Brown P.H., Alani R., Preis L.H., Szabo E., Birrer M.J. Suppression of oncogene-induced transformation by a deletion mutant of c-jun. Oncogene. 8:1993;877-886.
6. Brown P.H., Chen T.K., Birrer M.J. Mechanism of action of a dominant negative mutant of c-Jun. Oncogene. 9:1994;791-799.
7. Brown P.H., Kim S.-H., Wise S.C., Sabichi A.L., Birrer M.J. Dominant-negative mutants of cJun inhibit AP-1 activity through multiple mechanisms and with different potencies. Cell Growth Differ. 7:1996;1013-1021.
8. Chen J., Nye H.E., Kelz M.B., Hiroi N., Nakabeppu Y., Hope B.T., Nestler E.J. Regulation of ΔFosB and FosB-like proteins by electroconvulsive seizure and cocaine treatments. Mol. Pharmacol. 48:1995;880-889.
9. Chen J.S., Kelz M.B., Hope B.T., Nakabeppu Y., Nestler E.J. Chronic Fos-related antigens: stable variants of ΔFosB induced in brain by chronic treatments. J. Neurosci. 17:1997;4933-4941.
10. Chen J.S., Kelz M.B., Zeng G., Sakai N., Steffen C., Shockett P.E., Piccioto M.R., Duman R.S., Nestler E.J. Transgenic animals with inducible, targeted gene expression in brain. Mol. Pharmacol. 54:1998;495-503.
11. Chen J.S., Zhang Y.J., Kelz M.B., Steffen C., Ang E.S., Zeng L., Nestler E.J. Induction of cyclin-dependent kinase 5 in hippocampus by chronic electroconvulsive seizures: role of ΔFosB. J. Neurosci. 20:2000;8965-8971.
12. Cornish J.L., Kalivas P.W. Cocaine sensitization and craving: differing roles for dopamine and glutamate in the nucleus accumbens. J. Addict. Dis. 20:2001;43-54.
13. Couceyro P., Pollock K.M., Drews K., Douglass J. Cocaine differentially regulates activator protein-1 mRNA levels and DNA-binding complexes in the rat striatum and cerebellum. Mol. Pharmacol. 46:1994;667-676.
14. Daunais J.B., McGinty J.F. Acute and chronic cocaine administration differentially alters striatal opioid and nuclear transcription factor mRNAs. Synapse. 18:1994;35-45.
15. Dragunow M., Lawlor P., Chiasson B., Robertson H. c-fos antisense generates apomorphine and amphetamine-induced rotation. NeuroReport. 5:1993;305-306.
16. Everitt B.J., Wolf M.E. Psychomotor stimulant addiction: a neural systems perspective. J. Neurosci. 22:2002;3312-3320.
17. Forss-Petter S., Danielson P.E., Catsicas S., Battenberg E., Price J., Nerenberg M., Sutcliffe J.G. Transgenic mice expressing β-galactosidase in mature neurons under neuron-specific enolase promoter control. Neuron. 5:1990;187-197.
18. Gerfen C.R. The neostriatal mosaic: multiple levels of compartmental organization in the basal ganglia. Annu. Rev. Neurosci. 15:1992;285-320.
19. Graybiel A.M. The basal ganglia. Trends Neurosci. 18:1995;60-62.
20. Graybiel A.M., Moratalla R., Robertson H.A. Amphetamine and cocaine induce drug-specific activation of the c-fos gene in striosome-matrix compartments and limbic subdivisions of the striatum. Proc. Natl. Acad. Sci. USA. 87:1990;6912-6916.
21. Hallahan D.E., Dunphy E., Virudachalam S., Sukhatme V.P., Kufe D.W., Weichselbaum R.R. C-jun and Egr-1 participate in DNA synthesis and cell survival in response to ionizing radiation exposure. J. Biol. Chem. 270:1995;30303-30309.
22. Ham J., Babij C., Whitfield J., Pfarr C.M., Lallemand D., Yaniv M., Rubin L.L. A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death. Neuron. 14:1995;927-939.
23. Heilig M., Engel J.A., Soderpalm B. C-fos antisense in the nucleus accumbens blocks the locomotor stimulant action of cocaine. Eur. J. Pharmacol. 236:1993;339-340.
24. Hilberg F., Aguzzi A., Howells N., Wagner E.F. c-Jun is essential for normal mouse development and hepatogenesis. Nature. 365:1993;179-181.
25. Hirai S.I., Ryseck R.P., Mechta F., Bravo R., Yaniv M. Characterization of junD: a new member of the jun proto-oncogene family. EMBO J. 8:1989;1433-1439.
26. Hiroi N., Brown J., Haile C., Ye H., Greenberg M.E., Nestler E.J. FosB mutant mice: loss of chronic cocaine induction of Fos-related proteins and heightened sensitivity to cocaine's psychomotor and rewarding effects. Proc. Natl. Acad. Sci. USA. 94:1997;10397-10402.
27. Hope B., Kopofsky B., Hyman S., Nestler E.J. Regulation of immediate early gene expression and AP-1 binding in the rat nucleus accumbens by chronic cocaine. Proc. Natl. Acad. Sci. USA. 89:1992;5764-5768.
28. Hope B.T., Kelz M.B., Duman R.S., Nestler E.J. Chronic electroconvulsive seizure (ECS) treatment results in expression of a long-lasting AP-1 complex in brain with altered composition and characteristics. J. Neurosci. 14:1994;4318-4328.
29. Hope B.T., Nye H.E., Kelz M.B., Self D.W., Iadarola M.J., Nakabeppu Y., Duman R.S., Nestler E.J. Induction of a long lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments. Neuron. 13:1994;1235-1244.
30. Kelz M.B., Chen J., Carlezon W.A. Jr., Whisler K., Gilden L., Beckmann A.M., Steffen C., Zhang Y.-J., Marotti L., Self D.W., Tkatch T., Baranauskas G., Surmeier D.J., Neve R., Duman R.S., Piccioto M.R., Nestler E.J. Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine. Nature. 401:1999;272-276.
31. Kelz M.B., Nestler E.J. ΔFosB: a molecular switch underlying long-term neural plasticity. Curr. Opin. Neurol. 13:2000;715-720.
32. Koob G.F., Le Moal M. Drug abuse: hedonic homeostatic dysregulation. Science. 278:1997;52-58.
33. Kozak M. Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes. Nucleic Acids Res. 9:1981;5233-5252.
34. Leppä S., Saffrich R., Ansorge W., Bohmann D. Differential regulation of c-Jun by ERK and JNK during PC12 cell differentiation. EMBO J. 17:1998;4404-4413.
35. Li J.-J., Rhim J.S., Schlegel R., Vousden K.H., Colburn N.H. Expression of dominant negative Jun inhibits elevated AP-1 and NF-κB transactivation and suppresses anchorage independent growth of HPV immortalized human keratinocytes. Oncogene. 16:1998;2711-2721.
36. Lloyd A., Yancheva N., Wasylyk B. Transformation suppressor activity of a Jun transcription factor lacking its transactivation domain. Nature. 352:1991;635-638.
37. Lohman F.P., Gibbs S., Fischer D.F., Borgstein A.M., van de Putte P., Backendorf C. Involvement of c-JUN in the regulation of terminal differentiation genes in normal and malignant keratinocytes. Oncogene. 14:1997;1623-1627.
38. Moratalla R., Elibol B., Vallejo M., Graybiel A.M. Network-level changes in expression of inducible Fos-Jun proteins in the striatum during chronic cocaine treatment and withdrawal. Neuron. 17:1996;147-156.
39. Morgan J.I., Curran T. Immediate-early genes: ten years on. Trends Neurosci. 18:1995;66-67.
40. Nestler E.J. Molecular basis of long-term plasticity underlying drug addiction. Nat. Rev. Neurosci. 2:2001;19-128.
41. Nestler E.J., Hope B.T., Widnell K.L. Drug addiction: a model for the molecular basis of neural plasticity. Neuron. 11:1993;995-1006.
42. Nestler E.J., Barrot M., Self D.W. ΔFosB: a molecular switch for addiction. Proc. Natl. Acad. Sci. USA. 98:2001;11042-11046.
43. Nye H., Hope B.T., Kelz M., Iadarola M., Nestler E.J. Pharmacological studies of the regulation by cocaine of chronic Fra (Fos-related antigen) induction in the striatum and nucleus accumbens. J. Pharmacol. Exp. Ther. 275:1995;1671-1680.
44. Persico A.M., Uhl G.R. Transcription factors: potential roles in drug-induced neuroplasticity. Rev. Neurosci. 7:1996;233-275.
45. Ray P., Tang W., Wang P., Homer R., Kuhn C., Flavell R.A., Elias J.A. Regulated overexpression of interleukin 11 in the lung. Use to dissociate development-dependent and independent phenotypes. J. Clin. Invest. 100:1997;2501-2511.
46. Ryder K., Lau L.F., Nathans D. A gene activated by growth factors is related to the oncogene v-jun. Proc. Natl. Acad. Sci. USA. 85:1988;1487-1491.
47. Ryder K., Nathans D. Induction of protooncogene c-jun by serum growth factors. Proc Natl. Acad. Sci. USA. 85:1988;8464-8467.
48. Ryder K., Lanahan A., Perez-Albuerne E., Nathans D. Jun-D: a third member of the jun gene family. Proc. Natl. Acad. Sci. USA. 86:1989;1500-1503.
49. Self D.W., Nestler E.J. Relapse to drug seeking: neural and molecular mechanisms. Drug Alcohol Depend. 51:1998;49-60.
50. Shaham Y., Erb S., Stewart J. Stress-induced relapse to heroin and cocaine seeking in rats: a review. Brain Res. Rev. 33:2000;13-33.
51. Sommer W., Bjelke B., Ganten D., Fuxe K. Antisense oligonucleotide to c-fos induces ipsilateral rotational behaviour to D-amphetamine. NeuroReport. 5:1993;277-280.
52. Steiner H., Gerfen C.R. Role of dynorphin and enkephalin in the regulation of striatal output pathways and behavior. Exp. Brain Res. 123:1998;60-76.
53. Wise R.A. Drug-activation of brain reward pathways. Drug Alcohol Depend. 51:1998;13-22.
54. Young S.T., Porrino L.J., Iadarola M.J. Cocaine induces striatal c-fos-immunoreactive proteins via dopaminergic D1 receptors. Proc. Natl. Acad. Sci. USA. 88:1991;1291-1295.
55. C.R. Colby, K. Whisler, C. Steffen, E.J. Nestler, D.W. Self, ΔFosB enhances incentive for cocaine, J. Neurosci. in press.