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Volumn 47, Issue 6, 2010, Pages 1317-1324

Short- and long-term changes in gene expression mediated by the activation of TLR9

Author keywords

Gene regulation; Molecular biology; Rodent; Signal transduction

Indexed keywords

B LYMPHOCYTE RECEPTOR; CPG OLIGODEOXYNUCLEOTIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; TOLL LIKE RECEPTOR 9;

EID: 76949088399     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2009.11.014     Document Type: Article
Times cited : (39)

References (53)
  • 1
    • 0034680145 scopus 로고    scopus 로고
    • Toll-like receptors in the induction of the innate immune response
    • Aderem A., and Ulevitch R.J. Toll-like receptors in the induction of the innate immune response. Nature 406 (2000) 782-787
    • (2000) Nature , vol.406 , pp. 782-787
    • Aderem, A.1    Ulevitch, R.J.2
  • 2
    • 0034886143 scopus 로고    scopus 로고
    • Toll-like receptors: critical proteins linking innate and acquired immunity
    • Akira S., Takeda K., and Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat. Immunol. 2 (2001) 675-680
    • (2001) Nat. Immunol. , vol.2 , pp. 675-680
    • Akira, S.1    Takeda, K.2    Kaisho, T.3
  • 3
    • 0042208151 scopus 로고    scopus 로고
    • Local delivery of CpG oligodeoxynucleotides induces rapid changes in the genital mucosa and inhibits replication, but not entry, of herpes simplex virus type 2
    • Ashkar A.A., Bauer S., Mitchell W.J., Vieira J., and Rosenthal K.L. Local delivery of CpG oligodeoxynucleotides induces rapid changes in the genital mucosa and inhibits replication, but not entry, of herpes simplex virus type 2. J. Virol. 77 (2003) 8948-8956
    • (2003) J. Virol. , vol.77 , pp. 8948-8956
    • Ashkar, A.A.1    Bauer, S.2    Mitchell, W.J.3    Vieira, J.4    Rosenthal, K.L.5
  • 4
    • 0030239828 scopus 로고    scopus 로고
    • Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA
    • Ballas Z.D., Rasmussen W.L., and Krieg A.M. Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. J. Immunol. 157 (1996) 1840-1847
    • (1996) J. Immunol. , vol.157 , pp. 1840-1847
    • Ballas, Z.D.1    Rasmussen, W.L.2    Krieg, A.M.3
  • 9
    • 3142675843 scopus 로고    scopus 로고
    • CpG-oligonucleotides for cancer immunotherapy: review of the literature and potential applications in malignant glioma
    • Carpentier A.F., Auf G., and Delattre J.Y. CpG-oligonucleotides for cancer immunotherapy: review of the literature and potential applications in malignant glioma. Front. Biosci. 8 (2003) e115-e127
    • (2003) Front. Biosci. , vol.8
    • Carpentier, A.F.1    Auf, G.2    Delattre, J.Y.3
  • 10
    • 0038653486 scopus 로고    scopus 로고
    • An immunostimulatory oligodeoxynucleotide containing a cytidine-guanosine motif protects senescence-accelerated mice from lethal influenza virus by augmenting the T helper type 1 response
    • Dong L., Mori I., Hossain M.J., Liu B., and Kimura Y. An immunostimulatory oligodeoxynucleotide containing a cytidine-guanosine motif protects senescence-accelerated mice from lethal influenza virus by augmenting the T helper type 1 response. J. Gen. Virol. 84 (2003) 1623-1628
    • (2003) J. Gen. Virol. , vol.84 , pp. 1623-1628
    • Dong, L.1    Mori, I.2    Hossain, M.J.3    Liu, B.4    Kimura, Y.5
  • 11
    • 0033558121 scopus 로고    scopus 로고
    • Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria
    • Elkins K.L., Rhinehart-Jones T.R., Stibitz S., Conover J.S., and Klinman D.M. Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria. J. Immunol. 162 (1999) 2291-2298
    • (1999) J. Immunol. , vol.162 , pp. 2291-2298
    • Elkins, K.L.1    Rhinehart-Jones, T.R.2    Stibitz, S.3    Conover, J.S.4    Klinman, D.M.5
  • 12
    • 0036908870 scopus 로고    scopus 로고
    • Regulation of gene expression in mouse macrophages stimulated with bacterial CpG-DNA and lipopolysaccharide
    • Gao J.J., Diesl V., Wittmann T., Morrison D.C., Ryan J.L., Vogel S.N., and Follettie M.T. Regulation of gene expression in mouse macrophages stimulated with bacterial CpG-DNA and lipopolysaccharide. J. Leukoc. Biol. 72 (2002) 1234-1245
    • (2002) J. Leukoc. Biol. , vol.72 , pp. 1234-1245
    • Gao, J.J.1    Diesl, V.2    Wittmann, T.3    Morrison, D.C.4    Ryan, J.L.5    Vogel, S.N.6    Follettie, M.T.7
  • 13
    • 0034698739 scopus 로고    scopus 로고
    • Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6
    • Hacker H., Vabulas R.M., Takeuchi O., Hoshino K., Akira S., and Wagner H. Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6. J. Exp. Med. 192 (2000) 595-600
    • (2000) J. Exp. Med. , vol.192 , pp. 595-600
    • Hacker, H.1    Vabulas, R.M.2    Takeuchi, O.3    Hoshino, K.4    Akira, S.5    Wagner, H.6
  • 15
    • 0037726807 scopus 로고    scopus 로고
    • A phase I study of the safety and immunogenicity of recombinant hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide adjuvant
    • Halperin S.A., Van Nest G., Smith B., Abtahi S., Whiley H., and Eiden J.J. A phase I study of the safety and immunogenicity of recombinant hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide adjuvant. Vaccine 21 (2003) 2461-2467
    • (2003) Vaccine , vol.21 , pp. 2461-2467
    • Halperin, S.A.1    Van Nest, G.2    Smith, B.3    Abtahi, S.4    Whiley, H.5    Eiden, J.J.6
  • 16
    • 0036785631 scopus 로고    scopus 로고
    • Peritumoral CpG DNA elicits a coordinated response of CD8 T cells and innate effectors to cure established tumors in a murine colon carcinoma model
    • Heckelsmiller K., Rall K., Beck S., Schlamp A., Seiderer J., Jahrsdorfer B., Krug A., Rothenfusser S., Endres S., and Hartmann G. Peritumoral CpG DNA elicits a coordinated response of CD8 T cells and innate effectors to cure established tumors in a murine colon carcinoma model. J. Immunol. 169 (2002) 3892-3899
    • (2002) J. Immunol. , vol.169 , pp. 3892-3899
    • Heckelsmiller, K.1    Rall, K.2    Beck, S.3    Schlamp, A.4    Seiderer, J.5    Jahrsdorfer, B.6    Krug, A.7    Rothenfusser, S.8    Endres, S.9    Hartmann, G.10
  • 17
    • 24144434714 scopus 로고    scopus 로고
    • Immunostimulatory CpG oligonucleotides reduce tumor burden after intravesical administration in an orthotopic murine bladder cancer model
    • Hegele A., Dalpke A., Heeg K., Barth P., Varga Z., Hofmann R., and Olbert P. Immunostimulatory CpG oligonucleotides reduce tumor burden after intravesical administration in an orthotopic murine bladder cancer model. Tumour Biol. 26 (2005) 274-280
    • (2005) Tumour Biol. , vol.26 , pp. 274-280
    • Hegele, A.1    Dalpke, A.2    Heeg, K.3    Barth, P.4    Varga, Z.5    Hofmann, R.6    Olbert, P.7
  • 19
    • 0036858610 scopus 로고    scopus 로고
    • Immunostimulatory sequence oligodeoxynucleotide-based vaccination and immunomodulation: two unique but complementary strategies for the treatment of allergic diseases
    • Horner A.A., and Raz E. Immunostimulatory sequence oligodeoxynucleotide-based vaccination and immunomodulation: two unique but complementary strategies for the treatment of allergic diseases. J. Allergy Clin. Immunol. 110 (2002) 706-712
    • (2002) J. Allergy Clin. Immunol. , vol.110 , pp. 706-712
    • Horner, A.A.1    Raz, E.2
  • 20
    • 2542620714 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides improve the survival of pregnant and fetal mice following Listeria monocytogenes infection
    • Ito S., Ishii K., Shirot H., and Klinman D.M. CpG oligodeoxynucleotides improve the survival of pregnant and fetal mice following Listeria monocytogenes infection. Infect. Immun. 72 (2004) 3543-3548
    • (2004) Infect. Immun. , vol.72 , pp. 3543-3548
    • Ito, S.1    Ishii, K.2    Shirot, H.3    Klinman, D.M.4
  • 22
    • 17044447484 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides for immune stimulation in cancer immunotherapy
    • Jahrsdorfer B., and Weiner G.J. CpG oligodeoxynucleotides for immune stimulation in cancer immunotherapy. Curr. Opin. Invest. Drugs 4 (2003) 686-690
    • (2003) Curr. Opin. Invest. Drugs , vol.4 , pp. 686-690
    • Jahrsdorfer, B.1    Weiner, G.J.2
  • 24
    • 65549140232 scopus 로고    scopus 로고
    • Inductive and suppressive networks regulate TLR9-dependent gene expression in vivo
    • Klaschik S., Tross D., and Klinman D.M. Inductive and suppressive networks regulate TLR9-dependent gene expression in vivo. J. Leukoc. Biol. 85 (2009) 788-795
    • (2009) J. Leukoc. Biol. , vol.85 , pp. 788-795
    • Klaschik, S.1    Tross, D.2    Klinman, D.M.3
  • 25
    • 33748797690 scopus 로고    scopus 로고
    • CpG-mediated changes in gene expression in murine spleen cells identified by microarray analysis
    • Klaschik S., Gursel I., and Klinman D.M. CpG-mediated changes in gene expression in murine spleen cells identified by microarray analysis. Mol. Immunol. 44 (2007) 1095-1104
    • (2007) Mol. Immunol. , vol.44 , pp. 1095-1104
    • Klaschik, S.1    Gursel, I.2    Klinman, D.M.3
  • 26
    • 0001440847 scopus 로고    scopus 로고
    • Contribution of cells at the site of DNA vaccination to the generation of antigen specific immunity and memory
    • Klinman D.M., Sechler J.M.G., Conover J., Gu M., and Rosenberg A.S. Contribution of cells at the site of DNA vaccination to the generation of antigen specific immunity and memory. J. Immunol. 158 (1998) 3635-3639
    • (1998) J. Immunol. , vol.158 , pp. 3635-3639
    • Klinman, D.M.1    Sechler, J.M.G.2    Conover, J.3    Gu, M.4    Rosenberg, A.S.5
  • 27
    • 0029984358 scopus 로고    scopus 로고
    • CpG motifs expressed by bacterial DNA rapidly induce lymphocytes to secrete IL-6, IL-12 and IFNg
    • Klinman D.M., Yi A., Beaucage S.L., Conover J., and Krieg A.M. CpG motifs expressed by bacterial DNA rapidly induce lymphocytes to secrete IL-6, IL-12 and IFNg. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 2879-2883
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 2879-2883
    • Klinman, D.M.1    Yi, A.2    Beaucage, S.L.3    Conover, J.4    Krieg, A.M.5
  • 28
    • 53949106937 scopus 로고    scopus 로고
    • Nuclear factor-kappaB: fine-tuning a central integrator of diverse biologic stimuli
    • Krakauer T. Nuclear factor-kappaB: fine-tuning a central integrator of diverse biologic stimuli. Int. Rev. Immunol. 27 (2008) 286-292
    • (2008) Int. Rev. Immunol. , vol.27 , pp. 286-292
    • Krakauer, T.1
  • 29
    • 34248169629 scopus 로고    scopus 로고
    • Development of TLR9 agonists for cancer therapy
    • Krieg A.M. Development of TLR9 agonists for cancer therapy. J. Clin. Invest. 117 (2007) 1184-1194
    • (2007) J. Clin. Invest. , vol.117 , pp. 1184-1194
    • Krieg, A.M.1
  • 30
    • 0032168355 scopus 로고    scopus 로고
    • CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge
    • Krieg A.M., Homan L.L., Yi A.K., and Harty J.T. CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge. J. Immunol. 161 (1998) 2428-2434
    • (1998) J. Immunol. , vol.161 , pp. 2428-2434
    • Krieg, A.M.1    Homan, L.L.2    Yi, A.K.3    Harty, J.T.4
  • 33
    • 0036781052 scopus 로고    scopus 로고
    • NF-kappaB regulation in the immune system
    • Li Q., and Verma I.M. NF-kappaB regulation in the immune system. Nat. Rev. Immunol. 2 (2002) 725-734
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 725-734
    • Li, Q.1    Verma, I.M.2
  • 34
    • 20644450804 scopus 로고    scopus 로고
    • Negative regulation of toll-like receptor-mediated immune responses
    • Liew F.Y., Xu D., Brint E.K., and O'Neill L.A. Negative regulation of toll-like receptor-mediated immune responses. Nat. Rev. Immunol. 5 (2005) 446-458
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 446-458
    • Liew, F.Y.1    Xu, D.2    Brint, E.K.3    O'Neill, L.A.4
  • 36
    • 7244258899 scopus 로고    scopus 로고
    • Transcriptional activation induced in macrophages by Toll-like receptor (TLR) ligands: from expression profiling to a model of TLR signaling
    • Schmitz F., Mages J., Heit A., Lang R., and Wagner H. Transcriptional activation induced in macrophages by Toll-like receptor (TLR) ligands: from expression profiling to a model of TLR signaling. Eur. J. Immunol. 34 (2004) 2863-2873
    • (2004) Eur. J. Immunol. , vol.34 , pp. 2863-2873
    • Schmitz, F.1    Mages, J.2    Heit, A.3    Lang, R.4    Wagner, H.5
  • 37
    • 0031867535 scopus 로고    scopus 로고
    • Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells
    • Sparwasser T., Koch E., Vabulas R.M., Heeg K., Lipford G.B., Ellwart J.W., and Wager H. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells. Eur. J. Immunol. 28 (1998) 2045-2054
    • (1998) Eur. J. Immunol. , vol.28 , pp. 2045-2054
    • Sparwasser, T.1    Koch, E.2    Vabulas, R.M.3    Heeg, K.4    Lipford, G.B.5    Ellwart, J.W.6    Wager, H.7
  • 38
    • 0030816325 scopus 로고    scopus 로고
    • Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor-a-mediated shock
    • Sparwasser T., Miethke T., Lipford G., Erdmann A., Hacker H., Heeg K., and Wagner H. Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor-a-mediated shock. Eur. J. Immunol. 27 (1997) 1671-1679
    • (1997) Eur. J. Immunol. , vol.27 , pp. 1671-1679
    • Sparwasser, T.1    Miethke, T.2    Lipford, G.3    Erdmann, A.4    Hacker, H.5    Heeg, K.6    Wagner, H.7
  • 39
    • 0344436049 scopus 로고    scopus 로고
    • Immunostimulatory CpG-oligonucleotides cause extramedullary murine hemopoiesis
    • Sparwasser T., Hultner L., Koch E.S., Luz A., Lipford G.B., and Wagner H. Immunostimulatory CpG-oligonucleotides cause extramedullary murine hemopoiesis. J. Immunol. 162 (1999) 2368-2374
    • (1999) J. Immunol. , vol.162 , pp. 2368-2374
    • Sparwasser, T.1    Hultner, L.2    Koch, E.S.3    Luz, A.4    Lipford, G.B.5    Wagner, H.6
  • 40
    • 0030240062 scopus 로고    scopus 로고
    • Macrophages ingest and are activated by bacterial DNA
    • Stacey K.J., Sweet M.J., and Hume D.A. Macrophages ingest and are activated by bacterial DNA. J. Immunol. 157 (1996) 2116-2120
    • (1996) J. Immunol. , vol.157 , pp. 2116-2120
    • Stacey, K.J.1    Sweet, M.J.2    Hume, D.A.3
  • 41
    • 0032433054 scopus 로고    scopus 로고
    • Type I interferon-mediated stimulation of T cells by CpG DNA
    • Sun S., Zhang X., Tough D.F., and Sprent J. Type I interferon-mediated stimulation of T cells by CpG DNA. J. Exp. Med. 188 (1998) 2335-2342
    • (1998) J. Exp. Med. , vol.188 , pp. 2335-2342
    • Sun, S.1    Zhang, X.2    Tough, D.F.3    Sprent, J.4
  • 43
    • 0034671061 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides induce murine macrophages to up-regulate chemokine mRNA expression
    • Takeshita S., Takeshita F., Haddad D.E., Ishii K.J., and Klinman D.M. CpG oligodeoxynucleotides induce murine macrophages to up-regulate chemokine mRNA expression. Cell. Immunol. 206 (2000) 101-106
    • (2000) Cell. Immunol. , vol.206 , pp. 101-106
    • Takeshita, S.1    Takeshita, F.2    Haddad, D.E.3    Ishii, K.J.4    Klinman, D.M.5
  • 44
    • 76949090826 scopus 로고    scopus 로고
    • Global changes in gene expression and synergistic interactions induced by TLR9 and TLR3
    • Tross L., Petrenko L., Klaschik S., and Klinman D.M. Global changes in gene expression and synergistic interactions induced by TLR9 and TLR3. Mol. Immunol. 156 (2009) 528-534
    • (2009) Mol. Immunol. , vol.156 , pp. 528-534
    • Tross, L.1    Petrenko, L.2    Klaschik, S.3    Klinman, D.M.4
  • 45
    • 0037407856 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides protect normal and SIV-infected macaques from Leishmania infection
    • Verthelyi D., Gursel M., Kenney R.T., Lifson J.D., Liu S., Mican J., and Klinman D.M. CpG oligodeoxynucleotides protect normal and SIV-infected macaques from Leishmania infection. J. Immunol. 170 (2003) 4717-4723
    • (2003) J. Immunol. , vol.170 , pp. 4717-4723
    • Verthelyi, D.1    Gursel, M.2    Kenney, R.T.3    Lifson, J.D.4    Liu, S.5    Mican, J.6    Klinman, D.M.7
  • 46
    • 0033536013 scopus 로고    scopus 로고
    • Immunostimulatory oligodeoxynucleotides promote protective immunity and provide systemic therapy for leishmaniasis via IL-12 and IFNg dependent mechanisms
    • Walker P.S., Scharton-Kersten T., Krieg A.M., Love-Homan L., Rowton E.D., Udey M.C., and Vogel J.C. Immunostimulatory oligodeoxynucleotides promote protective immunity and provide systemic therapy for leishmaniasis via IL-12 and IFNg dependent mechanisms. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 6970-6975
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 6970-6975
    • Walker, P.S.1    Scharton-Kersten, T.2    Krieg, A.M.3    Love-Homan, L.4    Rowton, E.D.5    Udey, M.C.6    Vogel, J.C.7
  • 47
    • 0034668119 scopus 로고    scopus 로고
    • Increased resistance against acute polymicrobial sepsis in mice challenged with immunostimulatory CpG oligodeoxynucleotides is related to an enhanced innate effector cell response
    • Weighardt H., Feterowski C., Veit M., Rump M., Wagner H., and Holzmann B. Increased resistance against acute polymicrobial sepsis in mice challenged with immunostimulatory CpG oligodeoxynucleotides is related to an enhanced innate effector cell response. J. Immunol. 165 (2000) 4537-4543
    • (2000) J. Immunol. , vol.165 , pp. 4537-4543
    • Weighardt, H.1    Feterowski, C.2    Veit, M.3    Rump, M.4    Wagner, H.5    Holzmann, B.6
  • 48
    • 0348143180 scopus 로고    scopus 로고
    • A random variance model for detection of differential gene expression in small microarray experiments
    • Wright G.W., and Simon R.M. A random variance model for detection of differential gene expression in small microarray experiments. Bioinformatics 19 (2003) 2448-2455
    • (2003) Bioinformatics , vol.19 , pp. 2448-2455
    • Wright, G.W.1    Simon, R.M.2
  • 49
    • 0037114185 scopus 로고    scopus 로고
    • Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling
    • Yamamoto M., Sato S., Mori K., Hoshino K., Takeuchi O., Takeda K., and Akira S. Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling. J. Immunol. 169 (2002) 6668-6672
    • (2002) J. Immunol. , vol.169 , pp. 6668-6672
    • Yamamoto, M.1    Sato, S.2    Mori, K.3    Hoshino, K.4    Takeuchi, O.5    Takeda, K.6    Akira, S.7
  • 50
    • 0026625208 scopus 로고
    • Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN and augment IFN-mediated natural killer activity
    • Yamamoto S., Yamamoto T., Katoaka T., Kuramoto E., Yano O., and Tokunaga T. Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN and augment IFN-mediated natural killer activity. J. Immunol. 148 (1992) 4072-4076
    • (1992) J. Immunol. , vol.148 , pp. 4072-4076
    • Yamamoto, S.1    Yamamoto, T.2    Katoaka, T.3    Kuramoto, E.4    Yano, O.5    Tokunaga, T.6
  • 51
    • 1342294092 scopus 로고    scopus 로고
    • Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation
    • Yang Y.H., Dudoit S., Luu P., Lin D.M., Peng V., Ngai J., and Speed T.P. Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation. Nucleic Acids Res. 30 (2002) e15
    • (2002) Nucleic Acids Res. , vol.30
    • Yang, Y.H.1    Dudoit, S.2    Luu, P.3    Lin, D.M.4    Peng, V.5    Ngai, J.6    Speed, T.P.7
  • 52
    • 41949127055 scopus 로고    scopus 로고
    • TLR9 engagement on CD4 T lymphocytes represses gamma-radiation-induced apoptosis through activation of checkpoint kinase response elements
    • Zheng L., Asprodites N., Keene A.H., Rodriguez P., Brown K.D., and Davila E. TLR9 engagement on CD4 T lymphocytes represses gamma-radiation-induced apoptosis through activation of checkpoint kinase response elements. Blood 111 (2008) 2704-2713
    • (2008) Blood , vol.111 , pp. 2704-2713
    • Zheng, L.1    Asprodites, N.2    Keene, A.H.3    Rodriguez, P.4    Brown, K.D.5    Davila, E.6
  • 53
    • 0032521881 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine Leishmaniasis
    • Zimmermann S., Egeter O., Hausmann S., Lipford G.B., Rocken M., Wagner H., and Heeg K. CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine Leishmaniasis. J. Immunol. 160 (1998) 3627-3630
    • (1998) J. Immunol. , vol.160 , pp. 3627-3630
    • Zimmermann, S.1    Egeter, O.2    Hausmann, S.3    Lipford, G.B.4    Rocken, M.5    Wagner, H.6    Heeg, K.7


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