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Volumn 367, Issue 1607, 2012, Pages 3353-3363

Targeting the endocannabinoid system with cannabinoid receptor agonists: Pharmacological strategies and therapeutic possibilities

Author keywords

And CB2; Blood brain barrier; Cannabinoid CB1; Cannabinoid receptor agonists; Receptors; Therapeutic applications and strategies; 9 tetrahydrocannabinol

Indexed keywords


EID: 84868128338     PISSN: 09628436     EISSN: 14712970     Source Type: Journal    
DOI: 10.1098/rstb.2011.0381     Document Type: Review
Times cited : (290)

References (129)
  • 1
    • 33644804271 scopus 로고    scopus 로고
    • The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids
    • doi:10.1208/aapsj070364
    • Pertwee, R. G. 2005 The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids. AAPS J. 7, E625-E654. doi:10.1208/aapsj070364)
    • (2005) AAPS J , vol.7
    • Pertwee, R.G.1
  • 2
    • 67649418026 scopus 로고    scopus 로고
    • 1 antagonists
    • doi:10.1007/s00213-009-1506-7
    • Le Foll, B., Gorelick, D. A. & Goldberg, S. R. 2009 The future of endocannabinoid-oriented clinical research after CB1 antagonists. Psychopharmacology 205, 171-174. doi:10.1007/s00213-009-1506-7)
    • (2009) Psychopharmacology , vol.205 , pp. 171-174
    • Le Foll, B.1    Gorelick, D.A.2    Goldberg, S.R.3
  • 3
    • 65449146377 scopus 로고    scopus 로고
    • Emerging strategies for exploiting cannabinoid receptor agonists as medicines
    • doi:10.1111/j.1476-5381.2008.00048.x
    • Pertwee, R. G. 2009 Emerging strategies for exploiting cannabinoid receptor agonists as medicines. Br. J. Pharmacol. 156, 397-411. doi:10.1111/j.1476-5381.2008.00048.x)
    • (2009) Br. J. Pharmacol , vol.156 , pp. 397-411
    • Pertwee, R.G.1
  • 4
    • 68749092383 scopus 로고    scopus 로고
    • 2 receptors
    • ed. P. H. Reggio), 1st edn. New York, NY: Humana Press
    • Pertwee, R. G. & Thomas, A. 2009 Therapeutic applications for agents that act at CB1 and CB2 receptors. In The cannabinoid receptors (ed. P. H. Reggio), pp. 361-392, 1st edn. New York, NY: Humana Press.
    • (2009) The Cannabinoid Receptors , pp. 361-392
    • Pertwee, R.G.1    Thomas, A.2
  • 5
    • 38349156729 scopus 로고    scopus 로고
    • Cannabinoids and multiple sclerosis
    • doi:10.1007/s12035-007-0005-2
    • Pertwee, R. G. 2007 Cannabinoids and multiple sclerosis. Mol. Neurobiol. 36, 45-59. doi:10.1007/s12035-007-0005-2)
    • (2007) Mol. Neurobiol , vol.36 , pp. 45-59
    • Pertwee, R.G.1
  • 6
    • 74549185125 scopus 로고    scopus 로고
    • FAAH and MAGL inhibitors: Therapeutic opportunities from regulating endocannabinoid levels
    • Petrosino, S. & Di Marzo, V. 2010 FAAH and MAGL inhibitors: therapeutic opportunities from regulating endocannabinoid levels. Curr. Opin. Investig. Drugs 11, 51-62.
    • (2010) Curr. Opin. Investig. Drugs , vol.11 , pp. 51-62
    • Petrosino, S.1    Di Marzo, V.2
  • 7
    • 34548096786 scopus 로고    scopus 로고
    • 2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration
    • doi:10.1021/jm070317a
    • Dziadulewicz, E. K. et al. 2007 Naphthalen-1-yl- (4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. J. Med. Chem. 50, 3851-3856. doi:10.1021/jm070317a)
    • (2007) J. Med. Chem , vol.50 , pp. 3851-3856
    • Dziadulewicz, E.K.1
  • 8
    • 68749094776 scopus 로고    scopus 로고
    • 1) receptors for chronic pain
    • doi:10.1111/j.1472-8206.2008.00591.x
    • Boyce, S. 2008 Targeting peripheral cannabinoid 1 (CB1) receptors for chronic pain. Fundam. Clin. Pharmacol. 22(Suppl. 2), 5-28. doi:10.1111/j.1472-8206.2008.00591.x)
    • (2008) Fundam. Clin. Pharmacol , vol.22 , Issue.SUPPL. 2 , pp. 5-28
    • Boyce, S.1
  • 9
    • 84876417628 scopus 로고    scopus 로고
    • In 20th Annu. Symp. on the Cannabinoids; 2010, Research Triangle Park, NC: Int. Cannabinoid Research Society
    • Groblewski, T. et al. 2010 Pre-clinical pharmacological properties of novel peripherally-acting CB1-CB2 agonists. In 20th Annu. Symp. on the Cannabinoids; 2010, p. 37. Research Triangle Park, NC: Int. Cannabinoid Research Society.
    • (2010) 2 agonists , pp. 37
    • Groblewski, T.1
  • 10
    • 77957908619 scopus 로고    scopus 로고
    • A peripherally restricted cannabinoid receptor agonist produces robust antinociceptive effects in rodent models of inflammatory and neuropathic pain
    • doi:10.1016/j.pain.2010.07.019
    • Yu, X. H., Cao, C. Q., Martino, G., Puma, C., Morinville, A., St-Onge, S., Lessard, É., Perkins, M. N. & Laird, J. M. A. 2010 A peripherally restricted cannabinoid receptor agonist produces robust antinociceptive effects in rodent models of inflammatory and neuropathic pain. Pain 151, 337-344. doi:10.1016/j.pain.2010.07.019)
    • (2010) Pain , vol.151 , pp. 337-344
    • Yu, X.H.1    Cao, C.Q.2    Martino, G.3    Puma, C.4    Morinville, A.5    St-Onge, S.6    Lessard, É.7    Perkins, M.N.8    Laird, J.M.A.9
  • 11
    • 79952988955 scopus 로고    scopus 로고
    • 2 agonist from the cannabilactone class: Antinociception without central nervous system side-effects
    • doi:10.1016/j.pbb.2011.02.024
    • Rahn, E. J., Thakur, G. A., Wood, J. A. T., Zvonok, A. M., Makriyannis, A. & Hohmann, A. G. 2011 Pharmacological characterization of AM1710, a putative cannabinoid CB2 agonist from the cannabilactone class: antinociception without central nervous system side-effects. Pharmacol. Biochem. Behav. 98, 493-502. doi:10.1016/j.pbb.2011.02.024)
    • (2011) Pharmacol. Biochem. Behav , vol.98 , pp. 493-502
    • Rahn, E.J.1    Thakur, G.A.2    Wood, J.A.T.3    Zvonok, A.M.4    Makriyannis, A.5    Hohmann, A.G.6
  • 12
    • 80054917398 scopus 로고    scopus 로고
    • 2 receptor agonists
    • doi:10.1021/jm200916p
    • van der Stelt, M. et al. 2011 Discovery and optimization of 1-(4-(pyridin-2-yl)benzyl)imidazolidine-2,4-dione derivatives as a novel class of selective cannabinoid CB2 receptor agonists. J. Med. Chem. 54, 7350-7362. doi:10.1021/jm200916p)
    • (2011) J. Med. Chem , vol.54 , pp. 7350-7362
    • van der Stelt, M.1
  • 14
    • 84856651530 scopus 로고    scopus 로고
    • G-Carbolines: A novel class of cannabinoid agonists with high aqueous solubility and restricted CNS penetration
    • doi:10.1016/j.bmcl.2011.12.124
    • Cheng, Y.-X. et al. 2012 G-Carbolines: a novel class of cannabinoid agonists with high aqueous solubility and restricted CNS penetration. Bioorg. Med. Chem. Lett. 22, 1619-1624. doi:10.1016/j.bmcl.2011.12.124)
    • (2012) Bioorg. Med. Chem. Lett , vol.22 , pp. 1619-1624
    • Cheng, Y.-X.1
  • 15
    • 84859440850 scopus 로고    scopus 로고
    • 1 receptor agonists for the treatment of neuropathic pain
    • doi:10.1016/j.bmcl.2012.02.048
    • Adam, J. M. et al. 2012 Low brain penetrant CB1 receptor agonists for the treatment of neuropathic pain. Bioorg. Med. Chem. Lett. 22, 2932-2937. doi:10.1016/j.bmcl.2012.02.048)
    • (2012) Bioorg. Med. Chem. Lett , vol.22 , pp. 2932-2937
    • Adam, J.M.1
  • 16
    • 84876420552 scopus 로고    scopus 로고
    • In 20th Annu. Symp. on the Cannabinoids; 2010, Research Triangle Park, NC: Int. Cannabinoid Research Society
    • Groblewski, T. et al. 2010 Peripherally-acting CB1-CB2 agonists for pain: do they still hold promise? In 20th Annu. Symp. on the Cannabinoids; 2010, p. 38. Research Triangle Park, NC: Int. Cannabinoid Research Society.
    • (2010) 2 agonists for pain: Do they still hold promise? , pp. 38
    • Groblewski, T.1
  • 17
    • 79952902084 scopus 로고    scopus 로고
    • Antinociceptive effect of intrathecal cannabinoid receptor agonist WIN 55,212-2 in a rat bone tumor pain model
    • doi:10.1016/j.neulet.2010.12.052
    • Cui, J. H., Kim, W. M., Lee, H. G., Kim, Y. O., Kim, C. M. & Yoon, M. H. 2011 Antinociceptive effect of intrathecal cannabinoid receptor agonist WIN 55,212-2 in a rat bone tumor pain model. Neurosci. Lett. 493, 67-71. doi:10.1016/j.neulet.2010.12.052)
    • (2011) Neurosci. Lett , vol.493 , pp. 67-71
    • Cui, J.H.1    Kim, W.M.2    Lee, H.G.3    Kim, Y.O.4    Kim, C.M.5    Yoon, M.H.6
  • 18
    • 80054803771 scopus 로고    scopus 로고
    • Centrally mediated antinociceptive effects of cannabinoid receptor ligands in rat models of nociception
    • doi:10.1016/j.pbb.2011.09.004
    • Hama, A. & Sagen, J. 2011 Centrally mediated antinociceptive effects of cannabinoid receptor ligands in rat models of nociception. Pharmacol. Biochem. Behav. 100, 340-346. doi:10.1016/j.pbb.2011.09.004)
    • (2011) Pharmacol. Biochem. Behav , vol.100 , pp. 340-346
    • Hama, A.1    Sagen, J.2
  • 19
    • 44649182730 scopus 로고    scopus 로고
    • The cannabinoid receptor agonist, WIN 55, 212-2, attenuates tumor-evoked hyperalgesia through peripheral mechanisms
    • doi:10.1016/j.brainres.2008.03.063
    • Potenzieri, C., Harding-Rose, C. & Simone, D. A. 2008 The cannabinoid receptor agonist, WIN 55, 212-2, attenuates tumor-evoked hyperalgesia through peripheral mechanisms. Brain. Res. 1215, 69-75. doi:10.1016/j.brainres.2008.03.063)
    • (2008) Brain. Res , vol.1215 , pp. 69-75
    • Potenzieri, C.1    Harding-Rose, C.2    Simone, D.A.3
  • 20
    • 79961024146 scopus 로고    scopus 로고
    • Intrathecal administration of the cannabinoid 2 receptor agonist JWH015 can attenuate cancer pain and decrease mRNA expression of the 2B subunit of N-methyl-D-aspartic acid
    • doi:10.1213/ANE.0b013e31821d1062
    • Gu, X. P., Mei, F. M., Liu, Y., Zhang, R., Zhang, J. & Ma, Z. L. 2011 Intrathecal administration of the cannabinoid 2 receptor agonist JWH015 can attenuate cancer pain and decrease mRNA expression of the 2B subunit of N-methyl-D-aspartic acid. Anesth. Analg. 113, 405-411. doi:10.1213/ANE.0b013e31821d1062)
    • (2011) Anesth. Analg , vol.113 , pp. 405-411
    • Gu, X.P.1    Mei, F.M.2    Liu, Y.3    Zhang, R.4    Zhang, J.5    Ma, Z.L.6
  • 21
    • 79957687799 scopus 로고    scopus 로고
    • Increasing 2-arachidonoyl glycerol signaling in the periphery attenuates mechanical hyperalgesia in a model of bone cancer pain
    • doi:10.1016/j.phrs.2011.03.007
    • Khasabova, I. A., Chandiramani, A., Harding-Rose, C., Simone, D. A. & Seybold, V. S. 2011 Increasing 2-arachidonoyl glycerol signaling in the periphery attenuates mechanical hyperalgesia in a model of bone cancer pain. Pharmacol. Res. 64, 60-67. doi:10.1016/j.phrs.2011.03.007)
    • (2011) Pharmacol. Res , vol.64 , pp. 60-67
    • Khasabova, I.A.1    Chandiramani, A.2    Harding-Rose, C.3    Simone, D.A.4    Seybold, V.S.5
  • 22
  • 23
    • 0141832155 scopus 로고    scopus 로고
    • Topical cannabinoid antinociception: Synergy with spinal sites
    • doi:10.1016/S0304-3959(03)00068-X
    • Dogrul, A., Gul, H., Akar, A., Yildiz, O., Bilgin, F. & Guzeldemir, E. 2003 Topical cannabinoid antinociception: synergy with spinal sites. Pain 105, 11-16. doi:10.1016/S0304-3959(03)00068-X)
    • (2003) Pain , vol.105 , pp. 11-16
    • Dogrul, A.1    Gul, H.2    Akar, A.3    Yildiz, O.4    Bilgin, F.5    Guzeldemir, E.6
  • 24
    • 0141626772 scopus 로고    scopus 로고
    • Topical cannabinoid enhances topical morphine antinociception
    • doi:10.1016/S0304-3959(03)00245-8
    • Yesilyurt, O., Dogrul, A., Gul, H., Seyrek, M., Kusmez, O., Ozkan, Y. & Yildiz, O. 2003 Topical cannabinoid enhances topical morphine antinociception. Pain 105, 303-308. doi:10.1016/S0304-3959(03)00245-8)
    • (2003) Pain , vol.105 , pp. 303-308
    • Yesilyurt, O.1    Dogrul, A.2    Gul, H.3    Seyrek, M.4    Kusmez, O.5    Ozkan, Y.6    Yildiz, O.7
  • 25
    • 0344405669 scopus 로고    scopus 로고
    • Cannabinoid agonists attenuate capsaicininduced responses in human skin
    • doi:10.1016/S0304-3959(02)00401-3
    • Rukwied, R., Watkinson, A., McGlone, F. & Dvorak, M. 2003 Cannabinoid agonists attenuate capsaicininduced responses in human skin. Pain 102, 283-288. doi:10.1016/S0304-3959(02)00401-3)
    • (2003) Pain , vol.102 , pp. 283-288
    • Rukwied, R.1    Watkinson, A.2    McGlone, F.3    Dvorak, M.4
  • 26
    • 0037709373 scopus 로고    scopus 로고
    • Histamine induced responses are attenuated by a cannabinoid receptor agonist in human skin
    • doi:10.1007/s00011-003-1162-z
    • Dvorak, M., Watkinson, A., McGlone, F. & Rukwied, R. 2003 Histamine induced responses are attenuated by a cannabinoid receptor agonist in human skin. Inflamm. Res. 52, 238-245. doi:10.1007/s00011-003-1162-z)
    • (2003) Inflamm. Res , vol.52 , pp. 238-245
    • Dvorak, M.1    Watkinson, A.2    McGlone, F.3    Rukwied, R.4
  • 28
    • 34247862287 scopus 로고    scopus 로고
    • 2 receptor agonists
    • doi:10.2174/092986707780363023
    • Whiteside, G. T., Lee, G. P. & Valenzano, K. J. 2007 The role of the cannabinoid CB2 receptor in pain transmission and therapeutic potential of small molecule CB2 receptor agonists. Curr. Med. Chem. 14, 917-936. doi:10.2174/092986707780363023)
    • (2007) Curr. Med. Chem , vol.14 , pp. 917-936
    • Whiteside, G.T.1    Lee, G.P.2    Valenzano, K.J.3
  • 29
    • 38349119715 scopus 로고    scopus 로고
    • 2 receptors: A therapeutic target for the treatment of inflammatory and neuropathic pain
    • doi:10.1038/sj.bjp.0707531
    • Guindon, J. & Hohmann, A. G. 2008 Cannabinoid CB2 receptors: a therapeutic target for the treatment of inflammatory and neuropathic pain. Br. J. Pharmacol. 153, 319-334. doi:10.1038/sj.bjp.0707531)
    • (2008) Br. J. Pharmacol , vol.153 , pp. 319-334
    • Guindon, J.1    Hohmann, A.G.2
  • 30
    • 33645106816 scopus 로고    scopus 로고
    • 2 receptor-mediated antihyperalgesia: Possible direct involvement of neural mechanisms
    • doi:10.1111/j.1460-9568.2006.04684.x
    • Beltramo, M., Bernardini, N., Bertorelli, R., Campanella, M., Nicolussi, E., Fredduzzi, S. & Reggiani, A. 2006 CB2 receptor-mediated antihyperalgesia: possible direct involvement of neural mechanisms. Eur. J. Neurosci. 23, 1530-1538. doi:10.1111/j.1460-9568.2006.04684.x)
    • (2006) Eur. J. Neurosci , vol.23 , pp. 1530-1538
    • Beltramo, M.1    Bernardini, N.2    Bertorelli, R.3    Campanella, M.4    Nicolussi, E.5    Fredduzzi, S.6    Reggiani, A.7
  • 31
    • 80051798808 scopus 로고    scopus 로고
    • 2 agonist in an animal model of neuropathic pain
    • doi:10.1016/j.pain.2011.03.038
    • Gutierrez, T., Crystal, J. D., Zvonok, A. M., Makriyannis, A. & Hohmann, A. G. 2011 Selfmedication of a cannabinoid CB2 agonist in an animal model of neuropathic pain. Pain 152, 1976-1987. doi:10.1016/j.pain.2011.03.038)
    • (2011) Pain , vol.152 , pp. 1976-1987
    • Gutierrez, T.1    Crystal, J.D.2    Zvonok, A.M.3    Makriyannis, A.4    Hohmann, A.G.5
  • 32
    • 80052729004 scopus 로고    scopus 로고
    • Cannabinoid agonists inhibit neuropathic pain induced by brachial plexus avulsion in mice by affecting glial cells and MAP kinases
    • doi:10.1371/journal.pone.0024034
    • Paszcuk, A. F., Dutra, R. C., da Silva, K. A. B. S., Quintão, N. L. M., Campos, M. M. & Calixto, J. B. 2011 Cannabinoid agonists inhibit neuropathic pain induced by brachial plexus avulsion in mice by affecting glial cells and MAP kinases. PLoS ONE 6, e24034. doi:10.1371/journal.pone.0024034)
    • (2011) PLoS ONE , vol.6
    • Paszcuk, A.F.1    Dutra, R.C.2    da Silva, K.A.B.S.3    Quintão, N.L.M.4    Campos, M.M.5    Calixto, J.B.6
  • 33
    • 79960313458 scopus 로고    scopus 로고
    • Skeletal lipidomics: Regulation of bone metabolism by fatty acid amide family
    • doi:10.1111/j.1476-5381.2011.01474.x
    • Bab, I., Smoum, R., Bradshaw, H. & Mechoulam, R. 2011 Skeletal lipidomics: regulation of bone metabolism by fatty acid amide family. Br. J. Pharmacol. 163, 1441-1446. doi:10.1111/j.1476-5381.2011.01474.x)
    • (2011) Br. J. Pharmacol , vol.163 , pp. 1441-1446
    • Bab, I.1    Smoum, R.2    Bradshaw, H.3    Mechoulam, R.4
  • 34
    • 79960336157 scopus 로고    scopus 로고
    • The endocannabinoid system and cancer: Therapeutic implication
    • doi:10.1111/j.1476-5381.2011.01327.x
    • Guindon, J. & Hohmann, A. G. 2011 The endocannabinoid system and cancer: therapeutic implication. Br. J. Pharmacol. 163, 1447-1463. doi:10.1111/j.1476-5381.2011.01327.x)
    • (2011) Br. J. Pharmacol , vol.163 , pp. 1447-1463
    • Guindon, J.1    Hohmann, A.G.2
  • 35
    • 84859440706 scopus 로고    scopus 로고
    • 2 agonist as an antipruritic agent
    • doi:10.1016/j.bmcl.2012.02.072
    • Odan, M. et al. 2012 Discovery of S-777469: an orally available CB2 agonist as an antipruritic agent. Bioorg. Med. Chem. Lett. 22, 2803-2806. doi:10.1016/j.bmcl.2012.02.072)
    • (2012) Bioorg. Med. Chem. Lett , vol.22 , pp. 2803-2806
    • Odan, M.1
  • 36
    • 79959920826 scopus 로고    scopus 로고
    • Therapeutic potential of cannabinoids in the treatment of neuroinflammation associated with Parkinson's disease
    • Little, J. P., Villanueva, E. B. & Klegeris, A. 2011 Therapeutic potential of cannabinoids in the treatment of neuroinflammation associated with Parkinson's disease. Mini-Rev. Med. Chem. 11, 582-590.
    • (2011) Mini-Rev. Med. Chem , vol.11 , pp. 582-590
    • Little, J.P.1    Villanueva, E.B.2    Klegeris, A.3
  • 37
    • 79960317325 scopus 로고    scopus 로고
    • Prospects for cannabinoid therapies in basal ganglia disorders
    • doi:10.1111/j.1476-5381.2011.01365.x
    • Fernández-Ruiz, J. et al. 2011 Prospects for cannabinoid therapies in basal ganglia disorders. Br. J. Pharmacol. 163, 1365-1378. doi:10.1111/j.1476-5381.2011.01365.x)
    • (2011) Br. J. Pharmacol , vol.163 , pp. 1365-1378
    • Fernández-Ruiz, J.1
  • 38
    • 33746261289 scopus 로고    scopus 로고
    • 2 receptor selective compound, delays disease progression in a mouse model of amyotrophic lateral sclerosis
    • doi:10.1016/j.ejphar.2006.05.025
    • Kim, K., Moore, D. H., Makriyannis, A. & Abood, M. E. 2006 AM1241, a cannabinoid CB2 receptor selective compound, delays disease progression in a mouse model of amyotrophic lateral sclerosis. Eur. J. Pharmacol. 542, 100-105. doi:10.1016/j.ejphar.2006.05.025)
    • (2006) Eur. J. Pharmacol , vol.542 , pp. 100-105
    • Kim, K.1    Moore, D.H.2    Makriyannis, A.3    Abood, M.E.4
  • 39
    • 33947278309 scopus 로고    scopus 로고
    • 2 cannabinoid agonist AM- 1241 prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis when initiated at symptom onset
    • doi:10.1111/j.1471-4159.2006.04346.x
    • Shoemaker, J. L., Seely, K. A., Reed, R. L., Crow, J. P. & Prather, P. L. 2007 The CB2 cannabinoid agonist AM- 1241 prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis when initiated at symptom onset. J. Neurochem. 101, 87-98. doi:10.1111/j.1471-4159.2006.04346.x)
    • (2007) J. Neurochem , vol.101 , pp. 87-98
    • Shoemaker, J.L.1    Seely, K.A.2    Reed, R.L.3    Crow, J.P.4    Prather, P.L.5
  • 40
    • 38349111399 scopus 로고    scopus 로고
    • 2 receptor
    • doi:10.1038/sj.bjp.0707493
    • Dittel, B. N. 2008 Direct suppression of autoreactive lymphocytes in the central nervous system via the CB2 receptor. Br. J. Pharmacol. 153, 271-276. doi:10.1038/sj.bjp.0707493)
    • (2008) Br. J. Pharmacol , vol.153 , pp. 271-276
    • Dittel, B.N.1
  • 41
    • 80053571291 scopus 로고    scopus 로고
    • 2) immune regulation in health and disease
    • doi:10.1007/s12026-011-8210-5
    • Basu, S. & Dittel, B. N. 2011 Unraveling the complexities of cannabinoid receptor 2 (CB2) immune regulation in health and disease. Immunol. Res. 51, 26-38. doi:10.1007/s12026-011-8210-5)
    • (2011) Immunol. Res , vol.51 , pp. 26-38
    • Basu, S.1    Dittel, B.N.2
  • 42
    • 79955735991 scopus 로고    scopus 로고
    • HIV-1 infection and alcohol abuse: Neurocognitive impairment, mechanisms of neurodegeneration and therapeutic interventions
    • doi:10.1016/j.bbi.2011.03.001
    • Persidsky, Y., Ho, W. Z., Ramirez, S. H., Potula, R., Abood, M. E., Unterwald, E. & Tuma, R. 2011 HIV-1 infection and alcohol abuse: neurocognitive impairment, mechanisms of neurodegeneration and therapeutic interventions. Brain Behav. Immun. 25, S61-S70. doi:10.1016/j.bbi.2011.03.001)
    • (2011) Brain Behav. Immun , vol.25
    • Persidsky, Y.1    Ho, W.Z.2    Ramirez, S.H.3    Potula, R.4    Abood, M.E.5    Unterwald, E.6    Tuma, R.7
  • 43
    • 80051473369 scopus 로고    scopus 로고
    • Differential role of anandamide and 2-arachidonoylglycerol in memory and anxiety-like responses
    • doi:10.1016/j.biopsych.2011.04.022
    • Busquets-Garcia, A., Puighermanal, E., Pastor, A., de la Torre, R., Maldonado, R. & Ozaita, A. 2011 Differential role of anandamide and 2-arachidonoylglycerol in memory and anxiety-like responses. Biol. Psychiatry 70, 479-486. doi:10.1016/j.biopsych.2011.04.022)
    • (2011) Biol. Psychiatry , vol.70 , pp. 479-486
    • Busquets-Garcia, A.1    Puighermanal, E.2    Pastor, A.3    de la Torre, R.4    Maldonado, R.5    Ozaita, A.6
  • 44
    • 82955176995 scopus 로고    scopus 로고
    • 2 receptor-mediated regulation of impulsive-like behaviour in DBA/2 mice
    • doi:10.1111/j.1476-5381.2011.01542.x
    • Navarrete, F., Pérez-Ortiz, J. M. & Manzanares, J. 2012 Cannabinoid CB2 receptor-mediated regulation of impulsive-like behaviour in DBA/2 mice. Br. J. Pharmacol. 165, 260-273. doi:10.1111/j.1476-5381.2011.01542.x)
    • (2012) Br. J. Pharmacol , vol.165 , pp. 260-273
    • Navarrete, F.1    Pérez-Ortiz, J.M.2    Manzanares, J.3
  • 45
    • 80052213796 scopus 로고    scopus 로고
    • 2 receptors modulate cocaine's actions in mice
    • doi:10.1038/nn.2874
    • Xi, Z.-X. et al. 2011 Brain cannabinoid CB2 receptors modulate cocaine's actions in mice. Nat. Neurosci. 14, 1160-1166. doi:10.1038/nn.2874)
    • (2011) Nat. Neurosci , vol.14 , pp. 1160-1166
    • Xi, Z.-X.1
  • 46
    • 79959729749 scopus 로고    scopus 로고
    • Acute effects of a selective cannabinoid-2 receptor agonist on neuroinflammation in a model of traumatic brain injury
    • doi:10.1089/neu.2010.1672
    • Elliott, M. B., Tuma, R. F., Amenta, P. S., Barbe, M. F. & Jallo, J. I. 2011 Acute effects of a selective cannabinoid-2 receptor agonist on neuroinflammation in a model of traumatic brain injury. J. Neurotrauma 28, 973-981. doi:10.1089/neu.2010.1672)
    • (2011) J. Neurotrauma , vol.28 , pp. 973-981
    • Elliott, M.B.1    Tuma, R.F.2    Amenta, P.S.3    Barbe, M.F.4    Jallo, J.I.5
  • 47
    • 34250717998 scopus 로고    scopus 로고
    • 2 receptor activation decreases cerebral infarction in a mouse focal ischemia/reperfusion model
    • doi:10.1038/sj.jcbfm.9600447
    • Zhang, M., Martin, B. R., Adler, M.W., Razdan, R. K., Jallo, J. I. & Tuma, R. F. 2007 Cannabinoid CB2 receptor activation decreases cerebral infarction in a mouse focal ischemia/reperfusion model. J. Cereb. Blood Flow Metab. 27, 1387-1396. doi:10.1038/sj.jcbfm.9600447)
    • (2007) J. Cereb. Blood Flow Metab , vol.27 , pp. 1387-1396
    • Zhang, M.1    Martin, B.R.2    Adler, M.W.3    Razdan, R.K.4    Jallo, J.I.5    Tuma, R.F.6
  • 48
    • 38349144914 scopus 로고    scopus 로고
    • Endocannabinoids and cannabinoid receptors in ischaemia-reperfusion injury and preconditioning
    • doi:10.1038/sj.bjp.0707582
    • Pacher, P. & Haskó, G. 2008 Endocannabinoids and cannabinoid receptors in ischaemia-reperfusion injury and preconditioning. Br. J. Pharmacol. 153, 252-262. doi:10.1038/sj.bjp.0707582)
    • (2008) Br. J. Pharmacol , vol.153 , pp. 252-262
    • Pacher, P.1    Haskó, G.2
  • 50
    • 80055107075 scopus 로고    scopus 로고
    • Atheroprotection via cannabinoid receptor-2 is mediated by circulating and vascular cells in vivo
    • doi:10.1016/j.yjmcc.2011.08.008
    • Hoyer, F. F., Steinmetz, M., Zimmer, S., Becker, A., Lütjohann, D., Buchalla, R., Zimmer, A. & Nickenig, G. 2011 Atheroprotection via cannabinoid receptor-2 is mediated by circulating and vascular cells in vivo. J. Mol. Cell. Cardiol. 51, 1007-1014. doi:10.1016/j.yjmcc.2011.08.008)
    • (2011) J. Mol. Cell. Cardiol , vol.51 , pp. 1007-1014
    • Hoyer, F.F.1    Steinmetz, M.2    Zimmer, S.3    Becker, A.4    Lütjohann, D.5    Buchalla, R.6    Zimmer, A.7    Nickenig, G.8
  • 51
    • 38349119136 scopus 로고    scopus 로고
    • 2 receptors in the gastrointestinal tract: A regulatory system in states of inflammation
    • doi:10.1038/sj.bjp.0707486
    • Wright, K. L., Duncan, M. & Sharkey, K. A. 2008 Cannabinoid CB2 receptors in the gastrointestinal tract: a regulatory system in states of inflammation. Br. J. Pharmacol. 153, 263-270. doi:10.1038/sj.bjp.0707486)
    • (2008) Br. J. Pharmacol , vol.153 , pp. 263-270
    • Wright, K.L.1    Duncan, M.2    Sharkey, K.A.3
  • 52
    • 48249136051 scopus 로고    scopus 로고
    • Emerging role of cannabinoids in gastrointestinal and liver diseases: Basic and clinical aspects
    • doi:10.1136/gut.2008.148791
    • Izzo, A. A. & Camilleri, M. 2008 Emerging role of cannabinoids in gastrointestinal and liver diseases: basic and clinical aspects. Gut 57, 1140-1155. doi:10.1136/gut.2008.148791)
    • (2008) Gut , vol.57 , pp. 1140-1155
    • Izzo, A.A.1    Camilleri, M.2
  • 53
    • 84855765207 scopus 로고    scopus 로고
    • 2) agonist ameliorates colitis in IL-102/2 mice by attenuating the activation of T cells and promoting their apoptosis
    • doi:10.1016/j.taap.2011.11.005
    • Singh, U. P., Singh, N. P., Singh, B., Price, R. L., Nagarkatti, M. & Nagarkatti, P. S. 2012 Cannabinoid receptor-2 (CB2) agonist ameliorates colitis in IL-102/2 mice by attenuating the activation of T cells and promoting their apoptosis. Toxicol. Appl. Pharmacol. 258, 256-267. doi:10.1016/j.taap.2011.11.005)
    • (2012) Toxicol. Appl. Pharmacol , vol.258 , pp. 256-267
    • Singh, U.P.1    Singh, N.P.2    Singh, B.3    Price, R.L.4    Nagarkatti, M.5    Nagarkatti, P.S.6
  • 54
    • 33847171461 scopus 로고    scopus 로고
    • Cannabinoid receptors as new targets of antifibrosing strategies during chronic liver diseases
    • doi:10.1517/14728222.11.3.403
    • Mallat, A., Teixeira-Clerc, F., Deveaux, V. & Lotersztajn, S. 2007 Cannabinoid receptors as new targets of antifibrosing strategies during chronic liver diseases. Expert Opin. Ther. Targets 11, 403-409. doi:10.1517/14728222.11.3.403)
    • (2007) Expert Opin. Ther. Targets , vol.11 , pp. 403-409
    • Mallat, A.1    Teixeira-Clerc, F.2    Deveaux, V.3    Lotersztajn, S.4
  • 55
    • 38349095862 scopus 로고    scopus 로고
    • 2 receptors as new therapeutic targets for liver diseases
    • doi:10.1038/sj.bjp.0707511
    • Lotersztajn, S. et al. 2008 CB2 receptors as new therapeutic targets for liver diseases. Br. J. Pharmacol. 153, 286-289. doi:10.1038/sj.bjp.0707511)
    • (2008) Br. J. Pharmacol , vol.153 , pp. 286-289
    • Lotersztajn, S.1
  • 56
    • 79960297797 scopus 로고    scopus 로고
    • The endocannabinoid system as a key mediator during liver diseases: New insights and therapeutic openings
    • doi:10.1111/j.1476-5381.2011.01397.x
    • Mallat, A., Teixeira-Clerc, F., Deveaux, V., Manin, S. & Lotersztajn, S. 2011 The endocannabinoid system as a key mediator during liver diseases: new insights and therapeutic openings. Br. J. Pharmacol. 163, 1432-1440. doi:10.1111/j.1476-5381.2011.01397.x)
    • (2011) Br. J. Pharmacol , vol.163 , pp. 1432-1440
    • Mallat, A.1    Teixeira-Clerc, F.2    Deveaux, V.3    Manin, S.4    Lotersztajn, S.5
  • 57
    • 79551483215 scopus 로고    scopus 로고
    • Recent advances in the understanding of the role of the endocannabinoid system in liver diseases
    • doi:10.1016/j.dld.2010.08.010
    • Huang, L., Quinn, M. A., Frampton, G. A., Golden, L. E. & DeMorrow, S. 2011 Recent advances in the understanding of the role of the endocannabinoid system in liver diseases. Dig. Liver Dis. 43, 188-193. doi:10.1016/j.dld.2010.08.010)
    • (2011) Dig. Liver Dis , vol.43 , pp. 188-193
    • Huang, L.1    Quinn, M.A.2    Frampton, G.A.3    Golden, L.E.4    Demorrow, S.5
  • 58
    • 80053314254 scopus 로고    scopus 로고
    • 2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice
    • doi:10.1002/hep.24524
    • Louvet, A., Teixeira-Clerc, F., Chobert, M. N., Deveaux, V., Pavoine, C., Zimmer, A., Pecker, F., Mallat, A. & Lotersztajn, S. 2011 Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice. Hepatology 54, 1217-1226. doi:10.1002/hep.24524)
    • (2011) Hepatology , vol.54 , pp. 1217-1226
    • Louvet, A.1    Teixeira-Clerc, F.2    Chobert, M.N.3    Deveaux, V.4    Pavoine, C.5    Zimmer, A.6    Pecker, F.7    Mallat, A.8    Lotersztajn, S.9
  • 59
    • 80052897170 scopus 로고    scopus 로고
    • Protective role of cannabinoid receptor type 2 in a mouse model of diabetic nephropathy
    • doi:10.2337/db10-1809
    • Barutta, F. et al. 2011 Protective role of cannabinoid receptor type 2 in a mouse model of diabetic nephropathy. Diabetes 60, 2386-2396. doi:10.2337/db10-1809)
    • (2011) Diabetes , vol.60 , pp. 2386-2396
    • Barutta, F.1
  • 60
    • 72949117074 scopus 로고    scopus 로고
    • Cannabinoids and the skeleton: From marijuana to reversal of bone loss
    • doi:10.1080/07853890903121025
    • Bab, I., Zimmer, A. & Melamed, E. 2009 Cannabinoids and the skeleton: from marijuana to reversal of bone loss. Ann. Med. 41, 560-567. doi:10.1080/07853890903121025)
    • (2009) Ann. Med , vol.41 , pp. 560-567
    • Bab, I.1    Zimmer, A.2    Melamed, E.3
  • 61
    • 79960200114 scopus 로고    scopus 로고
    • G-protein coupled receptors regulating cough
    • doi:10.1016/j.coph.2011.06.005
    • Maher, S. A., Dubuis, E. D. & Belvisi, M. G. 2011 G-protein coupled receptors regulating cough. Curr. Opin. Pharmacol. 11, 248-253. doi:10.1016/j.coph.2011.06.005)
    • (2011) Curr. Opin. Pharmacol , vol.11 , pp. 248-253
    • Maher, S.A.1    Dubuis, E.D.2    Belvisi, M.G.3
  • 62
    • 0142166330 scopus 로고    scopus 로고
    • Cannabinoids: Potential anticancer agents
    • doi:10.1038/nrc1188
    • Guzmán, M. 2003 Cannabinoids: potential anticancer agents. Nat. Rev. Cancer 3, 745-755. doi:10.1038/nrc1188)
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 745-755
    • Guzmán, M.1
  • 64
    • 79958809001 scopus 로고    scopus 로고
    • Anti-tumoral action of cannabinoids on hepatocellular carcinoma: Role of AMPK-dependent activation of autophagy
    • doi:10.1038/cdd.2011.32
    • Vara, D., Salazar, M., Olea-Herrero, N., Guzmán, M., Velasco, G. & Díaz-Laviada, I. 2011 Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy. Cell Death Differ. 18, 1099-1111. doi:10.1038/cdd.2011.32)
    • (2011) Cell Death Differ , vol.18 , pp. 1099-1111
    • Vara, D.1    Salazar, M.2    Olea-Herrero, N.3    Guzmán, M.4    Velasco, G.5    Díaz-Laviada, I.6
  • 65
    • 80052532033 scopus 로고    scopus 로고
    • 2 in modulating breast cancer growth and invasion
    • doi:10.1371/journal.pone.0023901
    • Nasser, M. W., Qamri, Z., Deol, Y. S., Smith, D., Shilo, K., Zou, X. & Ganju, R. K. 2011 Crosstalk between chemokine receptor CXCR4 and cannabinoid receptor CB2 in modulating breast cancer growth and invasion. PLoS ONE 6, e23901. doi:10.1371/journal.pone.0023901)
    • (2011) PLoS ONE , vol.6
    • Nasser, M.W.1    Qamri, Z.2    Deol, Y.S.3    Smith, D.4    Shilo, K.5    Zou, X.6    Ganju, R.K.7
  • 66
    • 84856255709 scopus 로고    scopus 로고
    • 2 agonist and antagonist on intravenous nicotine self administration and reinstatement of nicotine seeking
    • doi:10.1371/journal.pone.0029900
    • Gamaleddin, I., Zvonok, A., Makriyannis, A., Goldberg, S. R. & Le Foll, B. 2012 Effects of a selective cannabinoid CB2 agonist and antagonist on intravenous nicotine self administration and reinstatement of nicotine seeking. PLoS ONE 7, e29900. doi:10.1371/journal.pone.0029900)
    • (2012) PLoS ONE , vol.7
    • Gamaleddin, I.1    Zvonok, A.2    Makriyannis, A.3    Goldberg, S.R.4    Le Foll, B.5
  • 67
    • 84863380403 scopus 로고    scopus 로고
    • Activation of cannabinoid receptor 2 attenuates leukocyte-endothelial cell interactions and blood-brain barrier dysfunction under inflammatory conditions
    • doi:10.1523/JNEUROSCI.4628-11.2012
    • Ramirez, S. H. et al. 2012 Activation of cannabinoid receptor 2 attenuates leukocyte-endothelial cell interactions and blood-brain barrier dysfunction under inflammatory conditions. J. Neurosci. 32, 4004-4016. doi:10.1523/JNEUROSCI.4628-11.2012)
    • (2012) J. Neurosci , vol.32 , pp. 4004-4016
    • Ramirez, S.H.1
  • 68
    • 83455201005 scopus 로고    scopus 로고
    • Modulation of inflammatory responses by a cannabinoid-2-selective agonist after spinal cord injury
    • doi:10.1089/neu.2011.1853
    • Adhikary, S., Li, H., Heller, J., Skarica, M., Zhang, M., Ganea, D. & Tuma, R. F. 2011 Modulation of inflammatory responses by a cannabinoid-2-selective agonist after spinal cord injury. J. Neurotrauma 28, 2417-2427. doi:10.1089/neu.2011.1853)
    • (2011) J. Neurotrauma , vol.28 , pp. 2417-2427
    • Adhikary, S.1    Li, H.2    Heller, J.3    Skarica, M.4    Zhang, M.5    Ganea, D.6    Tuma, R.F.7
  • 69
    • 33847119449 scopus 로고    scopus 로고
    • 2, cannabinoid receptors
    • doi:10.1038/sj.bjp.0707003
    • Pryce, G. & Baker, D. 2007 Control of spasticity in a multiple sclerosis model is mediated by CB1, not CB2, cannabinoid receptors. Br. J. Pharmacol. 150, 519-525. doi:10.1038/sj.bjp.0707003)
    • (2007) Br. J. Pharmacol , vol.150 , pp. 519-525
    • Pryce, G.1    Baker, D.2
  • 70
    • 79960892570 scopus 로고    scopus 로고
    • Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice
    • doi:10.1016/j.pbb.2011.06.022
    • Kinsey, S. G., Naidu, P. S., Cravatt, B. F., Dudley, D. T. & Lichtman, A.H. 2011 Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice. Pharmacol. Biochem. Behav. 99, 718-725. doi:10.1016/j.pbb.2011.06.022)
    • (2011) Pharmacol. Biochem. Behav , vol.99 , pp. 718-725
    • Kinsey, S.G.1    Naidu, P.S.2    Cravatt, B.F.3    Dudley, D.T.4    Lichtman, A.H.5
  • 71
    • 84855272776 scopus 로고    scopus 로고
    • Modulation of L-a-lysophosphatidylinositol/GPR55 mitogen-activated protein kinase (MAPK) signaling by cannabinoids
    • doi:10.1074/jbc.M111.296020
    • Anavi-Goffer, S., Baillie, G., Irving, A. J., Gertsch, J., Greig, I. R., Pertwee, R. G. & Ross, R. A. 2012 Modulation of L-a-lysophosphatidylinositol/GPR55 mitogen-activated protein kinase (MAPK) signaling by cannabinoids. J. Biol. Chem. 287, 91-104. doi:10.1074/jbc.M111.296020)
    • (2012) J. Biol. Chem , vol.287 , pp. 91-104
    • Anavi-Goffer, S.1    Baillie, G.2    Irving, A.J.3    Gertsch, J.4    Greig, I.R.5    Pertwee, R.G.6    Ross, R.A.7
  • 72
    • 1242317834 scopus 로고    scopus 로고
    • Effects of coadministration of cannabinoids and morphine on nociceptive behaviour, brain monoamines and HPA axis activity in a rat model of persistent pain
    • doi:10.1111/j.0953-816X.2004.03177.x
    • Finn, D. P., Beckett, S. R. G., Roe, C. H., Madjd, A., Fone, K. C. F., Kendall, D. A., Marsden, C. A. & Chapman, V. 2004 Effects of coadministration of cannabinoids and morphine on nociceptive behaviour, brain monoamines and HPA axis activity in a rat model of persistent pain. Eur. J. Neurosci. 19, 678-686. doi:10.1111/j.0953-816X.2004.03177.x)
    • (2004) Eur. J. Neurosci , vol.19 , pp. 678-686
    • Finn, D.P.1    Beckett, S.R.G.2    Roe, C.H.3    Madjd, A.4    Fone, K.C.F.5    Kendall, D.A.6    Marsden, C.A.7    Chapman, V.8
  • 73
    • 0041324602 scopus 로고    scopus 로고
    • Pharmacologic interaction between cannabinoid and either clonidine or neostigmine in the rat formalin test
    • doi:10.1097/00000542-200309000-00027
    • Yoon, M. H. & Choi, J. 2003 Pharmacologic interaction between cannabinoid and either clonidine or neostigmine in the rat formalin test. Anesthesiology 99, 701-707. doi:10.1097/00000542-200309000-00027)
    • (2003) Anesthesiology , vol.99 , pp. 701-707
    • Yoon, M.H.1    Choi, J.2
  • 74
    • 33847231287 scopus 로고    scopus 로고
    • Antinociceptive synergy between the cannabinoid receptor agonist WIN 55,212-2 and bupivacaine in the rat formalin test
    • doi:10.1213/01.ane.0000255291.38637.26
    • Kang, S., Kim, C. H., Lee, H., Kim, D. Y., Han, J. I., Chung, R. K. & Lee, G. Y. 2007 Antinociceptive synergy between the cannabinoid receptor agonist WIN 55,212-2 and bupivacaine in the rat formalin test. Anesth. Analg. 104, 719-725. doi:10.1213/01.ane.0000255291.38637.26)
    • (2007) Anesth. Analg , vol.104 , pp. 719-725
    • Kang, S.1    Kim, C.H.2    Lee, H.3    Kim, D.Y.4    Han, J.I.5    Chung, R.K.6    Lee, G.Y.7
  • 75
    • 32944463459 scopus 로고    scopus 로고
    • Local interactions between anandamide, an endocannabinoid, and ibuprofen, a nonsteroidal anti-inflammatory drug, in acute and inflammatory pain
    • doi:10.1016/j.pain.2005.12.007
    • Guindon, J., De Léan, A. & Beaulieu, P. 2006 Local interactions between anandamide, an endocannabinoid, and ibuprofen, a nonsteroidal anti-inflammatory drug, in acute and inflammatory pain. Pain 121, 85-93. doi:10.1016/j.pain.2005.12.007)
    • (2006) Pain , vol.121 , pp. 85-93
    • Guindon, J.1    de Léan, A.2    Beaulieu, P.3
  • 76
    • 77950552027 scopus 로고    scopus 로고
    • 1 agonist or antagonist and involves the serotonergic system in rats
    • doi:10.1016/j.lfs.2010.02.006
    • Ruggieri, V., Vitale, G., Filaferro, M., Frigeri, C., Pini, L. A. & Sandrini, M. 2010 The antinociceptive effect of acetylsalicylic acid is differently affected by a CB1 agonist or antagonist and involves the serotonergic system in rats. Life Sci. 86, 510-517. doi:10.1016/j.lfs.2010.02.006)
    • (2010) Life Sci , vol.86 , pp. 510-517
    • Ruggieri, V.1    Vitale, G.2    Filaferro, M.3    Frigeri, C.4    Pini, L.A.5    Sandrini, M.6
  • 77
    • 34848861063 scopus 로고    scopus 로고
    • Blockade of central cyclooxygenase (COX) pathways enhances the cannabinoid-induced antinociceptive effects on inflammatory temporomandibular joint (TMJ) nociception
    • doi:10.1016/j.pain.2007.01.015
    • Ahn, D. K., Choi, H. S., Yeo, S. P., Woo, Y. W., Lee, M. K., Yang, G. Y., Jeon, H. J., Park, J. S. & Mokha, S. S. 2007 Blockade of central cyclooxygenase (COX) pathways enhances the cannabinoid-induced antinociceptive effects on inflammatory temporomandibular joint (TMJ) nociception. Pain 132, 23-32. doi:10.1016/j.pain.2007.01.015)
    • (2007) Pain , vol.132 , pp. 23-32
    • Ahn, D.K.1    Choi, H.S.2    Yeo, S.P.3    Woo, Y.W.4    Lee, M.K.5    Yang, G.Y.6    Jeon, H.J.7    Park, J.S.8    Mokha, S.S.9
  • 78
    • 31444445712 scopus 로고    scopus 로고
    • The additive antinociceptive interaction between WIN 55,212-2, a cannabinoid agonist, and ketorolac
    • doi:10.1213/01.ane.0000194587.94260.1d
    • Ulugöl, A., Özyigit, F., Yeşilyurt, Ö. & Dogrul, A. 2006 The additive antinociceptive interaction between WIN 55,212-2, a cannabinoid agonist, and ketorolac. Anesth. Analg. 102, 443-447. doi:10.1213/01.ane.0000194587.94260.1d)
    • (2006) Anesth. Analg , vol.102 , pp. 443-447
    • Ulugöl, A.1    Özyigit, F.2    Yeşilyurt, Ö.3    Dogrul, A.4
  • 79
    • 0030604225 scopus 로고    scopus 로고
    • 9-tetrahydrocannabinol-induced analgesia by morphine in mice: Involvement of m- and k-opioid receptors
    • doi:10.1016/S0014-2999(96)00752-2
    • 9-tetrahydrocannabinol-induced analgesia by morphine in mice: involvement of m- and k-opioid receptors. Eur. J. Pharmacol. 318, 11-16. doi:10.1016/S0014-2999(96)00752-2)
    • (1996) Eur. J. Pharmacol , vol.318 , pp. 11-16
    • Reche, I.1    Fuentes, J.A.2    Ruiz-Gayo, M.3
  • 80
    • 0035150352 scopus 로고    scopus 로고
    • Cannabinoid receptors and pain
    • doi:10.1016/S0301-0082(00)00031-9
    • Pertwee, R. G. 2001 Cannabinoid receptors and pain. Prog. Neurobiol. 63, 569-611. doi:10.1016/S0301-0082(00)00031-9)
    • (2001) Prog. Neurobiol , vol.63 , pp. 569-611
    • Pertwee, R.G.1
  • 81
    • 0037373238 scopus 로고    scopus 로고
    • 9-tetrahydrocannabinol and opioids after oral administration
    • doi:10.1124/jpet.102.045575
    • 9-tetrahydrocannabinol and opioids after oral administration. J. Pharmacol. Exp. Ther. 304, 1010-1015. doi:10.1124/jpet.102.045575)
    • (2003) J. Pharmacol. Exp. Ther , vol.304 , pp. 1010-1015
    • Cichewicz, D.L.1    McCarthy, E.A.2
  • 82
    • 0346099153 scopus 로고    scopus 로고
    • Synergistic interactions between cannabinoid and opioid analgesics
    • doi:10.1016/j.lfs.2003.09.038
    • Cichewicz, D. L. 2004 Synergistic interactions between cannabinoid and opioid analgesics. Life Sci. 74, 1317-1324. doi:10.1016/j.lfs.2003.09.038)
    • (2004) Life Sci , vol.74 , pp. 1317-1324
    • Cichewicz, D.L.1
  • 83
    • 17144401168 scopus 로고    scopus 로고
    • 2-adrenoceptor agonists in acute pain models in mice
    • doi:10.1038/sj.bjp.0706045
    • Tham, S. M., Angus, J. A., Tudor, E. M. & Wright, C. E. 2005 Synergistic and additive interactions of the cannabinoid agonist CP55,940 with μ opioid receptor and α2-adrenoceptor agonists in acute pain models in mice. Br. J. Pharmacol. 144, 875-884. doi:10.1038/sj.bjp.0706045)
    • (2005) Br. J. Pharmacol , vol.144 , pp. 875-884
    • Tham, S.M.1    Angus, J.A.2    Tudor, E.M.3    Wright, C.E.4
  • 86
    • 34249108566 scopus 로고    scopus 로고
    • 9-tetrahydrocannabinol and morphine in the arthritic rat
    • doi:10.1016/j.ejphar.2007.04.010
    • 9-tetrahydrocannabinol and morphine in the arthritic rat. Eur. J. Pharmacol. 567, 125-130. doi:10.1016/j.ejphar.2007.04.010)
    • (2007) Eur. J. Pharmacol , vol.567 , pp. 125-130
    • Cox, M.L.1    Haller, V.L.2    Welch, S.P.3
  • 87
    • 34548483418 scopus 로고    scopus 로고
    • 9-tetrahydrocannabinol circumvents antinociceptive tolerance and apparent desensitization of receptors
    • doi:10.1016/j.ejphar.2007.06.001
    • 9-tetrahydrocannabinol circumvents antinociceptive tolerance and apparent desensitization of receptors. Eur. J. Pharmacol. 571, 129-137. doi:10.1016/j.ejphar.2007.06.001)
    • (2007) Eur. J. Pharmacol , vol.571 , pp. 129-137
    • Smith, P.A.1    Selley, D.E.2    Sim-Selley, L.J.3    Welch, S.P.4
  • 88
    • 46649097590 scopus 로고    scopus 로고
    • 9-tetrahydrocannabinol and m opioid receptor agonists in rhesus monkeys: Discrimination and antinociception
    • doi:10.1007/s00213-008-1157-0
    • 9-tetrahydrocannabinol and m opioid receptor agonists in rhesus monkeys: discrimination and antinociception. Psychopharmacology 199, 199-208. doi:10.1007/s00213-008-1157-0)
    • (2008) Psychopharmacology , vol.199 , pp. 199-208
    • Li, J.-X.1    McMahon, L.R.2    Gerak, L.R.3    Becker, G.L.4    France, C.P.5
  • 89
    • 67651028391 scopus 로고    scopus 로고
    • 2009 Interaction of the cannabinoid and opioid systems in the modulation of nociception
    • doi:10.1080/09540260902782794
    • Welch, S. P. 2009 Interaction of the cannabinoid and opioid systems in the modulation of nociception. Int. Rev. Psych. 21, 143-151. doi:10.1080/09540260902782794)
    • Int. Rev. Psych , vol.21 , pp. 143-151
    • Welch, S.P.1
  • 90
    • 72049125608 scopus 로고    scopus 로고
    • 1 receptor agonist and an NMDA receptor antagonist: Interactive effects
    • doi:10.1016/j.neuropharm.2009.08.005
    • Fischer, B. D., Ward, S. J., Henry, F. E. & Dykstra, L. A. 2010 Attenuation of morphine antinociceptive tolerance by a CB1 receptor agonist and an NMDA receptor antagonist: interactive effects. Neuropharmacology 58, 544-550. doi:10.1016/j.neuropharm.2009.08.005)
    • (2010) Neuropharmacology , vol.58 , pp. 544-550
    • Fischer, B.D.1    Ward, S.J.2    Henry, F.E.3    Dykstra, L.A.4
  • 91
    • 84855930166 scopus 로고    scopus 로고
    • 2 receptors mediated antinociception in mice
    • doi:10.1016/j.neuropharm.2011.09.013
    • Fang, Q., Han, Z.-L., Li, N., Wang, Z.-L., He, N. & Wang, R. 2012 Effects of neuropeptide FF system on CB1 and CB2 receptors mediated antinociception in mice. Neuropharmacology 62, 855-864. doi:10.1016/j.neuropharm.2011.09.013)
    • (2012) Neuropharmacology , vol.62 , pp. 855-864
    • Fang, Q.1    Han, Z.-L.2    Li, N.3    Wang, Z.-L.4    He, N.5    Wang, R.6
  • 92
    • 0031007584 scopus 로고    scopus 로고
    • Pain relief with oral cannabinoids in familial Mediterranean fever
    • doi:10.1111/j.1365-2044.1997.139-az0132.x
    • Holdcroft, A., Smith, M., Jacklin, A., Hodgson, H., Smith, B., Newton, M. & Evans, F. 1997 Pain relief with oral cannabinoids in familial Mediterranean fever. Anaesthesia 52, 483-488. doi:10.1111/j.1365-2044.1997.139-az0132.x)
    • (1997) Anaesthesia , vol.52 , pp. 483-488
    • Holdcroft, A.1    Smith, M.2    Jacklin, A.3    Hodgson, H.4    Smith, B.5    Newton, M.6    Evans, F.7
  • 93
    • 39549091694 scopus 로고    scopus 로고
    • Efficacy of dronabinol as an adjuvant treatment for chronic pain patients on opioid therapy
    • doi:10.1016/j.jpain.2007.10.018
    • Narang, S., Gibson, D., Wasan, A. D., Ross, E. L., Michna, E., Nedelikovic, S. S. & Jamison, R. N. 2008 Efficacy of dronabinol as an adjuvant treatment for chronic pain patients on opioid therapy. J. Pain 9, 254-264. doi:10.1016/j.jpain.2007.10.018)
    • (2008) J. Pain , vol.9 , pp. 254-264
    • Narang, S.1    Gibson, D.2    Wasan, A.D.3    Ross, E.L.4    Michna, E.5    Nedelikovic, S.S.6    Jamison, R.N.7
  • 95
    • 33646235388 scopus 로고    scopus 로고
    • 9-tetrahydrocannabinol and the opioid receptor agonist piritramide do not act synergistically in postoperative pain
    • doi:10.1007/s00101-005-0963-6
    • 9-tetrahydrocannabinol and the opioid receptor agonist piritramide do not act synergistically in postoperative pain. Anaesthesist 55, 391-400. doi:10.1007/s00101-005-0963-6)
    • (2006) Anaesthesist , vol.55 , pp. 391-400
    • Seeling, W.1
  • 96
    • 0141515748 scopus 로고    scopus 로고
    • The analgesic effect of oral D-9-tetrahydrocannabinol (THC), morphine, and a THC-morphine combination in healthy subjects under experimental pain conditions
    • doi:10.1016/S0304-3959(03)00163-5
    • Naef, M., Curatolo, M., Petersen-Felix, S., Arendt-Nielsen, L., Zbinden, A. & Brenneisen, R. 2003 The analgesic effect of oral D-9-tetrahydrocannabinol (THC), morphine, and a THC-morphine combination in healthy subjects under experimental pain conditions. Pain 105, 79-88. doi:10.1016/S0304-3959(03)00163-5)
    • (2003) Pain , vol.105 , pp. 79-88
    • Naef, M.1    Curatolo, M.2    Petersen-Felix, S.3    Arendt-Nielsen, L.4    Zbinden, A.5    Brenneisen, R.6
  • 97
    • 29844446057 scopus 로고    scopus 로고
    • Synergistic affective analgesic interaction between Δ-9-tetrahydrocannabinol and morphine
    • doi:10.1016/j.ejphar.2005.11.036
    • Roberts, J. D., Gennings, C. & Shih, M. 2006 Synergistic affective analgesic interaction between Δ-9-tetrahydrocannabinol and morphine. Eur. J. Pharmacol. 530, 54-58. doi:10.1016/j.ejphar.2005.11.036
    • (2006) Eur. J. Pharmacol , vol.530 , pp. 54-58
    • Roberts, J.D.1    Gennings, C.2    Shih, M.3
  • 100
    • 32844459527 scopus 로고    scopus 로고
    • Role of the cannabinoid system in the effects induced by nicotine on anxiety-like behaviour in mice
    • doi:10.1007/s00213-005-0251-9
    • Balerio, G. N., Aso, E. & Maldonado, R. 2006 Role of the cannabinoid system in the effects induced by nicotine on anxiety-like behaviour in mice. Psychopharmacology 184, 504-513. doi:10.1007/s00213-005-0251-9)
    • (2006) Psychopharmacology , vol.184 , pp. 504-513
    • Balerio, G.N.1    Aso, E.2    Maldonado, R.3
  • 101
    • 33846014230 scopus 로고    scopus 로고
    • 9-tetrahydrocannabinol and AM 404, the anandamide transport inhibitor, in Sprague-Dawley rats
    • doi:10.1016/j.ejphar.2006.10.038
    • 9-tetrahydrocannabinol and AM 404, the anandamide transport inhibitor, in Sprague-Dawley rats. Eur. J. Pharmacol. 555, 156-163. doi:10.1016/j.ejphar.2006.10.038)
    • Eur. J. Pharmacol , vol.555 , pp. 156-163
    • Braida, D.1    Limonta, V.2    Malabarba, L.3    Zani, A.4    Sala, M.5
  • 102
    • 46849100450 scopus 로고    scopus 로고
    • Activation of endocannabinoid transmission induces antidepressant-like effects in rats
    • Adamczyk, P., Golda, A., McCreary, A. C., Filip, M. & Przegalński, E. 2008 Activation of endocannabinoid transmission induces antidepressant-like effects in rats. J. Physiol. Pharmacol. 59, 217-228.
    • (2008) J. Physiol. Pharmacol , vol.59 , pp. 217-228
    • Adamczyk, P.1    Golda, A.2    McCreary, A.C.3    Filip, M.4    Przegalński, E.5
  • 103
    • 50649102129 scopus 로고    scopus 로고
    • The cannabinoid anticonvulsant effect on pentylenetetrazole-induced seizure is potentiated by ultra-low dose naltrexone in mice
    • doi:10.1016/j.eplepsyres.2008.04.010
    • Bahremand, A., Shafaroodi, H., Ghasemi, M., Nasrabady, S. E., Gholizadeh, S. & Dehpour, A. R. 2008 The cannabinoid anticonvulsant effect on pentylenetetrazole-induced seizure is potentiated by ultra-low dose naltrexone in mice. Epilepsy Res. 81, 44-51. doi:10.1016/j.eplepsyres.2008.04.010)
    • (2008) Epilepsy Res , vol.81 , pp. 44-51
    • Bahremand, A.1    Shafaroodi, H.2    Ghasemi, M.3    Nasrabady, S.E.4    Gholizadeh, S.5    Dehpour, A.R.6
  • 104
    • 82455210955 scopus 로고    scopus 로고
    • Effects of WIN 55,212-2 mesylate (a synthetic cannabinoid) on the protective action of clonazepam, ethosuximide, phenobarbital and valproate against pentylenetetrazole-induced clonic seizures in mice
    • doi:10.1016/j.pnpbp.2011.07.001
    • Luszczki, J. J., Andres-Mach, M., Barcicka-Klosowska, B., Florek-Luszczki, M., Haratym-Maj, A. & Czuczwar, S. J. 2011 Effects of WIN 55,212-2 mesylate (a synthetic cannabinoid) on the protective action of clonazepam, ethosuximide, phenobarbital and valproate against pentylenetetrazole-induced clonic seizures in mice. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 35, 1870-1876. doi:10.1016/j.pnpbp.2011.07.001)
    • (2011) Prog. Neuro-Psychopharmacol. Biol. Psychiatry , vol.35 , pp. 1870-1876
    • Luszczki, J.J.1    Andres-Mach, M.2    Barcicka-Klosowska, B.3    Florek-Luszczki, M.4    Haratym-Maj, A.5    Czuczwar, S.J.6
  • 105
    • 79251642782 scopus 로고    scopus 로고
    • Synthetic cannabinoid WIN 55,212-2 mesylate enhances the protective action of four classical antiepileptic drugs against maximal electroshock-induced seizures in mice
    • doi:10.1016/j.pbb.2011.01.002
    • Luszczki, J. J., Misiuta-Krzesinska, M., Florek, M., Tutka, P. & Czuczwar, S. J. 2011 Synthetic cannabinoid WIN 55,212-2 mesylate enhances the protective action of four classical antiepileptic drugs against maximal electroshock-induced seizures in mice. Pharmacol. Biochem. Behav. 98, 261-267. doi:10.1016/j.pbb.2011.01.002)
    • (2011) Pharmacol. Biochem. Behav , vol.98 , pp. 261-267
    • Luszczki, J.J.1    Misiuta-Krzesinska, M.2    Florek, M.3    Tutka, P.4    Czuczwar, S.J.5
  • 106
    • 73649113131 scopus 로고    scopus 로고
    • 1 receptor agonist, on the protective action of the various antiepileptic drugs in the mouse maximal electroshock-induced seizure model
    • doi:10.1016/j.pnpbp.2009.09.005
    • Luszczki, J. J., Czuczwar, P., Cioczek-Czuczwar, A., Dudra-Jastrzebska, M., Andres-Mach, M. & Czuczwar, S. J. 2010 Effect of arachidonyl-2 '-chloroethylamide, a selective cannabinoid CB1 receptor agonist, on the protective action of the various antiepileptic drugs in the mouse maximal electroshock-induced seizure model. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 34, 18-25. doi:10.1016/j.pnpbp.2009.09.005)
    • (2010) Prog. Neuro-Psychopharmacol. Biol. Psychiatry , vol.34 , pp. 18-25
    • Luszczki, J.J.1    Czuczwar, P.2    Cioczek-Czuczwar, A.3    Dudra-Jastrzebska, M.4    Andres-Mach, M.5    Czuczwar, S.J.6
  • 107
    • 55349089895 scopus 로고    scopus 로고
    • Evaluation of nteractions between cannabinoid compounds and diazepam in electroshock-induced seizure model in mice
    • doi:10.1007/s00702-008-0076-x
    • Naderi, N., Ahari, F. A., Shafaghi, B., Najarkolaei, A.H. & Motamedi, F. 2008 Evaluation of nteractions between cannabinoid compounds and diazepam in electroshock-induced seizure model in mice. J. Neural. Transm. 115, 1501-1511. doi:10.1007/s00702-008-0076-x)
    • (2008) J. Neural. Transm , vol.115 , pp. 1501-1511
    • Naderi, N.1    Ahari, F.A.2    Shafaghi, B.3    Najarkolaei, A.H.4    Motamedi, F.5
  • 108
    • 79957911695 scopus 로고    scopus 로고
    • Low-volume binary drug therapy for the treatment of hypovolemia
    • doi:10.1097/SHK.0b013e3182150e80
    • Bhattacharjee, H., Nadipuram, A., Kosanke, S., Kiani, M. F. & Moore, B. M. 2011 Low-volume binary drug therapy for the treatment of hypovolemia. Shock 35, 590-596. doi:10.1097/SHK.0b013e3182150e80)
    • (2011) Shock , vol.35 , pp. 590-596
    • Bhattacharjee, H.1    Nadipuram, A.2    Kosanke, S.3    Kiani, M.F.4    Moore, B.M.5
  • 109
    • 80054869394 scopus 로고    scopus 로고
    • Nonpsychotropic cannabinoids, abnormal cannabidiol and cannabigerol-dimethyl heptyl, act at novel cannabinoid receptors to reduce intraocular pressure
    • doi:10.1089/jop.2011.0041
    • Szczesniak, A.-M., Maor, Y., Robertson, H., Hung, O. & Kelly, M. E. M. 2011 Nonpsychotropic cannabinoids, abnormal cannabidiol and cannabigerol-dimethyl heptyl, act at novel cannabinoid receptors to reduce intraocular pressure. J. Ocular Pharmacol. Ther. 27, 427-435. doi:10.1089/jop.2011.0041)
    • (2011) J. Ocular Pharmacol. Ther , vol.27 , pp. 427-435
    • Szczesniak, A.-M.1    Maor, Y.2    Robertson, H.3    Hung, O.4    Kelly, M.E.M.5
  • 111
    • 3142697890 scopus 로고    scopus 로고
    • A comparative analysis of the potential of cannabinoids and ondansetron to suppress cisplatin-induced emesis in the Suncus murinus (house musk shrew)
    • doi:10.1007/s00213-003-1739-9
    • Kwiatkowska, M., Parker, L. A., Burton, P. & Mechoulam, R. 2004 A comparative analysis of the potential of cannabinoids and ondansetron to suppress cisplatin-induced emesis in the Suncus murinus (house musk shrew). Psychopharmacology 174, 254-259. doi:10.1007/s00213-003-1739-9)
    • (2004) Psychopharmacology , vol.174 , pp. 254-259
    • Kwiatkowska, M.1    Parker, L.A.2    Burton, P.3    Mechoulam, R.4
  • 112
    • 79959956124 scopus 로고    scopus 로고
    • Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism
    • doi:10.1038/cddis.2011.36
    • Donadelli, M. et al. 2011 Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism. Cell Death Dis. 2, e152. doi:10.1038/cddis.2011.36)
    • (2011) Cell Death Dis , vol.2
    • Donadelli, M.1
  • 113
    • 35948993422 scopus 로고    scopus 로고
    • 1 receptor G protein coupling switch that is prevented by ultra-low dose rimonabant
    • doi:10.1097/FBP.0b013e 3282f15890
    • Paquette, J. J., Wang, H.-Y., Bakshi, K. & Olmstead, M.C. 2007 Cannabinoid-induced tolerance is associated with a CB1 receptor G protein coupling switch that is prevented by ultra-low dose rimonabant. Behav. Pharmacol. 18, 767-776. doi:10.1097/FBP.0b013e 3282f15890)
    • (2007) Behav. Pharmacol , vol.18 , pp. 767-776
    • Paquette, J.J.1    Wang, H.-Y.2    Bakshi, K.3    Olmstead, M.C.4
  • 114
    • 34948881750 scopus 로고    scopus 로고
    • Ultra-low dose cannabinoid antagonist AM251 enhances cannabinoid anticonvulsant effects in the pentylenetetrazole-induced seizure in mice
    • doi:10.1016/j.neuropharm.2007.08.005
    • Gholizadeh, S., Shafaroodi, H., Ghasemi, M., Bahremand, A., Sharifzadeh, M. & Dehpour, A. R. 2007 Ultra-low dose cannabinoid antagonist AM251 enhances cannabinoid anticonvulsant effects in the pentylenetetrazole-induced seizure in mice. Neuropharmacology 53, 763-770. doi:10.1016/j.neuropharm.2007.08.005)
    • (2007) Neuropharmacology , vol.53 , pp. 763-770
    • Gholizadeh, S.1    Shafaroodi, H.2    Ghasemi, M.3    Bahremand, A.4    Sharifzadeh, M.5    Dehpour, A.R.6
  • 115
    • 84859054584 scopus 로고    scopus 로고
    • 2 receptors
    • doi:10.1111/j.1476-5381.2011.01410.x
    • 8-Tetrahydrocannabivarin protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress and inflammatory response via CB2 receptors. Br. J. Pharmacol. 165, 2450-2461. doi:10.1111/j.1476-5381.2011.01410.x)
    • (2012) Br. J. Pharmacol , vol.165 , pp. 2450-2461
    • Bátkai, S.1
  • 117
    • 78249233276 scopus 로고    scopus 로고
    • 1 prevents leukocyte infiltration and experimental fibrosis
    • doi:10.1002/art.27642
    • Marquart, S. et al. 2010 Inactivation of the cannabinoid receptor CB1 prevents leukocyte infiltration and experimental fibrosis. Arthritis Rheum. 62, 3467-3476. doi:10.1002/art.27642)
    • (2010) Arthritis Rheum , vol.62 , pp. 3467-3476
    • Marquart, S.1
  • 118
    • 40949116660 scopus 로고    scopus 로고
    • 2 receptor activation during cerebral ischemic/reperfusion injury
    • doi:10.1016/j.neuroscience.2008.01.022
    • Zhang, M., Martin, B. R., Adler, M.W., Razdan, R. K., Ganea, D. & Tuma, R. F. 2008 Modulation of the balance between cannabinoid CB1 and CB2 receptor activation during cerebral ischemic/reperfusion injury. Neuroscience 152, 753-760. doi:10.1016/j.neuroscience.2008.01.022)
    • (2008) Neuroscience , vol.152 , pp. 753-760
    • Zhang, M.1    Martin, B.R.2    Adler, M.W.3    Razdan, R.K.4    Ganea, D.5    Tuma, R.F.6
  • 119
    • 14344259844 scopus 로고    scopus 로고
    • 1 receptor antagonists as promising new medications for drug dependence
    • doi:10.1124/jpet.104.077974
    • Le Foll, B. & Goldberg, S. R. 2005 Cannabinoid CB1 receptor antagonists as promising new medications for drug dependence. J. Pharmacol. Exp. Ther. 312, 875-883. doi:10.1124/jpet.104.077974)
    • (2005) J. Pharmacol. Exp. Ther , vol.312 , pp. 875-883
    • Le Foll, B.1    Goldberg, S.R.2
  • 120
    • 77952645077 scopus 로고    scopus 로고
    • 9-tetrahydrocannabivarin can decrease signs of inflammation and inflammatory pain in mice
    • doi:10.1111/j.1476-5381.2010.00756.x
    • 9-tetrahydrocannabivarin can decrease signs of inflammation and inflammatory pain in mice. Br. J. Pharmacol. 160, 677-687. doi:10.1111/j.1476-5381.2010.00756.x)
    • (2010) Br. J. Pharmacol , vol.160 , pp. 677-687
    • Bolognini, D.1
  • 121
    • 38349158960 scopus 로고    scopus 로고
    • 9-tetrahydrocannabivarin
    • doi:10.1038/sj.bjp.0707442
    • 9-tetrahydrocannabivarin. Br. J. Pharmacol. 153, 199-215. doi:10.1038/sj.bjp.0707442)
    • (2008) Br. J. Pharmacol , vol.153 , pp. 199-215
    • Pertwee, R.G.1
  • 122
    • 2942596060 scopus 로고    scopus 로고
    • Cannabinoid agonistinduced sensitisation to morphine place preference in mice
    • doi:10.1097/01.wnr.000012621787116.8c
    • Manzanedo, C., Aguilar, M. A., Rodríguez-Arias, M., Navarro, M. & Miñarro, J. 2004 Cannabinoid agonistinduced sensitisation to morphine place preference in mice. Neuroreport 15, 1373-1377. doi:10.1097/01.wnr.000012621787116.8c)
    • (2004) Neuroreport , vol.15 , pp. 1373-1377
    • Manzanedo, C.1    Aguilar, M.A.2    Rodríguez-Arias, M.3    Navarro, M.4    Miñarro, J.5
  • 123
    • 33847008322 scopus 로고    scopus 로고
    • Adolescent cannabis exposure alters opiate intake and opioid limbic neuronal populations in adult rats
    • doi:10.1038/sj.npp.1301127
    • Ellgren, M., Spano, S. M. & Hurd, Y. L. 2007 Adolescent cannabis exposure alters opiate intake and opioid limbic neuronal populations in adult rats. Neuropsychopharmacology 32, 607-615. doi:10.1038/sj.npp.1301127)
    • (2007) Neuropsychopharmacology , vol.32 , pp. 607-615
    • Ellgren, M.1    Spano, S.M.2    Hurd, Y.L.3
  • 124
    • 0001823980 scopus 로고
    • In Vivo Interactions Between Psychotropic Cannabinoids and Other Drugs Involving Central and Peripheral Neurochemical Mediators
    • eds L. Murphy & A. Bartke, 1st edn. Boca Raton, FL: CRC Press
    • Pertwee, R. G. 1992 In vivo interactions between psychotropic cannabinoids and other drugs involving central and peripheral neurochemical mediators. In Marijuana/cannabinoids: neurobiology and neurophysiology (eds L. Murphy & A. Bartke), pp. 165-218, 1st edn. Boca Raton, FL: CRC Press.
    • (1992) Marijuana/cannabinoids: Neurobiology and Neurophysiology , pp. 165-218
    • Pertwee, R.G.1
  • 126
    • 84857919068 scopus 로고    scopus 로고
    • Repeated morphine treatment-mediated hyperalgesia, allodynia and spinal glial activation are blocked by co-administration of a selective cannabinoid receptor type-2 agonist
    • doi:10.1016/j.jneuroim.2011.12.021
    • Tumati, S., Largent-Milnes, T. M., Keresztes, A., Ren, J. Y., Roeske, W. R., Vanderah, T. W. & Varga, E. V. 2012 Repeated morphine treatment-mediated hyperalgesia, allodynia and spinal glial activation are blocked by co-administration of a selective cannabinoid receptor type-2 agonist. J. Neuroimmunol. 244, 23-31. doi:10.1016/j.jneuroim.2011.12.021)
    • (2012) J. Neuroimmunol , vol.244 , pp. 23-31
    • Tumati, S.1    Largent-Milnes, T.M.2    Keresztes, A.3    Ren, J.Y.4    Roeske, W.R.5    Vanderah, T.W.6    Varga, E.V.7
  • 127
    • 34147098441 scopus 로고    scopus 로고
    • Spinal cannabinoid receptor type 2 activation reduces hypersensitivity and spinal cord glial activation after paw incision
    • doi:10.1097/01.anes.0000264765.33673.6c
    • Romero-Sandoval, A. & Eisenach, J. C. 2007 Spinal cannabinoid receptor type 2 activation reduces hypersensitivity and spinal cord glial activation after paw incision. Anesthesiology 106, 787-794. doi:10.1097/01.anes.0000264765.33673.6c)
    • (2007) Anesthesiology , vol.106 , pp. 787-794
    • Romero-Sandoval, A.1    Eisenach, J.C.2
  • 128
    • 39749122600 scopus 로고    scopus 로고
    • 2 receptor in reducing mechanical allodynia in a mouse model of neuropathic pain
    • doi:10.1016/j.ejphar.2008.01.010
    • Yamamoto, W., Mikami, T. & Iwamura, H. 2008 Involvement of central cannabinoid CB2 receptor in reducing mechanical allodynia in a mouse model of neuropathic pain. Eur. J. Pharmacol. 583, 56-61. doi:10.1016/j.ejphar.2008.01.010)
    • (2008) Eur. J. Pharmacol , vol.583 , pp. 56-61
    • Yamamoto, W.1    Mikami, T.2    Iwamura, H.3
  • 129
    • 84859891803 scopus 로고    scopus 로고
    • 2R agonist, AM1710, controls pathological pain and restores basal cytokine levels
    • doi:10.1016/j.pain.2012.02.015
    • Wilkerson, J. L. et al. 2012 Intrathecal cannabilactone CB2R agonist, AM1710, controls pathological pain and restores basal cytokine levels. Pain 153, 1091-1106. doi:10.1016/j.pain.2012.02.015)
    • (2012) Pain , vol.153 , pp. 1091-1106
    • Wilkerson, J.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.