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Volumn 92, Issue 4, 2012, Pages 775-785

Activation of type I interferon-dependent genes characterizes the "core response" induced by CpG DNA

Author keywords

CAL 1; Gene regulation; Human; Oligonucleotide; pDC; TLR9

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; INTERFERON; OLIGONUCLEOTIDE; TOLL LIKE RECEPTOR 9;

EID: 84868137189     PISSN: 07415400     EISSN: 19383673     Source Type: Journal    
DOI: 10.1189/jlb.1011522     Document Type: Article
Times cited : (19)

References (49)
  • 2
    • 0042123694 scopus 로고    scopus 로고
    • Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells
    • Lund, J., Sato, A., Akira, S., Medzhitov, R., Iwasaki, A. (2003) Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J. Exp. Med. 198, 513-520.
    • (2003) J. Exp. Med. , vol.198 , pp. 513-520
    • Lund, J.1    Sato, A.2    Akira, S.3    Medzhitov, R.4    Iwasaki, A.5
  • 3
    • 48749085127 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells: Sensing nucleic acids in viral infection and autoimmune diseases
    • Gilliet, M., Cao, W., Liu, Y. J. (2008) Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases. Nat. Rev. Immunol. 8, 594-606.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 594-606
    • Gilliet, M.1    Cao, W.2    Liu, Y.J.3
  • 4
    • 1842631153 scopus 로고    scopus 로고
    • Immunotherapeutic uses of CpG oligodeoxynucleotides
    • Klinman, D. M. (2004) Immunotherapeutic uses of CpG oligodeoxynucleotides. Nat. Rev. Immunol. 4, 249-258.
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 249-258
    • Klinman, D.M.1
  • 5
    • 0036587573 scopus 로고    scopus 로고
    • Differential and competitive activation of human immune cells by distinct classes of CpG oligodeoxynucleotides
    • Gursel, M., Verthelyi, D., Gursel, I., Ishii, K. J., Klinman, D. M. (2002) Differential and competitive activation of human immune cells by distinct classes of CpG oligodeoxynucleotides. J. Leukoc. Biol. 71, 813-820.
    • (2002) J. Leukoc. Biol. , vol.71 , pp. 813-820
    • Gursel, M.1    Verthelyi, D.2    Gursel, I.3    Ishii, K.J.4    Klinman, D.M.5
  • 6
    • 0035865054 scopus 로고    scopus 로고
    • Human peripheral blood cells differentially recognize and respond to two distinct CpG motifs
    • Verthelyi, D., Ishii, K. J., Gursel, M., Takeshita, F., Klinman, D. M. (2001) Human peripheral blood cells differentially recognize and respond to two distinct CpG motifs. J. Immunol. 166, 2372-2377.
    • (2001) J. Immunol. , vol.166 , pp. 2372-2377
    • Verthelyi, D.1    Ishii, K.J.2    Gursel, M.3    Takeshita, F.4    Klinman, D.M.5
  • 7
    • 0036569711 scopus 로고    scopus 로고
    • Role of mitogen-activated protein kinases in CpG DNA-mediated IL-10 and IL-12 production: Central role of extracellular signal-regulated kinase in the negative feedback loop of the CpG DNA-mediated Th1 response
    • Yi, A. K., Yoon, J. G., Yeo, S. J., Hong, S. C., English, B. K., Krieg, A. M. (2002) Role of mitogen-activated protein kinases in CpG DNA-mediated IL-10 and IL-12 production: central role of extracellular signal-regulated kinase in the negative feedback loop of the CpG DNA-mediated Th1 response. J. Immunol. 168, 4711-4720.
    • (2002) J. Immunol. , vol.168 , pp. 4711-4720
    • Yi, A.K.1    Yoon, J.G.2    Yeo, S.J.3    Hong, S.C.4    English, B.K.5    Krieg, A.M.6
  • 9
    • 0037407691 scopus 로고    scopus 로고
    • Activation with CpG-A and CpG-B oligonucleotides reveals two distinct regulatory pathways of type I IFN synthesis in human plasmacytoid dendritic cells
    • Kerkmann, M., Rothenfusser, S., Hornung, V., Towarowski, A., Wagner, M., Sarris, A., Giese, T., Endres, S., Hartmann, G. (2003) Activation with CpG-A and CpG-B oligonucleotides reveals two distinct regulatory pathways of type I IFN synthesis in human plasmacytoid dendritic cells. J. Immunol. 170, 4465-4474.
    • (2003) J. Immunol. , vol.170 , pp. 4465-4474
    • Kerkmann, M.1    Rothenfusser, S.2    Hornung, V.3    Towarowski, A.4    Wagner, M.5    Sarris, A.6    Giese, T.7    Endres, S.8    Hartmann, G.9
  • 10
    • 77956689533 scopus 로고    scopus 로고
    • Bifurcation of Toll-like receptor 9 signaling by adaptor protein 3
    • Sasai, M., Linehan, M. M., Iwasaki, A. (2010) Bifurcation of Toll-like receptor 9 signaling by adaptor protein 3. Science 329, 1530-1534.
    • (2010) Science , vol.329 , pp. 1530-1534
    • Sasai, M.1    Linehan, M.M.2    Iwasaki, A.3
  • 11
    • 33746884630 scopus 로고    scopus 로고
    • Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation
    • Guiducci, C., Ott, G., Chan, J. H., Damon, E., Calacsan, C., Matray, T., Lee, K. D., Coffman, R. L., Barrat, F. J. (2006) Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation. J. Exp. Med. 203, 1999-2008.
    • (2006) J. Exp. Med. , vol.203 , pp. 1999-2008
    • Guiducci, C.1    Ott, G.2    Chan, J.H.3    Damon, E.4    Calacsan, C.5    Matray, T.6    Lee, K.D.7    Coffman, R.L.8    Barrat, F.J.9
  • 12
    • 17844380477 scopus 로고    scopus 로고
    • Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction
    • Honda, K., Ohba, Y., Yanai, H., Negishi, H., Mizutani, T., Takaoka, A., Taya, C., Taniguchi, T. (2005) Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction. Nature 434, 1035-1040.
    • (2005) Nature , vol.434 , pp. 1035-1040
    • Honda, K.1    Ohba, Y.2    Yanai, H.3    Negishi, H.4    Mizutani, T.5    Takaoka, A.6    Taya, C.7    Taniguchi, T.8
  • 13
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern-recognition receptors in innate immunity: Update on Toll-like receptors
    • Kawai, T., Akira, S. (2010) The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat. Immunol. 11, 373-384.
    • (2010) Nat. Immunol. , vol.11 , pp. 373-384
    • Kawai, T.1    Akira, S.2
  • 14
    • 65549140232 scopus 로고    scopus 로고
    • Inductive and suppressive networks regulate TLR9-dependent gene expression in vivo
    • Klaschik, S., Tross, D., Klinman, D. M. (2009) Inductive and suppressive networks regulate TLR9-dependent gene expression in vivo. J. Leukoc. Biol. 85, 788-795.
    • (2009) J. Leukoc. Biol. , vol.85 , pp. 788-795
    • Klaschik, S.1    Tross, D.2    Klinman, D.M.3
  • 15
    • 67650357977 scopus 로고    scopus 로고
    • Global changes in gene expression and synergistic interactions induced by TLR9 and TLR3
    • Tross, D., Petrenko, L., Klaschik, S., Zhu, Q., Klinman, D. M. (2009) Global changes in gene expression and synergistic interactions induced by TLR9 and TLR3. Mol. Immunol. 46, 2557-2564.
    • (2009) Mol. Immunol. , vol.46 , pp. 2557-2564
    • Tross, D.1    Petrenko, L.2    Klaschik, S.3    Zhu, Q.4    Klinman, D.M.5
  • 18
    • 76949088399 scopus 로고    scopus 로고
    • Short-and long-term changes in gene expression mediated by the activation of TLR9
    • Klaschik, S., Tross, D., Shirota, H., Klinman, D. M. (2010) Short-and long-term changes in gene expression mediated by the activation of TLR9. Mol. Immunol. 47, 1317-1324.
    • (2010) Mol. Immunol. , vol.47 , pp. 1317-1324
    • Klaschik, S.1    Tross, D.2    Shirota, H.3    Klinman, D.M.4
  • 22
    • 0032695108 scopus 로고    scopus 로고
    • Natural adjuvants: Endogenous activators of dendritic cells
    • Gallucci, S., Lolkema, M., Matzinger, P. (1999) Natural adjuvants: endogenous activators of dendritic cells. Nat. Med. 11, 1249-1255.
    • (1999) Nat. Med. , vol.11 , pp. 1249-1255
    • Gallucci, S.1    Lolkema, M.2    Matzinger, P.3
  • 23
    • 2042441512 scopus 로고    scopus 로고
    • CpG ODN mixtures optimally activate human PBMC: Interfaces between innate and adaptive immunity
    • (Jan. 22-27). In Keystone, CO, USA (abs. 22)
    • Leifer, C. A., Verthelyi, D., Klinman, D. M. (Jan. 22-27, 2001) CpG ODN mixtures optimally activate human PBMC: interfaces between innate and adaptive immunity. In Keystone Symposia, Keystone, CO, USA (abs. 22).
    • (2001) Keystone Symposia
    • Leifer, C.A.1    Verthelyi, D.2    Klinman, D.M.3
  • 24
    • 33748797690 scopus 로고    scopus 로고
    • CpG-mediated changes in gene expression in murine spleen cells identified by microarray analysis
    • Klaschik, S., Gursel, I., Klinman, D. M. (2007) CpG-mediated changes in gene expression in murine spleen cells identified by microarray analysis. Mol. Immunol. 44, 1095-1104.
    • (2007) Mol. Immunol. , vol.44 , pp. 1095-1104
    • Klaschik, S.1    Gursel, I.2    Klinman, D.M.3
  • 25
    • 0348143180 scopus 로고    scopus 로고
    • A random variance model for detection of differential gene expression in small microarray experiments
    • Wright, G. W., Simon, R. M. (2003) A random variance model for detection of differential gene expression in small microarray experiments. Bioinformatics 19, 2448-2455.
    • (2003) Bioinformatics , vol.19 , pp. 2448-2455
    • Wright, G.W.1    Simon, R.M.2
  • 27
    • 40249088259 scopus 로고    scopus 로고
    • The DNA sugar backbone 2' deoxyribose determines Toll-like receptor 9 activation
    • Haas, T., Metzger, J., Schmitz, F., Heit, A., Muller, T., Latz, E., Wagner, H. (2008) The DNA sugar backbone 2' deoxyribose determines Toll-like receptor 9 activation. Immunity 28, 315-323.
    • (2008) Immunity , vol.28 , pp. 315-323
    • Haas, T.1    Metzger, J.2    Schmitz, F.3    Heit, A.4    Muller, T.5    Latz, E.6    Wagner, H.7
  • 29
    • 33746214827 scopus 로고    scopus 로고
    • CXCL16 influences the nature and specificity of CpG-induced immune activation
    • Gursel, M., Gursel, I., Mostowski, H. S., Klinman, D. M. (2006) CXCL16 influences the nature and specificity of CpG-induced immune activation. J. Immunol. 177, 1575-1580.
    • (2006) J. Immunol. , vol.177 , pp. 1575-1580
    • Gursel, M.1    Gursel, I.2    Mostowski, H.S.3    Klinman, D.M.4
  • 30
    • 15244349785 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells in immunity
    • Colonna, M., Trinchieri, G., Liu, Y. J. (2004) Plasmacytoid dendritic cells in immunity. Nat. Immunol. 5, 1219-1226.
    • (2004) Nat. Immunol. , vol.5 , pp. 1219-1226
    • Colonna, M.1    Trinchieri, G.2    Liu, Y.J.3
  • 31
    • 79960835493 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells: One-trick ponies or workhorses of the immune system?
    • Reizis, B., Colonna, M., Trinchieri, G., Barrat, F., Gilliet, M. (2011) Plasmacytoid dendritic cells: one-trick ponies or workhorses of the immune system? Nat. Rev. Immunol. 11, 558-565.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 558-565
    • Reizis, B.1    Colonna, M.2    Trinchieri, G.3    Barrat, F.4    Gilliet, M.5
  • 33
    • 77951624701 scopus 로고    scopus 로고
    • CpG-B oligodeoxynucleotides inhibit TLR-dependent and-independent induction of type I IFN in dendritic cells
    • Liu, Y. C., Gray, R. C., Hardy, G. A., Kuchtey, J., Abbott, D. W., Emancipator, S. N., Harding, C. V. (2010) CpG-B oligodeoxynucleotides inhibit TLR-dependent and-independent induction of type I IFN in dendritic cells. J. Immunol. 184, 3367-3376.
    • (2010) J. Immunol. , vol.184 , pp. 3367-3376
    • Liu, Y.C.1    Gray, R.C.2    Hardy, G.A.3    Kuchtey, J.4    Abbott, D.W.5    Emancipator, S.N.6    Harding, C.V.7
  • 34
    • 46249115827 scopus 로고    scopus 로고
    • Interferon-inducible antiviral effectors
    • Sadler, A. J., Williams, B. R. (2008) Interferon-inducible antiviral effectors. Nat. Rev. Immunol. 8, 559-568.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 559-568
    • Sadler, A.J.1    Williams, B.R.2
  • 35
    • 24644451047 scopus 로고    scopus 로고
    • Influence of fiber detargeting on adenovirus-mediated innate and adaptive immune activation
    • Schoggins, J. W., Nociari, M., Philpott, N., Falck-Pedersen, E. (2005) Influence of fiber detargeting on adenovirus-mediated innate and adaptive immune activation. J. Virol. 79, 11627-11637.
    • (2005) J. Virol. , vol.79 , pp. 11627-11637
    • Schoggins, J.W.1    Nociari, M.2    Philpott, N.3    Falck-Pedersen, E.4
  • 37
    • 0025369703 scopus 로고
    • Transgenic mice with intracellular immunity to influenza virus
    • Arnheiter, H., Skuntz, S., Noteborn, M., Chang, S., Meier, E. (1990) Transgenic mice with intracellular immunity to influenza virus. Cell 62, 51-61.
    • (1990) Cell , vol.62 , pp. 51-61
    • Arnheiter, H.1    Skuntz, S.2    Noteborn, M.3    Chang, S.4    Meier, E.5
  • 39
    • 27744547954 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms in genes for 2'-5'-oligoadenylate synthetase and RNase L inpatients hospitalized with West Nile virus infection
    • Yakub, I., Lillibridge, K. M., Moran, A., Gonzalez, O. Y., Belmont, J., Gibbs, R. A., Tweardy, D. J. (2005) Single nucleotide polymorphisms in genes for 2'-5'-oligoadenylate synthetase and RNase L inpatients hospitalized with West Nile virus infection. J. Infect. Dis. 192, 1741-1748.
    • (2005) J. Infect. Dis. , vol.192 , pp. 1741-1748
    • Yakub, I.1    Lillibridge, K.M.2    Moran, A.3    Gonzalez, O.Y.4    Belmont, J.5    Gibbs, R.A.6    Tweardy, D.J.7
  • 41
    • 0033824231 scopus 로고    scopus 로고
    • Identification of a single nucleotide polymorphism in the MxA gene promoter (G/T at nt-88) correlated with the response of hepatitis C patients to interferon
    • Hijikata, M., Ohta, Y., Mishiro, S. (2000) Identification of a single nucleotide polymorphism in the MxA gene promoter (G/T at nt-88) correlated with the response of hepatitis C patients to interferon. Intervirology 43, 124-127.
    • (2000) Intervirology , vol.43 , pp. 124-127
    • Hijikata, M.1    Ohta, Y.2    Mishiro, S.3
  • 42
    • 0042208151 scopus 로고    scopus 로고
    • Local delivery of CpG oligodeoxynucleotides induces rapid changes in the genital mucosa and inhibits replication, but not entry, of herpes simplex virus type 2
    • Ashkar, A. A., Bauer, S., Mitchell, W. J., Vieira, J., Rosenthal, K. L. (2003) Local delivery of CpG oligodeoxynucleotides induces rapid changes in the genital mucosa and inhibits replication, but not entry, of herpes simplex virus type 2. J. Virol. 77, 8948-8956.
    • (2003) J. Virol. , vol.77 , pp. 8948-8956
    • Ashkar, A.A.1    Bauer, S.2    Mitchell, W.J.3    Vieira, J.4    Rosenthal, K.L.5
  • 43
    • 34247619680 scopus 로고    scopus 로고
    • Role of IFN-α/β signaling in the prevention of genital herpes virus type 2 infection
    • Svensson, A., Bellner, L., Magnusson, M., Eriksson, K. (2007) Role of IFN-α/β signaling in the prevention of genital herpes virus type 2 infection. J. Reprod. Immunol. 74, 114-123.
    • (2007) J. Reprod. Immunol. , vol.74 , pp. 114-123
    • Svensson, A.1    Bellner, L.2    Magnusson, M.3    Eriksson, K.4
  • 44
    • 33746671960 scopus 로고    scopus 로고
    • A crucial role for plasmacytoid dendritic cells in antiviral protection by CpG ODN-based vaginal microbicide
    • Shen, H., Iwasaki, A. (2006) A crucial role for plasmacytoid dendritic cells in antiviral protection by CpG ODN-based vaginal microbicide. J. Clin. Invest. 116, 2237-2243.
    • (2006) J. Clin. Invest. , vol.116 , pp. 2237-2243
    • Shen, H.1    Iwasaki, A.2
  • 46
    • 7444242674 scopus 로고    scopus 로고
    • Induction of systemic TH1-like innate immunity in normal volunteers following subcutaneous but not intravenous administration of CPG 7909, a synthetic B-class CpG oligodeoxynucleotide TLR9 agonist
    • Krieg, A. M., Efler, S. M., Wittpoth, M., Al Adhami, M. J., Davis, H. L. (2004) Induction of systemic TH1-like innate immunity in normal volunteers following subcutaneous but not intravenous administration of CPG 7909, a synthetic B-class CpG oligodeoxynucleotide TLR9 agonist. J Immunother. 27, 460-471.
    • (2004) J Immunother. , vol.27 , pp. 460-471
    • Krieg, A.M.1    Efler, S.M.2    Wittpoth, M.3    Al Adhami, M.J.4    Davis, H.L.5
  • 47
    • 0032168355 scopus 로고    scopus 로고
    • CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge
    • Krieg, A. M., Homan, L. L., Yi, A. K., Harty, J. T. (1998) CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge. J. Immunol. 161, 2428-2434.
    • (1998) J. Immunol. , vol.161 , pp. 2428-2434
    • Krieg, A.M.1    Homan, L.L.2    Yi, A.K.3    Harty, J.T.4
  • 48
    • 0033558121 scopus 로고    scopus 로고
    • Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria
    • Elkins, K. L., Rhinehart-Jones, T. R., Stibitz, S., Conover, J. S., Klinman, D. M. (1999) Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria. J. Immunol. 162, 2291-2298.
    • (1999) J. Immunol. , vol.162 , pp. 2291-2298
    • Elkins, K.L.1    Rhinehart-Jones, T.R.2    Stibitz, S.3    Conover, J.S.4    Klinman, D.M.5
  • 49
    • 0034668119 scopus 로고    scopus 로고
    • Increased resistance against acute polymicrobial sepsis in mice challenged with immunostimulatory CpG oligodeoxynucleotides is related to an enhanced innate effector cell response
    • Weighardt, H., Feterowski, C., Veit, M., Rump, M., Wagner, H., Holzmann, B. (2000) Increased resistance against acute polymicrobial sepsis in mice challenged with immunostimulatory CpG oligodeoxynucleotides is related to an enhanced innate effector cell response. J. Immunol. 165, 4537-4543.
    • (2000) J. Immunol. , vol.165 , pp. 4537-4543
    • Weighardt, H.1    Feterowski, C.2    Veit, M.3    Rump, M.4    Wagner, H.5    Holzmann, B.6


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