Global changes in gene expression and synergistic interactions induced by TLR9 and TLR3

Molecular Immunology

Volumn 46, Issue 13, 2009, Pages 2557-2564

  Tross, Debra ^a   Petrenko, Lev ^a   Klaschik, Sven ^a   Zhu, Qing ^a   Klinman, Dennis M ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

CpG oligodeoxynucleotides; Gene regulation; Molecular biology; Poly (I:C); Synergy; TLR

Indexed keywords

CPG OLIGODEOXYNUCLEOTIDE; POLYINOSINIC POLYCYTIDYLIC ACID; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 9;

ANIMAL CELL; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION; IMMUNE RESPONSE; MICROARRAY ANALYSIS; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN INTERACTION; UNINDEXED SEQUENCE;

ANIMALS; CELL LINE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; MACROPHAGES; MICE; OLIGODEOXYRIBONUCLEOTIDES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLY I-C; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 3; TOLL-LIKE RECEPTOR 9;

BACTERIA (MICROORGANISMS);

EID: 67650357977     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2009.05.011     Document Type: Article

References (31)

1. Alexopoulou L., Holt A.C., Medzhitov R., and Flavell R.A. Recognition of double-stranded RNA and activation of NF-kappaB by toll-like receptor 3. Nature 413 (2001) 732-738
2. Boonstra A., Rajsbaum R., Holman M., Marques R., Asselin-Paturel C., Pereira J.P., Bates E.E., Akira S., Vieira P., Liu Y.J., Trinchieri G., and O'Garra A. Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signals. J. Immunol. 177 (2006) 7551-7558
3. Calvano S.E., Xiao W., Richards D.R., Felciano R.M., Baker H.V., Cho R.J., Chen R.O., Brownstein B.H., Cobb J.P., Tschoeke S.K., Miller-Graziano C., Moldawer L.L., Mindrinos M.N., Davis R.W., Tompkins R.G., and Lowry S.F. A network-based analysis of systemic inflammation in humans. Nature 437 (2005) 1032-1037
4. Gautier G., Humbert M., Deauvieau F., Scuiller M., Hiscott J., Bates E.E., Trinchieri G., Caux C., and Garrone P. A type I interferon autocrine-paracrine loop is involved in toll-like receptor-induced interleukin-12p70 secretion by dendritic cells. J. Exp. Med. 201 (2005) 1435-1446
5. He H., Genovese K.J., Nisbet D.J., and Kogut M.H. Synergy of CpG oligodeoxynucleotide and double-stranded RNA (poly I:C) on nitric oxide induction in chicken peripheral blood monocytes. Mol. Immunol. 44 (2007) 3234-3242
6. Hemmi H., Takeuchi O., Kawai T., Sato S., Sanjo H., Matsumoto M., Hoshino K., Wagner H., Takeda K., and Akira S. A toll-like receptor recognizes bacterial DNA. Nature 408 (2000) 740-745
7. Hoebe K., Janssen E.M., Kim S.O., Alexopoulou L., Flavell R.A., Han J., and Beutler B. Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways. Nat. Immunol. 4 (2003) 1223-1229
8. Honda K., Yanai H., Negishi H., Asagiri M., Sato M., Mizutani T., Shimada N., Ohba Y., Takaoka A., Yoshida N., and Taniguchi T. IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature 434 (2005) 772-777
9. Huang C.C., Duffy K.E., San Mateo L.R., Amegadzie B.Y., Sarisky R.T., and Mbow M.L. A pathway analysis of poly(I:C)-induced global gene expression change in human peripheral blood mononuclear cells. Physiol. Genomics 26 (2006) 125-133
10. Jenner R.G., and Young R.A. Insights into host responses against pathogens from transcriptional profiling. Nat. Rev. Microbiol. 3 (2005) 281-294
11. Johansson C., Ingman M., and Jo W.M. Elevated neutrophil, macrophage and dendritic cell numbers characterize immune cell populations in mice chronically infected with Salmonella. Microb. Pathog. 41 (2006) 49-58
12. Klaschik S., Tross D., and Klinman D.M. Inductive and suppressive networks regulate TLR9-dependent gene expression in vivo. J. Leukocyte Biol. 85 (2009) 788-795
13. Klaschik S., Gursel I., and Klinman D.M. CpG-mediated changes in gene expression in murine spleen cells identified by microarray analysis. Mol. Immunol. 44 (2007) 1095-1104
14. Klinman D.M., Yi A., Beaucage S.L., Conover J., and Krieg A.M. CpG motifs expressed by bacterial DNA rapidly induce lymphocytes to secrete IL-6 IL-12 and IFNg. Proc. Natl. Acad. Sci. USA 93 (1996) 2879-2883
15. Krieg A.M., Yi A., Matson S., Waldschmidt T.J., Bishop G.A., Teasdale R., Koretzky G.A., and Klinman D.M. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374 (1995) 546-548
16. Kulka M., Alexopoulou L., Flavell R.A., and Metcalfe D.D. Activation of mast cells by double-stranded RNA: evidence for activation through toll-like receptor 3. J. Allergy Clin. Immunol. 114 (2004) 174-182
17. Latz E., Schoenemeyer A., Visintin A., Fitzgerald K.A., Monks B.G., Knetter C.F., Lien E., Nilsen N.J., Espevik T., and Golenbock D.T. TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nat. Immunol. 5 (2004) 190-198
18. Matsumoto M., Kikkawa S., Kohase M., Miyake K., and Seya T. Establishment of a monoclonal antibody against human toll-like receptor 3 that blocks double-stranded RNA-mediated signaling. Biochem. Biophys. Res. Commun. 293 (2002) 1364-1369
19. Napolitani G., Rinaldi A., Bertoni F., Sallusto F., and Lanzavecchia A. Selected toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells. Nat. Immunol. 6 (2005) 769-776
20. Sorensen L.N., Reinert L.S., Malmgaard L., Bartholdy C., Thomsen A.R., and Paludan S.R. TLR2 and TLR9 synergistically control herpes simplex virus infection in the brain. J. Immunol. 181 (2008) 8604-8612
21. Tabeta K., Georgel P., Janssen E., Du X., Hoebe K., Crozat K., Mudd S., Shamel L., Sovath S., Goode J., Alexopoulou L., Flavell R.A., and Beutler B. Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc. Natl. Acad. Sci. USA 101 (2004) 3516-3521
22. Takeshita F., and Klinman D.M. CpG ODN-mediated regulation of IL-12 p40 transcription. Eur. J. Immunol. 30 (2000) 1967-1976
23. Trinchieri G., and Sher A. Cooperation of toll-like receptor signals in innate immune defence. Nat. Rev. Immunol. 7 (2007) 179-190
24. Verthelyi D., Ishii K.J., Gursel M., Takeshita F., and Klinman D.M. Human peripheral blood cells differentially recognize and respond to two distinct CpG motifs. J. Immunol. 166 (2001) 2372-2377
25. Wells J.W., Cowled C.J., Farzaneh F., and Noble A. Combined triggering of dendritic cell receptors results in synergistic activation and potent cytotoxic immunity. J. Immunol. 181 (2008) 3422-3431
26. Whitmore M.M., DeVeer M.J., Edling A., Oates R.K., Simons B., Lindner D., and Williams B.R. Synergistic activation of innate immunity by double-stranded RNA and CpG DNA promotes enhanced antitumor activity. Cancer Res. 64 (2004) 5850-5860
27. Whitmore M.M., Iparraguirre A., Kubelka L., Weninger W., Hai T., and Williams B.R. Negative regulation of TLR-signaling pathways by activating transcription factor-3. J. Immunol. 179 (2007) 3622-3630
28. Wright G.W., and Simon R.M. A random variance model for detection of differential gene expression in small microarray experiments. Bioinformatics 19 (2003) 2448-2455
29. Yamamoto M., Sato S., Hemmi H., Hoshino K., Kaisho T., Sanjo H., Takeuchi O., Sugiyama M., Okabe M., Takeda K., and Akira S. Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301 (2003) 640-643
30. Zheng R., Cohen P.A., Paustian C.A., Johnson T.D., Lee W.T., Shu S., and Koski G.K. Paired Toll-like receptor agonists enhance vaccine therapy through induction of interleukin-12. Cancer Res. 68 (2008) 4045-4049
31. Zhu Q., Egelston C., Vivekanandhan A., Uematsu S., Akira S., Klinman D.M., Belyakov I.M., and Berzofsky J.A. Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: implications for vaccines. Proc. Natl. Acad. Sci. USA 105 (2008) 16260-16265